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Items: 1 to 50 of 267

1.

Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease.

Riley RT, Merrill AH Jr.

J Lipid Res. 2019 Jul;60(7):1183-1189. doi: 10.1194/jlr.S093815. Epub 2019 May 2.

PMID:
31048407
2.

Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.

Presa N, Clugston RD, Lingrell S, Kelly SE, Merrill AH Jr, Jana S, Kassiri Z, Gómez-Muñoz A, Vance DE, Jacobs RL, van der Veen JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):14-25. doi: 10.1016/j.bbadis.2018.10.010. Epub 2018 Oct 6.

PMID:
30300671
3.

Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.

Alsanafi M, Kelly SL, Jubair K, McNaughton M, Tate RJ, Merrill AH Jr, Pyne S, Pyne NJ.

Mol Cell Biol. 2018 Nov 13;38(23). pii: e00222-18. doi: 10.1128/MCB.00222-18. Print 2018 Dec 1.

4.

Eleven residues determine the acyl chain specificity of ceramide synthases.

Tidhar R, Zelnik ID, Volpert G, Ben-Dor S, Kelly S, Merrill AH Jr, Futerman AH.

J Biol Chem. 2018 Jun 22;293(25):9912-9921. doi: 10.1074/jbc.RA118.001936. Epub 2018 Apr 9.

5.

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

6.

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.

Dasari SK, Bialik S, Levin-Zaidman S, Levin-Salomon V, Merrill AH Jr, Futerman AH, Kimchi A.

Cell Death Differ. 2017 Jul;24(7):1288-1302. doi: 10.1038/cdd.2017.80. Epub 2017 Jun 2.

7.

Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.

Ferreira NS, Engelsby H, Neess D, Kelly SL, Volpert G, Merrill AH, Futerman AH, Færgeman NJ.

J Biol Chem. 2017 May 5;292(18):7588-7597. doi: 10.1074/jbc.M117.785345. Epub 2017 Mar 19.

8.

Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.

Volpert G, Ben-Dor S, Tarcic O, Duan J, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

J Cell Sci. 2017 Apr 15;130(8):1486-1493. doi: 10.1242/jcs.199968. Epub 2017 Mar 9.

9.

Opinion article on lipidomics: Inherent challenges of lipidomic analysis of sphingolipids.

Merrill AH Jr, Sullards MC.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Aug;1862(8):774-776. doi: 10.1016/j.bbalip.2017.01.009. Epub 2017 Feb 1. Review.

10.

Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1.

Deevska GM, Dotson PP 2nd, Karakashian AA, Isaac G, Wrona M, Kelly SB, Merrill AH Jr, Nikolova-Karakashian MN.

J Biol Chem. 2017 Mar 24;292(12):5110-5122. doi: 10.1074/jbc.M116.751602. Epub 2017 Jan 13.

11.

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.

Klein AD, Ferreira NS, Ben-Dor S, Duan J, Hardy J, Cox TM, Merrill AH Jr, Futerman AH.

Cell Rep. 2016 Sep 6;16(10):2546-2553. doi: 10.1016/j.celrep.2016.07.085. Epub 2016 Aug 25.

12.

Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.

Vardi A, Zigdon H, Meshcheriakova A, Klein AD, Yaacobi C, Eilam R, Kenwood BM, Rahim AA, Massaro G, Merrill AH Jr, Vitner EB, Futerman AH.

J Pathol. 2016 Aug;239(4):496-509. doi: 10.1002/path.4751. Epub 2016 Jul 5.

PMID:
27234572
13.

Development of pheochromocytoma in ceramide synthase 2 null mice.

Park WJ, Brenner O, Kogot-Levin A, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

Endocr Relat Cancer. 2015 Aug;22(4):623-32. doi: 10.1530/ERC-15-0058. Epub 2015 Jun 25.

14.

1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma.

Duan J, Merrill AH Jr.

J Biol Chem. 2015 Jun 19;290(25):15380-9. doi: 10.1074/jbc.R115.658823. Epub 2015 May 6. Review.

15.

Introduction to Thematic Minireview Series: Novel Bioactive Sphingolipids.

Merrill AH Jr, Carman GM.

J Biol Chem. 2015 Jun 19;290(25):15362-4. doi: 10.1074/jbc.R115.663708. Epub 2015 May 6. Review.

16.

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.

Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH Jr, Russell DW, Subramaniam S, Brown HA.

J Lipid Res. 2015 Mar;56(3):722-36. doi: 10.1194/jlr.P056002. Epub 2015 Jan 17.

17.

Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells.

Jiménez-Rojo N, Sot J, Busto JV, Shaw WA, Duan J, Merrill AH Jr, Alonso A, Goñi FM.

Biophys J. 2014 Dec 16;107(12):2850-2859. doi: 10.1016/j.bpj.2014.10.010.

18.

Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.

Park WJ, Park JW, Merrill AH, Storch J, Pewzner-Jung Y, Futerman AH.

Biochim Biophys Acta. 2014 Dec;1841(12):1754-66. Erratum in: Biochim Biophys Acta. 2015 Jul;1851(7):996.

19.

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM.

Nat Med. 2014 Aug;20(8):927-35. doi: 10.1038/nm.3610. Epub 2014 Jul 27.

20.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

21.

Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain.

Pinto SN, Laviad EL, Stiban J, Kelly SL, Merrill AH Jr, Prieto M, Futerman AH, Silva LC.

J Lipid Res. 2014 Jan;55(1):53-61. doi: 10.1194/jlr.M042002. Epub 2013 Oct 25.

22.

Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration.

Farfel-Becker T, Vitner EB, Kelly SL, Bame JR, Duan J, Shinder V, Merrill AH Jr, Dobrenis K, Futerman AH.

Hum Mol Genet. 2014 Feb 15;23(4):843-54. doi: 10.1093/hmg/ddt468. Epub 2013 Sep 24.

23.

Lipidomics technologies at the end of the first decade and the beginning of the next.

Merrill AH, Dennis EA, McDonald JG, Fahy E.

Adv Nutr. 2013 Sep 1;4(5):565-7. doi: 10.3945/an.113.004333.

24.

Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.

Park WJ, Park JW, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

J Biol Chem. 2013 Oct 25;288(43):30904-16. doi: 10.1074/jbc.M112.448852. Epub 2013 Sep 9.

25.

In memoriam: Charles (Chuck) Crawford Sweeley, Jr. (1930-2012).

Merrill AH Jr, Murphy RC, Smith WL, Vance DE, Wilson JE, Yu RK.

J Lipid Res. 2013 Jan;54(1):1-4. No abstract available.

26.

Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.

Zigdon H, Kogot-Levin A, Park JW, Goldschmidt R, Kelly S, Merrill AH Jr, Scherz A, Pewzner-Jung Y, Saada A, Futerman AH.

J Biol Chem. 2013 Feb 15;288(7):4947-56. doi: 10.1074/jbc.M112.402719. Epub 2013 Jan 2.

27.

Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.

Morad SA, Messner MC, Levin JC, Abdelmageed N, Park H, Merrill AH Jr, Cabot MC.

Cancer Chemother Pharmacol. 2013 Mar;71(3):635-45. doi: 10.1007/s00280-012-2050-4. Epub 2012 Dec 21.

PMID:
23263160
28.

Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction.

Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN.

PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650. Epub 2012 Oct 26.

29.

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK.

Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054.

30.

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.

Martinez TN, Chen X, Bandyopadhyay S, Merrill AH, Tansey MG.

Mol Neurodegener. 2012 Sep 13;7:45. doi: 10.1186/1750-1326-7-45.

31.

Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.

Lucki NC, Li D, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB.

Mol Cell Biol. 2012 Nov;32(21):4419-31. doi: 10.1128/MCB.00378-12. Epub 2012 Aug 27.

32.

Modulation of ceramide synthase activity via dimerization.

Laviad EL, Kelly S, Merrill AH Jr, Futerman AH.

J Biol Chem. 2012 Jun 15;287(25):21025-33. doi: 10.1074/jbc.M112.363580. Epub 2012 Apr 26.

33.

Sphingosine 1-phosphate (S1P) lyase deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.

Hagen-Euteneuer N, Lütjohann D, Park H, Merrill AH Jr, van Echten-Deckert G.

J Biol Chem. 2012 Mar 16;287(12):9128-36. doi: 10.1074/jbc.M111.302380. Epub 2012 Jan 30.

34.

Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.

Lucki NC, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB.

Mol Endocrinol. 2012 Feb;26(2):228-43. doi: 10.1210/me.2011-1150. Epub 2012 Jan 19.

35.

Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.

Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH Jr, Prieto M, Futerman AH.

J Lipid Res. 2012 Mar;53(3):430-6. doi: 10.1194/jlr.M022715. Epub 2012 Jan 9.

36.

Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.

Tidhar R, Ben-Dor S, Wang E, Kelly S, Merrill AH Jr, Futerman AH.

J Biol Chem. 2012 Jan 27;287(5):3197-206. doi: 10.1074/jbc.M111.280271. Epub 2011 Dec 5.

37.

Lipidomics and imaging mass spectrometry.

Murphy RC, Merrill AH Jr.

Biochim Biophys Acta. 2011 Nov;1811(11):635-6. doi: 10.1016/j.bbalip.2011.09.003. Epub 2011 Sep 17. No abstract available.

PMID:
21983393
38.

Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Merrill AH Jr.

Chem Rev. 2011 Oct 12;111(10):6387-422. doi: 10.1021/cr2002917. Epub 2011 Sep 26. Review. No abstract available.

39.

Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS).

Sullards MC, Liu Y, Chen Y, Merrill AH Jr.

Biochim Biophys Acta. 2011 Nov;1811(11):838-53. doi: 10.1016/j.bbalip.2011.06.027. Epub 2011 Jul 1. Review.

40.

Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.

Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH.

J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24.

41.

Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.

Haynes CA, Allegood JC, Wang EW, Kelly SL, Sullards MC, Merrill AH Jr.

J Lipid Res. 2011 Aug;52(8):1583-94. doi: 10.1194/jlr.D015586. Epub 2011 May 17.

42.

A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.

Momin AA, Park H, Portz BJ, Haynes CA, Shaner RL, Kelly SL, Jordan IK, Merrill AH Jr.

J Lipid Res. 2011 Jun;52(6):1073-83. doi: 10.1194/jlr.M010454. Epub 2011 Mar 17.

43.

Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.

Symolon H, Bushnev A, Peng Q, Ramaraju H, Mays SG, Allegood JC, Pruett ST, Sullards MC, Dillehay DL, Liotta DC, Merrill AH Jr.

Mol Cancer Ther. 2011 Apr;10(4):648-57. doi: 10.1158/1535-7163.MCT-10-0754. Epub 2011 Mar 11.

44.

Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation.

Quo CF, Moffitt RA, Merrill AH, Wang MD.

J Comput Biol. 2011 Feb;18(2):169-82. doi: 10.1089/cmb.2010.0215.

45.

Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism.

Gupta S, Maurya MR, Merrill AH Jr, Glass CK, Subramaniam S.

BMC Syst Biol. 2011 Feb 8;5:26. doi: 10.1186/1752-0509-5-26.

46.

A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.

Dickson MA, Carvajal RD, Merrill AH Jr, Gonen M, Cane LM, Schwartz GK.

Clin Cancer Res. 2011 Apr 15;17(8):2484-92. doi: 10.1158/1078-0432.CCR-10-2323. Epub 2011 Jan 21.

47.

A mouse macrophage lipidome.

Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S.

J Biol Chem. 2010 Dec 17;285(51):39976-85. doi: 10.1074/jbc.M110.182915. Epub 2010 Oct 5.

48.

Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy.

Sims K, Haynes CA, Kelly S, Allegood JC, Wang E, Momin A, Leipelt M, Reichart D, Glass CK, Sullards MC, Merrill AH Jr.

J Biol Chem. 2010 Dec 3;285(49):38568-79. doi: 10.1074/jbc.M110.170621. Epub 2010 Sep 27.

49.

An introduction to sphingolipid metabolism and analysis by new technologies.

Chen Y, Liu Y, Sullards MC, Merrill AH Jr.

Neuromolecular Med. 2010 Dec;12(4):306-19. doi: 10.1007/s12017-010-8132-8. Epub 2010 Aug 3. Review.

50.

Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system.

Chen Y, Liu Y, Allegood J, Wang E, Cachón-González B, Cox TM, Merrill AH Jr, Sullards MC.

Methods Mol Biol. 2010;656:131-46. doi: 10.1007/978-1-60761-746-4_7.

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