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Items: 1 to 50 of 118

1.

Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells.

Theobald SJ, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, Gerasch L, Schneider A, Sinzger C, Schaudien D, Lienenklaus S, Riese P, Guzman CA, Figueiredo C, von Kaisenberg C, Spineli LM, Glaesener S, Meyer-Bahlburg A, Ganser A, Schmitt M, Mach M, Messerle M, Stripecke R.

Front Immunol. 2018 Nov 22;9:2734. doi: 10.3389/fimmu.2018.02734. eCollection 2018.

2.

Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis.

Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T.

Sci Rep. 2018 Oct 4;8(1):14823. doi: 10.1038/s41598-018-33167-7.

3.

Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells.

Lueder Y, Heller K, Ritter C, Keyser KA, Wagner K, Liu X, Messerle M, Stahl FR, Halle S, Förster R.

PLoS Pathog. 2018 Aug 28;14(8):e1007252. doi: 10.1371/journal.ppat.1007252. eCollection 2018 Aug.

4.

Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B.

Chéneau C, Coulon F, Porkolab V, Fieschi F, Laurant S, Razanajaona-Doll D, Pin JJ, Borst EM, Messerle M, Bressollette-Bodin C, Halary F.

J Infect Dis. 2018 Jul 2;218(3):490-503. doi: 10.1093/infdis/jiy194.

5.

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.

Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C.

Nat Immunol. 2018 May;19(5):453-463. doi: 10.1038/s41590-018-0082-6. Epub 2018 Apr 9.

PMID:
29632329
6.

A Prominent Role of the Human Cytomegalovirus UL8 Glycoprotein in Restraining Proinflammatory Cytokine Production by Myeloid Cells at Late Times during Infection.

Pérez-Carmona N, Martínez-Vicente P, Farré D, Gabaev I, Messerle M, Engel P, Angulo A.

J Virol. 2018 Apr 13;92(9). pii: e02229-17. doi: 10.1128/JVI.02229-17. Print 2018 May 1.

7.

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Früh K, Edlefsen PT, Picker LJ.

Nat Med. 2018 Feb;24(2):130-143. doi: 10.1038/nm.4473. Epub 2018 Jan 15.

8.

The C-terminal part of the human cytomegalovirus terminase subunit pUL51 is central for terminase complex assembly.

Neuber S, Wagner K, Messerle M, Borst EM.

J Gen Virol. 2018 Jan;99(1):119-134. doi: 10.1099/jgv.0.000984. Epub 2017 Dec 5.

PMID:
29205134
9.

The M25 gene products are critical for the cytopathic effect of mouse cytomegalovirus.

Kutle I, Sengstake S, Templin C, Glaß M, Kubsch T, Keyser KA, Binz A, Bauerfeind R, Sodeik B, Čičin-Šain L, Dezeljin M, Messerle M.

Sci Rep. 2017 Nov 14;7(1):15588. doi: 10.1038/s41598-017-15783-x.

10.

Myeloid Dendritic Cells Repress Human Cytomegalovirus Gene Expression and Spread by Releasing Interferon-Unrelated Soluble Antiviral Factors.

Kasmapour B, Kubsch T, Rand U, Eiz-Vesper B, Messerle M, Vondran FWR, Wiegmann B, Haverich A, Cicin-Sain L.

J Virol. 2017 Dec 14;92(1). pii: e01138-17. doi: 10.1128/JVI.01138-17. Print 2018 Jan 1.

11.

Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20.

Charpak-Amikam Y, Kubsch T, Seidel E, Oiknine-Djian E, Cavaletto N, Yamin R, Schmiedel D, Wolf D, Gribaudo G, Messerle M, Cicin-Sain L, Mandelboim O.

Sci Rep. 2017 Aug 17;7(1):8661. doi: 10.1038/s41598-017-08866-2.

12.

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U.

Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063.

13.

Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.

Tršan T, Vuković K, Filipović P, Brizić AL, Lemmermann NAW, Schober K, Busch DH, Britt WJ, Messerle M, Krmpotić A, Jonjić S.

Eur J Immunol. 2017 Aug;47(8):1354-1367. doi: 10.1002/eji.201746964. Epub 2017 Jul 4.

14.

Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation.

Neuber S, Wagner K, Goldner T, Lischka P, Steinbrueck L, Messerle M, Borst EM.

J Virol. 2017 May 26;91(12). pii: e02384-16. doi: 10.1128/JVI.02384-16. Print 2017 Jun 15.

15.

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.

Thiel N, Keyser KA, Lemmermann NA, Oduro JD, Wagner K, Elsner C, Halenius A, Lenac Roviš T, Brinkmann MM, Jonjić S, Cicin-Sain L, Messerle M.

PLoS Pathog. 2016 Dec 7;12(12):e1006057. doi: 10.1371/journal.ppat.1006057. eCollection 2016 Dec.

16.

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.

Tomić A, Varanasi PR, Golemac M, Malić S, Riese P, Borst EM, Mischak-Weissinger E, Guzmán CA, Krmpotić A, Jonjić S, Messerle M.

PLoS Pathog. 2016 Dec 1;12(12):e1006015. doi: 10.1371/journal.ppat.1006015. eCollection 2016 Dec.

17.

Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.

Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, Tomic A, Kvestak D, Babic M, Tsukerman P, Colonna M, Koszinowski U, Messerle M, Mandelboim O, Krmpotic A, Jonjic S.

J Exp Med. 2016 Aug 22;213(9):1835-50. doi: 10.1084/jem.20151899. Epub 2016 Aug 8.

18.

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U.

PLoS Pathog. 2016 Apr 8;12(4):e1005546. doi: 10.1371/journal.ppat.1005546. eCollection 2016 Apr.

19.

The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome Encapsidation.

Borst EM, Bauerfeind R, Binz A, Stephan TM, Neuber S, Wagner K, Steinbrück L, Sodeik B, Lenac Roviš T, Jonjić S, Messerle M.

J Virol. 2016 Jun 10;90(13):5860-5875. doi: 10.1128/JVI.00384-16. Print 2016 Jul 1.

20.

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.

Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R.

Immunity. 2016 Feb 16;44(2):233-45. doi: 10.1016/j.immuni.2016.01.010. Epub 2016 Feb 9.

21.

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV.

Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R.

Mol Ther Methods Clin Dev. 2015 Jan 7;1:14060. doi: 10.1038/mtm.2014.60. eCollection 2015.

22.

Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.

Thiel N, Zischke J, Elbasani E, Kay-Fedorov P, Messerle M.

Viruses. 2015 Mar 23;7(3):1540-57. doi: 10.3390/v7031540. Review.

23.

Cytomegalovirus immune evasion of myeloid lineage cells.

Brinkmann MM, Dağ F, Hengel H, Messerle M, Kalinke U, Čičin-Šain L.

Med Microbiol Immunol. 2015 Jun;204(3):367-82. doi: 10.1007/s00430-015-0403-4. Epub 2015 Mar 17. Review.

PMID:
25776081
24.

Lack of XBP-1 impedes murine cytomegalovirus gene expression.

Drori A, Messerle M, Brune W, Tirosh B.

PLoS One. 2014 Oct 21;9(10):e110942. doi: 10.1371/journal.pone.0110942. eCollection 2014.

25.

Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells.

Gabaev I, Elbasani E, Ameres S, Steinbrück L, Stanton R, Döring M, Lenac Rovis T, Kalinke U, Jonjic S, Moosmann A, Messerle M.

J Virol. 2014 Dec;88(24):14326-39. doi: 10.1128/JVI.01691-14. Epub 2014 Oct 1.

26.

M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells.

Döring M, Lessin I, Frenz T, Spanier J, Kessler A, Tegtmeyer P, Dağ F, Thiel N, Trilling M, Lienenklaus S, Weiss S, Scheu S, Messerle M, Cicin-Sain L, Hengel H, Kalinke U.

J Virol. 2014 Dec;88(23):13638-50. doi: 10.1128/JVI.00216-14. Epub 2014 Sep 17.

27.

Mck2-dependent infection of alveolar macrophages promotes replication of MCMV in nodular inflammatory foci of the neonatal lung.

Stahl FR, Keyser KA, Heller K, Bischoff Y, Halle S, Wagner K, Messerle M, Förster R.

Mucosal Immunol. 2015 Jan;8(1):57-67. doi: 10.1038/mi.2014.42. Epub 2014 Jun 4.

PMID:
24894498
28.

Use of recombinant approaches to construct human cytomegalovirus mutants.

Dekhtiarenko I, Cičin-Šain L, Messerle M.

Methods Mol Biol. 2014;1119:59-79. doi: 10.1007/978-1-62703-788-4_5.

PMID:
24639218
29.

Cytomegalovirus m154 hinders CD48 cell-surface expression and promotes viral escape from host natural killer cell control.

Zarama A, Pérez-Carmona N, Farré D, Tomic A, Borst EM, Messerle M, Jonjic S, Engel P, Angulo A.

PLoS Pathog. 2014 Mar 13;10(3):e1004000. doi: 10.1371/journal.ppat.1004000. eCollection 2014 Mar. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004121.

30.

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.

Dağ F, Dölken L, Holzki J, Drabig A, Weingärtner A, Schwerk J, Lienenklaus S, Conte I, Geffers R, Davenport C, Rand U, Köster M, Weiß S, Adler B, Wirth D, Messerle M, Hauser H, Cičin-Šain L.

PLoS Pathog. 2014 Feb 20;10(2):e1003962. doi: 10.1371/journal.ppat.1003962. eCollection 2014 Feb.

31.

Analysis of essential viral gene functions after highly efficient adenofection of cells with cloned human cytomegalovirus genomes.

Elbasani E, Gabaev I, Steinbrück L, Messerle M, Borst EM.

Viruses. 2014 Jan 23;6(1):354-70. doi: 10.3390/v6010354.

32.

Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.

Stahl FR, Heller K, Halle S, Keyser KA, Busche A, Marquardt A, Wagner K, Boelter J, Bischoff Y, Kremmer E, Arens R, Messerle M, Förster R.

PLoS Pathog. 2013;9(12):e1003828. doi: 10.1371/journal.ppat.1003828. Epub 2013 Dec 12.

33.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T.

PLoS Pathog. 2013;9(9):e1003648. doi: 10.1371/journal.ppat.1003648. Epub 2013 Sep 26.

34.

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.

Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, Babic M, Tomic A, Golemac M, Brinkmann MM, Jäger W, Oxenius A, Polic B, Krmpotic A, Messerle M, Jonjic S.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16550-5. doi: 10.1073/pnas.1310215110. Epub 2013 Sep 19.

35.

A peptide inhibitor of cytomegalovirus infection from human hemofiltrate.

Borst EM, Ständker L, Wagner K, Schulz TF, Forssmann WG, Messerle M.

Antimicrob Agents Chemother. 2013 Oct;57(10):4751-60. doi: 10.1128/AAC.00854-13. Epub 2013 Jul 15.

36.

Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model.

Hantz S, Cotin S, Borst E, Couvreux A, Salmier A, Garrigue I, Merville P, Mengelle C, Attal M, Messerle M, Alain S.

Antiviral Res. 2013 Apr;98(1):130-4. doi: 10.1016/j.antiviral.2013.02.002. Epub 2013 Feb 13.

PMID:
23415883
37.

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

Busche A, Jirmo AC, Welten SP, Zischke J, Noack J, Constabel H, Gatzke AK, Keyser KA, Arens R, Behrens GM, Messerle M.

J Immunol. 2013 Mar 15;190(6):2767-77. doi: 10.4049/jimmunol.1200966. Epub 2013 Feb 6.

38.

The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89.

Borst EM, Kleine-Albers J, Gabaev I, Babic M, Wagner K, Binz A, Degenhardt I, Kalesse M, Jonjic S, Bauerfeind R, Messerle M.

J Virol. 2013 Feb;87(3):1720-32. doi: 10.1128/JVI.01955-12. Epub 2012 Nov 21.

39.

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection.

Rodríguez-Martín S, Kropp KA, Wilhelmi V, Lisnic VJ, Hsieh WY, Blanc M, Livingston A, Busche A, Tekotte H, Messerle M, Auer M, Fraser I, Jonjic S, Angulo A, Reddehase MJ, Ghazal P.

PLoS Pathog. 2012;8(8):e1002901. doi: 10.1371/journal.ppat.1002901. Epub 2012 Aug 30.

40.

The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.

Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Fedorov PC.

PLoS Pathog. 2011 Dec;7(12):e1002432. doi: 10.1371/journal.ppat.1002432. Epub 2011 Dec 8.

41.

Temporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes.

Lacaze P, Forster T, Ross A, Kerr LE, Salvo-Chirnside E, Lisnic VJ, López-Campos GH, García-Ramírez JJ, Messerle M, Trgovcich J, Angulo A, Ghazal P.

J Virol. 2011 Jun;85(12):6065-76. doi: 10.1128/JVI.02341-10. Epub 2011 Apr 6.

42.

Single cell detection of latent cytomegalovirus reactivation in host tissue.

Marquardt A, Halle S, Seckert CK, Lemmermann NA, Veres TZ, Braun A, Maus UA, Förster R, Reddehase MJ, Messerle M, Busche A.

J Gen Virol. 2011 Jun;92(Pt 6):1279-91. doi: 10.1099/vir.0.029827-0. Epub 2011 Feb 16.

PMID:
21325477
43.

Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.

Busche A, Schmitz S, Fleige H, Robbins SH, Walzer T, Stewart CA, Förster R, Messerle M, Prinz I.

J Immunol. 2011 Mar 1;186(5):2918-25. doi: 10.4049/jimmunol.1003232. Epub 2011 Jan 26.

44.
45.

Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.

Slavuljica I, Busche A, Babić M, Mitrović M, Gašparović I, Cekinović D, Markova Car E, Pernjak Pugel E, Ciković A, Lisnić VJ, Britt WJ, Koszinowski U, Messerle M, Krmpotić A, Jonjić S.

J Clin Invest. 2010 Dec;120(12):4532-45. doi: 10.1172/JCI43961. Epub 2010 Nov 22.

46.

Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm.

Drori A, Misaghi S, Haimovich J, Messerle M, Tirosh B.

Mol Immunol. 2010 May;47(9):1719-27. doi: 10.1016/j.molimm.2010.03.006. Epub 2010 Mar 28.

PMID:
20353876
47.

Conditional and reversible disruption of essential herpesvirus proteins.

Glass M, Busche A, Wagner K, Messerle M, Borst EM.

Nat Methods. 2009 Aug;6(8):577-9. doi: 10.1038/nmeth.1346. Epub 2009 Jul 5.

PMID:
19578384
48.

A redshifted codon-optimized firefly luciferase is a sensitive reporter for bioluminescence imaging.

Caysa H, Jacob R, Müther N, Branchini B, Messerle M, Söling A.

Photochem Photobiol Sci. 2009 Jan;8(1):52-6. doi: 10.1039/b814566k. Epub 2008 Oct 29.

PMID:
19247529
49.

The mouse cytomegalovirus immediate-early 1 gene is not required for establishment of latency or for reactivation in the lungs.

Busche A, Marquardt A, Bleich A, Ghazal P, Angulo A, Messerle M.

J Virol. 2009 May;83(9):4030-8. doi: 10.1128/JVI.02520-08. Epub 2009 Feb 11.

50.

Tumor-specific activity of cellular regulatory elements is down-regulated upon insertion into the herpes simplex virus genome.

Glass M, Söling A, Messerle M.

J Neurovirol. 2008 Nov;14(6):522-35. doi: 10.1080/13550280802348214.

PMID:
18979278

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