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Items: 1 to 50 of 124

1.

Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.

Carcolé M, Kummer S, Gonçalves L, Zamanillo D, Merlos M, Dickenson AH, Fernández-Pastor B, Cabañero D, Maldonado R.

Br J Pharmacol. 2019 Oct;176(20):3939-3955. doi: 10.1111/bph.14794. Epub 2019 Sep 12.

PMID:
31332781
2.

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.

Cortés-Montero E, Sánchez-Blázquez P, Onetti Y, Merlos M, Garzón J.

Front Pharmacol. 2019 Jun 12;10:634. doi: 10.3389/fphar.2019.00634. eCollection 2019.

3.

The Rhizophagus irregularis Genome Encodes Two CTR Copper Transporters That Mediate Cu Import Into the Cytosol and a CTR-Like Protein Likely Involved in Copper Tolerance.

Gómez-Gallego T, Benabdellah K, Merlos MA, Jiménez-Jiménez AM, Alcon C, Berthomieu P, Ferrol N.

Front Plant Sci. 2019 May 16;10:604. doi: 10.3389/fpls.2019.00604. eCollection 2019.

4.

Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain.

Carcolé M, Zamanillo D, Merlos M, Fernández-Pastor B, Cabañero D, Maldonado R.

Front Pharmacol. 2019 May 3;10:468. doi: 10.3389/fphar.2019.00468. eCollection 2019.

5.

Supraspinal and Peripheral, but Not Intrathecal, σ1R Blockade by S1RA Enhances Morphine Antinociception.

Vidal-Torres A, Fernández-Pastor B, Carceller A, Vela JM, Merlos M, Zamanillo D.

Front Pharmacol. 2019 Apr 24;10:422. doi: 10.3389/fphar.2019.00422. eCollection 2019.

6.

Burden of itch in ichthyosis: a multicentre study in 94 patients.

De Palma AM, Mazereeuw-Hautier J, Giehl K, Hernández-Martin A, Merlos M, Moons P, Morren MA.

J Eur Acad Dermatol Venereol. 2019 Nov;33(11):2095-2100. doi: 10.1111/jdv.15613. Epub 2019 May 6.

PMID:
31062435
7.

Co-crystal of tramadol-celecoxib: preclinical and clinical evaluation of a novel analgesic.

Gascon N, Almansa C, Merlos M, Miguel Vela J, Encina G, Morte A, Smith K, Plata-Salamán C.

Expert Opin Investig Drugs. 2019 May;28(5):399-409. doi: 10.1080/13543784.2019.1612557. Epub 2019 May 3. Review.

PMID:
31023091
8.

Repeated Sigma-1 Receptor Antagonist MR309 Administration Modulates Central Neuropathic Pain Development After Spinal Cord Injury in Mice.

Castany S, Codony X, Zamanillo D, Merlos M, Verdú E, Boadas-Vaello P.

Front Pharmacol. 2019 Mar 22;10:222. doi: 10.3389/fphar.2019.00222. eCollection 2019.

9.

A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain.

Martínez AL, Brea J, Monroy X, Merlos M, Burgueño J, Loza MI.

SLAS Discov. 2019 Feb;24(2):158-168. doi: 10.1177/2472555218810323. Epub 2018 Nov 1.

PMID:
30383474
10.

May a sigma-1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?

Paniagua N, Goicoechea C, Abalo R, López-Miranda V, Vela JM, Merlos M, Martín Fontelles MI, Girón R.

Eur J Pain. 2019 Mar;23(3):603-620. doi: 10.1002/ejp.1333. Epub 2018 Dec 10.

PMID:
30376213
11.

Creation and pilot test results of the dermatology-specific proxy instrument: the Infants and Toddlers Dermatology Quality of Life.

Chernyshov PV, Boffa MJ, Corso R, Pustišek N, Marinovic B, Manolache L, Salavastru CM, Tiplica GS, Kakourou T, Alexopoulos A, Nasi L, Wojciechowska-Zdrojowy M, Seniuta J, Szepietowski JC, Erkens A, Fölster-Holst R, Sampogna F, Chernyshov AV, Jemec GB, Esmann S, Mazereeuw-Hautier J, Merlos M, Tomas-Aragones L, Marron SE.

J Eur Acad Dermatol Venereol. 2018 Dec;32(12):2288-2294. doi: 10.1111/jdv.15229. Epub 2018 Sep 14.

PMID:
30169902
12.

Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.

Merlos M, Portillo-Salido E, Brenchat A, Aubel B, Buxens J, Fisas A, Codony X, Romero L, Zamanillo D, Vela JM.

Eur J Pharmacol. 2018 Aug 15;833:370-378. doi: 10.1016/j.ejphar.2018.06.022. Epub 2018 Jun 19.

13.

A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.

Burgueño J, Pujol M, Monroy X, Roche D, Varela MJ, Merlos M, Giraldo J.

Sci Rep. 2017 Nov 13;7(1):15389. doi: 10.1038/s41598-017-15258-z.

14.

Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice.

de la Puente B, Zamanillo D, Romero L, Vela JM, Merlos M, Portillo-Salido E.

Sci Rep. 2017 Oct 18;7(1):13428. doi: 10.1038/s41598-017-13987-9.

15.

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.

Sánchez-Blázquez P, Pozo-Rodrigálvarez A, Merlos M, Garzón J.

Mol Neurobiol. 2018 Jun;55(6):4940-4951. doi: 10.1007/s12035-017-0697-x. Epub 2017 Aug 5.

16.

Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain.

Merlos M, Burgueño J, Portillo-Salido E, Plata-Salamán CR, Vela JM.

Adv Exp Med Biol. 2017;964:85-107. doi: 10.1007/978-3-319-50174-1_8. Review.

PMID:
28315267
17.

Sigma-1 Receptor and Pain.

Merlos M, Romero L, Zamanillo D, Plata-Salamán C, Vela JM.

Handb Exp Pharmacol. 2017;244:131-161. doi: 10.1007/164_2017_9. Review.

PMID:
28275913
18.

The arbuscular mycorrhizal fungus Rhizophagus irregularis differentially regulates the copper response of two maize cultivars differing in copper tolerance.

Merlos MA, Zitka O, Vojtech A, Azcón-Aguilar C, Ferrol N.

Plant Sci. 2016 Dec;253:68-76. doi: 10.1016/j.plantsci.2016.09.010. Epub 2016 Sep 24.

PMID:
27968998
19.

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats.

Paniagua N, Girón R, Goicoechea C, López-Miranda V, Vela JM, Merlos M, Martín Fontelles MI.

Eur J Pain. 2017 Jan;21(1):61-72. doi: 10.1002/ejp.897. Epub 2016 Jun 24.

20.

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Merlos M, Garzón-Niño J.

Oncotarget. 2016 Aug 23;7(34):55840-55862. doi: 10.18632/oncotarget.10095. Review.

21.

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats.

Gris G, Portillo-Salido E, Aubel B, Darbaky Y, Deseure K, Vela JM, Merlos M, Zamanillo D.

Sci Rep. 2016 Apr 18;6:24591. doi: 10.1038/srep24591.

22.

Antinociception by Sigma-1 Receptor Antagonists: Central and Peripheral Effects.

Romero L, Merlos M, Vela JM.

Adv Pharmacol. 2016;75:179-215. doi: 10.1016/bs.apha.2015.11.003. Epub 2016 Jan 27. Review.

PMID:
26920013
23.

Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice.

de la Puente B, Romero-Alejo E, Vela JM, Merlos M, Zamanillo D, Portillo-Salido E.

J Pain Res. 2015 Oct 6;8:663-73. doi: 10.2147/JPR.S91230. eCollection 2015.

24.

Investigational sigma-1 receptor antagonists for the treatment of pain.

Vela JM, Merlos M, Almansa C.

Expert Opin Investig Drugs. 2015;24(7):883-96. doi: 10.1517/13543784.2015.1048334. Epub 2015 Jun 3. Review.

PMID:
26037209
25.

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Herrero-Labrador R, Martínez-Murillo R, Merlos M, Vela JM, Garzón J.

Antioxid Redox Signal. 2015 Apr 1;22(10):799-818. doi: 10.1089/ars.2014.5993. Epub 2015 Feb 18.

26.

Effects of centrally acting analgesics on spinal segmental reflexes and wind-up.

Mazo I, Roza C, Zamanillo D, Merlos M, Vela JM, Lopez-Garcia JA.

Eur J Pain. 2015 Aug;19(7):1012-20. doi: 10.1002/ejp.629. Epub 2014 Dec 2.

PMID:
25469831
27.

Defense related phytohormones regulation in arbuscular mycorrhizal symbioses depends on the partner genotypes.

Fernández I, Merlos M, López-Ráez JA, Martínez-Medina A, Ferrol N, Azcón C, Bonfante P, Flors V, Pozo MJ.

J Chem Ecol. 2014 Jul;40(7):791-803. doi: 10.1007/s10886-014-0473-6. Epub 2014 Jul 6.

PMID:
24997625
28.

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.

Gris G, Merlos M, Vela JM, Zamanillo D, Portillo-Salido E.

Behav Pharmacol. 2014 Jun;25(3):226-35. doi: 10.1097/FBP.0000000000000038.

PMID:
24776490
29.

Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats.

Rebollo A, Roglans N, Baena M, Padrosa A, Sánchez RM, Merlos M, Alegret M, Laguna JC.

J Nutr Biochem. 2014 Feb;25(2):250-8. doi: 10.1016/j.jnutbio.2013.10.014. Epub 2013 Nov 22.

30.

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells.

Rebollo A, Roglans N, Baena M, Sánchez RM, Merlos M, Alegret M, Laguna JC.

Biochim Biophys Acta. 2014 Apr 4;1841(4):514-24. doi: 10.1016/j.bbalip.2014.01.002. Epub 2014 Jan 13.

31.

Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats.

Vidal-Torres A, Fernández-Pastor B, Carceller A, Vela JM, Merlos M, Zamanillo D.

J Neurochem. 2014 May;129(3):484-94. doi: 10.1111/jnc.12648. Epub 2014 Jan 29.

32.

Modulation of peripheral μ-opioid analgesia by σ1 receptors.

Sánchez-Fernández C, Montilla-García Á, González-Cano R, Nieto FR, Romero L, Artacho-Cordón A, Montes R, Fernández-Pastor B, Merlos M, Baeyens JM, Entrena JM, Cobos EJ.

J Pharmacol Exp Ther. 2014 Jan;348(1):32-45. doi: 10.1124/jpet.113.208272. Epub 2013 Oct 23.

PMID:
24155346
33.

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

Vidal-Torres A, de la Puente B, Rocasalbas M, Touriño C, Bura SA, Fernández-Pastor B, Romero L, Codony X, Zamanillo D, Buschmann H, Merlos M, Baeyens JM, Maldonado R, Vela JM.

Eur J Pharmacol. 2013 Jul 5;711(1-3):63-72. doi: 10.1016/j.ejphar.2013.04.018. Epub 2013 Apr 28.

PMID:
23632394
34.

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

Díaz JL, Christmann U, Fernández A, Luengo M, Bordas M, Enrech R, Carro M, Pascual R, Burgueño J, Merlos M, Benet-Buchholz J, Cerón-Bertran J, Ramírez J, Reinoso RF, Fernández de Henestrosa AR, Vela JM, Almansa C.

J Med Chem. 2013 May 9;56(9):3656-65. doi: 10.1021/jm400181k. Epub 2013 Apr 26.

PMID:
23560650
35.

Sigma 1 receptor: a new therapeutic target for pain.

Zamanillo D, Romero L, Merlos M, Vela JM.

Eur J Pharmacol. 2013 Sep 15;716(1-3):78-93. doi: 10.1016/j.ejphar.2013.01.068. Epub 2013 Mar 13. Review.

PMID:
23500210
36.

σ1 receptors are involved in the visceral pain induced by intracolonic administration of capsaicin in mice.

González-Cano R, Merlos M, Baeyens JM, Cendán CM.

Anesthesiology. 2013 Mar;118(3):691-700. doi: 10.1097/ALN.0b013e318280a60a.

PMID:
23299362
37.

Is the H4 receptor a new drug target for allergies and asthma?

Salcedo C, Pontes C, Merlos M.

Front Biosci (Elite Ed). 2013 Jan 1;5:178-87. Review.

PMID:
23276980
38.

Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus.

Vilà L, Roglans N, Baena M, Barroso E, Alegret M, Merlos M, Laguna JC.

PLoS One. 2012;7(12):e51118. doi: 10.1371/journal.pone.0051118. Epub 2012 Dec 4.

39.

Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats.

Vidal-Torres A, Carceller A, Zamanillo D, Merlos M, Vela JM, Fernández-Pastor B.

J Pharmacol Sci. 2012;120(2):129-32. Epub 2012 Sep 15.

40.

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

Díaz JL, Cuberes R, Berrocal J, Contijoch M, Christmann U, Fernández A, Port A, Holenz J, Buschmann H, Laggner C, Serafini MT, Burgueño J, Zamanillo D, Merlos M, Vela JM, Almansa C.

J Med Chem. 2012 Oct 11;55(19):8211-24. doi: 10.1021/jm3007323. Epub 2012 Jul 27.

PMID:
22784008
41.

Disparities in stroke type and vascular risk factors between 2 Hispanic populations in Miami and Mexico city.

Romano JG, Arauz A, Koch S, Dong C, Marquez JM, Artigas C, Merlos M, Hernandez B, Roa LF, Rundek T, Sacco RL.

J Stroke Cerebrovasc Dis. 2013 Aug;22(6):828-33. doi: 10.1016/j.jstrokecerebrovasdis.2012.05.016. Epub 2012 Jun 29.

PMID:
22749627
42.

Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis.

Román J, Planell N, Lozano JJ, Aceituno M, Esteller M, Pontes C, Balsa D, Merlos M, Panés J, Salas A.

Inflamm Bowel Dis. 2013 Feb;19(2):221-9. doi: 10.1002/ibd.23020.

PMID:
22605655
43.

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.

Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM.

Br J Pharmacol. 2012 Aug;166(8):2289-306. doi: 10.1111/j.1476-5381.2012.01942.x.

44.

Electrochemistry of copper(II) induced complexes in mycorrhizal maize plant tissues.

Zitka O, Merlos MA, Adam V, Ferrol N, Pohanka M, Hubalek J, Zehnalek J, Trnkova L, Kizek R.

J Hazard Mater. 2012 Feb 15;203-204:257-63. doi: 10.1016/j.jhazmat.2011.12.018. Epub 2011 Dec 13.

PMID:
22209587
45.

[Aspirin versus anticoagulation in young patients with cerebral infarction secondary to primary antiphospholipid syndrome].

Arauz A, Roa LF, Hernandez B, Merlos M, Marquez JM, Artigas C, Perez A, Cantu-Brito C, Barinagarrementeria F.

Rev Neurol. 2011 Nov 16;53(10):584-90. Spanish.

46.

The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis.

Camuesco D, Rodríguez-Cabezas ME, Garrido-Mesa N, Cueto-Sola M, Bailón E, Comalada M, Arribas B, Merlos M, Balsa D, Zarzuelo A, Janer G, Xaus J, Román J, Gálvez J.

Br J Pharmacol. 2012 Feb;165(3):729-40. doi: 10.1111/j.1476-5381.2011.01598.x.

47.

Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.

Pou J, Rebollo A, Piera L, Merlos M, Roglans N, Laguna JC, Alegret M.

Biochim Biophys Acta. 2011 Jun;1813(6):1254-60. doi: 10.1016/j.bbamcr.2011.03.020. Epub 2011 Apr 15.

48.

Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.

Vilà L, Rebollo A, Ađalsteisson GS, Alegret M, Merlos M, Roglans N, Laguna JC.

Toxicol Appl Pharmacol. 2011 Feb 15;251(1):32-40. doi: 10.1016/j.taap.2010.11.011. Epub 2010 Nov 29.

PMID:
21122807
49.

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

Alvarez-Guardia D, Palomer X, Coll T, Serrano L, Rodríguez-Calvo R, Davidson MM, Merlos M, El Kochairi I, Michalik L, Wahli W, Vázquez-Carrera M.

Biochim Biophys Acta. 2011 Feb;1811(2):59-67. doi: 10.1016/j.bbalip.2010.11.002. Epub 2010 Nov 9.

PMID:
21070867
50.

The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.

Coll T, Barroso E, Alvarez-Guardia D, Serrano L, Salvadó L, Merlos M, Palomer X, Vázquez-Carrera M.

PPAR Res. 2010;2010. pii: 368467. doi: 10.1155/2010/368467. Epub 2010 Jul 27.

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