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Protein Synthesis Initiation in Eukaryotic Cells.

Merrick WC, Pavitt GD.

Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12). pii: a033092. doi: 10.1101/cshperspect.a033092. Review.


A Unique ISR Program Determines Cellular Responses to Chronic Stress.

Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M.

Mol Cell. 2017 Dec 7;68(5):885-900.e6. doi: 10.1016/j.molcel.2017.11.007.


The eIF2A knockout mouse.

Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA.

Cell Cycle. 2016 Nov 16;15(22):3115-3120. Epub 2016 Sep 29.


The Celebration of 40 years of structural biology at Aarhus University as seen through the eyes of a translationalist.

Merrick WC.

N Biotechnol. 2017 Sep 25;38(Pt A):26-28. doi: 10.1016/j.nbt.2016.09.004. Epub 2016 Sep 21. Review.


Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J.

Elife. 2015 Dec 10;4. pii: e10222. doi: 10.7554/eLife.10222.


eIF4F: a retrospective.

Merrick WC.

J Biol Chem. 2015 Oct 2;290(40):24091-9. doi: 10.1074/jbc.R115.675280. Epub 2015 Aug 31. Review.


OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.

Chen H, Song R, Wang G, Ding Z, Yang C, Zhang J, Zeng Z, Rubio V, Wang L, Zu N, Weiskoff AM, Minze LJ, Jeyabal PV, Mansour OC, Bai L, Merrick WC, Zheng S, Shi ZZ.

Sci Rep. 2015 Aug 18;5:13241. doi: 10.1038/srep13241.


Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.

Khan MA, Ma J, Walden WE, Merrick WC, Theil EC, Goss DJ.

Nucleic Acids Res. 2014 Jun;42(10):6567-77. doi: 10.1093/nar/gku248. Epub 2014 Apr 11.


Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M.

J Biol Chem. 2014 May 2;289(18):12593-611. doi: 10.1074/jbc.M113.543215. Epub 2014 Mar 19.


Control not at initiation? Bah, humbug!

Merrick WC, Harris ME.

EMBO J. 2014 Jan 7;33(1):3-4. doi: 10.1002/embj.201387388. Epub 2013 Dec 21.


Influence of translation factor activities on start site selection in six different mRNAs.

Barth-Baus D, Bhasker CR, Zoll W, Merrick WC.

Translation (Austin). 2013 Apr 1;1(1):e24419. doi: 10.4161/trla.24419. eCollection 2013.


Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation.

Ma J, Haldar S, Khan MA, Sharma SD, Merrick WC, Theil EC, Goss DJ.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8417-22. doi: 10.1073/pnas.1120045109. Epub 2012 May 14.


Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics.

Bentley AA, Merkulov SM, Peng Y, Rozmarynowycz R, Qi X, Pusztai-Carey M, Merrick WC, Yee VC, McCrae KR, Komar AA.

J Biol Chem. 2012 Jun 22;287(26):22142-50. doi: 10.1074/jbc.M112.372854. Epub 2012 May 10.


A new framework for understanding IRES-mediated translation.

Komar AA, Mazumder B, Merrick WC.

Gene. 2012 Jul 10;502(2):75-86. doi: 10.1016/j.gene.2012.04.039. Epub 2012 Apr 24. Review.


Insights into the role of yeast eIF2A in IRES-mediated translation.

Reineke LC, Cao Y, Baus D, Hossain NM, Merrick WC.

PLoS One. 2011;6(9):e24492. doi: 10.1371/journal.pone.0024492. Epub 2011 Sep 7.


Characterization of hibernating ribosomes in mammalian cells.

Krokowski D, Gaccioli F, Majumder M, Mullins MR, Yuan CL, Papadopoulou B, Merrick WC, Komar AA, Taylor D, Hatzoglou M.

Cell Cycle. 2011 Aug 15;10(16):2691-702. Epub 2011 Aug 15.


mRNA helicases: the tacticians of translational control.

Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N.

Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45. doi: 10.1038/nrm3083. Review.


Identification of an mRNP complex regulating tumorigenesis at the translational elongation step.

Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, Merrick WC, Howe PH.

Mol Cell. 2011 Feb 18;41(4):419-31. doi: 10.1016/j.molcel.2011.02.003.


GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor.

Dmitriev SE, Terenin IM, Andreev DE, Ivanov PA, Dunaevsky JE, Merrick WC, Shatsky IN.

J Biol Chem. 2010 Aug 27;285(35):26779-87. doi: 10.1074/jbc.M110.119693. Epub 2010 Jun 21.


Introduction to the thematic minireview series on protein synthesis.

Merrick WC.

J Biol Chem. 2010 Jul 9;285(28):21195-6. doi: 10.1074/jbc.R110.140012. Epub 2010 May 5. No abstract available.


Eukaryotic protein synthesis: still a mystery.

Merrick WC.

J Biol Chem. 2010 Jul 9;285(28):21197-201. doi: 10.1074/jbc.R110.111476. Epub 2010 May 5. No abstract available.


Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO.

Nat Chem Biol. 2010 Mar;6(3):209-217. Epub 2010 Jan 31.


Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression.

Reineke LC, Merrick WC.

RNA. 2009 Dec;15(12):2264-77. doi: 10.1261/rna.1722809. Epub 2009 Oct 27.


Differential contribution of the m7G-cap to the 5' end-dependent translation initiation of mammalian mRNAs.

Andreev DE, Dmitriev SE, Terenin IM, Prassolov VS, Merrick WC, Shatsky IN.

Nucleic Acids Res. 2009 Oct;37(18):6135-47. doi: 10.1093/nar/gkp665. Epub 2009 Aug 20.


Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap.

Kaye NM, Emmett KJ, Merrick WC, Jankowsky E.

J Biol Chem. 2009 Jun 26;284(26):17742-50. doi: 10.1074/jbc.M109.009001. Epub 2009 May 4.


General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation.

Svitkin YV, Evdokimova VM, Brasey A, Pestova TV, Fantus D, Yanagiya A, Imataka H, Skabkin MA, Ovchinnikov LP, Merrick WC, Sonenberg N.

EMBO J. 2009 Jan 7;28(1):58-68. doi: 10.1038/emboj.2008.259. Epub 2008 Dec 11.


A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae.

Reineke LC, Komar AA, Caprara MG, Merrick WC.

J Biol Chem. 2008 Jul 4;283(27):19011-25. doi: 10.1074/jbc.M803109200. Epub 2008 May 6.


An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation.

Zeenko VV, Wang C, Majumder M, Komar AA, Snider MD, Merrick WC, Kaufman RJ, Hatzoglou M.

RNA. 2008 Mar;14(3):593-602. doi: 10.1261/rna.825008. Epub 2008 Jan 29.


Analysis of eukaryotic translation in purified and semipurified systems.

Merrick WC, Hensold JO.

Curr Protoc Cell Biol. 2001 May;Chapter 11:Unit 11.9. doi: 10.1002/0471143030.cb1109s08.


Use of reticulocyte lysates for mechanistic studies of eukaryotic translation initiation.

Merrick WC, Barth-Baus D.

Methods Enzymol. 2007;429:1-21.


Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5.

Galkin O, Bentley AA, Gupta S, Compton BA, Mazumder B, Kinzy TG, Merrick WC, Hatzoglou M, Pestova TV, Hellen CU, Komar AA.

RNA. 2007 Dec;13(12):2116-28. Epub 2007 Sep 27.


MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F.

Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N.

Science. 2007 Sep 21;317(5845):1764-7. Epub 2007 Jul 26.


L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control.

Kapasi P, Chaudhuri S, Vyas K, Baus D, Komar AA, Fox PL, Merrick WC, Mazumder B.

Mol Cell. 2007 Jan 12;25(1):113-26.


Are we there yet?

Merrick WC.

Nat Chem Biol. 2007 Jan;3(1):19-20. No abstract available.


Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.

Terenzi F, Hui DJ, Merrick WC, Sen GC.

J Biol Chem. 2006 Nov 10;281(45):34064-71. Epub 2006 Sep 13.


Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability.

Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, Pelletier J.

Mol Biol Cell. 2006 Nov;17(11):4632-44. Epub 2006 Aug 23.


Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis.

Robert F, Gao HQ, Donia M, Merrick WC, Hamann MT, Pelletier J.

RNA. 2006 May;12(5):717-25. Epub 2006 Mar 15.


Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Merrick WC, Romo D, Liu JO.

Mol Cell. 2005 Dec 9;20(5):709-22.


Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.

Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, Perry G.

J Biol Chem. 2005 Jun 3;280(22):20978-86. Epub 2005 Mar 14.


Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A.

Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC.

J Biol Chem. 2005 Apr 22;280(16):15601-11. Epub 2005 Feb 16.


Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.

Fernandez J, Yaman I, Huang C, Liu H, Lopez AB, Komar AA, Caprara MG, Merrick WC, Snider MD, Kaufman RJ, Lamers WH, Hatzoglou M.

Mol Cell. 2005 Feb 4;17(3):405-16.


Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation.

Hui DJ, Terenzi F, Merrick WC, Sen GC.

J Biol Chem. 2005 Feb 4;280(5):3433-40. Epub 2004 Nov 23.


Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA.

J Biol Chem. 2004 Sep 10;279(37):38649-57. Epub 2004 Jul 2.


Cap-dependent and cap-independent translation in eukaryotic systems.

Merrick WC.

Gene. 2004 May 12;332:1-11. Review.


Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi.

Hui DJ, Bhasker CR, Merrick WC, Sen GC.

J Biol Chem. 2003 Oct 10;278(41):39477-82. Epub 2003 Jul 28.


Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells.

Komar AA, Lesnik T, Cullin C, Merrick WC, Trachsel H, Altmann M.

EMBO J. 2003 Mar 3;22(5):1199-209.


The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.

Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH.

Mol Cell Biol. 2003 Jan;23(1):26-37.

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