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Items: 1 to 50 of 86

1.

Double Monoubiquitination Modifies the Molecular Recognition Properties of p15PAF Promoting Binding to the Reader Module of Dnmt1.

González-Magaña A, de Opakua AI, Merino N, Monteiro H, Diercks T, Murciano-Calles J, Luque I, Bernadó P, Cordeiro TN, Biasio A, Blanco FJ.

ACS Chem Biol. 2019 Sep 18. doi: 10.1021/acschembio.9b00679. [Epub ahead of print]

PMID:
31479228
2.

Corrigendum: Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context.

Merino N, Aronson HS, Bojanova DP, Feyhl-Buska J, Wong ML, Zhang S, Giovannelli D.

Front Microbiol. 2019 Aug 13;10:1785. doi: 10.3389/fmicb.2019.01785. eCollection 2019.

3.

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.

Mikkelsen K, Harwood SL, Compte M, Merino N, Mølgaard K, Lykkemark S, Alvarez-Mendez A, Blanco FJ, Álvarez-Vallina L.

Front Immunol. 2019 Jul 31;10:1791. doi: 10.3389/fimmu.2019.01791. eCollection 2019.

4.

Hidden Concepts in the History and Philosophy of Origins-of-Life Studies: a Workshop Report.

Mariscal C, Barahona A, Aubert-Kato N, Aydinoglu AU, Bartlett S, Cárdenas ML, Chandru K, Cleland C, Cocanougher BT, Comfort N, Cornish-Bowden A, Deacon T, Froese T, Giovannelli D, Hernlund J, Hut P, Kimura J, Maurel MC, Merino N, Moreno A, Nakagawa M, Peretó J, Virgo N, Witkowski O, James Cleaves H 2nd.

Orig Life Evol Biosph. 2019 Aug 9. doi: 10.1007/s11084-019-09580-x. [Epub ahead of print] Review.

PMID:
31399826
5.

Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context.

Merino N, Aronson HS, Bojanova DP, Feyhl-Buska J, Wong ML, Zhang S, Giovannelli D.

Front Microbiol. 2019 Apr 15;10:780. doi: 10.3389/fmicb.2019.00780. eCollection 2019. Review. Erratum in: Front Microbiol. 2019 Aug 13;10:1785.

6.

The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.

Ormaza G, Rodríguez JA, Ibáñez de Opakua A, Merino N, Villate M, Gorroño I, Rábano M, Palmero I, Vilaseca M, Kypta R, Vivanco MDM, Rojas AL, Blanco FJ.

J Mol Biol. 2019 May 31;431(12):2298-2319. doi: 10.1016/j.jmb.2019.04.018. Epub 2019 Apr 24.

7.

Electrically Addressing the Spin of a Magnetic Porphyrin through Covalently Connected Graphene Electrodes.

Li J, Friedrich N, Merino N, de Oteyza DG, Peña D, Jacob D, Pascual JI.

Nano Lett. 2019 May 8;19(5):3288-3294. doi: 10.1021/acs.nanolett.9b00883. Epub 2019 Apr 11.

PMID:
30964303
8.

Xanthium strumarium´s xanthatins induces mitotic arrest and apoptosis in CT26WT colon carcinoma cells.

Piloto-Ferrer J, Sánchez-Lamar Á, Francisco M, González ML, Merino N, Aparicio G, Pérez C, Rodeiro I, Lopes MTP.

Phytomedicine. 2019 Apr;57:236-244. doi: 10.1016/j.phymed.2018.12.019. Epub 2018 Dec 17.

PMID:
30797985
9.

Comparative genomics of Bacteria commonly identified in the built environment.

Merino N, Zhang S, Tomita M, Suzuki H.

BMC Genomics. 2019 Jan 28;20(1):92. doi: 10.1186/s12864-018-5389-z.

10.

The p12 subunit of human polymerase δ uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA).

Gonzalez-Magaña A, Ibáñez de Opakua A, Romano-Moreno M, Murciano-Calles J, Merino N, Luque I, Rojas AL, Onesti S, Blanco FJ, De Biasio A.

J Biol Chem. 2019 Mar 15;294(11):3947-3956. doi: 10.1074/jbc.RA118.006391. Epub 2019 Jan 17.

PMID:
30655288
11.

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.

Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L.

Nat Commun. 2018 Nov 15;9(1):4809. doi: 10.1038/s41467-018-07195-w.

12.

Hindered and constrained: limited potential for thermal adaptation in post-metamorphic and adult Rana temporaria along elevational gradients.

Enriquez-Urzelai U, Palacio AS, Merino NM, Sacco M, Nicieza AG.

J Evol Biol. 2018 Dec;31(12):1852-1862. doi: 10.1111/jeb.13380. Epub 2018 Oct 19.

PMID:
30256481
13.

p15PAF binding to PCNA modulates the DNA sliding surface.

De March M, Barrera-Vilarmau S, Crespan E, Mentegari E, Merino N, Gonzalez-Magaña A, Romano-Moreno M, Maga G, Crehuet R, Onesti S, Blanco FJ, De Biasio A.

Nucleic Acids Res. 2018 Oct 12;46(18):9816-9828. doi: 10.1093/nar/gky723.

14.

Interkingdom microbial consortia mechanisms to guide biotechnological applications.

Zhang S, Merino N, Okamoto A, Gedalanga P.

Microb Biotechnol. 2018 Sep;11(5):833-847. doi: 10.1111/1751-7915.13300. Epub 2018 Jul 16. Review.

15.

Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.

Prieto J, Redondo P, López-Méndez B, D'Abramo M, Merino N, Blanco FJ, Duchateau P, Montoya G, Molina R.

Sci Rep. 2018 Jul 6;8(1):10286. doi: 10.1038/s41598-018-28599-0.

16.

Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.

Mølgaard K, Harwood SL, Compte M, Merino N, Bonet J, Alvarez-Cienfuegos A, Mikkelsen K, Nuñez-Prado N, Alvarez-Mendez A, Sanz L, Blanco FJ, Alvarez-Vallina L.

Cancer Immunol Immunother. 2018 Aug;67(8):1251-1260. doi: 10.1007/s00262-018-2181-5. Epub 2018 Jun 4.

PMID:
29869168
17.

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.

Harwood SL, Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Hernández-Pérez S, Merino N, Bonet J, Navarro R, Van Bergen En Henegouwen PMP, Lykkemark S, Mikkelsen K, Mølgaard K, Jabs F, Sanz L, Blanco FJ, Roda-Navarro P, Alvarez-Vallina L.

Oncoimmunology. 2017 Sep 27;7(1):e1377874. doi: 10.1080/2162402X.2017.1377874. eCollection 2017.

18.

The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant.

Tomás-Cortázar J, Martín-Ruiz I, Barriales D, Pascual-Itoiz MÁ, de Juan VG, Caro-Maldonado A, Merino N, Marina A, Blanco FJ, Flores JM, Sutherland JD, Barrio R, Rojas A, Martínez-Chantar ML, Carracedo A, Simó C, García-Cañas V, Abecia L, Lavín JL, Aransay AM, Rodríguez H, Anguita J.

Sci Rep. 2017 Sep 6;7(1):10740. doi: 10.1038/s41598-017-11354-2.

19.

The Gαi-GIV binding interface is a druggable protein-protein interaction.

DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M.

Sci Rep. 2017 Aug 17;7(1):8575. doi: 10.1038/s41598-017-08829-7.

20.

Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems.

Regalado AI, Mancebo B, Paixão A, López Y, Merino N, Sánchez LM.

Med Princ Pract. 2017;26(4):368-374. doi: 10.1159/000478015. Epub 2017 Jun 7.

21.

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.

22.

LALF32-51-E7 therapeutic vaccine induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the lungs.

Granadillo M, Batte A, Blanco A, Alfonso AB, Suárez J, Merino N, Carballo R, González BO, Prieto YC, Varas L, Soler D, Limonta M, Miyares M, Aldana L, Torrens I.

Clin Exp Metastasis. 2017 Apr;34(3-4):241-249. doi: 10.1007/s10585-017-9846-x. Epub 2017 Apr 17.

PMID:
28417212
23.

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil.

Ibáñez de Opakua A, Merino N, Villate M, Cordeiro TN, Ormaza G, Sánchez-Carbayo M, Diercks T, Bernadó P, Blanco FJ.

PLoS One. 2017 Feb 16;12(2):e0172507. doi: 10.1371/journal.pone.0172507. eCollection 2017.

24.

Structural basis of human PCNA sliding on DNA.

De March M, Merino N, Barrera-Vilarmau S, Crehuet R, Onesti S, Blanco FJ, De Biasio A.

Nat Commun. 2017 Jan 10;8:13935. doi: 10.1038/ncomms13935.

25.

The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region.

Ormaza G, Medagli B, Ibáñez de Opakua A, Rodríguez JA, Merino N, Villate M, Onesti S, Blanco FJ.

FEBS Lett. 2017 Jan;591(2):425-432. doi: 10.1002/1873-3468.12514. Epub 2016 Dec 22.

26.

Impact of 6:2 fluorotelomer alcohol aerobic biotransformation on a sediment microbial community.

Zhang S, Merino N, Wang N, Ruan T, Lu X.

Sci Total Environ. 2017 Jan 1;575:1361-1368. doi: 10.1016/j.scitotenv.2016.09.214. Epub 2016 Oct 15.

PMID:
27756549
27.

[Detection of Oropouche viral circulation in Madre de Dios region, Peru (december 2015 to january 2016)].

García MP, Merino NS, Figueroa D, Marcelo A, Tineo V E, Manrique C, Donaires F, Céspedes M, Cabrera R, Cabezas C.

Rev Peru Med Exp Salud Publica. 2016 Jun;33(2):380-1. Spanish. No abstract available.

28.

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.

Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Cuesta AM, Blanco-Toribio A, Harwood SL, Villate M, Merino N, Bonet J, Navarro R, Muñoz-Briones C, Sørensen KM, Mølgaard K, Oliva B, Sanz L, Blanco FJ, Alvarez-Vallina L.

Sci Rep. 2016 Jun 27;6:28643. doi: 10.1038/srep28643.

29.

Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions.

Prieto J, Redondo P, Merino N, Villate M, Montoya G, Blanco FJ, Molina R.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):473-9. doi: 10.1107/S2053230X16007512. Epub 2016 May 23.

30.

Dynamic of Immune Response induced in Hepatitis B Surface Antigen-transgenic Mice Immunized with a Novel Therapeutic Formulation.

Almeida FMF, Blanco A, Trujillo H, Hernández D, García D, Alba JS, Abad ML, Merino N, Lobaina Y, Aguilar Rubido JC.

Euroasian J Hepatogastroenterol. 2016 Jan-Jun;6(1):25-30. doi: 10.5005/jp-journals-10018-1161. Epub 2016 Jul 9.

31.

Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification.

Molina R, Redondo P, López-Méndez B, Villate M, Merino N, Blanco FJ, Valton J, Grizot S, Duchateau P, Prieto J, Montoya G.

J Biol Chem. 2015 Nov 27;290(48):28727-36. doi: 10.1074/jbc.M115.678342. Epub 2015 Sep 11.

32.

Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.

Blanco-Toribio A, Álvarez-Cienfuegos A, Sainz-Pastor N, Merino N, Compte M, Sanz L, Blanco FJ, Álvarez-Vallina L.

AMB Express. 2015 Dec;5(1):137. doi: 10.1186/s13568-015-0137-0. Epub 2015 Aug 4.

33.

Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair.

De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Cartón D, Luque I, Diercks T, Bernadó P, Montoya G, Blanco FJ.

Nat Commun. 2015 Mar 12;6:6439. doi: 10.1038/ncomms7439.

PMID:
25762514
34.

Safety evaluation of chitosan and chitosan acid salts from Panurilus argus lobster.

Lagarto A, Merino N, Valdes O, Dominguez J, Spencer E, de la Paz N, Aparicio G.

Int J Biol Macromol. 2015 Jan;72:1343-50. doi: 10.1016/j.ijbiomac.2014.10.030. Epub 2014 Oct 24.

PMID:
25450835
35.

XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation.

Mortuza GB, Cavazza T, Garcia-Mayoral MF, Hermida D, Peset I, Pedrero JG, Merino N, Blanco FJ, Lyngsø J, Bruix M, Pedersen JS, Vernos I, Montoya G.

Nat Commun. 2014 Sep 29;5:5072. doi: 10.1038/ncomms6072.

36.

Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats.

Garrido-Suárez BB, Garrido G, Castro-Labrada M, Merino N, Valdés O, Rodeiro I, Hernández I, Godoy-Figueiredo J, Ferreira SH, Delgado-Hernández R.

Pharmacol Biochem Behav. 2014 Sep;124:311-9. doi: 10.1016/j.pbb.2014.06.019. Epub 2014 Jun 27.

37.

A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.

Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL.

Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19.

PMID:
24953828
38.

Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA.

Redondo P, Merino N, Villate M, Blanco FJ, Montoya G, Molina R.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):256-9. doi: 10.1107/S2053230X1400065X. Epub 2014 Jan 22.

39.

p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins.

De Biasio A, Ibáñez de Opakua A, Cordeiro TN, Villate M, Merino N, Sibille N, Lelli M, Diercks T, Bernadó P, Blanco FJ.

Biophys J. 2014 Feb 18;106(4):865-74. doi: 10.1016/j.bpj.2013.12.046.

40.

Generation and characterization of monospecific and bispecific hexavalent trimerbodies.

Blanco-Toribio A, Sainz-Pastor N, Álvarez-Cienfuegos A, Merino N, Cuesta ÁM, Sánchez-Martín D, Bonet J, Santos-Valle P, Sanz L, Oliva B, Blanco FJ, Álvarez-Vallina L.

MAbs. 2013 Jan-Feb;5(1):70-9. doi: 10.4161/mabs.22698. Epub 2012 Dec 5.

41.

Proliferating cell nuclear antigen (PCNA) interactions in solution studied by NMR.

De Biasio A, Campos-Olivas R, Sánchez R, López-Alonso JP, Pantoja-Uceda D, Merino N, Villate M, Martin-Garcia JM, Castillo F, Luque I, Blanco FJ.

PLoS One. 2012;7(11):e48390. doi: 10.1371/journal.pone.0048390. Epub 2012 Nov 6. Erratum in: PLoS One. 2014;9(4):e95818.

42.

Production of meganucleases by cell-free protein synthesis for functional and structural studies.

Villate M, Merino N, Blanco FJ.

Protein Expr Purif. 2012 Oct;85(2):246-9. doi: 10.1016/j.pep.2012.07.013. Epub 2012 Aug 15.

PMID:
22917812
43.

Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma.

Rivera DG, Hernández I, Merino N, Luque Y, Álvarez A, Martín Y, Amador A, Nuevas L, Delgado R.

J Pharm Pharmacol. 2011 Oct;63(10):1336-45. doi: 10.1111/j.2042-7158.2011.01328.x.

PMID:
21899550
44.

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.

Muñoz IG, Prieto J, Subramanian S, Coloma J, Redondo P, Villate M, Merino N, Marenchino M, D'Abramo M, Gervasio FL, Grizot S, Daboussi F, Smith J, Chion-Sotinel I, Pâques F, Duchateau P, Alibés A, Stricher F, Serrano L, Blanco FJ, Montoya G.

Nucleic Acids Res. 2011 Jan;39(2):729-43. doi: 10.1093/nar/gkq801. Epub 2010 Sep 16.

45.

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease.

Grizot S, Smith J, Daboussi F, Prieto J, Redondo P, Merino N, Villate M, Thomas S, Lemaire L, Montoya G, Blanco FJ, Pâques F, Duchateau P.

Nucleic Acids Res. 2009 Sep;37(16):5405-19. doi: 10.1093/nar/gkp548. Epub 2009 Jul 7.

46.

Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections.

Vergara-Irigaray M, Valle J, Merino N, Latasa C, García B, Ruiz de Los Mozos I, Solano C, Toledo-Arana A, Penadés JR, Lasa I.

Infect Immun. 2009 Sep;77(9):3978-91. doi: 10.1128/IAI.00616-09. Epub 2009 Jul 6.

47.

In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang).

Garrido G, Rodeiro I, Hernández I, García G, Pérez G, Merino N, Núñez-Sellés A, Delgado R.

Drug Chem Toxicol. 2009;32(1):53-8. doi: 10.1080/01480540802432551.

PMID:
19514939
48.

Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.

Garrido-Suárez BB, Garrido G, Márquez L, Martínez I, Hernández I, Merino N, Luque Y, Delgado R, Bosch F.

Brain Res Bull. 2009 Aug 14;79(6):339-44. doi: 10.1016/j.brainresbull.2009.04.014. Epub 2009 May 3.

PMID:
19410637
49.

Ozone oxidative post-conditioning in acute renal failure.

Calunga JL, Trujillo Y, Menéndez S, Zamora Z, Alonso Y, Merino N, Montero T.

J Pharm Pharmacol. 2009 Feb;61(2):221-7. doi: 10.1211/jpp/61.02.0012.

PMID:
19178770
50.

Protein A-mediated multicellular behavior in Staphylococcus aureus.

Merino N, Toledo-Arana A, Vergara-Irigaray M, Valle J, Solano C, Calvo E, Lopez JA, Foster TJ, Penadés JR, Lasa I.

J Bacteriol. 2009 Feb;191(3):832-43. doi: 10.1128/JB.01222-08. Epub 2008 Dec 1.

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