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Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

McKenzie MD, Ghisi M, Oxley EP, Ngo S, Cimmino L, Esnault C, Liu R, Salmon JM, Bell CC, Ahmed N, Erlichster M, Witkowski MT, Liu GJ, Chopin M, Dakic A, Simankowicz E, Pomilio G, Vu T, Krsmanovic P, Su S, Tian L, Baldwin TM, Zalcenstein DA, DiRago L, Wang S, Metcalf D, Johnstone RW, Croker BA, Lancaster GI, Murphy AJ, Naik SH, Nutt SL, Pospisil V, Schroeder T, Wall M, Dawson MA, Wei AH, de Thé H, Ritchie ME, Zuber J, Dickins RA.

Cell Stem Cell. 2019 Aug 1;25(2):258-272.e9. doi: 10.1016/j.stem.2019.07.001.


Contamination Risk During Fecal Management Device Removal: An In vitro, Simulated Clinical Use Study.

Metcalf DG, GTsai L, Williams C, Pritchard D, Parsons D, Bowler PG.

Wound Manag Prev. 2019 Mar;65(3):30-37.


Perceptions of Wound Biofilm by Wound Care Clinicians.

Metcalf D, Bowler PG.

Wounds. 2019 Mar;31(3):E14-E17.


Clinical and in vitro performance of an antibiofilm Hydrofiber wound dressing.

Scully R, Hurlow J, Walker M, Metcalf D, Parsons D, Bowler P.

J Wound Care. 2018 Sep 2;27(9):584-592. doi: 10.12968/jowc.2018.27.9.584.


Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC.

Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21.


Examining the epidemiology and microbiology of Clostridium difficile carriage in elderly patients and residents of a healthcare facility in southern Ontario, Canada.

Mallia G, Van Toen J, Rousseau J, Jacob L, Boerlin P, Greer A, Metcalf D, Weese JS.

J Hosp Infect. 2018 Aug;99(4):461-468. doi: 10.1016/j.jhin.2018.01.020. Epub 2018 Mar 7.


Quantitative and Qualitative Analysis of the Impact of Adoption of a Mobile Application for the Assessment of Professionalism in Medical Trainees.

Cendán JC, Castiglioni A, Johnson TR, Eakins M, Verduin ML, Asmar A, Metcalf D, Hernandez C.

Acad Med. 2017 Nov;92(11S Association of American Medical Colleges Learn Serve Lead: Proceedings of the 56th Annual Research in Medical Education Sessions):S33-S42. doi: 10.1097/ACM.0000000000001922.


Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a.

Jackson JT, Shields BJ, Shi W, Di Rago L, Metcalf D, Nicola NA, McCormack MP.

Stem Cells. 2017 Aug;35(8):1948-1957. doi: 10.1002/stem.2648. Epub 2017 Jun 19.


Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte-Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763-767.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, Dunn AR.

J Immunol. 2017 Apr 1;198(7):2522-2526. No abstract available.


Wearables and the Internet of Things for Health: Wearable, Interconnected Devices Promise More Efficient and Comprehensive Health Care.

Metcalf D, Milliard ST, Gomez M, Schwartz M.

IEEE Pulse. 2016 Sep-Oct;7(5):35-39. doi: 10.1109/MPUL.2016.2592260.


Enhanced Performance and Mode of Action of a Novel Antibiofilm Hydrofiber® Wound Dressing.

Parsons D, Meredith K, Rowlands VJ, Short D, Metcalf DG, Bowler PG.

Biomed Res Int. 2016;2016:7616471. Epub 2016 Nov 20.


MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.

Sheikh BN, Metcalf D, Voss AK, Thomas T.

Exp Hematol. 2017 Mar;47:83-97.e8. doi: 10.1016/j.exphem.2016.10.006. Epub 2016 Oct 24.


Growth and Differentiation Factors.

Metcalf D.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0004-2015. Review.


MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.

Sheikh BN, Yang Y, Schreuder J, Nilsson SK, Bilardi R, Carotta S, McRae HM, Metcalf D, Voss AK, Thomas T.

Blood. 2016 Nov 10;128(19):2307-2318. doi: 10.1182/blood-2015-10-676072. Epub 2016 Sep 23.


Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.

Ushiki T, Huntington ND, Glaser SP, Kiu H, Georgiou A, Zhang JG, Metcalf D, Nicola NA, Roberts AW, Alexander WS.

PLoS One. 2016 Sep 1;11(9):e0162111. doi: 10.1371/journal.pone.0162111. eCollection 2016.


Evaluating the Effectiveness of a Front Windshield Sticker Reminder in Reducing Texting while Driving in Young Adults.

Rohl A, Eriksson S, Metcalf D.

Cureus. 2016 Jul 14;8(7):e691. doi: 10.7759/cureus.691.


Management of diabetic foot ulcers: evaluation of case studies.

Torkington-Stokes R, Metcalf D, Bowler P.

Br J Nurs. 2016 Aug 11;25(15 Suppl):S27-33. doi: 10.12968/bjon.2016.25.15.S27.


A clinical algorithm for wound biofilm identification.

Metcalf DG, Bowler PG, Hurlow J.

Acta Med Croatica. 2016 Mar;70(1):73-9.



Metcalf D, Parsons D, Bowler IP.

Acta Med Croatica. 2016 Mar;70(1):49-56.


Clinical safety and effectiveness evaluation of a new antimicrobial wound dressing designed to manage exudate, infection and biofilm.

Metcalf DG, Parsons D, Bowler PG.

Int Wound J. 2017 Feb;14(1):203-213. doi: 10.1111/iwj.12590. Epub 2016 Mar 22.


A next-generation antimicrobial wound dressing: a real-life clinical evaluation in the UK and Ireland.

Metcalf D, Parsons D, Bowler P.

J Wound Care. 2016 Mar;25(3):132, 134-8. doi: 10.12968/jowc.2016.25.3.132. Erratum in: J Wound Care. 2018 Apr 2;27(4):253. J Wound Care. 2018 Apr 2;27(4):253.


"It may not be sensible to fill the vacancies with non-EU labour".

Metcalf D.

Nurs Times. 2015 Dec 16;111(51-52):7. No abstract available.


Super-resolution microscopy as a potential approach to diagnosis of platelet granule disorders.

Westmoreland D, Shaw M, Grimes W, Metcalf DJ, Burden JJ, Gomez K, Knight AE, Cutler DF.

J Thromb Haemost. 2016 Apr;14(4):839-49. doi: 10.1111/jth.13269. Epub 2016 Mar 17.


Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration.

Okeke E, Parker T, Dingsdale H, Concannon M, Awais M, Voronina S, Molgó J, Begg M, Metcalf D, Knight AE, Sutton R, Haynes L, Tepikin AV.

Biochem J. 2016 Mar 15;473(6):757-67. doi: 10.1042/BJ20150364. Epub 2016 Jan 12.


Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Shields BJ, Jackson JT, Metcalf D, Shi W, Huang Q, Garnham AL, Glaser SP, Beck D, Pimanda JE, Bogue CW, Smyth GK, Alexander WS, McCormack MP.

Genes Dev. 2016 Jan 1;30(1):78-91. doi: 10.1101/gad.268425.115.


IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.


Intraguild predation leads to genetically based character shifts in the threespine stickleback.

Miller SE, Metcalf D, Schluter D.

Evolution. 2015 Dec;69(12):3194-203. doi: 10.1111/evo.12811. Epub 2015 Nov 23.


Enzyme-responsive polymers for microbial infection detection.

Schiffer D, Tegl G, Heinzle A, Sigl E, Metcalf D, Bowler P, Burnet M, Guebitz GM.

Expert Rev Mol Diagn. 2015;15(9):1125-31. doi: 10.1586/14737159.2015.1061935. Epub 2015 Jul 16. Review.


Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.

Lee SC, Miller S, Hyland C, Kauppi M, Lebois M, Di Rago L, Metcalf D, Kinkel SA, Josefsson EC, Blewitt ME, Majewski IJ, Alexander WS.

Blood. 2015 Jul 9;126(2):167-75. doi: 10.1182/blood-2014-12-615898. Epub 2015 Jun 2.


Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL.

J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25.


Clinical Biofilms: A Challenging Frontier in Wound Care.

Hurlow J, Couch K, Laforet K, Bolton L, Metcalf D, Bowler P.

Adv Wound Care (New Rochelle). 2015 May 1;4(5):295-301. Review.


Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

Ng AP, Hu Y, Metcalf D, Hyland CD, Ierino H, Phipson B, Wu D, Baldwin TM, Kauppi M, Kiu H, Di Rago L, Hilton DJ, Smyth GK, Alexander WS.

PLoS Genet. 2015 May 14;11(5):e1005211. doi: 10.1371/journal.pgen.1005211. eCollection 2015 May.


Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. No abstract available.


Implementation of a worksite wellness program targeting small businesses: the Pinnacol Assurance health risk management study.

Newman LS, Stinson KE, Metcalf D, Fang H, Brockbank Cv, Jinnett K, Reynolds S, Trotter M, Witter R, Tenney L, Atherly A, Goetzel RZ.

J Occup Environ Med. 2015 Jan;57(1):14-21. doi: 10.1097/JOM.0000000000000279.


A real-life clinical evaluation of a next-generation antimicrobial dressing on acute and chronic wounds.

Walker M, Metcalf D, Parsons D, Bowler P.

J Wound Care. 2015 Jan;24(1):11-22. doi: 10.12968/jowc.2015.24.1.11.


Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT.

Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036.


Clinician perceptions of wound biofilm.

Metcalf DG, Bowler PG.

Int Wound J. 2016 Oct;13(5):717-25. doi: 10.1111/iwj.12358. Epub 2014 Sep 8.


Flat clathrin lattices: stable features of the plasma membrane.

Grove J, Metcalf DJ, Knight AE, Wavre-Shapton ST, Sun T, Protonotarios ED, Griffin LD, Lippincott-Schwartz J, Marsh M.

Mol Biol Cell. 2014 Nov 5;25(22):3581-94. doi: 10.1091/mbc.E14-06-1154. Epub 2014 Aug 27.


Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor.

Sathe P, Metcalf D, Vremec D, Naik SH, Langdon WY, Huntington ND, Wu L, Shortman K.

Immunity. 2014 Jul 17;41(1):104-15. doi: 10.1016/j.immuni.2014.05.020.


A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Wang H, Yan M, Sun J, Jain S, Yoshimi R, Abolfath SM, Ozato K, Coleman WG Jr, Ng AP, Metcalf D, DiRago L, Nutt SL, Morse HC 3rd.

J Immunol. 2014 Aug 15;193(4):1766-77. doi: 10.4049/jimmunol.1301939. Epub 2014 Jul 14. Erratum in: J Immunol. 2014 Nov 1;193(9):4749.


The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods.

Oates A, Bowling FL, Boulton AJ, Bowler PG, Metcalf DG, McBain AJ.

J Diabetes Res. 2014;2014:153586. doi: 10.1155/2014/153586. Epub 2014 Apr 15.


RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.


Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE.

PLoS Pathog. 2014 May 8;10(5):e1004134. doi: 10.1371/journal.ppat.1004134. eCollection 2014 May.


A two-tier Golgi-based control of organelle size underpins the functional plasticity of endothelial cells.

Ferraro F, Kriston-Vizi J, Metcalf DJ, Martin-Martin B, Freeman J, Burden JJ, Westmoreland D, Dyer CE, Knight AE, Ketteler R, Cutler DF.

Dev Cell. 2014 May 12;29(3):292-304. doi: 10.1016/j.devcel.2014.03.021. Epub 2014 May 1.


Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.

Ng AP, Kauppi M, Metcalf D, Hyland CD, Josefsson EC, Lebois M, Zhang JG, Baldwin TM, Di Rago L, Hilton DJ, Alexander WS.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5884-9. doi: 10.1073/pnas.1404354111. Epub 2014 Apr 7.


TestSTORM: Simulator for optimizing sample labeling and image acquisition in localization based super-resolution microscopy.

Sinkó J, Kákonyi R, Rees E, Metcalf D, Knight AE, Kaminski CF, Szabó G, Erdélyi M.

Biomed Opt Express. 2014 Feb 18;5(3):778-87. doi: 10.1364/BOE.5.000778. eCollection 2014 Mar 1.


A clinical algorithm for wound biofilm identification.

Metcalf DG, Bowler PG, Hurlow J.

J Wound Care. 2014 Mar;23(3):137-8, 140-2.


Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Josefsson EC, Burnett DL, Lebois M, Debrincat MA, White MJ, Henley KJ, Lane RM, Moujalled D, Preston SP, O'Reilly LA, Pellegrini M, Metcalf D, Strasser A, Kile BT.

Nat Commun. 2014 Mar 17;5:3455. doi: 10.1038/ncomms4455.


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