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Items: 1 to 50 of 212

1.

A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex.

Annunziata A, Cucciolito ME, Esposito R, Imbimbo P, Petruk G, Ferraro G, Pinto V, Tuzi A, Monti DM, Merlino A, Ruffo F.

Dalton Trans. 2019 Jun 14;48(22):7794-7800. doi: 10.1039/c9dt01614g. Epub 2019 May 9.

PMID:
31069352
2.

Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies.

Monti DM, Ferraro G, Merlino A.

Nanomedicine. 2019 Apr 25. pii: S1549-9634(19)30081-4. doi: 10.1016/j.nano.2019.04.001. [Epub ahead of print] Review.

PMID:
31028889
3.

Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.

Miodragović Đ, Merlino A, Swindell EP, Bogachkov A, Ahn RW, Abuhadba S, Ferraro G, Marzo T, Mazar AP, Messori L, O'Halloran TV.

J Am Chem Soc. 2019 Apr 24;141(16):6453-6457. doi: 10.1021/jacs.8b13681. Epub 2019 Apr 15.

PMID:
30943017
4.

Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems.

Florio D, Malfitano AM, Di Somma S, Mügge C, Weigand W, Ferraro G, Iacobucci I, Monti M, Morelli G, Merlino A, Marasco D.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E829. doi: 10.3390/ijms20040829.

5.

Reaction with Proteins of a Five-Coordinate Platinum(II) Compound.

Ferraro G, Marzo T, Cucciolito ME, Ruffo F, Messori L, Merlino A.

Int J Mol Sci. 2019 Jan 26;20(3). pii: E520. doi: 10.3390/ijms20030520.

6.

Encapsulation of the Dinuclear Trithiolato-Bridged Arene Ruthenium Complex Diruthenium-1 in an Apoferritin Nanocage: Structure and Cytotoxicity.

Petruk G, Monti DM, Ferraro G, Pica A, D'Elia L, Pane F, Amoresano A, Furrer J, Kowalski K, Merlino A.

ChemMedChem. 2019 Mar 5;14(5):594-602. doi: 10.1002/cmdc.201800805. Epub 2019 Feb 11.

PMID:
30674089
7.

On the pH-Modulated Ru-Based Prodrug Activation Mechanism.

Caterino M, Herrmann M, Merlino A, Riccardi C, Montesarchio D, Mroginski MA, Musumeci D, Ruffo F, Paduano L, Hildebrandt P, Kozuch J, Vergara A.

Inorg Chem. 2019 Jan 22;58(2):1216-1223. doi: 10.1021/acs.inorgchem.8b02667. Epub 2019 Jan 7.

PMID:
30614697
8.

Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites.

Ferraro G, Pica A, Petruk G, Pane F, Amoresano A, Cilibrizzi A, Vilar R, Monti DM, Merlino A.

Nanomedicine (Lond). 2018 Dec;13(23):2995-3007. doi: 10.2217/nnm-2018-0259. Epub 2018 Dec 3.

PMID:
30501559
9.

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.

Kitajima S, Asahina H, Chen T, Guo S, Quiceno LG, Cavanaugh JD, Merlino AA, Tange S, Terai H, Kim JW, Wang X, Zhou S, Xu M, Wang S, Zhu Z, Thai TC, Takahashi C, Wang Y, Neve R, Stinson S, Tamayo P, Watanabe H, Kirschmeier PT, Wong KK, Barbie DA.

Cancer Cell. 2018 Sep 10;34(3):439-452.e6. doi: 10.1016/j.ccell.2018.08.009.

10.

Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity.

Saramago L, Gomes H, Aguilera E, Cerecetto H, González M, Cabrera M, Alzugaray MF, da Silva Vaz Junior I, Nunes da Fonseca R, Aguirre-López B, Cabrera N, Pérez-Montfort R, Merlino A, Moraes J, Álvarez G.

Vet Sci. 2018 Aug 23;5(3). pii: E74. doi: 10.3390/vetsci5030074.

11.

The NAMI A - human ferritin system: a biophysical characterization.

Ciambellotti S, Pratesi A, Severi M, Ferraro G, Alessio E, Merlino A, Messori L.

Dalton Trans. 2018 Aug 21;47(33):11429-11437. doi: 10.1039/c8dt00860d.

PMID:
30063237
12.
13.

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer.

Li S, Liu S, Deng J, Akbay EA, Hai J, Ambrogio C, Zhang L, Zhou F, Jenkins RW, Adeegbe DO, Gao P, Wang X, Paweletz CP, Herter-Sprie GS, Chen T, Gutiérrez-Quiceno L, Zhang Y, Merlino AA, Quinn MM, Zeng Y, Yu X, Liu Y, Fan L, Aguirre AJ, Barbie DA, Yi X, Wong KK.

Clin Cancer Res. 2018 Oct 1;24(19):4854-4864. doi: 10.1158/1078-0432.CCR-17-3438. Epub 2018 Jun 26.

14.

A case of extensive protein platination: the reaction of lysozyme with a Pt(ii)-terpyridine complex.

Ferraro G, Marzo T, Infrasca T, Cilibrizzi A, Vilar R, Messori L, Merlino A.

Dalton Trans. 2018 Jul 3;47(26):8716-8723. doi: 10.1039/c8dt01254g.

PMID:
29904761
15.

Crystal structure of the ferric homotetrameric β4 human hemoglobin.

Mazzarella L, Merlino A, Balasco N, Balsamo A, Vergara A.

Biophys Chem. 2018 Sep;240:9-14. doi: 10.1016/j.bpc.2018.05.003. Epub 2018 May 23.

PMID:
29857171
16.

Mimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer.

La Manna S, Lee E, Ouzounova M, Di Natale C, Novellino E, Merlino A, Korkaya H, Marasco D.

Int J Cancer. 2018 Nov 1;143(9):2177-2186. doi: 10.1002/ijc.31594. Epub 2018 Aug 11.

PMID:
29752723
17.

Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.

Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF.

Front Mol Biosci. 2018 Apr 19;5:40. doi: 10.3389/fmolb.2018.00040. eCollection 2018.

18.

Caged noble metals: Encapsulation of a cytotoxic platinum(II)-gold(I) compound within the ferritin nanocage.

Ferraro G, Petruk G, Maiore L, Pane F, Amoresano A, Cinellu MA, Monti DM, Merlino A.

Int J Biol Macromol. 2018 Aug;115:1116-1121. doi: 10.1016/j.ijbiomac.2018.04.142. Epub 2018 Apr 30.

PMID:
29709536
19.

Biotic and environmental stress induces nitration and changes in structure and function of the sea urchin major yolk protein toposome.

Castellano I, Migliaccio O, Ferraro G, Maffioli E, Marasco D, Merlino A, Zingone A, Tedeschi G, Palumbo A.

Sci Rep. 2018 Mar 15;8(1):4610. doi: 10.1038/s41598-018-22861-1.

20.

X-ray structure of bovine heart cytochrome c at high ionic strength.

Merlino A.

Biometals. 2018 Apr;31(2):277-284. doi: 10.1007/s10534-018-0090-x. Epub 2018 Mar 7.

PMID:
29516298
21.

Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands: Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules.

Cucciolito ME, D'Amora A, De Feo G, Ferraro G, Giorgio A, Petruk G, Monti DM, Merlino A, Ruffo F.

Inorg Chem. 2018 Mar 19;57(6):3133-3143. doi: 10.1021/acs.inorgchem.7b03118. Epub 2018 Mar 6.

PMID:
29509011
22.

Raman-markers of X-ray radiation damage of proteins.

Vergara A, Caterino M, Merlino A.

Int J Biol Macromol. 2018 May;111:1194-1205. doi: 10.1016/j.ijbiomac.2018.01.135. Epub 2018 Feb 19.

PMID:
29374529
23.

Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins.

Marzo T, Navas F, Cirri D, Merlino A, Ferraro G, Messori L, Quiroga AG.

J Inorg Biochem. 2018 Apr;181:11-17. doi: 10.1016/j.jinorgbio.2018.01.002. Epub 2018 Jan 10.

PMID:
29353085
24.

pH driven fibrillar aggregation of the super-sweet protein Y65R-MNEI: A step-by-step structural analysis.

Pica A, Leone S, Di Girolamo R, Donnarumma F, Emendato A, Rega MF, Merlino A, Picone D.

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):808-815. doi: 10.1016/j.bbagen.2017.12.012. Epub 2017 Dec 27.

PMID:
29288772
25.

Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D-Aromatic-Boron-Rich-Cluster into the 4-Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment.

Couto M, García MF, Alamón C, Cabrera M, Cabral P, Merlino A, Teixidor F, Cerecetto H, Viñas C.

Chemistry. 2018 Mar 2;24(13):3122-3126. doi: 10.1002/chem.201705181. Epub 2017 Dec 22.

PMID:
29194843
26.

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.

Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK.

Cancer Discov. 2018 Feb;8(2):216-233. doi: 10.1158/2159-8290.CD-17-0915. Epub 2017 Nov 3.

27.

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.

28.

Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells.

Monti DM, Ferraro G, Petruk G, Maiore L, Pane F, Amoresano A, Cinellu MA, Merlino A.

Dalton Trans. 2017 Nov 14;46(44):15354-15362. doi: 10.1039/c7dt02370g.

PMID:
29072740
29.

Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies.

Messori L, Merlino A.

Chem Commun (Camb). 2017 Oct 24;53(85):11622-11633. doi: 10.1039/c7cc06442j.

PMID:
29019481
30.

Principles and methods used to grow and optimize crystals of protein-metallodrug adducts, to determine metal binding sites and to assign metal ligands.

Russo Krauss I, Ferraro G, Pica A, Márquez JA, Helliwell JR, Merlino A.

Metallomics. 2017 Nov 15;9(11):1534-1547. doi: 10.1039/c7mt00219j.

PMID:
28967006
31.

Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma.

Liu Y, Li Y, Wang X, Liu F, Gao P, Quinn MM, Li F, Merlino AA, Benes C, Liu Q, Gray NS, Wong KK.

Cancer Res. 2017 Sep 15;77(18):5068-5076. doi: 10.1158/0008-5472.CAN-17-0567. Epub 2017 Jul 28.

32.

Cisplatin Binding Sites in Human H-Chain Ferritin.

Ferraro G, Ciambellotti S, Messori L, Merlino A.

Inorg Chem. 2017 Aug 7;56(15):9064-9070. doi: 10.1021/acs.inorgchem.7b01072. Epub 2017 Jul 24.

PMID:
28737381
33.

Ru-Based CO releasing molecules with azole ligands: interaction with proteins and the CO release mechanism disclosed by X-ray crystallography.

Pontillo N, Ferraro G, Messori L, Tamasi G, Merlino A.

Dalton Trans. 2017 Jul 25;46(29):9621-9629. doi: 10.1039/c7dt01991b.

PMID:
28702564
34.

A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin.

Picone D, Donnarumma F, Ferraro G, Gotte G, Fagagnini A, Butera G, Donadelli M, Merlino A.

J Inorg Biochem. 2017 Aug;173:105-112. doi: 10.1016/j.jinorgbio.2017.05.005. Epub 2017 May 9.

PMID:
28511060
35.

Mitochondria Targeting with Luminescent Rhenium(I) Complexes.

Skiba J, Bernaś T, Trzybiński D, Woźniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K.

Molecules. 2017 May 15;22(5). pii: E809. doi: 10.3390/molecules22050809.

36.

Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.

Guerra A, Gonzalez-Naranjo P, Campillo NE, Varela J, Lavaggi ML, Merlino A, Cerecetto H, González M, Gomez-Barrio A, Escario JA, Fonseca-Berzal C, Yaluf G, Paniagua-Solis J, Páez JA.

Eur J Med Chem. 2017 Aug 18;136:223-234. doi: 10.1016/j.ejmech.2017.04.075. Epub 2017 May 1.

PMID:
28499168
37.

X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage.

Pontillo N, Ferraro G, Helliwell JR, Amoresano A, Merlino A.

ACS Med Chem Lett. 2017 Feb 28;8(4):433-437. doi: 10.1021/acsmedchemlett.7b00025. eCollection 2017 Apr 13.

38.

Hypoxia and hydrogen sulfide differentially affect normal and tumor-derived vascular endothelium.

Bianco S, Mancardi D, Merlino A, Bussolati B, Munaron L.

Redox Biol. 2017 Aug;12:499-504. doi: 10.1016/j.redox.2017.03.015. Epub 2017 Mar 18.

39.

{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo.

Tamasi G, Merlino A, Scaletti F, Heffeter P, Legin AA, Jakupec MA, Berger W, Messori L, Keppler BK, Cini R.

Dalton Trans. 2017 Feb 28;46(9):3025-3040. doi: 10.1039/c6dt04295c.

PMID:
28207024
40.

Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy.

Merlino A, Marzo T, Messori L.

Chemistry. 2017 May 23;23(29):6942-6947. doi: 10.1002/chem.201605801. Epub 2017 Feb 14.

PMID:
28071831
41.

A driving force for polypeptide and protein collapse.

Merlino A, Pontillo N, Graziano G.

Phys Chem Chem Phys. 2016 Dec 21;19(1):751-756. doi: 10.1039/c6cp07397b.

PMID:
27929162
42.

Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance.

Hildebrandt J, Häfner N, Görls H, Kritsch D, Ferraro G, Dürst M, Runnebaum IB, Merlino A, Weigand W.

Dalton Trans. 2016 Nov 29;45(47):18876-18891.

PMID:
27897281
43.

Fine Sampling of the R→T Quaternary-Structure Transition of a Tetrameric Hemoglobin.

Vitagliano L, Mazzarella L, Merlino A, Vergara A.

Chemistry. 2017 Jan 12;23(3):605-613. doi: 10.1002/chem.201603421. Epub 2016 Dec 7.

PMID:
27808442
44.

Sweeter and stronger: enhancing sweetness and stability of the single chain monellin MNEI through molecular design.

Leone S, Pica A, Merlino A, Sannino F, Temussi PA, Picone D.

Sci Rep. 2016 Sep 23;6:34045. doi: 10.1038/srep34045.

45.

Cisplatin-Protein Interactions: Unexpected Drug Binding to N-Terminal Amine and Lysine Side Chains.

Russo Krauss I, Ferraro G, Merlino A.

Inorg Chem. 2016 Aug 15;55(16):7814-6. doi: 10.1021/acs.inorgchem.6b01234. Epub 2016 Aug 2.

PMID:
27482735
46.

Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach.

Ferraro F, Merlino A, Dell Oca N, Gil J, Tort JF, Gonzalez M, Cerecetto H, Cabrera M, Corvo I.

PLoS Negl Trop Dis. 2016 Jul 27;10(7):e0004834. doi: 10.1371/journal.pntd.0004834. eCollection 2016 Jul.

47.

Unusual mode of protein binding by a cytotoxic π-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand.

Hildebrandt J, Görls H, Häfner N, Ferraro G, Dürst M, Runnebaum IB, Weigand W, Merlino A.

Dalton Trans. 2016 Aug 2;45(31):12283-7. doi: 10.1039/c6dt02380k.

PMID:
27427335
48.

Mapping the protein-binding sites for iridium(iii)-based CO-releasing molecules.

Caterino M, Petruk AA, Vergara A, Ferraro G, Marasco D, Doctorovich F, Estrin DA, Merlino A.

Dalton Trans. 2016 Jul 26;45(30):12206-14. doi: 10.1039/c6dt01685e.

PMID:
27411388
49.

First Crystal Structure for a Gold Carbene-Protein Adduct.

Ferraro G, Gabbiani C, Merlino A.

Bioconjug Chem. 2016 Jul 20;27(7):1584-7. doi: 10.1021/acs.bioconjchem.6b00298. Epub 2016 Jul 6.

50.

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein.

Ferraro G, Monti DM, Amoresano A, Pontillo N, Petruk G, Pane F, Cinellu MA, Merlino A.

Chem Commun (Camb). 2016 Jul 21;52(61):9518-21. doi: 10.1039/c6cc02516a.

PMID:
27326513

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