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Items: 1 to 50 of 67

1.

Histopathology of Bordetella pertussis in the Baboon Model.

Zimmerman LI, Papin JF, Warfel J, Wolf RF, Kosanke SD, Merkel TJ.

Infect Immun. 2018 Aug 20. pii: IAI.00511-18. doi: 10.1128/IAI.00511-18. [Epub ahead of print]

PMID:
30126900
2.

Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough.

Kapil P, Papin JF, Wolf RF, Zimmerman LI, Wagner LD, Merkel TJ.

J Infect Dis. 2018 Mar 28;217(8):1231-1236. doi: 10.1093/infdis/jiy022.

PMID:
29346585
3.

Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.

Chen Q, Ng V, Warfel JM, Merkel TJ, Stibitz S.

J Bacteriol. 2017 Oct 17;199(22). pii: e00475-17. doi: 10.1128/JB.00475-17. Print 2017 Nov 15.

4.

Pertussis disease and transmission and host responses: insights from the baboon model of pertussis.

Pinto MV, Merkel TJ.

J Infect. 2017 Jun;74 Suppl 1:S114-S119. doi: 10.1016/S0163-4453(17)30201-3. Review.

PMID:
28646950
5.

Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development".

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00071-17. doi: 10.1128/CVI.00071-17. Print 2017 May. No abstract available.

6.

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo.

Sita TL, Kouri FM, Hurley LA, Merkel TJ, Chalastanis A, May JL, Ghelfi ST, Cole LE, Cayton TC, Barnaby SN, Sprangers AJ, Savalia N, James CD, Lee A, Mirkin CA, Stegh AH.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4129-4134. doi: 10.1073/pnas.1702736114. Epub 2017 Apr 3.

7.

Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.

Eby JC, Gray MC, Warfel JM, Merkel TJ, Hewlett EL.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00370-16. doi: 10.1128/CVI.00370-16. Print 2017 Jan.

8.

Relationships between Poly(ethylene glycol) Modifications on RNA-Spherical Nucleic Acid Conjugates and Cellular Uptake and Circulation Time.

Chinen AB, Ferrer JR, Merkel TJ, Mirkin CA.

Bioconjug Chem. 2016 Nov 16;27(11):2715-2721. Epub 2016 Oct 20.

9.

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development.

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2016 Nov 4;23(11):842-850. Print 2016 Nov. Erratum in: Clin Vaccine Immunol. 2017 May 5;24(5):.

10.

The multifaceted RisA regulon of Bordetella pertussis.

Coutte L, Huot L, Antoine R, Slupek S, Merkel TJ, Chen Q, Stibitz S, Hot D, Locht C.

Sci Rep. 2016 Sep 13;6:32774. doi: 10.1038/srep32774.

11.

Comparison of Three Whole-Cell Pertussis Vaccines in the Baboon Model of Pertussis.

Warfel JM, Zimmerman LI, Merkel TJ.

Clin Vaccine Immunol. 2015 Nov 11;23(1):47-54. doi: 10.1128/CVI.00449-15. Print 2016 Jan.

12.

Bordetella pertussis transmission.

Trainor EA, Nicholson TL, Merkel TJ.

Pathog Dis. 2015 Nov;73(8):ftv068. doi: 10.1093/femspd/ftv068. Epub 2015 Sep 14. Review.

13.

Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence.

Chinen AB, Guan CM, Ferrer JR, Barnaby SN, Merkel TJ, Mirkin CA.

Chem Rev. 2015 Oct 14;115(19):10530-74. doi: 10.1021/acs.chemrev.5b00321. Epub 2015 Aug 27. Review. No abstract available.

14.

Erratum for Boinett et al., Complete Genome Sequence of Bordetella pertussis D420.

Boinett CJ, Harris SR, Langridge GC, Trainor EA, Merkel TJ, Parkhill J.

Genome Announc. 2015 Jul 16;3(4). pii: e00842-15. doi: 10.1128/genomeA.00842-15. No abstract available.

15.

Complete Genome Sequence of Bordetella pertussis D420.

Boinett CJ, Harris SR, Langridge GC, Trainor EA, Merkel TJ, Parkhill J.

Genome Announc. 2015 Jun 11;3(3). pii: e00657-15. doi: 10.1128/genomeA.00657-15. Erratum in: Genome Announc. 2015;3(4). pii: e00842-15. doi: 10.1128/genomeA.00842-15.

16.

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.

Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng CY, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, Stegh AH.

Genes Dev. 2015 Apr 1;29(7):732-45. doi: 10.1101/gad.257394.114.

17.

Immunomodulatory spherical nucleic acids.

Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, Gryaznov SM.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3892-7. doi: 10.1073/pnas.1502850112. Epub 2015 Mar 16.

18.

Biocompatible infinite-coordination-polymer nanoparticle-nucleic-acid conjugates for antisense gene regulation.

Calabrese CM, Merkel TJ, Briley WE, Randeria PS, Narayan SP, Rouge JL, Walker DA, Scott AW, Mirkin CA.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):476-480. doi: 10.1002/anie.201407946. Epub 2014 Nov 13.

19.

The baboon model of pertussis: effective use and lessons for pertussis vaccines.

Warfel JM, Merkel TJ.

Expert Rev Vaccines. 2014 Oct;13(10):1241-52. doi: 10.1586/14760584.2014.946016. Epub 2014 Sep 3. Review.

PMID:
25182980
20.

Reply to Domenech de Cellès et al.: Infection and transmission of pertussis in the baboon model.

Warfel JM, Merkel TJ.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E718. No abstract available.

21.

Nonhuman primate and human challenge models of pertussis.

Merkel TJ, Halperin SA.

J Infect Dis. 2014 Apr 1;209 Suppl 1:S20-3. doi: 10.1093/infdis/jit493. Review.

22.

Pertussis pathogenesis--what we know and what we don't know.

Hewlett EL, Burns DL, Cotter PA, Harvill ET, Merkel TJ, Quinn CP, Stibitz ES.

J Infect Dis. 2014 Apr 1;209(7):982-5. doi: 10.1093/infdis/jit639. Review.

23.

Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant.

Feinen B, Petrovsky N, Verma A, Merkel TJ.

Clin Vaccine Immunol. 2014 Apr;21(4):580-6. doi: 10.1128/CVI.00019-14. Epub 2014 Feb 19.

24.

Maternal and neonatal vaccination protects newborn baboons from pertussis infection.

Warfel JM, Papin JF, Wolf RF, Zimmerman LI, Merkel TJ.

J Infect Dis. 2014 Aug 15;210(4):604-10. doi: 10.1093/infdis/jiu090. Epub 2014 Feb 12.

25.

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model.

Warfel JM, Zimmerman LI, Merkel TJ.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):787-92. doi: 10.1073/pnas.1314688110. Epub 2013 Nov 25.

26.

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.

Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH.

Sci Transl Med. 2013 Oct 30;5(209):209ra152. doi: 10.1126/scitranslmed.3006839.

27.

Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection.

Merkel TJ, Perera PY, Lee GM, Verma A, Hiroi T, Yokote H, Waldmann TA, Perera LP.

Hum Vaccin Immunother. 2013 Sep;9(9):1841-8. doi: 10.4161/hv.25337. Epub 2013 Jun 20.

28.

Evaluation of genetically inactivated alpha toxin for protection in multiple mouse models of Staphylococcus aureus infection.

Brady RA, Mocca CP, Prabhakara R, Plaut RD, Shirtliff ME, Merkel TJ, Burns DL.

PLoS One. 2013 Apr 29;8(4):e63040. doi: 10.1371/journal.pone.0063040. Print 2013.

29.

Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging.

Plaut RD, Mocca CP, Prabhakara R, Merkel TJ, Stibitz S.

PLoS One. 2013;8(3):e59232. doi: 10.1371/journal.pone.0059232. Epub 2013 Mar 12.

30.

Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection.

Eby JC, Gray MC, Warfel JM, Paddock CD, Jones TF, Day SR, Bowden J, Poulter MD, Donato GM, Merkel TJ, Hewlett EL.

Infect Immun. 2013 May;81(5):1390-8. doi: 10.1128/IAI.00110-13. Epub 2013 Feb 19.

31.

Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Prabhakara R, Foreman O, De Pascalis R, Lee GM, Plaut RD, Kim SY, Stibitz S, Elkins KL, Merkel TJ.

Infect Immun. 2013 Apr;81(4):1306-15. doi: 10.1128/IAI.01304-12. Epub 2013 Feb 4.

32.

Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates.

Warfel JM, Merkel TJ.

Mucosal Immunol. 2013 Jul;6(4):787-96. doi: 10.1038/mi.2012.117. Epub 2012 Nov 28.

PMID:
23187316
33.

Low modulus biomimetic microgel particles with high loading of hemoglobin.

Chen K, Merkel TJ, Pandya A, Napier ME, Luft JC, Daniel W, Sheiko S, DeSimone JM.

Biomacromolecules. 2012 Sep 10;13(9):2748-59. doi: 10.1021/bm3007242. Epub 2012 Aug 17.

34.

Airborne transmission of Bordetella pertussis.

Warfel JM, Beren J, Merkel TJ.

J Infect Dis. 2012 Sep 15;206(6):902-6. doi: 10.1093/infdis/jis443. Epub 2012 Jul 17.

35.

Dissemination bottleneck in a murine model of inhalational anthrax.

Plaut RD, Kelly VK, Lee GM, Stibitz S, Merkel TJ.

Infect Immun. 2012 Sep;80(9):3189-93. doi: 10.1128/IAI.00515-12. Epub 2012 Jul 2.

36.

Tunneling characteristics of Au-alkanedithiol-Au junctions formed via nanotransfer printing (nTP).

Niskala JR, Rice WC, Bruce RC, Merkel TJ, Tsui F, You W.

J Am Chem Soc. 2012 Jul 25;134(29):12072-82. doi: 10.1021/ja302602b. Epub 2012 Jul 12.

PMID:
22720785
37.

The effect of particle size on the biodistribution of low-modulus hydrogel PRINT particles.

Merkel TJ, Chen K, Jones SW, Pandya AA, Tian S, Napier ME, Zamboni WE, DeSimone JM.

J Control Release. 2012 Aug 20;162(1):37-44. doi: 10.1016/j.jconrel.2012.06.009. Epub 2012 Jun 15.

38.

Moraxella catarrhalis activates murine macrophages through multiple toll like receptors and has reduced clearance in lungs from TLR4 mutant mice.

Hassan F, Ren D, Zhang W, Merkel TJ, Gu XX.

PLoS One. 2012;7(5):e37610. doi: 10.1371/journal.pone.0037610. Epub 2012 May 25.

39.

Effect of aspect ratio and deformability on nanoparticle extravasation through nanopores.

Kersey FR, Merkel TJ, Perry JL, Napier ME, DeSimone JM.

Langmuir. 2012 Jun 12;28(23):8773-81. doi: 10.1021/la301279v. Epub 2012 May 29.

40.

Nonhuman primate model of pertussis.

Warfel JM, Beren J, Kelly VK, Lee G, Merkel TJ.

Infect Immun. 2012 Apr;80(4):1530-6. doi: 10.1128/IAI.06310-11. Epub 2012 Jan 17.

41.

Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice.

Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM.

J Immunol. 2012 Feb 1;188(3):1469-78. doi: 10.4049/jimmunol.1102310. Epub 2011 Dec 28.

42.

Amphiphilic co-networks with moisture-induced surface segregation for high-performance nonfouling coatings.

Wang Y, Finlay JA, Betts DE, Merkel TJ, Luft JC, Callow ME, Callow JA, DeSimone JM.

Langmuir. 2011 Sep 6;27(17):10365-9. doi: 10.1021/la202427z. Epub 2011 Aug 15.

PMID:
21827199
43.

Dodging drug-resistant cancer with diamonds.

Merkel TJ, DeSimone JM.

Sci Transl Med. 2011 Mar 9;3(73):73ps8. doi: 10.1126/scitranslmed.3002137.

PMID:
21389261
44.

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles.

Merkel TJ, Jones SW, Herlihy KP, Kersey FR, Shields AR, Napier M, Luft JC, Wu H, Zamboni WC, Wang AZ, Bear JE, DeSimone JM.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):586-91. doi: 10.1073/pnas.1010013108. Epub 2011 Jan 10.

45.

Generation of a library of particles having controlled sizes and shapes via the mechanical elongation of master templates.

Wang Y, Merkel TJ, Chen K, Fromen CA, Betts DE, DeSimone JM.

Langmuir. 2011 Jan 18;27(2):524-8. doi: 10.1021/la1045095. Epub 2010 Dec 17.

PMID:
21166444
46.

Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities.

Merkel TJ, Perera PY, Kelly VK, Verma A, Llewellyn ZN, Waldmann TA, Mosca JD, Perera LP.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18091-6. doi: 10.1073/pnas.1013083107. Epub 2010 Oct 4.

47.

Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking.

Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM.

Infect Immun. 2010 Jun;78(6):2418-28. doi: 10.1128/IAI.00170-10. Epub 2010 Mar 22.

48.

Scalable, shape-specific, top-down fabrication methods for the synthesis of engineered colloidal particles.

Merkel TJ, Herlihy KP, Nunes J, Orgel RM, Rolland JP, DeSimone JM.

Langmuir. 2010 Aug 17;26(16):13086-96. doi: 10.1021/la903890h.

49.

Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure.

Loving CL, Osorio M, Kim YG, Nuñez G, Hughes MA, Merkel TJ.

Infect Immun. 2009 Oct;77(10):4529-37. doi: 10.1128/IAI.00563-09. Epub 2009 Jul 20.

50.

Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge.

Osorio M, Wu Y, Singh S, Merkel TJ, Bhattacharyya S, Blake MS, Kopecko DJ.

Infect Immun. 2009 Apr;77(4):1475-82. doi: 10.1128/IAI.00828-08. Epub 2009 Jan 29.

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