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Items: 1 to 50 of 145

1.

Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-β.

Wu Z, Zhang W, Wu Y, Wang T, Wu S, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Merits A, Chen S, Cheng A.

J Immunol. 2019 Nov 8. pii: ji1900956. doi: 10.4049/jimmunol.1900956. [Epub ahead of print]

PMID:
31704883
2.

Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis.

Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, Zusinaite E, Dumpis U, Vitkauskiene A, Cox RJ, Kallio-Kokko H, Bergqvist A, Tenson T, Merits A, Oksenych V, Bjørås M, Anthonsen MW, Shum D, Kaarbø M, Vapalahti O, Windisch MP, Superti-Furga G, Snijder B, Kainov D, Kandasamy RK.

Front Immunol. 2019 Oct 4;10:2186. doi: 10.3389/fimmu.2019.02186. eCollection 2019.

3.

VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses.

Carissimo G, Chan YH, Utt A, Chua TK, Bakar FA, Merits A, Ng LFP.

Front Microbiol. 2019 Sep 24;10:2236. doi: 10.3389/fmicb.2019.02236. eCollection 2019.

4.

Chikungunya virus requires cellular chloride channels for efficient genome replication.

Müller M, Slivinski N, Todd EJAA, Khalid H, Li R, Karwatka M, Merits A, Mankouri J, Tuplin A.

PLoS Negl Trop Dis. 2019 Sep 4;13(9):e0007703. doi: 10.1371/journal.pntd.0007703. eCollection 2019 Sep.

5.

Structural and phenotypic analysis of Chikungunya virus RNA replication elements.

Kendall C, Khalid H, Müller M, Banda DH, Kohl A, Merits A, Stonehouse NJ, Tuplin A.

Nucleic Acids Res. 2019 Sep 26;47(17):9296-9312. doi: 10.1093/nar/gkz640.

6.

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription.

Utt A, Rausalu K, Jakobson M, Männik A, Alphey L, Fragkoudis R, Merits A.

J Virol. 2019 Aug 28;93(18). pii: e00794-19. doi: 10.1128/JVI.00794-19. Print 2019 Sep 15.

PMID:
31217251
7.

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

Chan YH, Teo TH, Utt A, Tan JJ, Amrun SN, Abu Bakar F, Yee WX, Becht E, Lee CY, Lee B, Rajarethinam R, Newell E, Merits A, Carissimo G, Lum FM, Ng LF.

EMBO Mol Med. 2019 Jun;11(6). pii: e10092. doi: 10.15252/emmm.201810092.

8.

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase.

Law YS, Utt A, Tan YB, Zheng J, Wang S, Chen MW, Griffin PR, Merits A, Luo D.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9558-9567. doi: 10.1073/pnas.1900656116. Epub 2019 Apr 18.

9.

Expanding the activity spectrum of antiviral agents.

Ianevski A, Andersen PI, Merits A, Bjørås M, Kainov D.

Drug Discov Today. 2019 May;24(5):1224-1228. doi: 10.1016/j.drudis.2019.04.006. Epub 2019 Apr 10. Review.

PMID:
30980905
10.

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.

Wichit S, Hamel R, Zanzoni A, Diop F, Cribier A, Talignani L, Diack A, Ferraris P, Liegeois F, Urbach S, Ekchariyawat P, Merits A, Yssel H, Benkirane M, Missé D.

Int J Mol Sci. 2019 Apr 5;20(7). pii: E1695. doi: 10.3390/ijms20071695.

11.

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018.

Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE.

Viruses. 2019 Mar 1;11(3). pii: E207. doi: 10.3390/v11030207.

12.

The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.

Matkovic R, Bernard E, Fontanel S, Eldin P, Chazal N, Hassan Hersi D, Merits A, Péloponèse JM Jr, Briant L.

J Virol. 2019 Feb 5;93(4). pii: e01764-18. doi: 10.1128/JVI.01764-18. Print 2019 Feb 15.

13.

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication.

Abraham R, Hauer D, McPherson RL, Utt A, Kirby IT, Cohen MS, Merits A, Leung AKL, Griffin DE.

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10457-E10466. doi: 10.1073/pnas.1812130115. Epub 2018 Oct 15.

14.

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs.

Liu X, Mutso M, Utt A, Lepland A, Herrero LJ, Taylor A, Bettadapura J, Rudd PA, Merits A, Mahalingam S.

MBio. 2018 Aug 21;9(4). pii: e00044-18. doi: 10.1128/mBio.00044-18.

15.

DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost.

Öhlund P, García-Arriaza J, Zusinaite E, Szurgot I, Männik A, Kraus A, Ustav M, Merits A, Esteban M, Liljeström P, Ljungberg K.

Sci Rep. 2018 Aug 20;8(1):12459. doi: 10.1038/s41598-018-31003-6.

16.

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents.

Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE.

Viruses. 2018 Aug 12;10(8). pii: E423. doi: 10.3390/v10080423. Review.

17.

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3.

Remenyi R, Gao Y, Hughes RE, Curd A, Zothner C, Peckham M, Merits A, Harris M.

J Virol. 2018 Jul 31;92(16). pii: e00477-18. doi: 10.1128/JVI.00477-18. Print 2018 Aug 15.

18.

ICTV Virus Taxonomy Profile: Togaviridae.

Chen R, Mukhopadhyay S, Merits A, Bolling B, Nasar F, Coffey LL, Powers A, Weaver SC, Ictv Report Consortium.

J Gen Virol. 2018 Jun;99(6):761-762. doi: 10.1099/jgv.0.001072. Epub 2018 May 10.

PMID:
29745869
19.

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.

Mutso M, Morro AM, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, Tarve L, Lulla A, Lulla V, Saul S, Thaa B, McInerney GM, Merits A, Varjak M.

Viruses. 2018 Apr 27;10(5). pii: E226. doi: 10.3390/v10050226.

20.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
21.

A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells.

Bartholomeeusen K, Utt A, Coppens S, Rausalu K, Vereecken K, Ariën KK, Merits A.

J Virol. 2018 Jun 29;92(14). pii: e00152-18. doi: 10.1128/JVI.00152-18. Print 2018 Jul 15.

22.

Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase.

Lulla V, Karo-Astover L, Rausalu K, Saul S, Merits A, Lulla A.

J Virol. 2018 Jun 29;92(14). pii: e00151-18. doi: 10.1128/JVI.00151-18. Print 2018 Jul 15.

23.

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells.

Varjak M, Dietrich I, Sreenu VB, Till BE, Merits A, Kohl A, Schnettler E.

Viruses. 2018 Feb 18;10(2). pii: E88. doi: 10.3390/v10020088.

24.

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection.

Oo A, Rausalu K, Merits A, Higgs S, Vanlandingham D, Bakar SA, Zandi K.

Antiviral Res. 2018 Feb;150:101-111. doi: 10.1016/j.antiviral.2017.12.012. Epub 2017 Dec 19.

PMID:
29269135
25.

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research.

Roberts GC, Zothner C, Remenyi R, Merits A, Stonehouse NJ, Harris M.

Sci Rep. 2017 Nov 7;7(1):14641. doi: 10.1038/s41598-017-15269-w.

26.

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses.

Royle J, Donald CL, Merits A, Kohl A, Varjak M.

Vet J. 2017 Dec;230:62-64. doi: 10.1016/j.tvjl.2017.10.009. Epub 2017 Oct 19.

27.

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.

Varjak M, Donald CL, Mottram TJ, Sreenu VB, Merits A, Maringer K, Schnettler E, Kohl A.

PLoS Negl Trop Dis. 2017 Oct 17;11(10):e0006010. doi: 10.1371/journal.pntd.0006010. eCollection 2017 Oct.

28.

Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on a Brazilian Zika virus isolate.

Mutso M, Saul S, Rausalu K, Susova O, Žusinaite E, Mahalingam S, Merits A.

J Gen Virol. 2017 Nov;98(11):2712-2724. doi: 10.1099/jgv.0.000938. Epub 2017 Oct 12.

PMID:
29022864
29.

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy.

Remenyi R, Roberts GC, Zothner C, Merits A, Harris M.

Sci Rep. 2017 Jul 18;7(1):5682. doi: 10.1038/s41598-017-05820-0.

30.

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template.

Hellström K, Kallio K, Utt A, Quirin T, Jokitalo E, Merits A, Ahola T.

J Virol. 2017 Aug 24;91(18). pii: e00787-17. doi: 10.1128/JVI.00787-17. Print 2017 Sep 15.

31.

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking.

Wichit S, Hamel R, Bernard E, Talignani L, Diop F, Ferraris P, Liegeois F, Ekchariyawat P, Luplertlop N, Surasombatpattana P, Thomas F, Merits A, Choumet V, Roques P, Yssel H, Briant L, Missé D.

Sci Rep. 2017 Jun 9;7(1):3145. doi: 10.1038/s41598-017-03316-5.

32.

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach.

Lum FM, Lin C, Susova OY, Teo TH, Fong SW, Mak TM, Lee LK, Chong CY, Lye DCB, Lin RTP, Merits A, Leo YS, Ng LFP.

J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276.

33.

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Roques P, Ljungberg K, Kümmerer BM, Gosse L, Dereuddre-Bosquet N, Tchitchek N, Hallengärd D, García-Arriaza J, Meinke A, Esteban M, Merits A, Le Grand R, Liljeström P.

JCI Insight. 2017 Mar 23;2(6):e83527. doi: 10.1172/jci.insight.83527.

34.

Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design.

Taylor A, Liu X, Zaid A, Goh LY, Hobson-Peters J, Hall RA, Merits A, Mahalingam S.

MBio. 2017 Feb 21;8(1). pii: e01970-16. doi: 10.1128/mBio.01970-16.

35.

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S.

Lancet Infect Dis. 2017 Apr;17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1. Review.

PMID:
28159534
36.

Fingolimod treatment abrogates chikungunya virus-induced arthralgia.

Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal1333. doi: 10.1126/scitranslmed.aal1333.

PMID:
28148838
37.

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

Ehteshami M, Tao S, Zandi K, Hsiao HM, Jiang Y, Hammond E, Amblard F, Russell OO, Merits A, Schinazi RF.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02395-16. doi: 10.1128/AAC.02395-16. Print 2017 Apr.

38.

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments.

Varghese FS, Rausalu K, Hakanen M, Saul S, Kümmerer BM, Susi P, Merits A, Ahola T.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02227-16. doi: 10.1128/AAC.02227-16. Print 2017 Mar.

39.

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

Rausalu K, Utt A, Quirin T, Varghese FS, Žusinaite E, Das PK, Ahola T, Merits A.

Sci Rep. 2016 Nov 15;6:37124. doi: 10.1038/srep37124.

40.

Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products.

Allas UL, Toom L, Selyutina A, Mäeorg U, Medina R, Merits A, Rinken A, Hauryliuk V, Kaldalu N, Tenson T.

Sci Rep. 2016 Nov 10;6:36844. doi: 10.1038/srep36844.

41.

Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

Maillard PV, Van der Veen AG, Deddouche-Grass S, Rogers NC, Merits A, Reis e Sousa C.

EMBO J. 2016 Dec 1;35(23):2505-2518. Epub 2016 Nov 4.

42.

Design and Validation of Novel Chikungunya Virus Protease Inhibitors.

Das PK, Puusepp L, Varghese FS, Utt A, Ahola T, Kananovich DG, Lopp M, Merits A, Karelson M.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7382-7395. Print 2016 Dec.

43.

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus.

Ramachandran M, Yu D, Dyczynski M, Baskaran S, Zhang L, Lulla A, Lulla V, Saul S, Nelander S, Dimberg A, Merits A, Leja-Jarblad J, Essand M.

Clin Cancer Res. 2017 Mar 15;23(6):1519-1530. doi: 10.1158/1078-0432.CCR-16-0925. Epub 2016 Sep 16.

44.

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera.

Chua CL, Sam IC, Merits A, Chan YF.

PLoS Negl Trop Dis. 2016 Aug 29;10(8):e0004960. doi: 10.1371/journal.pntd.0004960. eCollection 2016 Aug.

45.

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling.

Varghese FS, Thaa B, Amrun SN, Simarmata D, Rausalu K, Nyman TA, Merits A, McInerney GM, Ng LFP, Ahola T.

J Virol. 2016 Oct 14;90(21):9743-9757. doi: 10.1128/JVI.01382-16. Print 2016 Nov 1.

46.

Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.

Utt A, Das PK, Varjak M, Lulla V, Lulla A, Merits A.

J Virol. 2016 Aug 12;90(17):8030. doi: 10.1128/JVI.01167-16. Print 2016 Sep 1. No abstract available.

47.

Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection.

Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS.

Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002.

48.

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs.

Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF, Lecuit M.

Nat Commun. 2016 May 12;7:11320. doi: 10.1038/ncomms11320.

49.

Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Viira B, Selyutina A, García-Sosa AT, Karonen M, Sinkkonen J, Merits A, Maran U.

Bioorg Med Chem. 2016 Jun 1;24(11):2519-29. doi: 10.1016/j.bmc.2016.04.018. Epub 2016 Apr 8.

PMID:
27108399
50.

Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways.

Rainey SM, Martinez J, McFarlane M, Juneja P, Sarkies P, Lulla A, Schnettler E, Varjak M, Merits A, Miska EA, Jiggins FM, Kohl A.

PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536. eCollection 2016 Apr. Erratum in: PLoS Pathog. 2016 May;12(5):e1005639.

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