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Items: 50


Loss of flow responsive Tie1 results in Impaired
Aortic valve remodeling.

Qu X, Violette K, Sewell-Loftin MK, Soslow J, Saint-Jean L, Hinton RB, Merryman WD, Baldwin HS.

Dev Biol. 2019 Jul 15. pii: S0012-1606(19)30181-2. doi: 10.1016/j.ydbio.2019.07.011. [Epub ahead of print]


Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.

Bowler MA, Raddatz MA, Johnson CL, Lindman BR, Merryman WD.

JACC Basic Transl Sci. 2019 Feb 22;4(2):135-143. doi: 10.1016/j.jacbts.2018.12.003. eCollection 2019 Apr. Review.


Adaptive immune cells in calcific aortic valve disease.

Raddatz MA, Madhur MS, Merryman WD.

Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H141-H155. doi: 10.1152/ajpheart.00100.2019. Epub 2019 May 3.


Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism.

Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD.

Circ Res. 2018 Dec 7;123(12):e51-e64. doi: 10.1161/CIRCRESAHA.118.313397.


Cadherin-11 as a regulator of valve myofibroblast mechanobiology.

Bowler MA, Bersi MR, Ryzhova LM, Jerrell RJ, Parekh A, Merryman WD.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1614-H1626. doi: 10.1152/ajpheart.00277.2018. Epub 2018 Oct 25.


Loss of CENP-F Results in Dilated Cardiomyopathy with Severe Disruption of Cardiac Myocyte Architecture.

Manalo A, Schroer AK, Fenix AM, Shancer Z, Coogan J, Brolsma T, Burnette DT, Merryman WD, Bader DM.

Sci Rep. 2018 May 15;8(1):7546. doi: 10.1038/s41598-018-25774-1.


Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.

Angel PM, Narmoneva DA, Sewell-Loftin MK, Munjal C, Dupuis L, Landis BJ, Jegga A, Kern CB, Merryman WD, Baldwin HS, Bressan GM, Hinton RB.

Ann Biomed Eng. 2017 Nov;45(11):2548-2562. doi: 10.1007/s10439-017-1899-0. Epub 2017 Aug 15.


Targeting Cadherin-11 Prevents Notch1-Mediated Calcific Aortic Valve Disease.

Clark CR, Bowler MA, Snider JC, Merryman WD.

Circulation. 2017 Jun 13;135(24):2448-2450. doi: 10.1161/CIRCULATIONAHA.117.027771. No abstract available.


Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM.

J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2.


A developmental approach to induced pluripotent stem cells-based tissue engineered heart valves.

Vander Roest MJ, Merryman WD.

Future Cardiol. 2017 Jan;13(1):1-4. doi: 10.2217/fca-2016-0071. Epub 2016 Dec 19. Review. No abstract available.


I-Wire Heart-on-a-Chip II: Biomechanical analysis of contractile, three-dimensional cardiomyocyte tissue constructs.

Schroer AK, Shotwell MS, Sidorov VY, Wikswo JP, Merryman WD.

Acta Biomater. 2017 Jan 15;48:79-87. doi: 10.1016/j.actbio.2016.11.010. Epub 2016 Nov 3.


Lnc-ing NOTCH1 to Idiopathic Calcific Aortic Valve Disease.

Merryman WD, Clark CR.

Circulation. 2016 Dec 6;134(23):1863-1865. Epub 2016 Oct 27. No abstract available.


Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells.

Clark CR, Robinson JY, Sanchez NS, Townsend TA, Arrieta JA, Merryman WD, Trykall DZ, Olivey HE, Hong CC, Barnett JV.

Cell Signal. 2016 Jun;28(6):688-98. doi: 10.1016/j.cellsig.2016.03.004. Epub 2016 Mar 10.


Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.

West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD.

PLoS One. 2016 Feb 10;11(2):e0148657. doi: 10.1371/journal.pone.0148657. eCollection 2016.


Quantitative Imaging Assessment of an Alternative Approach to Surgical Mitral Valve Leaflet Resection: An Acute Porcine Study.

Boronyak SM, Fredi JL, Young MN, Dumont DM, Williams PE, Byram BC, Merryman WD.

Ann Biomed Eng. 2016 Jul;44(7):2240-50. doi: 10.1007/s10439-015-1494-1. Epub 2015 Oct 27.


Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel JE, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC.

Circ Res. 2015 Dec 4;117(12):995-1000. doi: 10.1161/CIRCRESAHA.115.307580. Epub 2015 Oct 1.


Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.

Chen J, Ryzhova LM, Sewell-Loftin MK, Brown CB, Huppert SS, Baldwin HS, Merryman WD.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1597-605. doi: 10.1161/ATVBAHA.114.305095. Epub 2015 May 28.


Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease.

Schroer AK, Merryman WD.

J Cell Sci. 2015 May 15;128(10):1865-75. doi: 10.1242/jcs.162891. Epub 2015 Apr 27. Review.


An Inflection Point Method for the Determination of Pulmonary Transit Time From Contrast Echocardiography.

Boronyak SM, Monahan K, Brittain EL, Merryman WD.

IEEE Trans Biomed Eng. 2015 Jul;62(7):1853-61. doi: 10.1109/TBME.2015.2405764. Epub 2015 Feb 19.


Microvessel mechanobiology in pulmonary arterial hypertension: cause and effect.

Bloodworth NC, West JD, Merryman WD.

Hypertension. 2015 Mar;65(3):483-9. doi: 10.1161/HYPERTENSIONAHA.114.04652. Epub 2014 Dec 22. Review. No abstract available.


In vitro models of aortic valve calcification: solidifying a system.

Bowler MA, Merryman WD.

Cardiovasc Pathol. 2015 Jan-Feb;24(1):1-10. doi: 10.1016/j.carpath.2014.08.003. Epub 2014 Aug 15. Review.


Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM.

Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. doi: 10.1152/ajpcell.00057.2014. Epub 2014 May 28.


In vitro assessment of a combined radiofrequency ablation and cryo-anchoring catheter for treatment of mitral valve prolapse.

Boronyak SM, Merryman WD.

J Biomech. 2014 Mar 21;47(5):973-80. doi: 10.1016/j.jbiomech.2014.01.021. Epub 2014 Jan 21.


Potential drug targets for calcific aortic valve disease.

Hutcheson JD, Aikawa E, Merryman WD.

Nat Rev Cardiol. 2014 Apr;11(4):218-31. doi: 10.1038/nrcardio.2014.1. Epub 2014 Jan 21. Review.


Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells.

Sewell-Loftin MK, DeLaughter DM, Peacock JR, Brown CB, Baldwin HS, Barnett JV, Merryman WD.

Biomaterials. 2014 Mar;35(9):2809-15. doi: 10.1016/j.biomaterials.2013.12.051. Epub 2014 Jan 14.


Murine bladder wall biomechanics following partial bladder obstruction.

Chen J, Drzewiecki BA, Merryman WD, Pope JC 4th.

J Biomech. 2013 Oct 18;46(15):2752-5. doi: 10.1016/j.jbiomech.2013.07.022. Epub 2013 Jul 27.


Mechanisms of calcification in aortic valve disease: role of mechanokinetics and mechanodynamics.

Merryman WD, Schoen FJ.

Curr Cardiol Rep. 2013 May;15(5):355. doi: 10.1007/s11886-013-0355-5. Review.


Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.

Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):114-20. doi: 10.1161/ATVBAHA.112.300278. Epub 2012 Nov 15.


The once and future state of percutaneous mitral valve repair.

Boronyak SM, Merryman WD.

Future Cardiol. 2012 Sep;8(5):779-93. Review.


A novel technique for quantifying mouse heart valve leaflet stiffness with atomic force microscopy.

Sewell-Loftin MK, Brown CB, Baldwin HS, Merryman WD.

J Heart Valve Dis. 2012 Jul;21(4):513-20.


5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.

Hutcheson JD, Ryzhova LM, Setola V, Merryman WD.

J Mol Cell Cardiol. 2012 Nov;53(5):707-14. doi: 10.1016/j.yjmcc.2012.08.012. Epub 2012 Aug 23.


Development of a simultaneous cryo-anchoring and radiofrequency ablation catheter for percutaneous treatment of mitral valve prolapse.

Boronyak SM, Merryman WD.

Ann Biomed Eng. 2012 Sep;40(9):1971-81. doi: 10.1007/s10439-012-0571-y. Epub 2012 Apr 25.


Calcific nodule morphogenesis by heart valve interstitial cells is strain dependent.

Fisher CI, Chen J, Merryman WD.

Biomech Model Mechanobiol. 2013 Jan;12(1):5-17. doi: 10.1007/s10237-012-0377-8. Epub 2012 Feb 4.


Intracellular Ca(2+) accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts.

Hutcheson JD, Venkataraman R, Baudenbacher FJ, Merryman WD.

J Biomech. 2012 Mar 15;45(5):888-94. doi: 10.1016/j.jbiomech.2011.11.031. Epub 2011 Dec 15.


Hydrogels and microtechnologies for engineering the cellular microenvironment.

Gauvin R, Parenteau-Bareil R, Dokmeci MR, Merryman WD, Khademhosseini A.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 May-Jun;4(3):235-46. doi: 10.1002/wnan.171. Epub 2011 Dec 5. Review.


EMT-inducing biomaterials for heart valve engineering: taking cues from developmental biology.

Sewell-Loftin MK, Chun YW, Khademhosseini A, Merryman WD.

J Cardiovasc Transl Res. 2011 Oct;4(5):658-71. doi: 10.1007/s12265-011-9300-4. Epub 2011 Jul 13. Review.


Serotonin receptors and heart valve disease--it was meant 2B.

Hutcheson JD, Setola V, Roth BL, Merryman WD.

Pharmacol Ther. 2011 Nov;132(2):146-57. doi: 10.1016/j.pharmthera.2011.03.008. Epub 2011 Apr 2. Review.


Sensing and modulation of invadopodia across a wide range of rigidities.

Parekh A, Ruppender NS, Branch KM, Sewell-Loftin MK, Lin J, Boyer PD, Candiello JE, Merryman WD, Guelcher SA, Weaver AM.

Biophys J. 2011 Feb 2;100(3):573-582. doi: 10.1016/j.bpj.2010.12.3733.


Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.

Zhou Y, Hagood JS, Lu B, Merryman WD, Murphy-Ullrich JE.

J Biol Chem. 2010 Jul 16;285(29):22382-93. doi: 10.1074/jbc.M110.126227. Epub 2010 May 12.


Viscoelastic properties of the aortic valve interstitial cell.

Merryman WD, Bieniek PD, Guilak F, Sacks MS.

J Biomech Eng. 2009 Apr;131(4):041005. doi: 10.1115/1.3049821.


What modulates the aortic valve interstitial cell phenotype?

Merryman WD.

Future Cardiol. 2008 May;4(3):247-52. doi: 10.2217/14796678.4.3.247.


Insights into (the interstitium of) degenerative aortic valve disease.

Merryman WD.

J Am Coll Cardiol. 2008 Apr 8;51(14):1415; author reply 1416. doi: 10.1016/j.jacc.2007.11.068. No abstract available.


Development of a tissue engineered heart valve for pediatrics: a case study in bioengineering ethics.

Merryman WD.

Sci Eng Ethics. 2008 Mar;14(1):93-101. doi: 10.1007/s11948-008-9053-x. Epub 2008 Feb 12.


Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast.

Merryman WD, Lukoff HD, Long RA, Engelmayr GC Jr, Hopkins RA, Sacks MS.

Cardiovasc Pathol. 2007 Sep-Oct;16(5):268-76. Epub 2007 May 17.


Differences in tissue-remodeling potential of aortic and pulmonary heart valve interstitial cells.

Merryman WD, Liao J, Parekh A, Candiello JE, Lin H, Sacks MS.

Tissue Eng. 2007 Sep;13(9):2281-9.


An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction.

Fujimoto KL, Tobita K, Merryman WD, Guan J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR.

J Am Coll Cardiol. 2007 Jun 12;49(23):2292-300. Epub 2007 May 25.


In-vivo dynamic deformation of the mitral valve anterior leaflet.

Sacks MS, Enomoto Y, Graybill JR, Merryman WD, Zeeshan A, Yoganathan AP, Levy RJ, Gorman RC, Gorman JH 3rd.

Ann Thorac Surg. 2006 Oct;82(4):1369-77.


Frequency response of pig intervertebral disc cells subjected to dynamic hydrostatic pressure.

Kasra M, Merryman WD, Loveless KN, Goel VK, Martin JD, Buckwalter JA.

J Orthop Res. 2006 Oct;24(10):1967-73.


The effects of cellular contraction on aortic valve leaflet flexural stiffness.

Merryman WD, Huang HY, Schoen FJ, Sacks MS.

J Biomech. 2006;39(1):88-96. Epub 2005 Jan 7.


Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis.

Merryman WD, Youn I, Lukoff HD, Krueger PM, Guilak F, Hopkins RA, Sacks MS.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H224-31. Epub 2005 Aug 26.

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