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Items: 1 to 50 of 85

1.

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation.

Villoslada P, Vila G, Colafrancesco V, Moreno B, Fernandez-Diez B, Vazquez R, Pertsovskaya I, Zubizarreta I, Pulido-Valdeolivas I, Messeguer J, Vendrell-Navarro G, Frade JM, López-Sánchez N, Teixido M, Giralt E, Masso M, Dugas JC, Leonoudakis D, Lariosa-Willingham KD, Steinman L, Messeguer A.

Neurotherapeutics. 2019 Feb 27. doi: 10.1007/s13311-019-00717-4. [Epub ahead of print]

PMID:
30815844
2.

Dynamic Covalent Identification of an Efficient Heparin Ligand.

Corredor M, Carbajo D, Domingo C, Pérez Y, Bujons J, Messeguer A, Alfonso I.

Angew Chem Int Ed Engl. 2018 Sep 10;57(37):11973-11977. doi: 10.1002/anie.201806770. Epub 2018 Aug 10.

PMID:
29998599
3.

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J, Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C, Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P, Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B.

Sci Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.

PMID:
28003549
4.

Regioselective Synthesis of a Family of β-Lactams Bearing a Triazole Moiety as Potential Apoptosis Inhibitors.

Garrido M, Corredor M, Orzáez M, Alfonso I, Messeguer A.

ChemistryOpen. 2016 Aug 2;5(5):485-494. eCollection 2016 Oct.

5.

Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.

Vázquez-Jiménez L, Garrido M, Miceli M, Prats E, Ferrer-Montiel A, Teixidó M, Jimeno C, Messeguer A.

Eur J Med Chem. 2016 Nov 10;123:788-802. doi: 10.1016/j.ejmech.2016.08.007. Epub 2016 Aug 6.

PMID:
27541262
6.

Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.

Corredor M, Bonet R, Moure A, Domingo C, Bujons J, Alfonso I, Pérez Y, Messeguer À.

Biophys J. 2016 Mar 29;110(6):1291-303. doi: 10.1016/j.bpj.2016.01.033.

7.

Apaf1 inhibition promotes cell recovery from apoptosis.

Gortat A, Sancho M, Mondragón L, Messeguer À, Pérez-Payá E, Orzáez M.

Protein Cell. 2015 Nov;6(11):833-43. doi: 10.1007/s13238-015-0200-2. Epub 2015 Sep 11.

8.

Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety.

Corredor M, Garrido M, Bujons J, Orzáez M, Pérez-Payá E, Alfonso I, Messeguer A.

Chemistry. 2015 Sep 28;21(40):14122-8. doi: 10.1002/chem.201502380. Epub 2015 Aug 13.

PMID:
26270744
9.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.

PMID:
26192347
10.

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin.

Vendrell-Navarro G, Rúa F, Bujons J, Brockmeyer A, Janning P, Ziegler S, Messeguer A, Waldmann H.

Chembiochem. 2015 Jul 27;16(11):1580-7. doi: 10.1002/cbic.201500169. Epub 2015 Jun 17.

PMID:
26010161
11.

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero JG, Landeta O, Basañez G, Carbajo RJ, Pineda-Lucena A, Bujons J, Moure A, Messeguer A, Lagunas C, Herrero C, Pérez-Payá E.

PLoS One. 2014 Oct 20;9(10):e110979. doi: 10.1371/journal.pone.0110979. eCollection 2014.

12.

Comparison of serum BDNF levels in deficit and nondeficit chronic schizophrenia and healthy controls.

Valiente-Gómez A, Amann BL, Mármol F, Oliveira C, Messeguer A, Lafuente A, Pomarol-Clotet E, Bernardo Arroyo M.

Psychiatry Res. 2014 Dec 15;220(1-2):197-200. doi: 10.1016/j.psychres.2014.08.039. Epub 2014 Aug 30.

PMID:
25219612
13.

Effect of triazine derivatives on neuronal nicotinic receptors.

Vázquez-Romero A, Criado M, Messeguer A, Vidal-Mosquera M, Mulet J, Sala F, Sala S.

ACS Chem Neurosci. 2014 Aug 20;5(8):683-9. doi: 10.1021/cn5000748. Epub 2014 Jul 7.

14.

15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles.

Corredor M, Bujons J, Messeguer À, Alfonso I.

Org Biomol Chem. 2013 Nov 14;11(42):7318-25. doi: 10.1039/c3ob41587b.

PMID:
24064959
15.

Vestibulotoxic properties of potential metabolites of allylnitrile.

Rúa F, Buffard M, Sedó-Cabezón L, Hernández-Mir G, de la Torre A, Saldaña-Ruíz S, Chabbert C, Bayona JM, Messeguer A, Llorens J.

Toxicol Sci. 2013 Sep;135(1):182-92. doi: 10.1093/toxsci/kft127. Epub 2013 Jun 12.

PMID:
23761299
16.

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid.

Corredor M, Bujons J, Orzáez M, Sancho M, Pérez-Payá E, Alfonso I, Messeguer A.

Eur J Med Chem. 2013 May;63:892-6. doi: 10.1016/j.ejmech.2013.03.004. Epub 2013 Mar 14.

17.

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

Andreu-Fernández V, Genovés A, Messeguer A, Orzáez M, Sancho M, Pérez-Payá E.

PLoS One. 2013;8(2):e56881. doi: 10.1371/journal.pone.0056881. Epub 2013 Feb 21.

18.

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

Ucero AC, Berzal S, Ocaña-Salceda C, Sancho M, Orzáez M, Messeguer A, Ruiz-Ortega M, Egido J, Vicent MJ, Ortiz A, Ramos AM.

PLoS One. 2013;8(1):e51992. doi: 10.1371/journal.pone.0051992. Epub 2013 Jan 2.

19.

Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.

Moure A, Orzáez M, Sancho M, Messeguer A.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7097-9. doi: 10.1016/j.bmcl.2012.09.078. Epub 2012 Sep 29.

PMID:
23079529
20.

Advances in modulating thermosensory TRP channels.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R.

Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. doi: 10.1517/13543776.2012.711320. Epub 2012 Jul 27. Review.

PMID:
22835143
21.

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.

Vidal-Mosquera M, Fernández-Carvajal A, Moure A, Valente P, Planells-Cases R, González-Ros JM, Bujons J, Ferrer-Montiel A, Messeguer A.

J Med Chem. 2011 Nov 10;54(21):7441-52. doi: 10.1021/jm200981s. Epub 2011 Oct 10.

PMID:
21950613
22.

A novel free radical scavenger rescues retinal cells in vivo.

O'Driscoll C, Doonan F, Sanvicens N, Messeguer A, Cotter TG.

Exp Eye Res. 2011 Jul;93(1):65-74. doi: 10.1016/j.exer.2011.04.007. Epub 2011 May 25.

PMID:
21635890
23.

Chemical modulation of peptoids: synthesis and conformational studies on partially constrained derivatives.

Moure A, Sanclimens G, Bujons J, Masip I, Alvarez-Larena A, Pérez-Payá E, Alfonso I, Messeguer A.

Chemistry. 2011 Jul 4;17(28):7927-39. doi: 10.1002/chem.201100216. Epub 2011 May 24.

PMID:
21611988
24.

Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS).

Messeguer A.

Chem Biol Interact. 2011 Jun 30;192(1-2):136-41. doi: 10.1016/j.cbi.2010.10.006. Epub 2010 Oct 21.

PMID:
20970410
25.

Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation.

Scheper J, Guerra-Rebollo M, Sanclimens G, Moure A, Masip I, González-Ruiz D, Rubio N, Crosas B, Meca-Cortés O, Loukili N, Plans V, Morreale A, Blanco J, Ortiz AR, Messeguer A, Thomson TM.

PLoS One. 2010 Jun 30;5(6):e11403. doi: 10.1371/journal.pone.0011403.

26.

Molecules that modulate Apaf-1 activity.

Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ.

Med Res Rev. 2011 Jul;31(4):649-75. doi: 10.1002/med.20198. Epub 2010 Jan 22. Review.

PMID:
20099266
27.

Oral human papillomavirus in healthy individuals: a systematic review of the literature.

Kreimer AR, Bhatia RK, Messeguer AL, González P, Herrero R, Giuliano AR.

Sex Transm Dis. 2010 Jun;37(6):386-91. doi: 10.1097/OLQ.0b013e3181c94a3b. Review.

PMID:
20081557
28.

Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats.

Pérez-Asensio FJ, de la Rosa X, Jiménez-Altayó F, Gorina R, Martínez E, Messeguer A, Vila E, Chamorro A, Planas AM.

J Cereb Blood Flow Metab. 2010 Mar;30(3):638-52. doi: 10.1038/jcbfm.2009.237. Epub 2009 Nov 11.

29.

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex.

Carme Mulero M, Orzáez M, Messeguer J, Messeguer A, Pérez-Payá E, Pérez-Riba M.

Anal Biochem. 2010 Mar 1;398(1):99-103. doi: 10.1016/j.ab.2009.10.045. Epub 2009 Nov 3.

30.

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

Vicent MJ, Cascales L, Carbajo RJ, Cortés N, Messeguer A, Pérez Payá E.

J Control Release. 2010 Mar 3;142(2):277-85. doi: 10.1016/j.jconrel.2009.10.026. Epub 2009 Oct 30.

PMID:
19883706
31.

Participation of oxidative stress on rat middle cerebral artery changes induced by focal cerebral ischemia: beneficial effects of 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6).

Jiménez-Altayó F, Caracuel L, Pérez-Asensio FJ, Martínez-Revelles S, Messeguer A, Planas AM, Vila E.

J Pharmacol Exp Ther. 2009 Nov;331(2):429-36. doi: 10.1124/jpet.109.157131. Epub 2009 Aug 19.

PMID:
19692633
32.

A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration.

Montolio M, Messeguer J, Masip I, Guijarro P, Gavin R, Antonio Del Río J, Messeguer A, Soriano E.

Chem Biol. 2009 Jul 31;16(7):691-701. doi: 10.1016/j.chembiol.2009.05.006. Epub 2009 Jul 16.

33.

Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity.

Mulero MC, Aubareda A, Orzáez M, Messeguer J, Serrano-Candelas E, Martínez-Hoyer S, Messeguer A, Pérez-Payá E, Pérez-Riba M.

J Biol Chem. 2009 Apr 3;284(14):9394-401. doi: 10.1074/jbc.M805889200. Epub 2009 Feb 3.

34.

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

Mondragón L, Galluzzi L, Mouhamad S, Orzáez M, Vicencio JM, Vitale I, Moure A, Messeguer A, Perez-Paya E, Kroemer G.

Apoptosis. 2009 Feb;14(2):182-90. doi: 10.1007/s10495-008-0310-x.

PMID:
19152031
35.

Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosis.

García-Villoria J, Navarro-Sastre A, Fons C, Pérez-Cerdá C, Baldellou A, Fuentes-Castelló MA, González I, Hernández-Gonzalez A, Fernández C, Campistol J, Delpiccolo C, Cortés N, Messeguer A, Briones P, Ribes A.

Clin Biochem. 2009 Jan;42(1-2):27-33. doi: 10.1016/j.clinbiochem.2008.10.006. Epub 2008 Oct 25. Erratum in: Clin Biochem. 2016 Jan;49(1-2):197.

PMID:
18996107
36.

Synthesis of a positional scanning library of pentamers of N-alkylglycines assisted by microwave activation and validation via the identification of trypsin inhibitors.

Messeguer J, Cortés N, García-Sanz N, Navarro-Vendrell G, Ferrer-Montiel A, Messeguer A.

J Comb Chem. 2008 Nov-Dec;10(6):974-80. doi: 10.1021/cc800144x. Epub 2008 Oct 11.

PMID:
18847288
37.

NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.

Valera E, Sánchez-Martín FJ, Ferrer-Montiel AV, Messeguer A, Merino JM.

Neurochem Int. 2008 Nov;53(5):148-54. doi: 10.1016/j.neuint.2008.07.007. Epub 2008 Jul 25.

PMID:
18694792
38.

Physiology and pharmacology of the vanilloid receptor.

Messeguer A, Planells-Cases R, Ferrer-Montiel A.

Curr Neuropharmacol. 2006 Jan;4(1):1-15.

39.

New anti-RNS and -RCS products for cosmetic treatment.

Cebrián J, Messeguer A, Facino RM, García Antón JM.

Int J Cosmet Sci. 2005 Oct;27(5):271-8. doi: 10.1111/j.1467-2494.2005.00279.x.

PMID:
18492208
40.

Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine.

Martínez-Cabot A, Varela B, Lloveras M, Campos R, Marco MP, Messeguer A.

Anal Bioanal Chem. 2008 May;391(2):617-24. doi: 10.1007/s00216-008-2019-7. Epub 2008 Apr 17.

PMID:
18418587
41.

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors.

Mondragón L, Orzáez M, Sanclimens G, Moure A, Armiñán A, Sepúlveda P, Messeguer A, Vicent MJ, Pérez-Payá E.

J Med Chem. 2008 Feb 14;51(3):521-9. doi: 10.1021/jm701195j. Epub 2008 Jan 16.

PMID:
18197610
42.

CR-6 protects glutathione peroxidase activity in experimental diabetes.

Miranda M, Muriach M, Almansa I, Arnal E, Messeguer A, Díaz-Llopis M, Romero FJ, Bosch-Morell F.

Free Radic Biol Med. 2007 Dec 1;43(11):1494-8. Epub 2007 Aug 14.

PMID:
17964420
44.

In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome.

Martínez-Cabot A, Morató A, Commandeur JN, Vermeulen NP, Messeguer A.

Chem Res Toxicol. 2007 Aug;20(8):1218-24. Epub 2007 Aug 3.

PMID:
17672514
45.
46.

Smallest peptoids with antiproliferative activity on human neoplastic cells.

Mas-Moruno C, Cruz LJ, Mora P, Francesch A, Messeguer A, Pérez-Paya E, Albericio F.

J Med Chem. 2007 May 17;50(10):2443-9. Epub 2007 Apr 14.

PMID:
17432841
47.

Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis.

Orzáez M, Mondragón L, Marzo I, Sanclimens G, Messeguer A, Pérez-Payá E, Vicent MJ.

Peptides. 2007 May;28(5):958-68. Epub 2007 Mar 3.

PMID:
17408805
48.

Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.

Miranda M, Bosch-Morell F, Johnsen-Soriano S, Barcia J, Almansa I, Asensio S, Araiz J, Messeguer A, Romero FJ.

Neurochem Res. 2007 Jul;32(7):1156-62. Epub 2007 Mar 31.

PMID:
17401664
49.

Combinatorial chemistry in cancer research.

Messeguer A, Cortés N.

Clin Transl Oncol. 2007 Feb;9(2):83-92. Review.

PMID:
17329219
50.

LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil.

Reig N, Calaf RE, Messeguer A, Morató A, Escabros J, Gelpí E, Abian J.

J Mass Spectrom. 2007 Apr;42(4):527-41.

PMID:
17295417

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