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Items: 15

1.

Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs).

Handlon AL, Schaller LT, Leesnitzer LM, Merrihew RV, Poole C, Ulrich JC, Wilson JW, Cadilla R, Turnbull P.

ACS Med Chem Lett. 2015 Nov 19;7(1):83-8. doi: 10.1021/acsmedchemlett.5b00377. eCollection 2016 Jan 14.

2.

Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARĪ³ partial agonist.

Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH, Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM, Xu RX, Virley DJ.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in: Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to Willson, Timothy M].

PMID:
21798739
3.

Phenoxyacetic acids as PPARĪ“ partial agonists: synthesis, optimization, and in vivo efficacy.

Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, Epperly AH, Leesnitzer LM, Merrihew RV, Xu RX, Lambert MH, Jin J.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2345-50. doi: 10.1016/j.bmcl.2011.02.077. Epub 2011 Mar 15.

PMID:
21414782
4.

Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.

Shearer BG, Wiethe RW, Ashe A, Billin AN, Way JM, Stanley TB, Wagner CD, Xu RX, Leesnitzer LM, Merrihew RV, Shearer TW, Jeune MR, Ulrich JC, Willson TM.

J Med Chem. 2010 Feb 25;53(4):1857-61. doi: 10.1021/jm900464j.

PMID:
20128594
5.

Discovery of a novel class of PPARdelta partial agonists.

Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA, Lambert MH, Xu RX, Leesnitzer LM, Merrihew RV, Huet S, Willson TM.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5018-22. doi: 10.1016/j.bmcl.2008.08.011. Epub 2008 Aug 9.

PMID:
18722772
6.

Baculoviruses and mammalian cell-based assays for drug screening.

Condreay JP, Ames RS, Hassan NJ, Kost TA, Merrihew RV, Mossakowska DE, Pountney DJ, Romanos MA.

Adv Virus Res. 2006;68:255-86. Review. No abstract available.

PMID:
16997014
7.

Cloning, tissue expression, and regulation of beagle dog CYP4A genes.

Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL.

Toxicol Sci. 2006 Aug;92(2):356-67. Epub 2006 May 4.

PMID:
16675513
8.

The application of BacMam technology in nuclear receptor drug discovery.

Boudjelal M, Mason SJ, Katso RM, Fleming JM, Parham JH, Condreay JP, Merrihew RV, Cairns WJ.

Biotechnol Annu Rev. 2005;11:101-25. Review.

PMID:
16216775
9.

Evaluation of cell-based assays for steroid nuclear receptors delivered by recombinant baculoviruses.

Katso RM, Parham JH, Caivano M, Clay WC, Condreay JP, Gray DW, Lindley KM, Mason SJ, Rieger J, Wakes NC, Cairns WJ, Merrihew RV.

J Biomol Screen. 2005 Oct;10(7):715-24. Epub 2005 Aug 29.

PMID:
16129777
10.

Baculovirus-mediated gene delivery into mammalian cells.

Merrihew RV, Kost TA, Condreay JP.

Methods Mol Biol. 2004;246:355-65.

PMID:
14970604
11.

Chromosomal integration of transduced recombinant baculovirus DNA in mammalian cells.

Merrihew RV, Clay WC, Condreay JP, Witherspoon SM, Dallas WS, Kost TA.

J Virol. 2001 Jan;75(2):903-9.

12.

Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.

Merrihew RV, Cruickshank RD, Conway K, Weissman BE.

Exp Cell Res. 2000 Aug 25;259(1):191-203.

PMID:
10942591
13.

The influence of a (GT)29 microsatellite sequence on homologous recombination in the hamster adenine phosphoribosyltransferase gene.

Sargent RG, Merrihew RV, Nairn R, Adair G, Meuth M, Wilson JH.

Nucleic Acids Res. 1996 Feb 15;24(4):746-53.

14.

High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome.

Merrihew RV, Marburger K, Pennington SL, Roth DB, Wilson JH.

Mol Cell Biol. 1996 Jan;16(1):10-8.

15.

Efficient modification of the APRT gene by FLP/FRT site-specific targeting.

Merrihew RV, Sargent RG, Wilson JH.

Somat Cell Mol Genet. 1995 Sep;21(5):299-307.

PMID:
8619127

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