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Stable Immobilization of Enzymes in a Macro- and Mesoporous Silica Monolith.

Hou C, Ghéczy N, Messmer D, Szymańska K, Adamcik J, Mezzenga R, Jarzębski AB, Walde P.

ACS Omega. 2019 Apr 29;4(4):7795-7806. doi: 10.1021/acsomega.9b00286. eCollection 2019 Apr 30.


Main-chain scission of individual macromolecules induced by solvent swelling.

Messmer D, Bertran O, Kissner R, Alemán C, Schlüter AD.

Chem Sci. 2019 May 8;10(24):6125-6139. doi: 10.1039/c9sc01639b. eCollection 2019 Jun 28.


Can one determine the density of an individual synthetic macromolecule?

Messmer D, Sánchez-Ferrer A, Tacke S, Yu H, Nüsse H, Klingauf J, Wepf R, Kröger M, Halperin A, Mezzenga R, Schlüter AD.

Soft Matter. 2019 Aug 28;15(32):6547-6556. doi: 10.1039/c9sm01220f. Epub 2019 Jul 30.


Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires.

Anantharaman SB, Messmer D, Sadeghpour A, Salentinig S, Nüesch F, Heier J.

Nanoscale. 2019 Apr 4;11(14):6929-6938. doi: 10.1039/c8nr10357g.


3D Conformations of Thick Synthetic Polymer Chains Observed by Cryogenic Electron Microscopy.

Messmer D, Böttcher C, Yu H, Halperin A, Binder K, Kröger M, Schlüter AD.

ACS Nano. 2019 Mar 26;13(3):3466-3473. doi: 10.1021/acsnano.8b09621. Epub 2019 Mar 8.


Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

Jacintho JD, Baccei CS, Bravo Y, Broadhead A, Chen A, Correa L, Fischer K, Laffitte B, Lee C, Lorrain DS, Messmer D, Prasit P, Stebbins KJ, Stock NS.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):503-508. doi: 10.1016/j.bmcl.2018.12.045. Epub 2018 Dec 21.


Dual, Site-Specific Modification of Antibodies by Using Solid-Phase Immobilized Microbial Transglutaminase.

Spycher PR, Amann CA, Wehrmüller JE, Hurwitz DR, Kreis O, Messmer D, Ritler A, Küchler A, Blanc A, Béhé M, Walde P, Schibli R.

Chembiochem. 2017 Oct 5;18(19):1923-1927. doi: 10.1002/cbic.201700188. Epub 2017 Aug 29.


In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.

Stebbins KJ, Broadhead AR, Cabrera G, Correa LD, Messmer D, Bundey R, Baccei C, Bravo Y, Chen A, Stock NS, Prasit P, Lorrain DS.

Eur J Pharmacol. 2017 Aug 15;809:130-140. doi: 10.1016/j.ejphar.2017.05.008. Epub 2017 May 5.


Preparation and Applications of Dendronized Polymer-Enzyme Conjugates.

Küchler A, Messmer D, Schlüter AD, Walde P.

Methods Enzymol. 2017;590:445-474. doi: 10.1016/bs.mie.2017.01.014. Epub 2017 Mar 17.


Exploring the Loading Capacity of Generation Six to Eight Dendronized Polymers in Aqueous Solution.

Maltar-Strmečki N, Yu H, Messmer D, Zhang B, Schlüter AD, Hinderberger D.

Chemphyschem. 2016 Sep 5;17(17):2767-72. doi: 10.1002/cphc.201600580. Epub 2016 Jul 6.


A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo.

Messmer D, Lorrain K, Stebbins K, Bravo Y, Stock N, Cabrera G, Correa L, Chen A, Jacintho J, Chiorazzi N, Yan XJ, Spaner D, Prasit P, Lorrain D.

Mol Med. 2015 Jun 9;21:410-9. doi: 10.2119/molmed.2015.00139.


Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.

Campbell DF, Saenz R, Bharati IS, Seible D, Zhang L, Esener S, Messmer B, Larsson M, Messmer D.

Breast Cancer Res. 2015 Mar 31;17:48. doi: 10.1186/s13058-015-0552-9.


TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant.

Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D.

J Transl Med. 2014 Aug 14;12:211. doi: 10.1186/1479-5876-12-211.


Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53.

Fecteau JF, Corral LG, Ghia EM, Gaidarova S, Futalan D, Bharati IS, Cathers B, Schwaederlé M, Cui B, Lopez-Girona A, Messmer D, Kipps TJ.

Blood. 2014 Sep 4;124(10):1637-44. doi: 10.1182/blood-2014-03-559591. Epub 2014 Jul 2.


Identification of the first potent, selective and bioavailable PPARα antagonist.

Bravo Y, Baccei CS, Broadhead A, Bundey R, Chen A, Clark R, Correa L, Jacintho JD, Lorrain DS, Messmer D, Stebbins K, Prasit P, Stock N.

Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. doi: 10.1016/j.bmcl.2014.03.090. Epub 2014 Apr 4.


Activity of the HMGB1-derived immunostimulatory peptide Hp91 resides in the helical C-terminal portion and is enhanced by dimerization.

Saenz R, Messmer B, Futalan D, Tor Y, Larsson M, Daniels G, Esener S, Messmer D.

Mol Immunol. 2014 Feb;57(2):191-9. doi: 10.1016/j.molimm.2013.09.007. Epub 2013 Oct 26.


IL-1α expression in pancreatic ductal adenocarcinoma affects the tumor cell migration and is regulated by the p38MAPK signaling pathway.

Tjomsland V, Bojmar L, Sandström P, Bratthäll C, Messmer D, Spångeus A, Larsson M.

PLoS One. 2013 Aug 12;8(8):e70874. doi: 10.1371/journal.pone.0070874. eCollection 2013.


Targeting cancer with a bi-functional peptide: in vitro and in vivo results.

Meschenmoser K, Kim Y, Franken S, Nowak M, Feldmann G, Bendas G, Wolfgarten M, Messmer D, Schmidt-Wolf IG.

In Vivo. 2013 Jul-Aug;27(4):431-42.


Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia.

Fecteau JF, Messmer D, Zhang S, Cui B, Chen L, Kipps TJ.

Blood. 2013 Feb 7;121(6):971-4. doi: 10.1182/blood-2012-08-447813. Epub 2012 Dec 18.


p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells.

Che KF, Shankar EM, Muthu S, Zandi S, Sigvardsson M, Hinkula J, Messmer D, Larsson M.

Mol Med. 2012 Oct 24;18:1169-82. doi: 10.2119/molmed.2012.00103.


Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL).

O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM.

Leukemia. 2012 Jul;26(7):1689-92. doi: 10.1038/leu.2012.6. Epub 2012 Jan 12. No abstract available.


The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma.

Tjomsland V, Niklasson L, Sandström P, Borch K, Druid H, Bratthäll C, Messmer D, Larsson M, Spångeus A.

Clin Dev Immunol. 2011;2011:212810. doi: 10.1155/2011/212810. Epub 2011 Dec 6.


Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).

Fecteau JF, Bharati IS, O'Hayre M, Handel TM, Kipps TJ, Messmer D.

Mol Med. 2012 Feb 10;18:19-28. doi: 10.2119/molmed.2011.00164.


Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts.

Tjomsland V, Spångeus A, Välilä J, Sandström P, Borch K, Druid H, Falkmer S, Falkmer U, Messmer D, Larsson M.

Neoplasia. 2011 Aug;13(8):664-75.


Comparative healing of human cutaneous surgical incisions created by the PEAK PlasmaBlade, conventional electrosurgery, and a standard scalpel.

Ruidiaz ME, Messmer D, Atmodjo DY, Vose JG, Huang EJ, Kummel AC, Rosenberg HL, Gurtner GC.

Plast Reconstr Surg. 2011 Jul;128(1):104-11. doi: 10.1097/PRS.0b013e31821741ed.


Effect of oxygen levels on the physiology of dendritic cells: implications for adoptive cell therapy.

Futalan D, Huang CT, Schmidt-Wolf IG, Larsson M, Messmer D.

Mol Med. 2011 Sep-Oct;17(9-10):910-6. doi: 10.2119/molmed.2011.00031. Epub 2011 Jun 1.


Quantitative automated image analysis system with automated debris filtering for the detection of breast carcinoma cells.

Martin DT, Sandoval S, Ta CN, Ruidiaz ME, Cortes-Mateos MJ, Messmer D, Kummel AC, Blair SL, Wang-Rodriguez J.

Acta Cytol. 2011;55(3):271-80. doi: 10.1159/000324029. Epub 2011 Apr 27.


Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy.

Ma W, Smith T, Bogin V, Zhang Y, Ozkan C, Ozkan M, Hayden M, Schroter S, Carrier E, Messmer D, Kumar V, Minev B.

J Transl Med. 2011 Mar 31;9:34. doi: 10.1186/1479-5876-9-34.


Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells.

Shankar EM, Che KF, Messmer D, Lifson JD, Larsson M.

Mol Med. 2011 Mar-Apr;17(3-4):229-40. doi: 10.2119/molmed.2010.00175. Epub 2010 Nov 17.


Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib.

Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel TM, Kipps TJ.

Blood. 2011 Jan 20;117(3):882-9. doi: 10.1182/blood-2010-04-282400. Epub 2010 Nov 15.


Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor.

Tjomsland V, Spångeus A, Sandström P, Borch K, Messmer D, Larsson M.

PLoS One. 2010 Oct 15;5(10):e13441. doi: 10.1371/journal.pone.0013441.


HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen.

Saenz R, Souza Cda S, Huang CT, Larsson M, Esener S, Messmer D.

Vaccine. 2010 Nov 3;28(47):7556-62. doi: 10.1016/j.vaccine.2010.08.054. Epub 2010 Aug 25.


Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis.

O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM.

PLoS One. 2010 Jul 22;5(7):e11716. doi: 10.1371/journal.pone.0011716.


HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells.

Che KF, Sabado RL, Shankar EM, Tjomsland V, Messmer D, Bhardwaj N, Lifson JD, Larsson M.

Eur J Immunol. 2010 Aug;40(8):2248-58. doi: 10.1002/eji.201040377.


Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC).

Hontscha C, Borck Y, Zhou H, Messmer D, Schmidt-Wolf IG.

J Cancer Res Clin Oncol. 2011 Feb;137(2):305-10. doi: 10.1007/s00432-010-0887-7. Epub 2010 Apr 21.


Delivery of a peptide via poly(D,L-lactic-co-glycolic) acid nanoparticles enhances its dendritic cell-stimulatory capacity.

Clawson C, Huang CT, Futalan D, Seible DM, Saenz R, Larsson M, Ma W, Minev B, Zhang F, Ozkan M, Ozkan C, Esener S, Messmer D.

Nanomedicine. 2010 Oct;6(5):651-61. doi: 10.1016/j.nano.2010.03.001. Epub 2010 Mar 27.


Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

Tjomsland V, Sandström P, Spångeus A, Messmer D, Emilsson J, Falkmer U, Falkmer S, Magnusson KE, Borch K, Larsson M.

BMC Cancer. 2010 Mar 9;10:87. doi: 10.1186/1471-2407-10-87.


DeNAno: Selectable deoxyribonucleic acid nanoparticle libraries.

Steiner JM, Sartor M, Sanchez AB, Messmer D, Freed A, Esener S, Messmer BT.

J Biotechnol. 2010 Feb 15;145(4):330-3. doi: 10.1016/j.jbiotec.2009.12.002. Epub 2009 Dec 4.


Enhanced inhibition of tumor growth with depletion of CD25 regulatory cells and intratumoral immunization with tumor RNA-pulsed dendritic cells in a C57BL/6 pancreatic tumor model.

Linke A, Brossart P, Schmidt-Wolf IG, Gonzalez-Carmona MA, Ziske C, Messmer D, Schmitz V, Sauerbruch T.

Pancreas. 2009 Jul;38(5):602-4. doi: 10.1097/MPA.0b013e3181a11bde. No abstract available.


Increase of in vivo antitumoral activity by CD40L (CD154) gene transfer into pancreatic tumor cell-dendritic cell hybrids.

Ziske C, Etzrodt PE, Eliu AS, Gorschlüter M, Strehl J, Flieger D, Messmer D, Schmitz V, Gonzalez-Carmona MA, Sievers E, Brossart P, Sauerbruch T, Schmidt-Wolf IG.

Pancreas. 2009 Oct;38(7):758-65. doi: 10.1097/MPA.0b013e3181ae5e1a.


Automated microscopy to evaluate surgical specimens via touch prep in breast cancer.

Cortes-Mateos MJ, Martin D, Sandoval S, Ruidiaz ME, Messmer D, Wang-Rodriguez J, Trogler W, Kummel AC, Blair SL.

Ann Surg Oncol. 2009 Mar;16(3):709-20. doi: 10.1245/s10434-008-0274-7. Epub 2009 Jan 10.


Enhanced touch preps improve the ease of interpretation of intraoperative breast cancer margins.

Blair SL, Wang-Rodriguez J, Cortes-Mateos MJ, Messmer D, Sandoval S, Messmer B, Trogler W, Kummel A.

Am Surg. 2007 Oct;73(10):973-6.


Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation.

Messmer D, Hatsukari I, Hitosugi N, Schmidt-Wolf IG, Singhal PC.

Mol Med. 2006 Nov-Dec;12(11-12):284-90.


DEC-205-mediated internalization of HIV-1 results in the establishment of silent infection in renal tubular cells.

Hatsukari I, Singh P, Hitosugi N, Messmer D, Valderrama E, Teichberg S, Chaung W, Gross E, Schmidtmayerova H, Singhal PC.

J Am Soc Nephrol. 2007 Mar;18(3):780-7. Epub 2007 Feb 7.


Dendritic cell activating peptides induce distinct cytokine profiles.

Telusma G, Datta S, Mihajlov I, Ma W, Li J, Yang H, Newman W, Messmer BT, Minev B, Schmidt-Wolf IG, Tracey KJ, Chiorazzi N, Messmer D.

Int Immunol. 2006 Nov;18(11):1563-73. Epub 2006 Sep 11.


Dendritic cells pulsed with alpha-galactosylceramide induce anti-tumor immunity against pancreatic cancer in vivo.

Nagaraj S, Ziske C, Strehl J, Messmer D, Sauerbruch T, Schmidt-Wolf IG.

Int Immunol. 2006 Aug;18(8):1279-83. Epub 2006 Jun 13.


High-mobility group box 1 (HMGB1) protein: friend and foe.

Ulloa L, Messmer D.

Cytokine Growth Factor Rev. 2006 Jun;17(3):189-201. Epub 2006 Mar 2. Review.


CD154 gene therapy for human B-cell malignancies.

Messmer D, Kipps TJ.

Ann N Y Acad Sci. 2005 Dec;1062:51-60. Review.


Treatment of solid tumors with immunotoxins.

Messmer D, Kipps TJ.

Breast Cancer Res. 2005;7(5):184-6. Epub 2005 Jul 12.


ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ.

J Biol Chem. 2005 Nov 4;280(44):36541-4. Epub 2005 Aug 22.

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