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Items: 1 to 50 of 128

1.
2.

Nobel laureates' letter to President Bush.

Arrow KJ, Axelrod J, Benacerraf B, Berg P, Bishop JM, Bloembergen N, Brown HC, Cibelli J, Cohen S, Cooper LN, Corey EJ, Cronin JW, Curl R Jr, Dulbecco R, Fischer EH, Fitch VL, Fogel R, Friedman JI, Furchgott RF, Gell-Mann M, Gilbert W, Gilman A, Glaser D, Glashow SL, Green RM, Greengard P, Guillemin R, Hayflick L, Hauptman HA, Heckman JJ, Heeger A, Herschbach D, Hubel DH, Hulse R, Kandel E, Karle J, Klein LR, Kohn W, Kornberg A, Krebs EG, Lanza RP, Laughlin R, Lederman L, Lee DM, Lewis E, Lipscomb W Jr, Marcus RA, McFadden D, Merrifield RB, Merton R, Modigliani F, Molina MJ, Murad F, Nirenberg MW, North DC, Olah GA, Osheroff D, Palade GE, Perl M, Ramsey NF, Richter B, Roberts RJ, Samuelson PA, Schwartz M, Sharp PA, Smalley RE, Smith HO, Solow RM, Stormer H, Taube H, Taylor R, Thomas ED, Tobin J, Tonegawa S, Townes C, Watson JD, Weinberg S, Weller TH, West MD, Wieschaus EF, Wiesel TN, Wilson RW.

Washington Post. 2001 Feb 22:A02. No abstract available.

PMID:
12462241
3.

Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling.

Unson CG, Wu CR, Jiang Y, Yoo B, Cheung C, Sakmar TP, Merrifield RB.

Biochemistry. 2002 Oct 1;41(39):11795-803.

PMID:
12269822
4.

Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase.

Jiang Y, Cypess AM, Muse ED, Wu CR, Unson CG, Merrifield RB, Sakmar TP.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10102-7. Epub 2001 Aug 21.

5.

Mass spectrometric evaluation of synthetic peptides as primary structure models for peptide and protein deamidation.

Robinson NE, Robinson AB, Merrifield RB.

J Pept Res. 2001 Jun;57(6):483-93.

PMID:
11437952
6.
7.

Orientation of cecropin A helices in phospholipid bilayers determined by solid-state NMR spectroscopy.

Marassi FM, Opella SJ, Juvvadi P, Merrifield RB.

Biophys J. 1999 Dec;77(6):3152-5.

8.

Structure-activity studies of normal and retro pig cecropin-melittin hybrids.

Juvvadi P, Vunnam S, Yoo B, Merrifield RB.

J Pept Res. 1999 Mar;53(3):244-51.

PMID:
10231712
9.

Positively charged residues at positions 12, 17, and 18 of glucagon ensure maximum biological potency.

Unson CG, Wu CR, Cheung CP, Merrifield RB.

J Biol Chem. 1998 Apr 24;273(17):10308-12.

11.

Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria.

Durvasula RV, Gumbs A, Panackal A, Kruglov O, Aksoy S, Merrifield RB, Richards FF, Beard CB.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3274-8.

12.

Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine.

Vunnam S, Juvvadi P, Merrifield RB.

J Pept Res. 1997 Jan;49(1):59-66.

PMID:
9128101
13.

Hydrophobic effects on antibacterial and channel-forming properties of cecropin A-melittin hybrids.

Juvvadi P, Vunnam S, Merrifield EL, Boman HG, Merrifield RB.

J Pept Sci. 1996 Jul-Aug;2(4):223-32.

PMID:
9231329
14.

Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.

Unson CG, Cypess AM, Wu CR, Goldsmith PK, Merrifield RB, Sakmar TP.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):310-5.

15.
16.

D-enantiomers of 15-residue cecropin A-melittin hybrids.

Merrifield EL, Mitchell SA, Ubach J, Boman HG, Andreu D, Merrifield RB.

Int J Pept Protein Res. 1995 Sep-Oct;46(3-4):214-20.

PMID:
8537174
17.

Retro and retroenantio analogs of cecropin-melittin hybrids.

Merrifield RB, Juvvadi P, Andreu D, Ubach J, Boman A, Boman HG.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3449-53.

18.

Roles of aspartic acid 15 and 21 in glucagon action: receptor anchor and surrogates for aspartic acid 9.

Unson CG, Wu CR, Merrifield RB.

Biochemistry. 1994 Jun 7;33(22):6884-7.

PMID:
8204623
19.

Multiple-site replacement analogs of glucagon. A molecular basis for antagonist design.

Unson CG, Wu CR, Fitzpatrick KJ, Merrifield RB.

J Biol Chem. 1994 Apr 29;269(17):12548-51.

20.

Identification of an essential serine residue in glucagon: implication for an active site triad.

Unson CG, Merrifield RB.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):454-8.

21.

Design and synthesis of antimicrobial peptides.

Merrifield RB, Merrifield EL, Juvvadi P, Andreu D, Boman HG.

Ciba Found Symp. 1994;186:5-20; discussion 20-6. Review.

PMID:
7768157
22.

The role of histidine-1 in glucagon action.

Unson CG, Macdonald D, Merrifield RB.

Arch Biochem Biophys. 1993 Feb 1;300(2):747-50.

PMID:
8382034
23.

Antibacterial peptides designed as analogs or hybrids of cecropins and melittin.

Wade D, Andreu D, Mitchell SA, Silveira AM, Boman A, Boman HG, Merrifield RB.

Int J Pept Protein Res. 1992 Nov;40(5):429-36.

PMID:
1483838
24.

Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.

Andreu D, Ubach J, Boman A, Wåhlin B, Wade D, Merrifield RB, Boman HG.

FEBS Lett. 1992 Jan 20;296(2):190-4.

25.

Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding.

Unson CG, Macdonald D, Ray K, Durrah TL, Merrifield RB.

J Biol Chem. 1991 Feb 15;266(5):2763-6.

26.

All-D amino acid-containing channel-forming antibiotic peptides.

Wade D, Boman A, Wåhlin B, Drain CM, Andreu D, Boman HG, Merrifield RB.

Proc Natl Acad Sci U S A. 1990 Jun;87(12):4761-5.

27.

Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids.

Boman HG, Wade D, Boman IA, Wåhlin B, Merrifield RB.

FEBS Lett. 1989 Dec 18;259(1):103-6.

28.

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.

Unson CG, Gurzenda EM, Merrifield RB.

Peptides. 1989 Nov-Dec;10(6):1171-7.

PMID:
2560175
29.

Design, synthesis and antibacterial activity of cecropin-like model peptides.

Fink J, Boman A, Boman HG, Merrifield RB.

Int J Pept Protein Res. 1989 Jun;33(6):412-21.

PMID:
2777475
30.

The chemical synthesis of cecropin D and an analog with enhanced antibacterial activity.

Fink J, Merrifield RB, Boman A, Boman HG.

J Biol Chem. 1989 Apr 15;264(11):6260-7.

31.

Chemical synthesis and enzymic processing of precursor forms of cecropins A and B.

Boman HC, Boman IA, Andreu D, Li ZQ, Merrifield RB, Schlenstedt G, Zimmermann R.

J Biol Chem. 1989 Apr 5;264(10):5852-60.

32.
33.

Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase.

Stenflo J, Holme E, Lindstedt S, Chandramouli N, Huang LH, Tam JP, Merrifield RB.

Proc Natl Acad Sci U S A. 1989 Jan;86(2):444-7.

34.

Potentiation of glucose-induced insulin release in islets by desHis1[Glu9]glucagon amide.

Kofod H, Unson CG, Merrifield RB.

Int J Pept Protein Res. 1988 Dec;32(6):436-40.

PMID:
3073146
35.

Mass spectrometric evaluation of synthetic peptides for deletions and insertions.

Merrifield RB, Singer J, Chait BT.

Anal Biochem. 1988 Nov 1;174(2):399-414.

PMID:
3239745
36.

Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time.

Tam JP, Riemen MW, Merrifield RB.

Pept Res. 1988 Sep-Oct;1(1):6-18.

PMID:
2980781
37.

Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.

Christensen B, Fink J, Merrifield RB, Mauzerall D.

Proc Natl Acad Sci U S A. 1988 Jul;85(14):5072-6.

39.

Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects.

Steiner H, Andreu D, Merrifield RB.

Biochim Biophys Acta. 1988 Apr 7;939(2):260-6.

PMID:
3128324
40.

Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids.

Kofod H, Andreu D, Thams P, Merrifield RB, Hedeskov CJ, Hansen B, Lernmark A.

Am J Physiol. 1988 Apr;254(4 Pt 1):E454-8.

PMID:
2833112
41.
43.

4-Methoxybenzyloxycarbonyl amino acids in solid phase peptide synthesis.

Wang SS, Chen ST, Wang KT, Merrifield RB.

Int J Pept Protein Res. 1987 Nov;30(5):662-7.

PMID:
3436702
44.

Synthetic peptide antagonists of glucagon.

Unson CG, Andreu D, Gurzenda EM, Merrifield RB.

Proc Natl Acad Sci U S A. 1987 Jun;84(12):4083-7.

45.
46.

Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms.

Trimble ER, Bruzzone R, Biden TJ, Meehan CJ, Andreu D, Merrifield RB.

Proc Natl Acad Sci U S A. 1987 May;84(10):3146-50.

47.

Synthesis and hormonal activity of [Tyr22] glucagon and [desHis1, Tyr22] glucagon.

Lu GS, Mojsov S, Merrifield RB.

Int J Pept Protein Res. 1987 Apr;29(4):545-57.

PMID:
3454664
48.

Solid phase synthesis of thymosin beta 9.

Chandramouli N, Bhargava KK, Incefy GS, Modak MJ, Merrifield RB.

Int J Pept Protein Res. 1986 Nov;28(5):536-41.

PMID:
3818171
49.
50.

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