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Items: 1 to 50 of 77

1.

The influence of Ho3+ doping on 13C DNP in the presence of BDPA.

Khattri RB, Sirusi AA, Suh EH, Kovacs Z, Merritt ME.

Phys Chem Chem Phys. 2019 Aug 15. doi: 10.1039/c9cp03717a. [Epub ahead of print]

PMID:
31414686
2.

Remodeling of substrate consumption in the murine sTAC model of heart failure.

Turer A, Altamirano F, Schiattarella GG, May H, Gillette TG, Malloy CR, Merritt ME.

J Mol Cell Cardiol. 2019 Sep;134:144-153. doi: 10.1016/j.yjmcc.2019.07.007. Epub 2019 Jul 21.

PMID:
31340162
3.

Single-walled Carbon Nanotubes Repress Viral-Induced Defense Pathways through Oxidative Stress.

Chen H, Humes ST, Robinson SE, Loeb JC, Sabaraya IV, Saleh NB, Khattri RB, Merritt ME, Martyniuk CJ, Lednicky JA, Sabo-Attwood T.

Nanotoxicology. 2019 Jul 22:1-48. doi: 10.1080/17435390.2019.1645903. [Epub ahead of print]

PMID:
31328592
4.

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.

Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J.

Cancer Discov. 2019 Jun 12. pii: CD-19-0152. doi: 10.1158/2159-8290.CD-19-0152. [Epub ahead of print]

PMID:
31189531
5.

Regulation of Renal NaDC1 Expression and Citrate Excretion by NBCe1-A.

Osis G, Webster KL, Harris AN, Lee HW, Chen C, Fang L, Romero MF, Khattri RB, Merritt ME, Verlander JW, Weiner ID.

Am J Physiol Renal Physiol. 2019 Jun 12. doi: 10.1152/ajprenal.00015.2019. [Epub ahead of print]

PMID:
31188034
6.

Nuclear Magnetic Resonance Measurement of Metabolic Flux Using 13C and 1H Signals.

Ragavan M, Merritt ME.

Methods Mol Biol. 2019;1996:29-40. doi: 10.1007/978-1-4939-9488-5_3.

PMID:
31127544
7.

Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral.

Lohr KE, Khattri RB, Guingab-Cagmat J, Camp EF, Merritt ME, Garrett TJ, Patterson JT.

Sci Rep. 2019 Apr 15;9(1):6067. doi: 10.1038/s41598-019-42434-0.

8.

Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone.

Kirpich A, Ragavan M, Bankson JA, McIntyre LM, Merritt ME.

J Chem Inf Model. 2019 Jan 28;59(1):605-614. doi: 10.1021/acs.jcim.8b00745. Epub 2019 Jan 15.

PMID:
30602117
9.

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R.

Neoplasia. 2019 Jan;21(1):1-16. doi: 10.1016/j.neo.2018.09.006. Epub 2018 Nov 23. Review.

10.

Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology.

von Morze C, Merritt ME.

NMR Biomed. 2018 Jun 5:e3937. doi: 10.1002/nbm.3937. [Epub ahead of print]

PMID:
29870085
11.

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.

Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang DT, Merritt ME.

J Biol Chem. 2018 Jun 22;293(25):9604-9613. doi: 10.1074/jbc.RA118.002838. Epub 2018 May 8.

12.

In vivo hyperpolarization transfer in a clinical MRI scanner.

von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME.

Magn Reson Med. 2018 Aug;80(2):480-487. doi: 10.1002/mrm.27154. Epub 2018 Feb 27.

13.

Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals.

Bastiaansen JAM, Yoshihara HAI, Capozzi A, Schwitter J, Gruetter R, Merritt ME, Comment A.

Magn Reson Med. 2018 May;79(5):2451-2459. doi: 10.1002/mrm.27122. Epub 2018 Feb 6.

14.

The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T.

Sirusi AA, Suh EH, Kovacs Z, Merritt ME.

Phys Chem Chem Phys. 2018 Jan 3;20(2):728-731. doi: 10.1039/c7cp07198a.

15.

Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.

von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME.

Magn Reson Med. 2018 Jul;80(1):36-41. doi: 10.1002/mrm.27000. Epub 2017 Nov 28.

16.

The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.

Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME.

J Biol Chem. 2017 Nov 3;292(44):18203-18216. doi: 10.1074/jbc.M117.813923. Epub 2017 Sep 15.

17.

A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design.

Ragavan M, Kirpich A, Fu X, Burgess SC, McIntyre LM, Merritt ME.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1215-H1223. doi: 10.1152/ajpheart.00016.2017. Epub 2017 Apr 14.

18.

Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.

Beg MS, Huang X, Silvers MA, Gerber DE, Bolluyt J, Sarode V, Fattah F, Deberardinis RJ, Merritt ME, Xie XJ, Leff R, Laheru D, Boothman DA.

J Surg Oncol. 2017 Jul;116(1):83-88. doi: 10.1002/jso.24624. Epub 2017 Mar 27.

19.

Hyperpolarized δ-[1-13 C]gluconolactone as a probe of the pentose phosphate pathway.

Moreno KX, Harrison CE, Merritt ME, Kovacs Z, Malloy CR, Sherry AD.

NMR Biomed. 2017 Jun;30(6). doi: 10.1002/nbm.3713. Epub 2017 Mar 8.

20.

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.

Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W.

Cell Rep. 2017 Feb 14;18(7):1660-1673. doi: 10.1016/j.celrep.2017.01.059.

21.

Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.

Wang JX, Merritt ME, Sherry AD, Malloy CR.

Magn Reson Med. 2016 Oct;76(4):1033-8. doi: 10.1002/mrm.26286. Epub 2016 Jul 4.

22.
23.

A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.

Wang JX, Merritt ME, Sherry D, Malloy CR.

Magn Reson Chem. 2016 Aug;54(8):665-73. doi: 10.1002/mrc.4435. Epub 2016 Apr 5.

24.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2016 Apr 1;126(4):1605. doi: 10.1172/JCI86695. Epub 2016 Apr 1. No abstract available.

25.

Metabolism of hyperpolarized [1-(13)C]pyruvate through alternate pathways in rat liver.

Jin ES, Moreno KX, Wang JX, Fidelino L, Merritt ME, Sherry AD, Malloy CR.

NMR Biomed. 2016 Apr;29(4):466-74. doi: 10.1002/nbm.3479. Epub 2016 Feb 2.

26.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2015 Dec;125(12):4447-62. doi: 10.1172/JCI82204. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1605. Livingston, Kenneth [corrected to Livingston, Kenneth A].

27.

Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.

Moreno KX, Moore CL, Burgess SC, Sherry AD, Malloy CR, Merritt ME.

Metabolomics. 2015 Oct;11(5):1144-1156. Epub 2015 Jan 9.

28.

Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.

Bankson JA, Walker CM, Ramirez MS, Stefan W, Fuentes D, Merritt ME, Lee J, Sandulache VC, Chen Y, Phan L, Chou PC, Rao A, Yeung SC, Lee MH, Schellingerhout D, Conrad CA, Malloy C, Sherry AD, Lai SY, Hazle JD.

Cancer Res. 2015 Nov 15;75(22):4708-17. doi: 10.1158/0008-5472.CAN-15-0171. Epub 2015 Sep 29.

29.

Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.

Lumata L, Yang C, Ragavan M, Carpenter N, DeBerardinis RJ, Merritt ME.

Methods Enzymol. 2015;561:73-106. doi: 10.1016/bs.mie.2015.04.006. Epub 2015 Jun 14. Review.

30.

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.

Gokhale A, Mullin AP, Zlatic SA, Easley CA 4th, Merritt ME, Raj N, Larimore J, Gordon DE, Peden AA, Sanyal S, Faundez V.

J Neurosci. 2015 May 13;35(19):7643-53. doi: 10.1523/JNEUROSCI.4724-14.2015.

31.

Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.

Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR.

Nat Med. 2015 Feb;21(2):108-9. doi: 10.1038/nm.3789. No abstract available.

32.

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ.

Mol Cell. 2014 Nov 6;56(3):414-24. doi: 10.1016/j.molcel.2014.09.025. Epub 2014 Oct 21.

33.

Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.

Comment A, Merritt ME.

Biochemistry. 2014 Dec 2;53(47):7333-57. doi: 10.1021/bi501225t. Epub 2014 Nov 18. Review.

34.

Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.

Moreno KX, Satapati S, DeBerardinis RJ, Burgess SC, Malloy CR, Merritt ME.

J Biol Chem. 2014 Dec 26;289(52):35859-67. doi: 10.1074/jbc.M114.613265. Epub 2014 Oct 28.

35.

Propionate stimulates pyruvate oxidation in the presence of acetate.

Purmal C, Kucejova B, Sherry AD, Burgess SC, Malloy CR, Merritt ME.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1134-41. doi: 10.1152/ajpheart.00407.2014. Epub 2014 Aug 22.

36.

Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.

Khemtong C, Carpenter NR, Lumata LL, Merritt ME, Moreno KX, Kovacs Z, Malloy CR, Sherry AD.

Magn Reson Med. 2015 Aug;74(2):312-9. doi: 10.1002/mrm.25419. Epub 2014 Aug 28.

37.

Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.

Lumata LL, Martin R, Jindal AK, Kovacs Z, Conradi MS, Merritt ME.

MAGMA. 2015 Apr;28(2):195-205. doi: 10.1007/s10334-014-0455-2. Epub 2014 Aug 14.

38.

Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion.

Cobert ML, Merritt ME, West LM, Ayers C, Jessen ME, Peltz M.

J Thorac Cardiovasc Surg. 2014 Nov;148(5):2310-2315.e1. doi: 10.1016/j.jtcvs.2014.02.023. Epub 2014 Feb 8.

39.

Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.

Yang C, Harrison C, Jin ES, Chuang DT, Sherry AD, Malloy CR, Merritt ME, DeBerardinis RJ.

J Biol Chem. 2014 Feb 28;289(9):6212-24. doi: 10.1074/jbc.M113.543637. Epub 2014 Jan 10.

40.

Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.

Lumata L, Kovacs Z, Sherry AD, Malloy C, Hill S, van Tol J, Yu L, Song L, Merritt ME.

Phys Chem Chem Phys. 2013 Jun 28;15(24):9800-7. doi: 10.1039/c3cp50186h.

41.

Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization.

Lumata L, Merritt ME, Kovacs Z.

Phys Chem Chem Phys. 2013 May 21;15(19):7032-5. doi: 10.1039/c3cp50750e.

42.

Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.

Lumata LL, Merritt ME, Malloy CR, Sherry AD, van Tol J, Song L, Kovacs Z.

J Magn Reson. 2013 Feb;227:14-9. doi: 10.1016/j.jmr.2012.11.006. Epub 2012 Nov 19.

43.

Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.

Lumata L, Merritt ME, Malloy CR, Sherry AD, Kovacs Z.

J Phys Chem A. 2012 May 31;116(21):5129-38. doi: 10.1021/jp302399f. Epub 2012 May 18.

44.

Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.

Evbuomwan OM, Merritt ME, Kiefer GE, Dean Sherry A.

Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):19-25. doi: 10.1002/cmmi.459.

45.

Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.

Merritt ME, Harrison C, Sherry AD, Malloy CR, Burgess SC.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19084-9. doi: 10.1073/pnas.1111247108. Epub 2011 Nov 7.

46.

Differences in regional myocardial perfusion, metabolism, MVO2, and edema after coronary sinus machine perfusion preservation of canine hearts.

Cobert ML, Merritt ME, West LM, Jessen ME, Peltz M.

ASAIO J. 2011 Nov-Dec;57(6):481-6. doi: 10.1097/MAT.0b013e31823769d5.

PMID:
22036719
47.

Production and NMR characterization of hyperpolarized (107,109)Ag complexes.

Lumata L, Merritt ME, Hashami Z, Ratnakar SJ, Kovacs Z.

Angew Chem Int Ed Engl. 2012 Jan 9;51(2):525-7. doi: 10.1002/anie.201106073. Epub 2011 Oct 13.

48.

Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8.

Moreno KX, Harrison C, Sherry AD, Malloy CR, Merritt ME.

J Magn Reson. 2011 Dec;213(1):187-91. doi: 10.1016/j.jmr.2011.09.012. Epub 2011 Oct 4.

49.

Glucose is an ineffective substrate for preservation of machine perfused donor hearts.

Cobert ML, Peltz M, West LM, Merritt ME, Jessen ME.

J Surg Res. 2012 Apr;173(2):198-205. doi: 10.1016/j.jss.2011.05.028. Epub 2011 Jun 23.

PMID:
21816432
50.

Could 13C MRI assist clinical decision-making for patients with heart disease?

Malloy CR, Merritt ME, Sherry AD.

NMR Biomed. 2011 Oct;24(8):973-9. doi: 10.1002/nbm.1718. Epub 2011 May 24. Review.

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