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Clinical outcomes of non-small-cell lung cancer patients with BRAF mutations: results from the French Cooperative Thoracic Intergroup biomarkers France study.

Couraud S, Barlesi F, Fontaine-Deraluelle C, Debieuvre D, Merlio JP, Moreau L, Beau-Faller M, Veillon R, Mosser J, Al Freijat F, Bringuier PP, Léna H, Ouafik L, Westeel V, Morel A, Audigier-Valette C, Missy P, Langlais A, Morin F, Souquet PJ, Planchard D; Biomarkers France Contributors.

Eur J Cancer. 2019 Jul;116:86-97. doi: 10.1016/j.ejca.2019.04.016. Epub 2019 Jun 8.


Mutations of the B-cell receptor pathway confer chemoresistance in primary cutaneous diffuse large B-cell lymphoma leg-type.

Ducharme O, Beylot-Barry M, Pham-Ledard A, Bohers E, Viailly PJ, Bandres T, Faur N, Frison E, Vergier B, Jardin F, Merlio JP, Gros A.

J Invest Dermatol. 2019 May 28. pii: S0022-202X(19)31572-6. doi: 10.1016/j.jid.2019.05.008. [Epub ahead of print]


Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases.

Menguy S, Beylot-Barry M, Parrens M, Ledard AP, Frison E, Comoz F, Battistella M, Szablewski V, Balme B, Croue A, Franck F, Ortonne N, Tournier E, Lamant L, Carlotti A, De Muret A, Le Gall F, Lorton MH, Merlio JP, Vergier B.

Histopathology. 2019 Jun;74(7):1067-1080. doi: 10.1111/his.13832. Epub 2019 Apr 25.


Calcium Independent Effect of Orai1 and STIM1 in Non-Hodgkin B Cell Lymphoma Dissemination.

Latour S, Mahouche I, Cherrier F, Azzi-Martin L, Velasco V, Soubeyran P, Merlio JP, Poglio S, Bresson-Bepoldin L.

Cancers (Basel). 2018 Oct 26;10(11). pii: E402. doi: 10.3390/cancers10110402.


SATB1 Is a Pivotal Epigenetic Biomarker in Cutaneous T-Cell Lymphomas.

Poglio S, Merlio JP.

J Invest Dermatol. 2018 Aug;138(8):1694-1696. doi: 10.1016/j.jid.2018.04.018.


A Single-Arm Phase II Trial of Lenalidomide in Relapsing or Refractory Primary Cutaneous Large B-Cell Lymphoma, Leg Type.

Beylot-Barry M, Mermin D, Maillard A, Bouabdallah R, Bonnet N, Duval-Modeste AB, Mortier L, Ingen-Housz-Oro S, Ram-Wolff C, Barete S, Dalle S, Maubec E, Quereux G, Templier I, Bagot M, Grange F, Joly P, Vergier B, Vially PJ, Gros A, Pham-Ledard A, Frison E, Merlio JP.

J Invest Dermatol. 2018 Sep;138(9):1982-1989. doi: 10.1016/j.jid.2018.03.1516. Epub 2018 Mar 27.


Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas.

Menguy S, Frison E, Prochazkova-Carlotti M, Dalle S, Dereure O, Boulinguez S, Dalac S, Machet L, Ram-Wolff C, Verneuil L, Gros A, Vergier B, Beylot-Barry M, Merlio JP, Pham-Ledard A.

Mod Pathol. 2018 Aug;31(8):1332-1342. doi: 10.1038/s41379-018-0041-7. Epub 2018 Mar 26.


PD-L1 and PD-L2 Are Differentially Expressed by Macrophages or Tumor Cells in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type.

Menguy S, Prochazkova-Carlotti M, Beylot-Barry M, Saltel F, Vergier B, Merlio JP, Pham-Ledard A.

Am J Surg Pathol. 2018 Mar;42(3):326-334. doi: 10.1097/PAS.0000000000000983.


Clinical and molecular characteristics of non-small-cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide French Cooperative Thoracic Intergroup (IFCT) program.

Leduc C, Merlio JP, Besse B, Blons H, Debieuvre D, Bringuier PP, Monnet I, Rouquette I, Fraboulet-Moreau S, Lemoine A, Pouessel D, Mosser J, Vaylet F, Langlais A, Missy P, Morin F, Moro-Sibilot D, Cadranel J, Barlesi F, Beau-Faller M; French Cooperative Thoracic Intergroup (IFCT).

Ann Oncol. 2017 Nov 1;28(11):2715-2724. doi: 10.1093/annonc/mdx404.


Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas.

Leclaire Alirkilicarslan A, Dupuy A, Pujals A, Parrens M, Vergier B, Robson A, Delfau-Larue MH, Ingen-Housz-Oro S, Chosidow O, Haioun C, Beylot-Barry M, Merlio JP, Copie-Bergman C, Gaulard P, Ortonne N.

Am J Surg Pathol. 2017 Dec;41(12):1581-1592. doi: 10.1097/PAS.0000000000000956.


Molecular analysis of immunoglobulin variable genes supports a germinal center experienced normal counterpart in primary cutaneous diffuse large B-cell lymphoma, leg-type.

Pham-Ledard A, Prochazkova-Carlotti M, Deveza M, Laforet MP, Beylot-Barry M, Vergier B, Parrens M, Feuillard J, Merlio JP, Gachard N.

J Dermatol Sci. 2017 Nov;88(2):238-246. doi: 10.1016/j.jdermsci.2017.07.008. Epub 2017 Jul 26.


EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR wild-type pre-treated advanced nonsmall cell lung cancer in daily practice.

Tomasini P, Brosseau S, Mazières J, Merlio JP, Beau-Faller M, Mosser J, Wislez M, Ouafik L, Besse B, Rouquette I, Debieuvre D, Escande F, Westeel V, Audigier-Valette C, Missy P, Langlais A, Morin F, Moro-Sibilot D, Zalcman G, Barlesi F.

Eur Respir J. 2017 Aug 10;50(2). pii: 1700514. doi: 10.1183/13993003.00514-2017. Print 2017 Aug.


Assessment of BRAFV600E mutation in pulmonary Langerhans cell histiocytosis in tissue biopsies and bronchoalveolar lavages by droplet digital polymerase chain reaction.

Pierry C, Caumont C, Blanchard E, Brochet C, Dournes G, Gros A, Bandres T, Verdon S, Marty M, Bégueret H, Merlio JP.

Virchows Arch. 2018 Feb;472(2):247-258. doi: 10.1007/s00428-017-2185-0. Epub 2017 Jul 15.


Identification of Somatic Mutations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Massive Parallel Sequencing.

Mareschal S, Pham-Ledard A, Viailly PJ, Dubois S, Bertrand P, Maingonnat C, Fontanilles M, Bohers E, Ruminy P, Tournier I, Courville P, Lenormand B, Duval AB, Andrieu E, Verneuil L, Vergier B, Tilly H, Joly P, Frebourg T, Beylot-Barry M, Merlio JP, Jardin F.

J Invest Dermatol. 2017 Sep;137(9):1984-1994. doi: 10.1016/j.jid.2017.04.010. Epub 2017 May 4.


TP53 alterations in primary and secondary Sézary syndrome: A diagnostic tool for the assessment of malignancy in patients with erythroderma.

Gros A, Laharanne E, Vergier M, Prochazkova-Carlotti M, Pham-Ledard A, Bandres T, Poglio S, Berhouet S, Vergier B, Vial JP, Chevret E, Beylot-Barry M, Merlio JP.

PLoS One. 2017 Mar 16;12(3):e0173171. doi: 10.1371/journal.pone.0173171. eCollection 2017.


Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France.

Guibert N, Barlesi F, Descourt R, Léna H, Besse B, Beau-Faller M, Mosser J, Pichon E, Merlio JP, Ouafik L, Guichard F, Mastroianni B, Moreau L, Wdowik A, Sabourin JC, Lemoine A, Missy P, Langlais A, Moro-Sibilot D, Mazières J.

J Thorac Oncol. 2017 Jun;12(6):963-973. doi: 10.1016/j.jtho.2017.02.001. Epub 2017 Feb 9.


Evaluation of a fast and fully automated platform to diagnose EGFR and KRAS mutations in formalin-fixed and paraffin-embedded non-small cell lung cancer samples in less than one day.

Lambros L, Caumont C, Guibourg B, Barel F, Quintin-Roué I, Marcorelles P, Merlio JP, Uguen A.

J Clin Pathol. 2017 Jun;70(6):544-549. doi: 10.1136/jclinpath-2016-204202. Epub 2017 Feb 2.


Hybridization Capture-Based Next-Generation Sequencing to Evaluate Coding Sequence and Deep Intronic Mutations in the NF1 Gene.

Cunha KS, Oliveira NS, Fausto AK, de Souza CC, Gros A, Bandres T, Idrissi Y, Merlio JP, de Moura Neto RS, Silva R, Geller M, Cappellen D.

Genes (Basel). 2016 Dec 17;7(12). pii: E133. doi: 10.3390/genes7120133.


Routine molecular profiling of patients with NSCLC - Authors' reply.

Mazières J, Merlio JP, Missy P, Moro-Sibilot D, Barlesi F.

Lancet. 2016 Sep 10;388(10049):1054-1055. doi: 10.1016/S0140-6736(16)31136-9. No abstract available.


Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.

Mélard P, Idrissi Y, Andrique L, Poglio S, Prochazkova-Carlotti M, Berhouet S, Boucher C, Laharanne E, Chevret E, Pham-Ledard A, De Souza Góes AC, Guyonnet-Duperat V, Bibeyran A, Moreau-Gaudry F, Vergier B, Beylot-Barry M, Merlio JP, Cappellen D.

Oncotarget. 2016 Oct 18;7(42):68734-68748. doi: 10.18632/oncotarget.11930.


Telomerase Activation in Hematological Malignancies.

Ropio J, Merlio JP, Soares P, Chevret E.

Genes (Basel). 2016 Sep 7;7(9). pii: E61. doi: 10.3390/genes7090061. Review.


Proliferative Nodules vs Melanoma Arising in Giant Congenital Melanocytic Nevi During Childhood.

Vergier B, Laharanne E, Prochazkova-Carlotti M, de la Fouchardière A, Merlio JP, Kadlub N, Avril MF, Bodemer C, Lacoste C, Boralevi F, Taieb A, Ezzedine K, Fraitag S.

JAMA Dermatol. 2016 Oct 1;152(10):1147-1151. doi: 10.1001/jamadermatol.2016.2667.


Challenging a dogma: co-mutations exist in MAPK pathway genes in colorectal cancer.

Grellety T, Gros A, Pedeutour F, Merlio JP, Duranton-Tanneur V, Italiano A, Soubeyran I.

Virchows Arch. 2016 Oct;469(4):459-64. doi: 10.1007/s00428-016-1991-0. Epub 2016 Jul 11.


Sézary Syndrome: Translating Genetic Diversity into Personalized Medicine.

Chevret E, Merlio JP.

J Invest Dermatol. 2016 Jul;136(7):1319-1324. doi: 10.1016/j.jid.2016.04.027.


MYD88 Somatic Mutation Is a Diagnostic Criterion in Primary Cutaneous Large B-Cell Lymphoma.

Menguy S, Gros A, Pham-Ledard A, Battistella M, Ortonne N, Comoz F, Balme B, Szablewski V, Lamant L, Carlotti A, Lorton MH, de Muret A, Le Gall F, Franck F, Croue A, Cappellen D, Beylot-Barry M, Merlio JP, Vergier B.

J Invest Dermatol. 2016 Aug;136(8):1741-1744. doi: 10.1016/j.jid.2016.04.018. Epub 2016 May 14. No abstract available.


Intrahepatic Xenograft of Cutaneous T-Cell Lymphoma Cell Lines: A Useful Model for Rapid Biological and Therapeutic Evaluation.

Andrique L, Poglio S, Prochazkova-Carlotti M, Kadin ME, Giese A, Idrissi Y, Beylot-Barry M, Merlio JP, Chevret E.

Am J Pathol. 2016 Jul;186(7):1775-1785. doi: 10.1016/j.ajpath.2016.03.012. Epub 2016 May 13.


Spleen Histologic Appearance in Common Variable Immunodeficiency: Analysis of 17 Cases.

Furudoï A, Gros A, Stanislas S, Hamidou M, Furudoï E, Oksenhendler É, Merlio JP, Viallard JF, Parrens M.

Am J Surg Pathol. 2016 Jul;40(7):958-67. doi: 10.1097/PAS.0000000000000661.


Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT).

Barlesi F, Mazieres J, Merlio JP, Debieuvre D, Mosser J, Lena H, Ouafik L, Besse B, Rouquette I, Westeel V, Escande F, Monnet I, Lemoine A, Veillon R, Blons H, Audigier-Valette C, Bringuier PP, Lamy R, Beau-Faller M, Pujol JL, Sabourin JC, Penault-Llorca F, Denis MG, Lantuejoul S, Morin F, Tran Q, Missy P, Langlais A, Milleron B, Cadranel J, Soria JC, Zalcman G; Biomarkers France contributors.

Lancet. 2016 Apr 2;387(10026):1415-1426. doi: 10.1016/S0140-6736(16)00004-0. Epub 2016 Jan 15.


Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma.

Caumont C, Veillon R, Gros A, Laharanne E, Bégueret H, Merlio JP.

Lung Cancer. 2016 Feb;92:15-8. doi: 10.1016/j.lungcan.2015.12.001. Epub 2015 Dec 4.


Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma.

Furudoï A, Caumont C, Dutriaux C, Cappellen D, Goussot JF, Vergier B, Merlio C, Barberis C, Merlio JP, Gros A.

Hum Pathol. 2016 Feb;48:167-71. doi: 10.1016/j.humpath.2015.09.025. Epub 2015 Oct 9.


Evaluation of Quantitative Fluorescence in situ Hybridization for Relative Measurement of Telomere Length in Placental Mesenchymal Core Cells.

Toutain J, Prochazkova-Carlotti M, Horovitz J, Saura R, Merlio JP, Chevret E.

Gynecol Obstet Invest. 2016;81(1):54-60. doi: 10.1159/000381896. Epub 2015 May 20.


PLCG1 Gene Mutations Are Uncommon in Cutaneous T-Cell Lymphomas.

Caumont C, Gros A, Boucher C, Mélard P, Prochazkova-Carlotti M, Laharanne E, Pham-Ledard A, Vergier B, Chevret E, Beylot-Barry M, Merlio JP, Cappellen D.

J Invest Dermatol. 2015 Sep;135(9):2334-2337. doi: 10.1038/jid.2015.161. Epub 2015 Apr 24. No abstract available.


Detection of BRAF V600 mutations in melanoma: evaluation of concordance between the Cobas® 4800 BRAF V600 mutation test and the methods used in French National Cancer Institute (INCa) platforms in a real-life setting.

Mourah S, Denis MG, Narducci FE, Solassol J, Merlin JL, Sabourin JC, Scoazec JY, Ouafik L, Emile JF, Heller R, Souvignet C, Bergougnoux L, Merlio JP.

PLoS One. 2015 Mar 19;10(3):e0120232. doi: 10.1371/journal.pone.0120232. eCollection 2015.


[Cutaneous lymphoproliferations: proposal for the use of diagnostic algorithms based on 2760 cases of cutaneous lymphoproliferations taken from the INCa networks (LYMPHOPATH and GFELC) over a two-year period].

Laban É, Beylot-Barry M, Ortonne N, Battistella M, Carlotti A, de Muret A, Wechsler J, Balme B, Petrella T, Lamant L, Frouin É, Merlio JP, Vergier B.

Ann Pathol. 2015 Apr;35(2):131-47. doi: 10.1016/j.annpat.2015.02.001. Epub 2015 Mar 13. French.


Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with follicular lymphoma presenting as primary skin lesions.

Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M.

Am J Clin Pathol. 2015 Mar;143(3):362-73. doi: 10.1309/AJCP4SUBR4NPSPTN.


Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.

Ilie M, Long-Mira E, Funck-Brentano E, Lassalle S, Butori C, Lespinet-Fabre V, Bordone O, Gay A, Zahaf K, Poissonnet G, Lacour JP, Bahadoran P, Ballotti R, Gros A, Dutriaux C, Saiag P, Merlio JP, Vergier B, Emile JF, Hofman V, Hofman P.

J Am Acad Dermatol. 2015 May;72(5):786-93. doi: 10.1016/j.jaad.2015.01.012. Epub 2015 Feb 7.


Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases.

Fauconneau A, Pham-Ledard A, Cappellen D, Frison E, Prochazkova-Carlotti M, Parrens M, Dalle S, Joly P, Viraben R, Franck F, Ingen-Housz-Oro S, Giacchero D, Jullié ML, Vergier B, Merlio JP, Beylot-Barry M.

Br J Dermatol. 2015 Jun;172(6):1547-1554. doi: 10.1111/bjd.13690. Epub 2015 May 16.


High frequency and clinical prognostic value of MYD88 L265P mutation in primary cutaneous diffuse large B-cell lymphoma, leg-type.

Pham-Ledard A, Beylot-Barry M, Barbe C, Leduc M, Petrella T, Vergier B, Martinez F, Cappellen D, Merlio JP, Grange F.

JAMA Dermatol. 2014 Nov;150(11):1173-9. doi: 10.1001/jamadermatol.2014.821.


BRAFV600E mutation analysis by immunohistochemistry in patients with thoracic metastases from colorectal cancer.

Ilie MI, Long-Mira E, Hofman V, Mouroux J, Vignaud JM, Gauchotte G, Begueret H, Merlio JP, Emile JF, Hébuterne X, Hofman P.

Pathology. 2014 Jun;46(4):311-5. doi: 10.1097/PAT.0000000000000113.


Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances.

Cabillic F, Gros A, Dugay F, Begueret H, Mesturoux L, Chiforeanu DC, Dufrenot L, Jauffret V, Dachary D, Corre R, Lespagnol A, Soler G, Dagher J, Catros V, Le Calve M, Merlio JP, Belaud-Rotureau MA.

J Thorac Oncol. 2014 Mar;9(3):295-306. doi: 10.1097/JTO.0000000000000072.


Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma.

Chevret E, Andrique L, Prochazkova-Carlotti M, Ferrer J, Cappellen D, Laharanne E, Idrissi Y, Boettiger A, Sahraoui W, Ruiz F, Pham-Ledard A, Vergier B, Belloc F, Dubus P, Beylot-Barry M, Merlio JP.

Blood. 2014 Mar 20;123(12):1850-9. doi: 10.1182/blood-2013-05-500686. Epub 2014 Jan 27.


CD20 antigen may be expressed by reactive or lymphomatous cells of transformed mycosis fungoides: diagnostic and prognostic impact.

Jullié ML, Carlotti M, Vivot A Jr, Beylot-Barry M, Ortonne N, Frouin E, Carlotti A, de Muret A, Balme B, Franck F, Merlio JP, Vergier B.

Am J Surg Pathol. 2013 Dec;37(12):1845-54. doi: 10.1097/PAS.0000000000000091.


Multiple genetic alterations in primary cutaneous large B-cell lymphoma, leg type support a common lymphomagenesis with activated B-cell-like diffuse large B-cell lymphoma.

Pham-Ledard A, Prochazkova-Carlotti M, Andrique L, Cappellen D, Vergier B, Martinez F, Grange F, Petrella T, Beylot-Barry M, Merlio JP.

Mod Pathol. 2014 Mar;27(3):402-11. doi: 10.1038/modpathol.2013.156. Epub 2013 Sep 13.


Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing.

Boursault L, Haddad V, Vergier B, Cappellen D, Verdon S, Bellocq JP, Jouary T, Merlio JP.

PLoS One. 2013 Aug 20;8(8):e70826. doi: 10.1371/journal.pone.0070826. eCollection 2013.


Performance and cost efficiency of KRAS mutation testing for metastatic colorectal cancer in routine diagnosis: the MOKAECM study, a nationwide experience.

Blons H, Rouleau E, Charrier N, Chatellier G, Côté JF, Pages JC, de Fraipont F, Boyer JC, Merlio JP, Morel A, Gorisse MC, de Cremoux P, Leroy K, Milano G, Ouafik L, Merlin JL, Le Corre D, Aucouturier P, Sabourin JC, Nowak F, Frebourg T, Emile JF, Durand-Zaleski I, Laurent-Puig P; MOKAECM Collaborative Group.

PLoS One. 2013 Jul 25;8(7):e68945. doi: 10.1371/journal.pone.0068945. Print 2013.


STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

Couronné L, Scourzic L, Pilati C, Della Valle V, Duffourd Y, Solary E, Vainchenker W, Merlio JP, Beylot-Barry M, Damm F, Stern MH, Gaulard P, Lamant L, Delabesse E, Merle-Beral H, Nguyen-Khac F, Fontenay M, Tilly H, Bastard C, Zucman-Rossi J, Bernard OA, Mercher T.

Haematologica. 2013 Nov;98(11):1748-52. doi: 10.3324/haematol.2013.085068. Epub 2013 Jul 19.


Reduced placental telomere length during pregnancies complicated by intrauterine growth restriction.

Toutain J, Prochazkova-Carlotti M, Cappellen D, Jarne A, Chevret E, Ferrer J, Idrissi Y, Pelluard F, Carles D, Maugey-Laulon B, Lacombe D, Horovitz J, Merlio JP, Saura R.

PLoS One. 2013;8(1):e54013. doi: 10.1371/journal.pone.0054013. Epub 2013 Jan 11.


Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients.

Ilie M, Long E, Hofman V, Dadone B, Marquette CH, Mouroux J, Vignaud JM, Begueret H, Merlio JP, Capper D, von Deimling A, Emile JF, Hofman P.

Ann Oncol. 2013 Mar;24(3):742-8. doi: 10.1093/annonc/mds534. Epub 2012 Nov 6.


IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas.

Gachard N, Parrens M, Soubeyran I, Petit B, Marfak A, Rizzo D, Devesa M, Delage-Corre M, Coste V, Laforêt MP, de Mascarel A, Merlio JP, Bouabdhalla K, Milpied N, Soubeyran P, Schmitt A, Bordessoule D, Cogné M, Feuillard J.

Leukemia. 2013 Jan;27(1):183-9. doi: 10.1038/leu.2012.257. Epub 2012 Sep 4.


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