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Items: 28


The enigmatic role of Mfd in replication-transcription conflicts in bacteria.

Ragheb M, Merrikh H.

DNA Repair (Amst). 2019 Sep;81:102659. doi: 10.1016/j.dnarep.2019.102659. Epub 2019 Jul 8. Review.


Inhibiting the Evolution of Antibiotic Resistance.

Ragheb MN, Thomason MK, Hsu C, Nugent P, Gage J, Samadpour AN, Kariisa A, Merrikh CN, Miller SI, Sherman DR, Merrikh H.

Mol Cell. 2019 Jan 3;73(1):157-165.e5. doi: 10.1016/j.molcel.2018.10.015. Epub 2018 Nov 15.


Gene inversion potentiates bacterial evolvability and virulence.

Merrikh CN, Merrikh H.

Nat Commun. 2018 Nov 7;9(1):4662. doi: 10.1038/s41467-018-07110-3.


Crystal structure of a membrane-bound O-acyltransferase.

Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W.

Nature. 2018 Oct;562(7726):286-290. doi: 10.1038/s41586-018-0568-2. Epub 2018 Oct 3.


The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria.

Lang KS, Merrikh H.

Annu Rev Microbiol. 2018 Sep 8;72:71-88. doi: 10.1146/annurev-micro-090817-062514. Epub 2018 Jun 1. Review.


The bacterial replisome has factory-like localization.

Mangiameli SM, Cass JA, Merrikh H, Wiggins PA.

Curr Genet. 2018 Oct;64(5):1029-1036. doi: 10.1007/s00294-018-0830-z. Epub 2018 Apr 9. Review.


DNA gyrase activity regulates DnaA-dependent replication initiation in Bacillus subtilis.

Samadpour AN, Merrikh H.

Mol Microbiol. 2018 Apr;108(2):115-127. doi: 10.1111/mmi.13920. Epub 2018 Mar 6.


Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.

Loftie-Eaton W, Bashford K, Quinn H, Dong K, Millstein J, Hunter S, Thomason MK, Merrikh H, Ponciano JM, Top EM.

Nat Ecol Evol. 2017 Sep;1(9):1354-1363. doi: 10.1038/s41559-017-0243-2. Epub 2017 Aug 7.


Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis.

Lang KS, Hall AN, Merrikh CN, Ragheb M, Tabakh H, Pollock AJ, Woodward JJ, Dreifus JE, Merrikh H.

Cell. 2017 Aug 10;170(4):787-799.e18. doi: 10.1016/j.cell.2017.07.044.


Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts.

Merrikh H.

Trends Microbiol. 2017 Jul;25(7):515-521. doi: 10.1016/j.tim.2017.01.008. Epub 2017 Feb 16.


The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria.

Mangiameli SM, Veit BT, Merrikh H, Wiggins PA.

PLoS Genet. 2017 Jan 23;13(1):e1006582. doi: 10.1371/journal.pgen.1006582. eCollection 2017 Jan.


Transcription leads to pervasive replisome instability in bacteria.

Mangiameli SM, Merrikh CN, Wiggins PA, Merrikh H.

Elife. 2017 Jan 16;6. pii: e19848. doi: 10.7554/eLife.19848.


The Accelerated Evolution of Lagging Strand Genes Is Independent of Sequence Context.

Merrikh CN, Weiss E, Merrikh H.

Genome Biol Evol. 2016 Dec 1;8(12):3696-3702. doi: 10.1093/gbe/evw274.


The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units.

Merrikh CN, Brewer BJ, Merrikh H.

PLoS Genet. 2015 Jun 12;11(6):e1005289. doi: 10.1371/journal.pgen.1005289. eCollection 2015 Jun.


Replication Restart after Replication-Transcription Conflicts Requires RecA in Bacillus subtilis.

Million-Weaver S, Samadpour AN, Merrikh H.

J Bacteriol. 2015 Jul;197(14):2374-82. doi: 10.1128/JB.00237-15. Epub 2015 May 4.


An underlying mechanism for the increased mutagenesis of lagging-strand genes in Bacillus subtilis.

Million-Weaver S, Samadpour AN, Moreno-Habel DA, Nugent P, Brittnacher MJ, Weiss E, Hayden HS, Miller SI, Liachko I, Merrikh H.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1096-105. doi: 10.1073/pnas.1416651112. Epub 2015 Feb 23.


Accelerated gene evolution through replication-transcription conflicts.

Paul S, Million-Weaver S, Chattopadhyay S, Sokurenko E, Merrikh H.

Nature. 2013 Mar 28;495(7442):512-5. doi: 10.1038/nature11989.


Replication-transcription conflicts in bacteria.

Merrikh H, Zhang Y, Grossman AD, Wang JD.

Nat Rev Microbiol. 2012 Jun 6;10(7):449-58. doi: 10.1038/nrmicro2800. Review.


Control of the replication initiator DnaA by an anti-cooperativity factor.

Merrikh H, Grossman AD.

Mol Microbiol. 2011 Oct;82(2):434-46. doi: 10.1111/j.1365-2958.2011.07821.x. Epub 2011 Sep 14.


Co-directional replication-transcription conflicts lead to replication restart.

Merrikh H, Machón C, Grainger WH, Grossman AD, Soultanas P.

Nature. 2011 Feb 24;470(7335):554-7. doi: 10.1038/nature09758.


The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids.

Rahn-Lee L, Merrikh H, Grossman AD, Losick R.

J Bacteriol. 2011 Mar;193(6):1302-7. doi: 10.1128/JB.01390-10. Epub 2011 Jan 14.


Primosomal proteins DnaD and DnaB are recruited to chromosomal regions bound by DnaA in Bacillus subtilis.

Smits WK, Merrikh H, Bonilla CY, Grossman AD.

J Bacteriol. 2011 Feb;193(3):640-8. doi: 10.1128/JB.01253-10. Epub 2010 Nov 19.


Growth phase and (p)ppGpp control of IraD, a regulator of RpoS stability, in Escherichia coli.

Merrikh H, Ferrazzoli AE, Lovett ST.

J Bacteriol. 2009 Dec;191(24):7436-46. doi: 10.1128/JB.00412-09. Epub 2009 Oct 9.


YabA of Bacillus subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress.

Goranov AI, Breier AM, Merrikh H, Grossman AD.

Mol Microbiol. 2009 Oct;74(2):454-66. doi: 10.1111/j.1365-2958.2009.06876.x. Epub 2009 Sep 8.


A DNA damage response in Escherichia coli involving the alternative sigma factor, RpoS.

Merrikh H, Ferrazzoli AE, Bougdour A, Olivier-Mason A, Lovett ST.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):611-6. doi: 10.1073/pnas.0803665106. Epub 2009 Jan 5.


The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis.

Celenza JL, Quiel JA, Smolen GA, Merrikh H, Silvestro AR, Normanly J, Bender J.

Plant Physiol. 2005 Jan;137(1):253-62. Epub 2004 Dec 3.


A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.

Dower K, Kuperwasser N, Merrikh H, Rosbash M.

RNA. 2004 Dec;10(12):1888-99.


Altered arachidonic acid biosynthesis and antioxidant protection mechanisms in Schwann cells grown in elevated glucose.

Mîinea C, Kuruvilla R, Merrikh H, Eichberg J.

J Neurochem. 2002 Jun;81(6):1253-62.

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