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Items: 1 to 50 of 189

1.

A study for therapeutic treatment against Parkinson's Disease via Chou's 5-steps rule.

Lan J, Liu J, Liao C, Merkler DJ, Han Q, Li J.

Curr Top Med Chem. 2019 Oct 19. doi: 10.2174/1568026619666191019111528. [Epub ahead of print]

PMID:
31629395
2.

Initial Viral Inoculum Determines Kinapse-and Synapse-Like T Cell Motility in Reactive Lymph Nodes.

Sivapatham S, Ficht X, Barreto de Albuquerque J, Page N, Merkler D, Stein JV.

Front Immunol. 2019 Sep 6;10:2086. doi: 10.3389/fimmu.2019.02086. eCollection 2019.

3.

In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance.

Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV.

J Immunol. 2019 Nov 1;203(9):2377-2387. doi: 10.4049/jimmunol.1900075. Epub 2019 Sep 23.

PMID:
31548330
4.

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T.

Nat Neurosci. 2019 Oct;22(10):1731-1742. doi: 10.1038/s41593-019-0479-z. Epub 2019 Sep 9.

PMID:
31501572
5.

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins.

Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T.

J Immunol. 2019 Sep 15;203(6):1417-1427. doi: 10.4049/jimmunol.1900468. Epub 2019 Aug 9.

6.

Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster.

Anderson RL, Wallis DJ, Aguirre A, Holliday D, Merkler DJ.

Arch Insect Biochem Physiol. 2019 Aug 6:e21608. doi: 10.1002/arch.21608. [Epub ahead of print]

PMID:
31385627
7.

Melanocytic colonization of choroid plexus papilloma: A previously undocumented source of pigment storage in the plexogenic epithelium.

Egervari K, Lobrinus JA, Merkler D, Vajtai I.

Clin Neuropathol. 2019 Sep/Oct;38(5):249-252. doi: 10.5414/NP301200. No abstract available.

PMID:
31296285
8.

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice.

Steinbach K, Vincenti I, Egervari K, Kreutzfeldt M, van der Meer F, Page N, Klimek B, Rossitto-Borlat I, Di Liberto G, Muschaweckh A, Wagner I, Hammad K, Stadelmann C, Korn T, Hartley O, Pinschewer DD, Merkler D.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaav5519. doi: 10.1126/scitranslmed.aav5519.

PMID:
31243152
9.

Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient.

Breville G, Lascano AM, Merkler D, Roth S, Lalive PH.

Mult Scler Relat Disord. 2019 Sep;34:63-65. doi: 10.1016/j.msard.2019.06.017. Epub 2019 Jun 17.

PMID:
31229736
10.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D.

Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17.

PMID:
31207605
11.

CD8+ T cells induce cachexia during chronic viral infection.

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.

Nat Immunol. 2019 Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20.

PMID:
31110314
12.

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort.

Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A, Proitsi P, Nevado-Holgado A, Hye A, Bos I, Vos S, Vandenberghe R, Teunissen C, Ten Kate M, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey F, Sala I, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Engelborghs S, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Barkhof F, Ashton N, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C.

Alzheimers Dement. 2019 Jun;15(6):817-827. doi: 10.1016/j.jalz.2019.03.004. Epub 2019 May 8.

13.

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis.

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA.

Nat Neurosci. 2019 Jun;22(6):887-896. doi: 10.1038/s41593-019-0385-4. Epub 2019 Apr 22.

PMID:
31011226
14.

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.

Immunity. 2019 Mar 19;50(3):763. doi: 10.1016/j.immuni.2019.02.011. No abstract available.

PMID:
30893589
15.

Binding-based proteomic profiling and the fatty acid amides.

Merkler DJ, Leahy JW.

Trends Res. 2018 Nov;1(4). doi: 10.15761/TR.1000120. Epub 2018 Nov 12.

16.

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients.

Migliorini D, Dutoit V, Allard M, Hallez NG, Marinari E, Widmer V, Philippin G, Corlazzoli F, Gustave R, Kreutzfeldt M, Blazek N, Wasem J, Hottinger A, Koka A, Momjian S, Lobrinus A, Merkler D, Vargas MI, Walker PR, Patrikidou A, Dietrich PY.

Neuro Oncol. 2019 Feb 12. doi: 10.1093/neuonc/noz040. [Epub ahead of print]

PMID:
30753611
17.

Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

Steinbach K, Vincenti I, Merkler D.

Front Immunol. 2018 Nov 30;9:2827. doi: 10.3389/fimmu.2018.02827. eCollection 2018. Review.

18.

Bm-iAANAT3: Expression and characterization of a novel arylalkylamine N-acyltransferase from Bombyx mori.

Battistini MR, O'Flynn BG, Shoji C, Suarez G, Galloway LC, Merkler DJ.

Arch Biochem Biophys. 2019 Jan;661:107-116. doi: 10.1016/j.abb.2018.11.015. Epub 2018 Nov 16.

PMID:
30452894
19.

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T.

Nat Immunol. 2018 Dec;19(12):1341-1351. doi: 10.1038/s41590-018-0237-5. Epub 2018 Oct 29.

20.

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements.

Fabbiano S, Suárez-Zamorano N, Chevalier C, Lazarević V, Kieser S, Rigo D, Leo S, Veyrat-Durebex C, Gaïa N, Maresca M, Merkler D, Gomez de Agüero M, Macpherson A, Schrenzel J, Trajkovski M.

Cell Metab. 2018 Dec 4;28(6):907-921.e7. doi: 10.1016/j.cmet.2018.08.005. Epub 2018 Aug 30.

21.

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping.

Di Liberto G, Pantelyushin S, Kreutzfeldt M, Page N, Musardo S, Coras R, Steinbach K, Vincenti I, Klimek B, Lingner T, Salinas G, Lin-Marq N, Staszewski O, Costa Jordão MJ, Wagner I, Egervari K, Mack M, Bellone C, Blümcke I, Prinz M, Pinschewer DD, Merkler D.

Cell. 2018 Oct 4;175(2):458-471.e19. doi: 10.1016/j.cell.2018.07.049. Epub 2018 Aug 30.

22.

Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori.

Anderson RL, Battistini MR, Wallis DJ, Shoji C, O'Flynn BG, Dillashaw JE, Merkler DJ.

Prostaglandins Leukot Essent Fatty Acids. 2018 Aug;135:10-17. doi: 10.1016/j.plefa.2018.06.001. Epub 2018 Jun 15.

23.

The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research.

Steinemann N, Kuhle J, Calabrese P, Kesselring J, Disanto G, Merkler D, Pot C, Ajdacic-Gross V, Rodgers S, Puhan MA, von Wyl V; Swiss Multiple Sclerosis Registry.

BMC Neurol. 2018 Aug 13;18(1):111. doi: 10.1186/s12883-018-1118-0.

24.

Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis.

O'Flynn BG, Suarez G, Hawley AJ, Merkler DJ.

Front Mol Biosci. 2018 Jul 26;5:66. doi: 10.3389/fmolb.2018.00066. eCollection 2018. Review.

25.

Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report.

El-Ayadi M, Egervari K, Merkler D, McKee TA, Gumy-Pause F, Stichel D, Capper D, Pietsch T, Ansari M, von Bueren AO.

Front Neurol. 2018 Jun 19;9:398. doi: 10.3389/fneur.2018.00398. eCollection 2018.

26.

Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits.

Loy K, Schmalz A, Hoche T, Jacobi A, Kreutzfeldt M, Merkler D, Bareyre FM.

J Neurotrauma. 2018 Dec 15;35(24):2904-2915. doi: 10.1089/neu.2017.5544. Epub 2018 Aug 10.

PMID:
29943672
27.

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV.

J Exp Med. 2018 Jul 2;215(7):1869-1890. doi: 10.1084/jem.20170896. Epub 2018 Jun 6.

28.

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.

Immunity. 2018 May 15;48(5):937-950.e8. doi: 10.1016/j.immuni.2018.04.005. Erratum in: Immunity. 2019 Mar 19;50(3):763.

29.

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B.

Immunity. 2018 Mar 20;48(3):599. doi: 10.1016/j.immuni.2018.02.014. No abstract available.

30.

Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans.

Handa S, Dempsey DR, Ramamoorthy D, Cook N, Guida WC, Spradling TJ, White JK, Woodcock HL, Merkler DJ.

Biochem Mol Biol J. 2018;4(1). pii: 2. doi: 10.21767/2471-8084.100051. Epub 2018 Jan 29.

31.

Insect Arylalkylamine N-Acetyltransferases as Potential Targets for Novel Insecticide Design.

O'Flynn BG, Hawley AJ, Merkler DJ.

Biochem Mol Biol J. 2018;4(1). pii: 4. doi: 10.21767/2471-8084.100053. Epub 2018 Feb 6.

32.

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner.

Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay TL, Blank T, Kreutzfeldt M, Merkler D, Ziegler-Waldkirch S, Matthias P, Meyer-Luehmann M, Prinz M.

Immunity. 2018 Mar 20;48(3):514-529.e6. doi: 10.1016/j.immuni.2018.02.016. Epub 2018 Mar 13.

33.

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B.

Immunity. 2018 Feb 20;48(2):380-395.e6. doi: 10.1016/j.immuni.2018.01.011. Epub 2018 Feb 6. Erratum in: Immunity. 2018 Mar 20;48(3):599.

34.

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.

Nunes-Hasler P, Maschalidi S, Lippens C, Castelbou C, Bouvet S, Guido D, Bermont F, Bassoy EY, Page N, Merkler D, Hugues S, Martinvalet D, Manoury B, Demaurex N.

Nat Commun. 2017 Nov 24;8(1):1852. doi: 10.1038/s41467-017-01600-6.

35.

The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs.

Spiljar M, Merkler D, Trajkovski M.

Front Immunol. 2017 Oct 30;8:1353. doi: 10.3389/fimmu.2017.01353. eCollection 2017. Review.

36.

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.

Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ.

Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6.

37.

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.

Remy MM, Sahin M, Flatz L, Regen T, Xu L, Kreutzfeldt M, Fallet B, Doras C, Rieger T, Bestmann L, Hanisch UK, Kaufmann BA, Merkler D, Pinschewer DD.

Cell Host Microbe. 2017 Sep 13;22(3):354-365.e5. doi: 10.1016/j.chom.2017.07.008. Epub 2017 Aug 17.

38.

Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours.

Andrianova MA, Chetan GK, Sibin MK, Mckee T, Merkler D, Narasinga RK, Ribaux P, Blouin JL, Makrythanasis P, Seplyarskiy VB, Antonarakis SE, Nikolaev SI.

J Pathol. 2017 Nov;243(3):331-341. doi: 10.1002/path.4957. Epub 2017 Sep 28.

PMID:
28805995
39.

Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients.

Lalive PH, Kreutzfeldt M, Devergne O, Metz I, Bruck W, Merkler D, Pot C.

J Neuroinflammation. 2017 Jul 24;14(1):144. doi: 10.1186/s12974-017-0919-1.

40.

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy.

Kallert SM, Darbre S, Bonilla WV, Kreutzfeldt M, Page N, Müller P, Kreuzaler M, Lu M, Favre S, Kreppel F, Löhning M, Luther SA, Zippelius A, Merkler D, Pinschewer DD.

Nat Commun. 2017 May 26;8:15327. doi: 10.1038/ncomms15327.

41.

Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase.

Aboalroub AA, Bachman AB, Zhang Z, Keramisanou D, Merkler DJ, Gelis I.

PLoS One. 2017 May 9;12(5):e0177270. doi: 10.1371/journal.pone.0177270. eCollection 2017.

42.

Clival chordoma: a single-centre outcome analysis.

Jägersberg M, El Rahal A, Dammann P, Merkler D, Weber DC, Schaller K.

Acta Neurochir (Wien). 2017 Oct;159(10):1815-1823. doi: 10.1007/s00701-017-3163-7. Epub 2017 May 7.

PMID:
28478512
43.

N-FATTY ACYLGLYCINES: UNDERAPPRECIATED ENDOCANNABINOID-LIKE FATTY ACID AMIDES?

Anderson RL, Merkler DJ.

J Biol Nat. 2017;8(4):156-165. Epub 2018 Mar 3.

44.

Interferon-driven deletion of antiviral B cells at the onset of chronic infection.

Fallet B, Narr K, Ertuna YI, Remy M, Sommerstein R, Cornille K, Kreutzfeldt M, Page N, Zimmer G, Geier F, Straub T, Pircher H, Larimore K, Greenberg PD, Merkler D, Pinschewer DD.

Sci Immunol. 2016 Oct 21;1(4). pii: eaah6817. doi: 10.1126/sciimmunol.aah6817.

45.

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.

Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M.

Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275.

46.

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.

Ozga AJ, Moalli F, Abe J, Swoger J, Sharpe J, Zehn D, Kreutzfeldt M, Merkler D, Ripoll J, Stein JV.

J Exp Med. 2016 Nov 14;213(12):2811-2829. Epub 2016 Oct 31.

47.

B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.

Bjarnadóttir K, Benkhoucha M, Merkler D, Weber MS, Payne NL, Bernard CCA, Molnarfi N, Lalive PH.

Sci Rep. 2016 Oct 6;6:34594. doi: 10.1038/srep34594.

48.

Investigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity.

Larson D, Powers A, Ambrosi JP, Tanji M, Napolitano A, Flores EG, Baumann F, Pellegrini L, Jennings CJ, Buck BJ, McLaurin BT, Merkler D, Robinson C, Morris P, Dogan M, Dogan AU, Pass HI, Pastorino S, Carbone M, Yang H.

J Toxicol Environ Health B Crit Rev. 2016;19(5-6):213-230.

49.

Thiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions.

White JK, Handa S, Vankayala SL, Merkler DJ, Woodcock HL.

J Phys Chem B. 2016 Sep 22;120(37):9922-34. doi: 10.1021/acs.jpcb.6b07248. Epub 2016 Sep 12.

50.

TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells.

Parsa R, Lund H, Tosevski I, Zhang XM, Malipiero U, Beckervordersandforth J, Merkler D, Prinz M, Gyllenberg A, James T, Warnecke A, Hillert J, Alfredsson L, Kockum I, Olsson T, Fontana A, Suter T, Harris RA.

Glia. 2016 Nov;64(11):1925-37. doi: 10.1002/glia.23033. Epub 2016 Aug 1.

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