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Items: 1 to 50 of 124

1.

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles.

Keil TWM, Feldmann DP, Costabile G, Zhong Q, da Rocha S, Merkel OM.

Eur J Pharm Biopharm. 2019 Oct;143:61-69. doi: 10.1016/j.ejpb.2019.08.012. Epub 2019 Aug 21.

PMID:
31445157
2.

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases.

Kandil R, Xie Y, Mehta A, Merkel O.

Methods Mol Biol. 2020;2059:155-166. doi: 10.1007/978-1-4939-9798-5_7.

PMID:
31435920
3.

Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells.

Kandil R, Xie Y, Heermann R, Isert L, Jung K, Mehta A, Merkel OM.

Adv Ther (Weinh). 2019 Jul;2(7). pii: 1900047. doi: 10.1002/adtp.201900047. Epub 2019 Apr 26.

4.

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles.

Mehta A, Dalle Vedove E, Isert L, Merkel OM.

Pharm Res. 2019 Jul 9;36(9):133. doi: 10.1007/s11095-019-2665-9.

PMID:
31289919
5.

The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells.

Hartl N, Adams F, Costabile G, Isert L, Döblinger M, Xiao X, Liu R, Merkel OM.

Nanomaterials (Basel). 2019 Jul 8;9(7). pii: E986. doi: 10.3390/nano9070986.

6.

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.

Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R.

Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986. [Epub ahead of print]

7.

Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer.

Feldmann DP, Jones S, Douglas K, Shields AF, Merkel OM.

Methods Mol Biol. 2019;1974:355-369. doi: 10.1007/978-1-4939-9220-1_24.

PMID:
31099014
8.

Dry powder inhalation of siRNA.

Keil TW, Merkel OM.

Ther Deliv. 2019 May 1;10(5):265-267. doi: 10.4155/tde-2019-0018. Epub 2019 May 16. No abstract available.

9.

Pulmonary delivery of siRNA as a novel treatment for lung diseases.

Kandil R, Merkel OM.

Ther Deliv. 2019 Apr;10(4):203-206. doi: 10.4155/tde-2019-0009.

10.

Nose-to-brain delivery of biologics.

Schwarz B, Merkel OM.

Ther Deliv. 2019 Apr;10(4):207-210. doi: 10.4155/tde-2019-0013.

PMID:
30991920
11.

Recent Progress of Polymeric Nanogels for Gene Delivery.

Kandil R, Merkel OM.

Curr Opin Colloid Interface Sci. 2019 Feb;39:11-23. doi: 10.1016/j.cocis.2019.01.005. Epub 2019 Jan 16.

12.

Flow Cytometry-Based Cell Type-Specific Assessment of Target Regulation by Pulmonary siRNA Delivery.

Merkel OM, Marsh LM, Garn H, Kissel T.

Methods Mol Biol. 2019;1943:365-375. doi: 10.1007/978-1-4939-9092-4_24.

PMID:
30838629
13.

Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining.

Kandil R, Feldmann D, Xie Y, Merkel OM.

Methods Mol Biol. 2019;1943:323-331. doi: 10.1007/978-1-4939-9092-4_21.

14.

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review.

Babačić H, Mehta A, Merkel O, Schoser B.

PLoS One. 2019 Feb 22;14(2):e0212198. doi: 10.1371/journal.pone.0212198. eCollection 2019.

15.

Lipids and polymers in pharmaceutical technology: Lifelong companions.

Siepmann J, Faham A, Clas SD, Boyd BJ, Jannin V, Bernkop-Schnürch A, Zhao H, Lecommandoux S, Evans JC, Allen C, Merkel OM, Costabile G, Alexander MR, Wildman RD, Roberts CJ, Leroux JC.

Int J Pharm. 2019 Mar 10;558:128-142. doi: 10.1016/j.ijpharm.2018.12.080. Epub 2019 Jan 9. Review.

16.

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity.

Andima M, Costabile G, Isert L, Ndakala AJ, Derese S, Merkel OM.

Pharmaceutics. 2018 Nov 15;10(4). pii: E232. doi: 10.3390/pharmaceutics10040232.

17.

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression.

Kaltenecker D, Themanns M, Mueller KM, Spirk K, Suske T, Merkel O, Kenner L, Luís A, Kozlov A, Haybaeck J, Müller M, Han X, Moriggl R.

Cytokine. 2018 Oct 30. pii: S1043-4666(18)30398-3. doi: 10.1016/j.cyto.2018.10.010. [Epub ahead of print]

18.

Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles.

Costabile G, Gasteyer KI, Nadithe V, Van Denburgh K, Lin Q, Sharma S, Reineke JJ, Firestine SM, Merkel OM.

AAPS PharmSciTech. 2018 Nov;19(8):3561-3570. doi: 10.1208/s12249-018-1187-9. Epub 2018 Sep 25.

PMID:
30255472
19.

miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels.

Musilova K, Devan J, Cerna K, Seda V, Pavlasova G, Sharma S, Oppelt J, Pytlik R, Prochazka V, Prouzova Z, Trbusek M, Zlamalikova L, Liskova K, Kruzova L, Jarosova M, Mareckova A, Kornauth C, Simonitsch-Klupp I, Schiefer AI, Merkel O, Mocikova H, Burda P, Machova Polakova K, Kren L, Mayer J, Zent CS, Trneny M, Evans AG, Janikova A, Mraz M.

Blood. 2018 Nov 29;132(22):2389-2400. doi: 10.1182/blood-2018-06-855502. Epub 2018 Sep 13.

PMID:
30213873
20.

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.

Prutsch N, Gurnhofer E, Suske T, Liang HC, Schlederer M, Roos S, Wu LC, Simonitsch-Klupp I, Alvarez-Hernandez A, Kornauth C, Leone DA, Svinka J, Eferl R, Limberger T, Aufinger A, Shirsath N, Wolf P, Hielscher T, Aberger F, Schmoellerl J, Stoiber D, Strobl B, Jäger U, Staber PB, Grebien F, Moriggl R, Müller M, Inghirami GG, Sanda T, Look AT, Turner SD, Kenner L, Merkel O.

Leukemia. 2019 Mar;33(3):696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21.

PMID:
30131584
21.

Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model.

Jones SK, Douglas K, Shields AF, Merkel OM.

Biomaterials. 2018 Sep;178:183-192. doi: 10.1016/j.biomaterials.2018.06.014. Epub 2018 Jun 13.

22.

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy.

Dalle Vedove E, Costabile G, Merkel OM.

Adv Healthc Mater. 2018 Jul;7(14):e1701398. doi: 10.1002/adhm.201701398. Epub 2018 May 2. Review.

23.

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.

Garces de Los Fayos Alonso I, Liang HC, Turner SD, Lagger S, Merkel O, Kenner L.

Cancers (Basel). 2018 Mar 28;10(4). pii: E93. doi: 10.3390/cancers10040093. Review.

24.

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.

Schleussner N, Merkel O, Costanza M, Liang HC, Hummel F, Romagnani C, Durek P, Anagnostopoulos I, Hummel M, Jöhrens K, Niedobitek A, Griffin PR, Piva R, Sczakiel HL, Woessmann W, Damm-Welk C, Hinze C, Stoiber D, Gillissen B, Turner SD, Kaergel E, von Hoff L, Grau M, Lenz G, Dörken B, Scheidereit C, Kenner L, Janz M, Mathas S.

Leukemia. 2018 Sep;32(9):1994-2007. doi: 10.1038/s41375-018-0045-9. Epub 2018 Mar 28.

25.

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.

Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH, Merkel OM.

J Control Release. 2018 Apr 28;276:50-58. doi: 10.1016/j.jconrel.2018.02.017. Epub 2018 Feb 20.

26.

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia.

Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmüller J, Nürnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schäfer SC, Büttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M.

Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7.

27.

Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.

Gemechu JM, Sharma A, Yu D, Xie Y, Merkel OM, Moszczynska A.

Sci Rep. 2018 Jan 24;8(1):1517. doi: 10.1038/s41598-017-18526-0.

28.

THE EFFECTS OF MIGRATORY FLIGHT ON HEMATOLOGIC PARAMETERS IN NORTHERN BALD IBISES ( GERONTICUS EREMITA).

Stanclova G, Schwendenwein I, Merkel O, Kenner L, Dittami J, Fritz J, Scope A.

J Zoo Wildl Med. 2017 Dec;48(4):1154-1164. doi: 10.1638/2016-0258.1.

PMID:
29297805
29.

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study.

Snijder B, Vladimer GI, Krall N, Miura K, Schmolke AS, Kornauth C, Lopez de la Fuente O, Choi HS, van der Kouwe E, Gültekin S, Kazianka L, Bigenzahn JW, Hoermann G, Prutsch N, Merkel O, Ringler A, Sabler M, Jeryczynski G, Mayerhoefer ME, Simonitsch-Klupp I, Ocko K, Felberbauer F, Müllauer L, Prager GW, Korkmaz B, Kenner L, Sperr WR, Kralovics R, Gisslinger H, Valent P, Kubicek S, Jäger U, Staber PB, Superti-Furga G.

Lancet Haematol. 2017 Dec;4(12):e595-e606. doi: 10.1016/S2352-3026(17)30208-9. Epub 2017 Nov 15.

30.

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.

Boidol B, Kornauth C, van der Kouwe E, Prutsch N, Kazianka L, Gültekin S, Hoermann G, Mayerhoefer ME, Hopfinger G, Hauswirth A, Panny M, Aretin MB, Hilgarth B, Sperr WR, Valent P, Simonitsch-Klupp I, Moriggl R, Merkel O, Kenner L, Jäger U, Kubicek S, Staber PB.

Blood. 2017 Dec 7;130(23):2499-2503. doi: 10.1182/blood-2017-05-785683. Epub 2017 Sep 27.

31.

When the guardian sleeps: Reactivation of the p53 pathway in cancer.

Merkel O, Taylor N, Prutsch N, Staber PB, Moriggl R, Turner SD, Kenner L.

Mutat Res. 2017 Jul;773:1-13. doi: 10.1016/j.mrrev.2017.02.003. Epub 2017 Feb 17. Review.

PMID:
28927521
32.

Revisiting the value of competition assays in folate receptor-mediated drug delivery.

Jones SK, Sarkar A, Feldmann DP, Hoffmann P, Merkel OM.

Biomaterials. 2017 Sep;138:35-45. doi: 10.1016/j.biomaterials.2017.05.034. Epub 2017 May 22.

33.

The impact of microfluidic mixing of triblock micelleplexes on in vitro / in vivo gene silencing and intracellular trafficking.

Feldmann DP, Xie Y, Jones SK, Yu D, Moszczynska A, Merkel OM.

Nanotechnology. 2017 Jun 2;28(22):224001. doi: 10.1088/1361-6528/aa6d15. Epub 2017 May 10.

34.

Tackling breast cancer chemoresistance with nano-formulated siRNA.

Jones SK, Merkel OM.

Gene Ther. 2016 Dec;23(12):821-828. doi: 10.1038/gt.2016.67. Epub 2016 Sep 20. Review.

35.

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine.

Xie Y, Killinger B, Moszczynska A, Merkel OM.

Molecules. 2016 Oct 10;21(10). pii: E1334.

36.

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.

Hassler MR, Pulverer W, Lakshminarasimhan R, Redl E, Hacker J, Garland GD, Merkel O, Schiefer AI, Simonitsch-Klupp I, Kenner L, Weisenberger DJ, Weinhaeusel A, Turner SD, Egger G.

Cell Rep. 2016 Oct 4;17(2):596-608. doi: 10.1016/j.celrep.2016.09.018.

37.

Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages.

Mohammadi M, Li Y, Abebe DG, Xie Y, Kandil R, Kraus T, Gomez-Lopez N, Fujiwara T, Merkel OM.

J Control Release. 2016 Dec 28;244(Pt B):269-279. doi: 10.1016/j.jconrel.2016.08.020. Epub 2016 Aug 24.

PMID:
27565213
38.

Biodegradable Three-Layered Micelles and Injectable Hydrogels.

Abebe DG, Kandil R, Kraus T, Elsayed M, Fujiwara T, Merkel OM.

Methods Mol Biol. 2016;1445:175-85. doi: 10.1007/978-1-4939-3718-9_11.

PMID:
27436319
39.

JAK-STAT signaling in cancer: From cytokines to non-coding genome.

Pencik J, Pham HT, Schmoellerl J, Javaheri T, Schlederer M, Culig Z, Merkel O, Moriggl R, Grebien F, Kenner L.

Cytokine. 2016 Nov;87:26-36. doi: 10.1016/j.cyto.2016.06.017. Epub 2016 Jun 24. Review.

40.

Breaking a paradigm: IL-6/STAT3 signaling suppresses metastatic prostate cancer upon ARF expression.

Culig Z, Pencik J, Merkel O, Kenner L.

Mol Cell Oncol. 2016 Apr 4;3(2):e1090048. doi: 10.1080/23723556.2015.1090048. eCollection 2016 Mar.

41.

Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles.

Movassaghian S, Xie Y, Hildebrandt C, Rosati R, Li Y, Kim NH, Conti DS, da Rocha SR, Yang ZQ, Merkel OM.

Mol Pharm. 2016 Aug 1;13(8):2605-21. doi: 10.1021/acs.molpharmaceut.5b00948. Epub 2016 Jun 27.

42.

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.

Zhong Q, Merkel OM, Reineke JJ, da Rocha SR.

Mol Pharm. 2016 Jun 6;13(6):1866-78. doi: 10.1021/acs.molpharmaceut.6b00036. Epub 2016 May 13.

43.

The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.

Beckmann AM, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M, Stirnberg M.

Biol Chem. 2016 Aug 1;397(8):777-90. doi: 10.1515/hsz-2015-0263.

PMID:
27078672
44.

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

Xie Y, Kim NH, Nadithe V, Schalk D, Thakur A, Kılıç A, Lum LG, Bassett DJP, Merkel OM.

J Control Release. 2016 May 10;229:120-129. doi: 10.1016/j.jconrel.2016.03.029. Epub 2016 Mar 19.

45.

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.

Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD.

Nat Commun. 2016 Jan 12;7:10087. doi: 10.1038/ncomms10087.

46.

Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.

Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.

Exp Dermatol. 2016 Apr;25(4):305-10. doi: 10.1111/exd.12934. Epub 2016 Feb 13. Erratum in: Exp Dermatol. 2017 May;26(5):467.

47.

Stem cell hunt in NHL.

Merkel O, Kenner L, Turner SD.

Oncoscience. 2015 Sep 3;2(10):809-10. eCollection 2015. No abstract available.

48.

Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol).

Liu L, Zheng M, Librizzi D, Renette T, Merkel OM, Kissel T.

Mol Pharm. 2016 Jan 4;13(1):134-43. doi: 10.1021/acs.molpharmaceut.5b00575. Epub 2015 Dec 16.

PMID:
26641134
49.

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.

Jones SK, Lizzio V, Merkel OM.

Biomacromolecules. 2016 Jan 11;17(1):76-87. doi: 10.1021/acs.biomac.5b01189. Epub 2015 Dec 16.

50.

Indium-Labeling of siRNA for Small Animal SPECT Imaging.

Jones S, Merkel O.

Methods Mol Biol. 2016;1372:79-88. doi: 10.1007/978-1-4939-3148-4_6.

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