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Items: 22

1.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.

Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21.

2.

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7.

3.

Generation and Characterization of Functional Human Hypothalamic Neurons.

Kirwan P, Jura M, Merkle FT.

Curr Protoc Neurosci. 2017 Oct 24;81:3.33.1-3.33.24. doi: 10.1002/cpns.40.

PMID:
29064566
4.

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

Merkle FT, Ghosh S, Kamitaki N, Mitchell J, Avior Y, Mello C, Kashin S, Mekhoubad S, Ilic D, Charlton M, Saphier G, Handsaker RE, Genovese G, Bar S, Benvenisty N, McCarroll SA, Eggan K.

Nature. 2017 May 11;545(7653):229-233. doi: 10.1038/nature22312. Epub 2017 Apr 26.

5.

Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.

Santos DP, Kiskinis E, Eggan K, Merkle FT.

Curr Protoc Stem Cell Biol. 2016 Aug 17;38:5B.6.1-5B.6.60. doi: 10.1002/cpsc.15.

6.

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K.

Sci Transl Med. 2016 Jul 13;8(347):347ra93. doi: 10.1126/scitranslmed.aaf6038.

7.

Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.

Merkle FT, Neuhausser WM, Santos D, Valen E, Gagnon JA, Maas K, Sandoe J, Schier AF, Eggan K.

Cell Rep. 2015 May 12;11(6):875-883. doi: 10.1016/j.celrep.2015.04.007. Epub 2015 Apr 30.

8.

Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9.

Liu J, Merkle FT, Gandhi AV, Gagnon JA, Woods IG, Chiu CN, Shimogori T, Schier AF, Prober DA.

Development. 2015 Mar 15;142(6):1113-24. doi: 10.1242/dev.117424. Epub 2015 Feb 27.

9.

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.

Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF.

Development. 2015 Feb 15;142(4):633-43. doi: 10.1242/dev.117978.

10.

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K.

Cell Stem Cell. 2014 Jun 5;14(6):781-95. doi: 10.1016/j.stem.2014.03.004. Epub 2014 Apr 3.

11.

Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.

Merkle FT, Fuentealba LC, Sanders TA, Magno L, Kessaris N, Alvarez-Buylla A.

Nat Neurosci. 2014 Feb;17(2):207-14. doi: 10.1038/nn.3610. Epub 2013 Dec 22.

12.

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.

Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K.

Nat Neurosci. 2013 Dec;16(12):1725-7. doi: 10.1038/nn.3566. Epub 2013 Nov 3.

13.

Modeling human disease with pluripotent stem cells: from genome association to function.

Merkle FT, Eggan K.

Cell Stem Cell. 2013 Jun 6;12(6):656-68. doi: 10.1016/j.stem.2013.05.016.

14.

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L.

Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008.

15.

Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective.

Seeley WW, Merkle FT, Gaus SE, Craig AD, Allman JM, Hof PR.

Cereb Cortex. 2012 Feb;22(2):245-50. doi: 10.1093/cercor/bhr005. Epub 2011 Jun 8.

PMID:
21653703
16.

The heterogeneity of adult neural stem cells and the emerging complexity of their niche.

Alvarez-Buylla A, Kohwi M, Nguyen TM, Merkle FT.

Cold Spring Harb Symp Quant Biol. 2008;73:357-65. doi: 10.1101/sqb.2008.73.019. Epub 2008 Nov 6. Review.

PMID:
19022766
17.

Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.

Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A.

Cell Stem Cell. 2008 Sep 11;3(3):265-78. doi: 10.1016/j.stem.2008.07.004.

18.

Origin and function of olfactory bulb interneuron diversity.

Lledo PM, Merkle FT, Alvarez-Buylla A.

Trends Neurosci. 2008 Aug;31(8):392-400. doi: 10.1016/j.tins.2008.05.006. Epub 2008 Jul 5. Review.

19.

Mosaic organization of neural stem cells in the adult brain.

Merkle FT, Mirzadeh Z, Alvarez-Buylla A.

Science. 2007 Jul 20;317(5836):381-4. Epub 2007 Jul 5.

20.

Neural stem cells in mammalian development.

Merkle FT, Alvarez-Buylla A.

Curr Opin Cell Biol. 2006 Dec;18(6):704-9. Epub 2006 Oct 12. Review.

PMID:
17046226
21.

Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.

Spassky N, Merkle FT, Flames N, Tramontin AD, García-Verdugo JM, Alvarez-Buylla A.

J Neurosci. 2005 Jan 5;25(1):10-8.

22.

Radial glia give rise to adult neural stem cells in the subventricular zone.

Merkle FT, Tramontin AD, García-Verdugo JM, Alvarez-Buylla A.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17528-32. Epub 2004 Dec 1.

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