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Items: 1 to 50 of 100

1.

Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase.

Semmelmann F, Straub K, Nazet J, Rajendran C, Merkl R, Sterner R.

J Mol Biol. 2019 May 20. pii: S0022-2836(19)30293-1. doi: 10.1016/j.jmb.2019.05.021. [Epub ahead of print]

PMID:
31121180
2.

A fold-independent interface residue is crucial for complex formation and allosteric signaling in class I glutamine amidotransferases.

Semmelmann F, Hupfeld E, Heizinger L, Merkl R, Sterner R.

Biochemistry. 2019 May 22. doi: 10.1021/acs.biochem.9b00286. [Epub ahead of print]

PMID:
31117390
3.

Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.

Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U.

PLoS One. 2019 May 2;14(5):e0216320. doi: 10.1371/journal.pone.0216320. eCollection 2019.

4.

Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.

Semmelmann F, Kabeya N, Malcicka M, Bruckmann A, Broschwitz B, Straub K, Merkl R, Monroig O, Sterner R, Ruther J, Ellers J.

J Exp Biol. 2019 May 16;222(Pt 10). pii: jeb201038. doi: 10.1242/jeb.201038.

PMID:
31019064
5.

Sequence selection by FitSS4ASR alleviates ancestral sequence reconstruction as exemplified for geranylgeranylglyceryl phosphate synthase.

Straub K, Linde M, Kropp C, Blanquart S, Babinger P, Merkl R.

Biol Chem. 2019 Jan 9. pii: /j/bchm.ahead-of-print/hsz-2018-0344/hsz-2018-0344.xml. doi: 10.1515/hsz-2018-0344. [Epub ahead of print]

PMID:
30864398
6.

Sequence selection by FitSS4ASR alleviates ancestral sequence reconstruction as exemplified for geranylgeranylglyceryl phosphate synthase.

Straub K, Linde M, Kropp C, Blanquart S, Babinger P, Merkl R.

Biol Chem. 2019 Feb 25;400(3):367-381. doi: 10.1515/hsz-2018-0344.

PMID:
30763032
7.

Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1.

Hoffmeister H, Fuchs A, Strobl L, Sprenger F, Gröbner-Ferreira R, Michaelis S, Hoffmann P, Nazet J, Merkl R, Längst G.

J Biol Chem. 2019 Mar 1;294(9):3294-3310. doi: 10.1074/jbc.RA118.005685. Epub 2019 Jan 15.

PMID:
30647132
8.

The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.

Ziegler C, Graf J, Faderl S, Schedlbauer J, Strieder N, Förstl B, Spang R, Bruckmann A, Merkl R, Hombach S, Kretz M.

EMBO Rep. 2019 Feb;20(2). pii: e46612. doi: 10.15252/embr.201846612. Epub 2019 Jan 8.

PMID:
30622217
9.

Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.

Schwartz U, Németh A, Diermeier S, Exler JH, Hansch S, Maldonado R, Heizinger L, Merkl R, Längst G.

Nucleic Acids Res. 2018 Nov 28. doi: 10.1093/nar/gky1203. [Epub ahead of print]

10.

Ancestral Sequence Reconstruction as a Tool for the Elucidation of a Stepwise Evolutionary Adaptation.

Straub K, Merkl R.

Methods Mol Biol. 2019;1851:171-182. doi: 10.1007/978-1-4939-8736-8_9.

PMID:
30298397
11.

Development of photoswitchable inhibitors for β-galactosidase.

Rustler K, Mickert MJ, Nazet J, Merkl R, Gorris HH, König B.

Org Biomol Chem. 2018 Oct 17;16(40):7430-7437. doi: 10.1039/c8ob02122h.

PMID:
30264846
12.

Pathomechanism of mutated and secreted retinoschisin in X-linked juvenile retinoschisis.

Plössl K, Schmid V, Straub K, Schmid C, Ammon M, Merkl R, Weber BHF, Friedrich U.

Exp Eye Res. 2018 Dec;177:23-34. doi: 10.1016/j.exer.2018.07.021. Epub 2018 Jul 21.

PMID:
30040949
13.

Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.

Kneuttinger AC, Winter M, Simeth NA, Heyn K, Merkl R, König B, Sterner R.

Chembiochem. 2018 May 29. doi: 10.1002/cbic.201800219. [Epub ahead of print]

PMID:
29808949
14.

Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures.

Linde M, Heyn K, Merkl R, Sterner R, Babinger P.

Biochemistry. 2018 Apr 24;57(16):2335-2348. doi: 10.1021/acs.biochem.7b01284. Epub 2018 Apr 11.

PMID:
29600842
15.

The Adaptor Protein ENY2 Is a Component of the Deubiquitination Module of the Arabidopsis SAGA Transcriptional Co-activator Complex but not of the TREX-2 Complex.

Pfab A, Bruckmann A, Nazet J, Merkl R, Grasser KD.

J Mol Biol. 2018 May 11;430(10):1479-1494. doi: 10.1016/j.jmb.2018.03.018. Epub 2018 Mar 26.

PMID:
29588169
16.

Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase.

Schlee S, Klein T, Schumacher M, Nazet J, Merkl R, Steinhoff HJ, Sterner R.

Biochemistry. 2018 Jun 12;57(23):3265-3277. doi: 10.1021/acs.biochem.8b00167. Epub 2018 Mar 8.

PMID:
29498826
17.

Evolutionary diversification of protein-protein interactions by interface add-ons.

Plach MG, Semmelmann F, Busch F, Busch M, Heizinger L, Wysocki VH, Merkl R, Sterner R.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8333-E8342. doi: 10.1073/pnas.1707335114. Epub 2017 Sep 18.

18.

Rosetta:MSF: a modular framework for multi-state computational protein design.

Löffler P, Schmitz S, Hupfeld E, Sterner R, Merkl R.

PLoS Comput Biol. 2017 Jun 12;13(6):e1005600. doi: 10.1371/journal.pcbi.1005600. eCollection 2017 Jun.

19.

AGeNNT: annotation of enzyme families by means of refined neighborhood networks.

Kandlinger F, Plach MG, Merkl R.

BMC Bioinformatics. 2017 May 25;18(1):274. doi: 10.1186/s12859-017-1689-6.

20.

Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.

Veprinskiy V, Heizinger L, Plach MG, Merkl R.

BMC Evol Biol. 2017 Jan 26;17(1):36. doi: 10.1186/s12862-017-0886-2.

21.

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.

Silberhorn E, Schwartz U, Löffler P, Schmitz S, Symelka A, de Koning-Ward T, Merkl R, Längst G.

PLoS Pathog. 2016 Dec 29;12(12):e1006080. doi: 10.1371/journal.ppat.1006080. eCollection 2016 Dec.

22.

The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events.

Sørensen BB, Ehrnsberger HF, Esposito S, Pfab A, Bruckmann A, Hauptmann J, Meister G, Merkl R, Schubert T, Längst G, Melzer M, Grasser M, Grasser KD.

Plant Mol Biol. 2017 Feb;93(3):283-298. doi: 10.1007/s11103-016-0561-9. Epub 2016 Dec 21.

PMID:
28004241
23.

Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex.

Holinski A, Heyn K, Merkl R, Sterner R.

Proteins. 2017 Feb;85(2):312-321. doi: 10.1002/prot.25225. Epub 2017 Jan 5.

PMID:
27936490
24.

Gene silencing pathways found in the green alga Volvox carteri reveal insights into evolution and origins of small RNA systems in plants.

Dueck A, Evers M, Henz SR, Unger K, Eichner N, Merkl R, Berezikov E, Engelmann JC, Weigel D, Wenzl S, Meister G.

BMC Genomics. 2016 Nov 2;17(1):853.

25.

Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.

Busch F, Rajendran C, Heyn K, Schlee S, Merkl R, Sterner R.

Cell Chem Biol. 2016 Jun 23;23(6):709-15. doi: 10.1016/j.chembiol.2016.05.009. Epub 2016 Jun 9.

26.

Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.

Plach MG, Reisinger B, Sterner R, Merkl R.

PLoS Genet. 2016 Jan 29;12(1):e1005836. doi: 10.1371/journal.pgen.1005836. eCollection 2016 Jan.

27.

An assessment of catalytic residue 3D ensembles for the prediction of enzyme function.

Žváček C, Friedrichs G, Heizinger L, Merkl R.

BMC Bioinformatics. 2015 Nov 4;16:359. doi: 10.1186/s12859-015-0807-6.

28.

Conversion of anthranilate synthase into isochorismate synthase: implications for the evolution of chorismate-utilizing enzymes.

Plach MG, Löffler P, Merkl R, Sterner R.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11270-4. doi: 10.1002/anie.201505063.

PMID:
26352034
29.

Ancestral protein reconstruction: techniques and applications.

Merkl R, Sterner R.

Biol Chem. 2016 Jan;397(1):1-21. doi: 10.1515/hsz-2015-0158. Review.

PMID:
26351909
30.

The extended AT-hook is a novel RNA binding motif.

Filarsky M, Zillner K, Araya I, Villar-Garea A, Merkl R, Längst G, Németh A.

RNA Biol. 2015;12(8):864-76. doi: 10.1080/15476286.2015.1060394.

31.

Maize EMBRYO SAC family peptides interact differentially with pollen tubes and fungal cells.

Woriedh M, Merkl R, Dresselhaus T.

J Exp Bot. 2015 Aug;66(17):5205-16. doi: 10.1093/jxb/erv268. Epub 2015 Jun 12.

32.

Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.

Ece S, Evran S, Janda JO, Merkl R, Sterner R.

Protein Eng Des Sel. 2015 Jun;28(6):147-51. doi: 10.1093/protein/gzv001. Epub 2015 Feb 12.

PMID:
25680359
33.

TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.

Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Längst G, Papantonis A.

Genome Biol. 2014 Dec 3;15(12):536. doi: 10.1186/s13059-014-0536-6.

34.

TrpB2 enzymes are O-phospho-l-serine dependent tryptophan synthases.

Busch F, Rajendran C, Mayans O, Löffler P, Merkl R, Sterner R.

Biochemistry. 2014 Sep 30;53(38):6078-83. doi: 10.1021/bi500977y. Epub 2014 Sep 17.

PMID:
25184516
35.

Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage.

Hauptmann J, Kater L, Löffler P, Merkl R, Meister G.

RNA. 2014 Oct;20(10):1532-8. doi: 10.1261/rna.045203.114. Epub 2014 Aug 11.

36.

[Skin changes in the face. " I have such odd acne around the nose". Perioral dermatitis].

Müller A, Merkl RK, Möbius D.

MMW Fortschr Med. 2014 May 28;156(10):7, 47. German. No abstract available.

PMID:
24930211
37.

Oleic acid is a precursor of linoleic acid and the male sex pheromone in Nasonia vitripennis.

Blaul B, Steinbauer R, Merkl P, Merkl R, Tschochner H, Ruther J.

Insect Biochem Mol Biol. 2014 Aug;51:33-40. doi: 10.1016/j.ibmb.2014.05.007. Epub 2014 May 27.

PMID:
24874439
38.

H2rs: deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.

Janda JO, Popal A, Bauer J, Busch M, Klocke M, Spitzer W, Keller J, Merkl R.

BMC Bioinformatics. 2014 Apr 27;15:118. doi: 10.1186/1471-2105-15-118.

39.

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.

Loedige I, Stotz M, Qamar S, Kramer K, Hennig J, Schubert T, Löffler P, Längst G, Merkl R, Urlaub H, Meister G.

Genes Dev. 2014 Apr 1;28(7):749-64. doi: 10.1101/gad.236513.113.

40.

Exploiting protein symmetry to design light-controllable enzyme inhibitors.

Reisinger B, Kuzmanovic N, Löffler P, Merkl R, König B, Sterner R.

Angew Chem Int Ed Engl. 2014 Jan 7;53(2):595-8. doi: 10.1002/anie.201307207. Epub 2013 Nov 25.

PMID:
24520030
41.

Evidence for the existence of elaborate enzyme complexes in the Paleoarchean era.

Reisinger B, Sperl J, Holinski A, Schmid V, Rajendran C, Carstensen L, Schlee S, Blanquart S, Merkl R, Sterner R.

J Am Chem Soc. 2014 Jan 8;136(1):122-9. doi: 10.1021/ja4115677. Epub 2013 Dec 23.

42.

CLIPS-4D: a classifier that distinguishes structurally and functionally important residue-positions based on sequence and 3D data.

Janda JO, Meier A, Merkl R.

Bioinformatics. 2013 Dec 1;29(23):3029-35. doi: 10.1093/bioinformatics/btt519. Epub 2013 Sep 18.

PMID:
24048358
43.

Antioxidant effect of mono- and dihydroxyphenols in sunflower oil with different levels of naturally present tocopherols.

Hrádková I, Merkl R, Smidrkal J, Kyselka J, Filip V.

Eur J Lipid Sci Technol. 2013 Jul;115(7):747-755. Epub 2013 May 17.

44.

[The nodule hurts more and more... Deep venous thrombosis].

Müller A, Möbius D, Merkl RK.

MMW Fortschr Med. 2013 Jul 25;155(13):5. German. No abstract available.

PMID:
23964484
45.

[Objective and subjective findings. There are considerable differences].

Möbius D, Müller A, Merkl RK.

MMW Fortschr Med. 2013 Apr 4;155(6):5. German. No abstract available.

PMID:
23729047
46.

Turning catalytically inactive human Argonaute proteins into active slicer enzymes.

Hauptmann J, Dueck A, Harlander S, Pfaff J, Merkl R, Meister G.

Nat Struct Mol Biol. 2013 Jul;20(7):814-7. doi: 10.1038/nsmb.2577. Epub 2013 May 12.

PMID:
23665583
47.

[Are the bones coming through the skin here? Urate arthritis].

Möbius D, Müller A, Merkl RK.

MMW Fortschr Med. 2013 Feb 21;155(3):5. German. No abstract available.

PMID:
23573751
48.

[Sequela of a cough attack: "A cracking noise when breathing"].

Müller A, Möbius D, Merkl RK.

MMW Fortschr Med. 2012 Nov 29;154(21):5. German. No abstract available.

PMID:
23270045
49.

Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple-sequence alignments.

Dietrich S, Borst N, Schlee S, Schneider D, Janda JO, Sterner R, Merkl R.

Biochemistry. 2012 Jul 17;51(28):5633-41. Epub 2012 Jul 6.

PMID:
22737967
50.

Dimerization determines substrate specificity of a bacterial prenyltransferase.

Peterhoff D, Zellner H, Guldan H, Merkl R, Sterner R, Babinger P.

Chembiochem. 2012 Jun 18;13(9):1297-303. doi: 10.1002/cbic.201200127. Epub 2012 May 21. Erratum in: Chembiochem. 2012 Aug 13;13(12):1710.

PMID:
22614947

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