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Items: 30

1.

Mitochondrial UPR: A Double-Edged Sword.

Tian Y, Merkwirth C, Dillin A.

Trends Cell Biol. 2016 Aug;26(8):563-5. doi: 10.1016/j.tcb.2016.06.006. Epub 2016 Jul 6.

PMID:
27394966
2.

Signaling Networks Determining Life Span.

Riera CE, Merkwirth C, De Magalhaes Filho CD, Dillin A.

Annu Rev Biochem. 2016 Jun 2;85:35-64. doi: 10.1146/annurev-biochem-060815-014451. Review.

PMID:
27294438
3.

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.

Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A.

Cell. 2016 May 19;165(5):1209-1223. doi: 10.1016/j.cell.2016.04.012. Epub 2016 Apr 28.

4.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT.

Am J Pathol. 2016 May;186(5):1128-39. doi: 10.1016/j.ajpath.2015.12.018.

PMID:
27105734
5.

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

Wai T, García-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, Rupérez FJ, Barbas C, Ibañez B, Langer T.

Science. 2015 Dec 4;350(6265):aad0116. doi: 10.1126/science.aad0116.

PMID:
26785494
6.

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T.

J Cell Biol. 2016 Jan 18;212(2):157-66. doi: 10.1083/jcb.201507022.

7.

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.

Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT.

EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916.

8.

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.

Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A.

Cell. 2014 May 22;157(5):1023-36. doi: 10.1016/j.cell.2014.03.051.

9.

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P.

Diabetes. 2013 Oct;62(10):3488-99. doi: 10.2337/db13-0152. Epub 2013 Jul 17.

10.

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A.

Aging Cell. 2013 Jun;12(3):518-22. doi: 10.1111/acel.12067.

11.

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke HS, Jordan SD, Rugarli EI, Langer T.

PLoS Genet. 2012;8(11):e1003021. doi: 10.1371/journal.pgen.1003021. Epub 2012 Nov 8.

12.

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.

Vilchez D, Boyer L, Morantte I, Lutz M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A.

Nature. 2012 Sep 13;489(7415):304-8. doi: 10.1038/nature11468.

13.

RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A.

Nature. 2012 Sep 13;489(7415):263-8. doi: 10.1038/nature11315.

PMID:
22922647
14.

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, Wiesner RJ.

Stem Cells. 2011 Sep;29(9):1459-68. doi: 10.1002/stem.695.

15.

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.

Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27.

PMID:
21441927
16.

Prohibitins and the functional compartmentalization of mitochondrial membranes.

Osman C, Merkwirth C, Langer T.

J Cell Sci. 2009 Nov 1;122(Pt 21):3823-30. doi: 10.1242/jcs.037655. Review.

17.

Nanoparticle design characterized by in silico preparation parameter prediction using ensemble models.

Neumann D, Merkwirth C, Lamprecht A.

J Pharm Sci. 2010 Apr;99(4):1982-96. doi: 10.1002/jps.21941.

PMID:
19877172
18.

SLP-2 is required for stress-induced mitochondrial hyperfusion.

Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC.

EMBO J. 2009 Jun 3;28(11):1589-600. doi: 10.1038/emboj.2009.89. Epub 2009 Apr 9.

19.

Mitofusin 2 builds a bridge between ER and mitochondria.

Merkwirth C, Langer T.

Cell. 2008 Dec 26;135(7):1165-7. doi: 10.1016/j.cell.2008.12.005.

20.

Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.

Merkwirth C, Langer T.

Biochim Biophys Acta. 2009 Jan;1793(1):27-32. doi: 10.1016/j.bbamcr.2008.05.013. Epub 2008 Jun 17. Review.

21.

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.

Merkwirth C, Dargazanli S, Tatsuta T, Geimer S, Löwer B, Wunderlich FT, von Kleist-Retzow JC, Waisman A, Westermann B, Langer T.

Genes Dev. 2008 Feb 15;22(4):476-88. doi: 10.1101/gad.460708.

22.

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.

Hövelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Wörns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Brüning JC, Galle PR, Wallach D, Fässler R, Waisman A.

J Exp Med. 2007 Oct 29;204(11):2615-27. Epub 2007 Oct 8.

23.

A fully computational model for predicting percutaneous drug absorption.

Neumann D, Kohlbacher O, Merkwirth C, Lengauer T.

J Chem Inf Model. 2006 Jan-Feb;46(1):424-9.

PMID:
16426076
24.

POEM: Parameter Optimization using Ensemble Methods: application to target specific scoring functions.

Antes I, Merkwirth C, Lengauer T.

J Chem Inf Model. 2005 Sep-Oct;45(5):1291-302.

PMID:
16180906
25.

Automatic generation of complementary descriptors with molecular graph networks.

Merkwirth C, Lengauer T.

J Chem Inf Model. 2005 Sep-Oct;45(5):1159-68.

PMID:
16180893
26.

Thrombin inhibitors identified by computer-assisted multiparameter design.

Riester D, Wirsching F, Salinas G, Keller M, Gebinoga M, Kamphausen S, Merkwirth C, Goetz R, Wiesenfeldt M, Stürzebecher J, Bode W, Friedrich R, Thürk M, Schwienhorst A.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8597-602. Epub 2005 Jun 3.

27.

Ensemble methods for classification in cheminformatics.

Merkwirth C, Mauser H, Schulz-Gasch T, Roche O, Stahl M, Lengauer T.

J Chem Inf Comput Sci. 2004 Nov-Dec;44(6):1971-8.

PMID:
15554666
28.

Association of HCV-related mixed cryoglobulinemia with specific mutational pattern of the HCV E2 protein and CD81 expression on peripheral B lymphocytes.

Hofmann WP, Herrmann E, Kronenberger B, Merkwirth C, Welsch C, Lengauer T, Zeuzem S, Sarrazin C.

Blood. 2004 Aug 15;104(4):1228-9. No abstract available.

29.

Fast nearest-neighbor searching for nonlinear signal processing

Merkwirth C, Parlitz U, Lauterborn W.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Aug;62(2 Pt A):2089-97.

PMID:
11088675
30.

Prediction of spatiotemporal time series based on reconstructed local states

Parlitz U, Merkwirth C.

Phys Rev Lett. 2000 Feb 28;84(9):1890-3.

PMID:
11017653

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