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Items: 1 to 50 of 149


Abstinence-dependent dissociable central amygdala microcircuits control drug craving.

Venniro M, Russell TI, Ramsey LA, Richie CT, Lesscher HMB, Giovanetti SM, Messing RO, Shaham Y.

Proc Natl Acad Sci U S A. 2020 Mar 23. pii: 202001615. doi: 10.1073/pnas.2001615117. [Epub ahead of print]


Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4.

Maiya R, Pomrenze MB, Tran T, Tiwari GR, Beckham A, Paul MT, Dayne Mayfield R, Messing RO.

Mol Psychiatry. 2020 Mar 6. doi: 10.1038/s41380-020-0706-8. [Epub ahead of print]


A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder.

Ferguson LB, Patil S, Moskowitz BA, Ponomarev I, Harris RA, Mayfield RD, Messing RO.

Brain Sci. 2019 Dec 16;9(12). pii: E381. doi: 10.3390/brainsci9120381.


Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning.

Pomrenze MB, Giovanetti SM, Maiya R, Gordon AG, Kreeger LJ, Messing RO.

Cell Rep. 2019 Oct 1;29(1):13-21.e4. doi: 10.1016/j.celrep.2019.08.083.


Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption.

Wang J, Blasio A, Chapman HL, Doebelin C, Liaw V, Kuryatov A, Giovanetti SM, Lindstrom J, Lin L, Cameron MD, Kamenecka TM, Pomrenze MB, Messing RO.

Neuropsychopharmacology. 2020 Jan;45(2):301-308. doi: 10.1038/s41386-019-0475-8. Epub 2019 Aug 8.


Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O.

Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0.


Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:55-65. doi: 10.1016/j.bbi.2018.12.004. Epub 2018 Dec 11.


Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:66-76. doi: 10.1016/j.bbi.2018.12.006. Epub 2018 Dec 11.


A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety.

Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K, Morikawa H, Hopf FW, Messing RO.

J Neurosci. 2019 Feb 6;39(6):1030-1043. doi: 10.1523/JNEUROSCI.2143-18.2018. Epub 2018 Dec 10.


Killing the Buζζ: accumbal PKMζ blunts cocaine seeking and reward.

Maiya R, Messing RO.

Neuropsychopharmacology. 2019 Feb;44(3):463-464. doi: 10.1038/s41386-018-0263-x. Epub 2018 Nov 18. No abstract available.


Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.

Blednov YA, Da Costa AJ, Tarbox T, Ponomareva O, Messing RO, Harris RA.

Alcohol Clin Exp Res. 2018 May;42(5):926-938. doi: 10.1111/acer.13616. Epub 2018 Mar 24.


Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance.

Blednov YA, Da Costa AJ, Harris RA, Messing RO.

Alcohol Clin Exp Res. 2018 May;42(5):939-951. doi: 10.1111/acer.13615. Epub 2018 Mar 24.


Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice.

Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO.

Biol Psychiatry. 2018 Aug 1;84(3):193-201. doi: 10.1016/j.biopsych.2017.10.017. Epub 2017 Dec 2.


The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?

Pomrenze MB, Fetterly TL, Winder DG, Messing RO.

Alcohol Clin Exp Res. 2017 Dec;41(12):1986-1999. doi: 10.1111/acer.13507. Epub 2017 Oct 25. Review.


PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model.

He Y, Wilkie DJ, Nazari J, Wang R, Messing RO, DeSimone J, Molokie RE, Wang ZJ.

J Clin Invest. 2016 Aug 1;126(8):3053-7. doi: 10.1172/JCI86165. Epub 2016 Jun 27.


Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice.

Maiya R, McMahon T, Wang D, Kanter B, Gandhi D, Chapman HL, Miller J, Messing RO.

Neuropharmacology. 2016 Aug;107:40-48. doi: 10.1016/j.neuropharm.2016.02.036. Epub 2016 Mar 3.


Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?

Blasio A, Messing RO.

Biol Psychiatry. 2016 Mar 15;79(6):425-6. doi: 10.1016/j.biopsych.2015.12.013. No abstract available.


A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO.

Front Neurosci. 2015 Dec 24;9:487. doi: 10.3389/fnins.2015.00487. eCollection 2015.


A Selective Role for Lmo4 in Cue-Reward Learning.

Maiya R, Mangieri RA, Morrisett RA, Heberlein U, Messing RO.

J Neurosci. 2015 Jul 1;35(26):9638-47. doi: 10.1523/JNEUROSCI.1740-15.2015.


PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization.

Lee AM, Wu DF, Dadgar J, Wang D, McMahon T, Messing RO.

Br J Pharmacol. 2015 Sep;172(17):4430-41. doi: 10.1111/bph.13228. Epub 2015 Jul 26.


Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils.

Weng YC, Wang G, Messing RO, Chou WH.

J Biomed Sci. 2015 Mar 20;22:21. doi: 10.1186/s12929-015-0129-z.


D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats.

Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW.

Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24.


Generation and characterization of ATP analog-specific protein kinase Cδ.

Kumar V, Weng YC, Geldenhuys WJ, Wang D, Han X, Messing RO, Chou WH.

J Biol Chem. 2015 Jan 23;290(4):1936-51. doi: 10.1074/jbc.M114.598698. Epub 2014 Dec 10.


Peripheral systems: neuropathy.

Maiya RP, Messing RO.

Handb Clin Neurol. 2014;125:513-25. doi: 10.1016/B978-0-444-62619-6.00029-X. Review.


Alcohol dependence: molecular and behavioral evidence.

Trudell JR, Messing RO, Mayfield J, Harris RA.

Trends Pharmacol Sci. 2014 Jul;35(7):317-23. doi: 10.1016/ Epub 2014 May 25. Review.


Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.

Schuster DJ, Metcalf MD, Kitto KF, Messing RO, Fairbanks CA, Wilcox GL.

Br J Pharmacol. 2015 Jan;172(2):642-53. doi: 10.1111/bph.12774. Epub 2014 Nov 24.


Quo vadis? Peering into the future.

Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR.

Ann Neurol. 2013 Dec;74(6):A5-7. doi: 10.1002/ana.24091. No abstract available.


Have the Annals editors added value?

Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL.

Ann Neurol. 2013 Nov;74(5):A7-9. doi: 10.1002/ana.24077. No abstract available.


Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs.

Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL.

J Neurosci. 2013 Aug 14;33(33):13538-46. doi: 10.1523/JNEUROSCI.4013-12.2013.


Deletion of Prkcz increases intermittent ethanol consumption in mice.

Lee AM, Zou ME, Lim JP, Stecher J, McMahon T, Messing RO.

Alcohol Clin Exp Res. 2014 Jan;38(1):170-8. doi: 10.1111/acer.12211. Epub 2013 Aug 1.


Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW.

Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30.


Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area.

Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A.

Alcohol Clin Exp Res. 2013 Oct;37(10):1680-7. doi: 10.1111/acer.12153. Epub 2013 Jun 13.


Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*.

Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW.

Biophys J. 2012 Dec 5;103(11):2331-40. doi: 10.1016/j.bpj.2012.10.034.


Prkcz null mice show normal learning and memory.

Lee AM, Kanter BR, Wang D, Lim JP, Zou ME, Qiu C, McMahon T, Dadgar J, Fischbach-Weiss SC, Messing RO.

Nature. 2013 Jan 17;493(7432):416-9. doi: 10.1038/nature11803. Epub 2013 Jan 2.


SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans.

Jee C, Lee J, Lim JP, Parry D, Messing RO, McIntire SL.

Genes Brain Behav. 2013 Mar;12(2):250-62. doi: 10.1111/j.1601-183X.2012.00829.x. Epub 2012 Sep 4.


Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

Lim JP, Zou ME, Janak PH, Messing RO.

Brain Behav. 2012 Jan;2(1):22-31. doi: 10.1002/brb3.29.


PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.

Wu DF, Chandra D, McMahon T, Wang D, Dadgar J, Kharazia VN, Liang YJ, Waxman SG, Dib-Hajj SD, Messing RO.

J Clin Invest. 2012 Apr;122(4):1306-15. doi: 10.1172/JCI61934. Epub 2012 Mar 19.


The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers.

Mitchell JM, Grossman LE, Coker AR, Messing RO.

J Clin Psychopharmacol. 2012 Apr;32(2):269-72. doi: 10.1097/JCP.0b013e318248ba69.


Fighting decision fatigue.

Stewart AF, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR, Johnston SC, Hauser SL.

Ann Neurol. 2012 Jan;71(1):A5-A15. doi: 10.1002/ana.23531. No abstract available.


Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens.

Lee AM, Messing RO.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16080-5. doi: 10.1073/pnas.1106277108. Epub 2011 Sep 12.


Signaling pathways mediating alcohol effects.

Ron D, Messing RO.

Curr Top Behav Neurosci. 2013;13:87-126. doi: 10.1007/7854_2011_161. Review.


Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.

Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z.

J Clin Invest. 2011 Jul;121(7):2709-22. doi: 10.1172/JCI45586.


How Should Addiction-Related Research at the National Institutes of Health be Reorganized?

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD.

Front Psychiatry. 2011 May 3;2:2. doi: 10.3389/fpsyt.2011.00002. eCollection 2011. No abstract available.


Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details.

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD.

Alcohol Clin Exp Res. 2011 Apr;35(4):572-80. doi: 10.1111/j.1530-0277.2011.01493.x.


Mouse model of middle cerebral artery occlusion.

Chiang T, Messing RO, Chou WH.

J Vis Exp. 2011 Feb 13;(48). pii: 2761. doi: 10.3791/2761.


GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor.

Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO.

J Neurosci. 2010 Oct 20;30(42):13955-65. doi: 10.1523/JNEUROSCI.0270-10.2010.


PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.

Li X, Pabla N, Wei Q, Dong G, Messing RO, Wang CY, Dong Z.

J Am Soc Nephrol. 2010 Jul;21(7):1115-24. doi: 10.1681/ASN.2009070760. Epub 2010 Apr 15.


The substrates and binding partners of protein kinase Cepsilon.

Newton PM, Messing RO.

Biochem J. 2010 Mar 29;427(2):189-96. doi: 10.1042/BJ20091302. Review.


Status report: the Annals in 2010.

Hauser SL, Johnston SC, Ferriero DM, Lowenstein DH, Josephson SA, Messing RO, Oksenberg JR, Stewart AF.

Ann Neurol. 2010 Jan;67(1):A5-12. doi: 10.1002/ana.21970. No abstract available.


Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL.

Alcohol. 2009 Nov;43(7):509-19. doi: 10.1016/j.alcohol.2009.01.002. Review.

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