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Items: 44


Gene Drives: Dynamics and Regulatory Matters-A Report from the Workshop "Evaluation of Spatial and Temporal Control of Gene Drives," April 4-5, 2019, Vienna.

Giese B, Frieß JL, Barton NH, Messer PW, Débarre F, Schetelig MF, Windbichler N, Meimberg H, Boëte C.

Bioessays. 2019 Oct 7:e1900151. doi: 10.1002/bies.201900151. [Epub ahead of print] No abstract available.


CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect.

Champer J, Wen Z, Luthra A, Reeves R, Chung J, Liu C, Lee YL, Liu J, Yang E, Messer PW, Clark AG.

Genetics. 2019 May;212(1):333-341. doi: 10.1534/genetics.119.302037. Epub 2019 Mar 27.


Maximum Likelihood Estimation of Fitness Components in Experimental Evolution.

Liu J, Champer J, Langmüller AM, Liu C, Chung J, Reeves R, Luthra A, Lee YL, Vaughn AH, Clark AG, Messer PW.

Genetics. 2019 Mar;211(3):1005-1017. doi: 10.1534/genetics.118.301893. Epub 2019 Jan 24.


Molecular safeguarding of CRISPR gene drive experiments.

Champer J, Chung J, Lee YL, Liu C, Yang E, Wen Z, Clark AG, Messer PW.

Elife. 2019 Jan 22;8. pii: e41439. doi: 10.7554/eLife.41439.


Evolutionary Modeling in SLiM 3 for Beginners.

Haller BC, Messer PW.

Mol Biol Evol. 2019 May 1;36(5):1101-1109. doi: 10.1093/molbev/msy237.


Tree-sequence recording in SLiM opens new horizons for forward-time simulation of whole genomes.

Haller BC, Galloway J, Kelleher J, Messer PW, Ralph PL.

Mol Ecol Resour. 2019 Mar;19(2):552-566. doi: 10.1111/1755-0998.12968. Epub 2019 Feb 21.


SLiM 3: Forward Genetic Simulations Beyond the Wright-Fisher Model.

Haller BC, Messer PW.

Mol Biol Evol. 2019 Mar 1;36(3):632-637. doi: 10.1093/molbev/msy228.


Narrow thermal tolerance and low dispersal drive higher speciation in tropical mountains.

Polato NR, Gill BA, Shah AA, Gray MM, Casner KL, Barthelet A, Messer PW, Simmons MP, Guayasamin JM, Encalada AC, Kondratieff BC, Flecker AS, Thomas SA, Ghalambor CK, Poff NL, Funk WC, Zamudio KR.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12471-12476. doi: 10.1073/pnas.1809326115. Epub 2018 Nov 5.


Signatures of Insecticide Selection in the Genome of Drosophila melanogaster.

Duneau D, Sun H, Revah J, San Miguel K, Kunerth HD, Caldas IV, Messer PW, Scott JG, Buchon N.

G3 (Bethesda). 2018 Nov 6;8(11):3469-3480. doi: 10.1534/g3.118.200537.


Reducing resistance allele formation in CRISPR gene drive.

Champer J, Liu J, Oh SY, Reeves R, Luthra A, Oakes N, Clark AG, Messer PW.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5522-5527. doi: 10.1073/pnas.1720354115. Epub 2018 May 7.


Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations.

Champer J, Reeves R, Oh SY, Liu C, Liu J, Clark AG, Messer PW.

PLoS Genet. 2017 Jul 20;13(7):e1006796. doi: 10.1371/journal.pgen.1006796. eCollection 2017 Jul.


asymptoticMK: A Web-Based Tool for the Asymptotic McDonald-Kreitman Test.

Haller BC, Messer PW.

G3 (Bethesda). 2017 May 5;7(5):1569-1575. doi: 10.1534/g3.117.039693.


The role of the vaginal microbiome in gynaecological cancer.

Champer M, Wong AM, Champer J, Brito IL, Messer PW, Hou JY, Wright JD.

BJOG. 2018 Feb;125(3):309-315. doi: 10.1111/1471-0528.14631. Epub 2017 Apr 12. Review.


Evolution of Resistance Against CRISPR/Cas9 Gene Drive.

Unckless RL, Clark AG, Messer PW.

Genetics. 2017 Feb;205(2):827-841. doi: 10.1534/genetics.116.197285. Epub 2016 Dec 10.


Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB.

Genome Biol. 2016 Nov 29;17(1):246.


SLiM 2: Flexible, Interactive Forward Genetic Simulations.

Haller BC, Messer PW.

Mol Biol Evol. 2017 Jan;34(1):230-240. doi: 10.1093/molbev/msw211. Epub 2016 Oct 3.


Plumage Genes and Little Else Distinguish the Genomes of Hybridizing Warblers.

Toews DP, Taylor SA, Vallender R, Brelsford A, Butcher BG, Messer PW, Lovette IJ.

Curr Biol. 2016 Sep 12;26(17):2313-8. doi: 10.1016/j.cub.2016.06.034. Epub 2016 Aug 18.


Can Population Genetics Adapt to Rapid Evolution?

Messer PW, Ellner SP, Hairston NG Jr.

Trends Genet. 2016 Jul;32(7):408-418. doi: 10.1016/j.tig.2016.04.005. Epub 2016 May 13. Review.


Evaluating the performance of selection scans to detect selective sweeps in domestic dogs.

Schlamp F, van der Made J, Stambler R, Chesebrough L, Boyko AR, Messer PW.

Mol Ecol. 2016 Jan;25(1):342-56. doi: 10.1111/mec.13485.


Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction.

Unckless RL, Messer PW, Connallon T, Clark AG.

Genetics. 2015 Oct;201(2):425-31. doi: 10.1534/genetics.115.177592. Epub 2015 Jul 30.


Quantification of GC-biased gene conversion in the human genome.

Glémin S, Arndt PF, Messer PW, Petrov D, Galtier N, Duret L.

Genome Res. 2015 Aug;25(8):1215-28. doi: 10.1101/gr.185488.114. Epub 2015 May 20.


Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps.

Garud NR, Messer PW, Buzbas EO, Petrov DA.

PLoS Genet. 2015 Feb 23;11(2):e1005004. doi: 10.1371/journal.pgen.1005004. eCollection 2015 Feb.


Evolutionary genomics. Conundrum of jumbled mosquito genomes.

Clark AG, Messer PW.

Science. 2015 Jan 2;347(6217):27-8. doi: 10.1126/science.aaa3600. No abstract available.


Soft selective sweeps in complex demographic scenarios.

Wilson BA, Petrov DA, Messer PW.

Genetics. 2014 Oct;198(2):669-84. doi: 10.1534/genetics.114.165571. Epub 2014 Jul 24.


Genome-wide signals of positive selection in human evolution.

Enard D, Messer PW, Petrov DA.

Genome Res. 2014 Jun;24(6):885-95. doi: 10.1101/gr.164822.113. Epub 2014 Mar 11.


Population genomics of rapid adaptation by soft selective sweeps.

Messer PW, Petrov DA.

Trends Ecol Evol. 2013 Nov;28(11):659-69. doi: 10.1016/j.tree.2013.08.003. Epub 2013 Sep 25. Review.


Strong purifying selection at synonymous sites in D. melanogaster.

Lawrie DS, Messer PW, Hershberg R, Petrov DA.

PLoS Genet. 2013 May;9(5):e1003527. doi: 10.1371/journal.pgen.1003527. Epub 2013 May 30.


SLiM: simulating evolution with selection and linkage.

Messer PW.

Genetics. 2013 Aug;194(4):1037-9. doi: 10.1534/genetics.113.152181. Epub 2013 May 24.


Frequent adaptation and the McDonald-Kreitman test.

Messer PW, Petrov DA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8615-20. doi: 10.1073/pnas.1220835110. Epub 2013 May 6.


Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).

Staubach F, Lorenc A, Messer PW, Tang K, Petrov DA, Tautz D.

PLoS Genet. 2012;8(8):e1002891. doi: 10.1371/journal.pgen.1002891. Epub 2012 Aug 30.


Estimating the strength of selective sweeps from deep population diversity data.

Messer PW, Neher RA.

Genetics. 2012 Jun;191(2):593-605. doi: 10.1534/genetics.112.138461. Epub 2012 Apr 4.


Heterozygote advantage as a natural consequence of adaptation in diploids.

Sellis D, Callahan BJ, Petrov DA, Messer PW.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20666-71. doi: 10.1073/pnas.1114573108. Epub 2011 Dec 5.


Faster than neutral evolution of constrained sequences: the complex interplay of mutational biases and weak selection.

Lawrie DS, Petrov DA, Messer PW.

Genome Biol Evol. 2011;3:383-95. doi: 10.1093/gbe/evr032. Epub 2011 Apr 17.


Evidence that adaptation in Drosophila is not limited by mutation at single sites.

Karasov T, Messer PW, Petrov DA.

PLoS Genet. 2010 Jun 17;6(6):e1000924. doi: 10.1371/journal.pgen.1000924.


Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila.

González J, Karasov TL, Messer PW, Petrov DA.

PLoS Genet. 2010 Apr 8;6(4):e1000905. doi: 10.1371/journal.pgen.1000905.


Redescription of Stenolophus thoracicus Casey (Coleoptera, Carabidae, Harpalini), a valid species.

Bousquet Y, Messer PW.

Zookeys. 2010 Aug 27;(53):25-31. doi: 10.3897/zookeys.53.470.


Measuring the rates of spontaneous mutation from deep and large-scale polymorphism data.

Messer PW.

Genetics. 2009 Aug;182(4):1219-32. doi: 10.1534/genetics.109.105692. Epub 2009 Jun 15.


Inferring the strength of selection in Drosophila under complex demographic models.

González J, Macpherson JM, Messer PW, Petrov DA.

Mol Biol Evol. 2009 Mar;26(3):513-26. doi: 10.1093/molbev/msn270. Epub 2008 Nov 24.


Effects of long-range correlations in DNA on sequence alignment score statistics.

Messer PW, Bundschuh R, Vingron M, Arndt PF.

J Comput Biol. 2007 Jun;14(5):655-68. Review.


The majority of recent short DNA insertions in the human genome are tandem duplications.

Messer PW, Arndt PF.

Mol Biol Evol. 2007 May;24(5):1190-7. Epub 2007 Feb 24.


CorGen--measuring and generating long-range correlations for DNA sequence analysis.

Messer PW, Arndt PF.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W692-5.


Solvable sequence evolution models and genomic correlations.

Messer PW, Arndt PF, Lässig M.

Phys Rev Lett. 2005 Apr 8;94(13):138103. Epub 2005 Apr 8.


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