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Items: 1 to 50 of 98

1.

Signaling pathways involved in anti-inflammatory effects of Pulsed Electromagnetic Field in microglial cells.

Merighi S, Gessi S, Bencivenni S, Battistello E, Vincenzi F, Setti S, Cadossi M, Borea PA, Cadossi R, Varani K.

Cytokine. 2019 Aug 7;125:154777. doi: 10.1016/j.cyto.2019.154777. [Epub ahead of print]

PMID:
31400640
2.

Targeting A3 and A2A adenosine receptors in the fight against cancer.

Merighi S, Battistello E, Giacomelli L, Varani K, Vincenzi F, Borea PA, Gessi S.

Expert Opin Ther Targets. 2019 Aug;23(8):669-678. doi: 10.1080/14728222.2019.1630380. Epub 2019 Jun 12.

PMID:
31189400
3.

Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.

Gessi S, Merighi S, Bencivenni S, Battistello E, Vincenzi F, Setti S, Cadossi M, Borea PA, Cadossi R, Varani K.

J Cell Physiol. 2019 Jan 17. doi: 10.1002/jcp.28149. [Epub ahead of print]

PMID:
30656694
4.

Pharmacology of Adenosine Receptors: The State of the Art.

Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K.

Physiol Rev. 2018 Jul 1;98(3):1591-1625. doi: 10.1152/physrev.00049.2017. Review.

5.

Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type 2 Ligands.

Ragusa G, Bencivenni S, Morales P, Callaway T, Hurst DP, Asproni B, Merighi S, Loriga G, Pinna GA, Reggio PH, Gessi S, Murineddu G.

ChemMedChem. 2018 Jun 6;13(11):1102-1114. doi: 10.1002/cmdc.201800152. Epub 2018 Apr 16.

PMID:
29575721
6.

The Role of Adenosine Receptors in Psychostimulant Addiction.

Ballesteros-Yáñez I, Castillo CA, Merighi S, Gessi S.

Front Pharmacol. 2018 Jan 10;8:985. doi: 10.3389/fphar.2017.00985. eCollection 2017. Review.

7.

Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455.

Gessi S, Bencivenni S, Battistello E, Vincenzi F, Colotta V, Catarzi D, Varano F, Merighi S, Borea PA, Varani K.

Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888. eCollection 2017.

8.

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.

Jacobson KA, Merighi S, Varani K, Borea PA, Baraldi S, Aghazadeh Tabrizi M, Romagnoli R, Baraldi PG, Ciancetta A, Tosh DK, Gao ZG, Gessi S.

Med Res Rev. 2018 Jul;38(4):1031-1072. doi: 10.1002/med.21456. Epub 2017 Jul 6. Review.

9.

Biochemical and Pharmacological Role of A1 Adenosine Receptors and Their Modulation as Novel Therapeutic Strategy.

Varani K, Vincenzi F, Merighi S, Gessi S, Borea PA.

Adv Exp Med Biol. 2017;1051:193-232. doi: 10.1007/5584_2017_61. Review.

PMID:
28676923
10.

Role and Function of A2A and A₃ Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis.

Ravani A, Vincenzi F, Bortoluzzi A, Padovan M, Pasquini S, Gessi S, Merighi S, Borea PA, Govoni M, Varani K.

Int J Mol Sci. 2017 Mar 24;18(4). pii: E697. doi: 10.3390/ijms18040697.

11.

Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields.

Varani K, Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Setti S, Cadossi M, Borea PA, Cadossi R.

Mediators Inflamm. 2017;2017:2740963. doi: 10.1155/2017/2740963. Epub 2017 Feb 1. Review.

12.

Pathological overproduction: the bad side of adenosine.

Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K.

Br J Pharmacol. 2017 Jul;174(13):1945-1960. doi: 10.1111/bph.13763. Epub 2017 Mar 31. Review.

13.

Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment.

Merighi S, Borea PA, Varani K, Gessi S.

J Invest Dermatol. 2017 Jan;137(1):11-13. doi: 10.1016/j.jid.2016.08.001. Review.

14.

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists.

Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Gessi S, Merighi S, Borea PA.

Med Res Rev. 2017 Jul;37(4):936-983. doi: 10.1002/med.21427. Epub 2016 Dec 15. Review.

PMID:
27976413
15.

A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway.

Merighi S, Bencivenni S, Vincenzi F, Varani K, Borea PA, Gessi S.

Pharmacol Res. 2017 Mar;117:9-19. doi: 10.1016/j.phrs.2016.11.024. Epub 2016 Dec 11.

PMID:
27974241
16.

Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety.

Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Romagnoli R, Baraldi PG, Borea PA, Varani K.

Neuropharmacology. 2016 Dec;111:283-292. doi: 10.1016/j.neuropharm.2016.09.015. Epub 2016 Sep 14.

PMID:
27639989
17.

Pulsed Electromagnetic Field Exposure Reduces Hypoxia and Inflammation Damage in Neuron-Like and Microglial Cells.

Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Setti S, Cadossi R, Borea PA, Varani K.

J Cell Physiol. 2017 May;232(5):1200-1208. doi: 10.1002/jcp.25606. Epub 2016 Oct 7.

PMID:
27639248
18.

Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2 receptor antagonists/inverse agonists.

Dore A, Asproni B, Scampuddu A, Gessi S, Murineddu G, Cichero E, Fossa P, Merighi S, Bencivenni S, Pinna GA.

Bioorg Med Chem. 2016 Nov 1;24(21):5291-5301. doi: 10.1016/j.bmc.2016.08.055. Epub 2016 Aug 29.

PMID:
27624523
19.

The activation of μ-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microglia.

Gessi S, Borea PA, Bencivenni S, Fazzi D, Varani K, Merighi S.

FEBS Lett. 2016 Sep;590(17):2813-26. doi: 10.1002/1873-3468.12313. Epub 2016 Jul 28.

20.

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

Borea PA, Gessi S, Merighi S, Varani K.

Trends Pharmacol Sci. 2016 Jun;37(6):419-434. doi: 10.1016/j.tips.2016.02.006. Epub 2016 Mar 2. Review.

PMID:
26944097
21.

PKCε as a novel promoter of skeletal muscle differentiation and regeneration.

Di Marcantonio D, Galli D, Carubbi C, Gobbi G, Queirolo V, Martini S, Merighi S, Vaccarezza M, Maffulli N, Sykes SM, Vitale M, Mirandola P.

Exp Cell Res. 2015 Nov 15;339(1):10-9. doi: 10.1016/j.yexcr.2015.09.017. Epub 2015 Sep 30.

22.

Adenosine receptors and diabetes: Focus on the A(2B) adenosine receptor subtype.

Merighi S, Borea PA, Gessi S.

Pharmacol Res. 2015 Sep;99:229-36. doi: 10.1016/j.phrs.2015.06.015. Epub 2015 Jul 2. Review.

PMID:
26142494
23.

A2a and a2b adenosine receptors affect HIF-1α signaling in activated primary microglial cells.

Merighi S, Borea PA, Stefanelli A, Bencivenni S, Castillo CA, Varani K, Gessi S.

Glia. 2015 Nov;63(11):1933-1952. doi: 10.1002/glia.22861. Epub 2015 May 15.

PMID:
25980546
24.

Synthesis and Biological Evaluation of Pyrazolo[3,4-b]pyridin-4-ones as a New Class of Topoisomerase II Inhibitors.

Tabrizi MA, Baraldi PG, Baraldi S, Prencipe F, Preti D, Saponaro G, Romagnoli R, Gessi S, Merighi S, Stefanelli A, Fazzi D, Borea PA, Maia RC, Romeiro NC, Fraga CA, Barreiro EJ.

Med Chem. 2015;11(4):342-53.

PMID:
25494808
25.

The A3 adenosine receptor: history and perspectives.

Borea PA, Varani K, Vincenzi F, Baraldi PG, Tabrizi MA, Merighi S, Gessi S.

Pharmacol Rev. 2015;67(1):74-102. doi: 10.1124/pr.113.008540. Review.

PMID:
25387804
26.

Targeting adenosine receptors to prevent inflammatory skin diseases.

Gessi S, Merighi S, Borea PA.

Exp Dermatol. 2014 Aug;23(8):553-4. doi: 10.1111/exd.12474.

PMID:
24961687
27.

TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice.

Vincenzi F, Targa M, Romagnoli R, Merighi S, Gessi S, Baraldi PG, Borea PA, Varani K.

Neuropharmacology. 2014 Jun;81:6-14. doi: 10.1016/j.neuropharm.2014.01.028. Epub 2014 Jan 31.

PMID:
24486382
28.

A(1) and A(3) adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes.

Gessi S, Merighi S, Stefanelli A, Fazzi D, Varani K, Borea PA.

Pharmacol Res. 2013 Oct;76:157-70. doi: 10.1016/j.phrs.2013.08.002. Epub 2013 Aug 19.

PMID:
23969284
29.

Morphine mediates a proinflammatory phenotype via μ-opioid receptor-PKCɛ-Akt-ERK1/2 signaling pathway in activated microglial cells.

Merighi S, Gessi S, Varani K, Fazzi D, Stefanelli A, Borea PA.

Biochem Pharmacol. 2013 Aug 15;86(4):487-96. doi: 10.1016/j.bcp.2013.05.027. Epub 2013 Jun 21.

PMID:
23796752
30.

Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.

Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, Cadossi R, Goldring MB, Borea PA, Varani K.

PLoS One. 2013 May 31;8(5):e65561. doi: 10.1371/journal.pone.0065561. Print 2013.

31.

Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated.

Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, Gentile M, Granieri E, Borea PA, Varani K.

Eur J Immunol. 2013 Aug;43(8):2206-16. doi: 10.1002/eji.201343314. Epub 2013 Jun 3.

32.

Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.

Vincenzi F, Targa M, Corciulo C, Tabrizi MA, Merighi S, Gessi S, Saponaro G, Baraldi PG, Borea PA, Varani K.

Pain. 2013 Jun;154(6):864-73. doi: 10.1016/j.pain.2013.02.007. Epub 2013 Feb 26.

PMID:
23518609
33.

A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.

Vincenzi F, Padovan M, Targa M, Corciulo C, Giacuzzo S, Merighi S, Gessi S, Govoni M, Borea PA, Varani K.

PLoS One. 2013;8(1):e54195. doi: 10.1371/journal.pone.0054195. Epub 2013 Jan 11.

34.

Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.

Gessi S, Merighi S, Stefanelli A, Mirandola P, Bonfatti A, Fini S, Sensi A, Marci R, Varani K, Borea PA, Vesce F.

Biochim Biophys Acta. 2012 Nov;1822(11):1660-70. doi: 10.1016/j.bbadis.2012.07.013. Epub 2012 Jul 31.

35.

Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes.

Merighi S, Gessi S, Varani K, Fazzi D, Borea PA.

Pharmacol Res. 2012 Nov;66(5):428-36. doi: 10.1016/j.phrs.2012.07.002. Epub 2012 Jul 27.

PMID:
22842066
36.

The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.

Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, Cadossi R, Borea PA, Varani K.

PLoS One. 2012;7(6):e39317. doi: 10.1371/journal.pone.0039317. Epub 2012 Jun 25.

37.

Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.

Baraldi PG, Saponaro G, Romagnoli R, Aghazadeh Tabrizi M, Baraldi S, Moorman AR, Cosconati S, Di Maro S, Marinelli L, Gessi S, Merighi S, Varani K, Borea PA, Preti D.

J Med Chem. 2012 Jun 14;55(11):5380-90. doi: 10.1021/jm300323t. Epub 2012 May 18.

PMID:
22568637
38.

Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.

Merighi S, Gessi S, Varani K, Fazzi D, Mirandola P, Borea PA.

Br J Pharmacol. 2012 Aug;166(8):2371-85. doi: 10.1111/j.1476-5381.2012.01948.x.

39.

Adenosine receptor targeting in health and disease.

Gessi S, Merighi S, Fazzi D, Stefanelli A, Varani K, Borea PA.

Expert Opin Investig Drugs. 2011 Dec;20(12):1591-609. doi: 10.1517/13543784.2011.627853. Epub 2011 Oct 22. Review.

PMID:
22017198
40.

Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.

Merighi S, Gessi S, Varani K, Simioni C, Fazzi D, Mirandola P, Borea PA.

Br J Pharmacol. 2012 Mar;165(6):1773-1788. doi: 10.1111/j.1476-5381.2011.01673.x. Retraction in: Br J Pharmacol. 2017 Aug;174(15):2609.

41.

Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.

Simoni D, Rondanin R, Marchetti P, Rullo C, Baruchello R, Grisolia G, Barbato G, Giovannini R, Marchioro C, Capelli AM, Virginio C, Bozzoli A, Borea PA, Merighi S, Donati D.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5423-7. doi: 10.1016/j.bmcl.2011.06.127. Epub 2011 Jul 20.

PMID:
21824774
42.

Adenosine receptors in health and disease.

Gessi S, Merighi S, Varani K, Borea PA.

Adv Pharmacol. 2011;61:41-75. doi: 10.1016/B978-0-12-385526-8.00002-3. Review.

PMID:
21586355
43.

Glucocorticoid's pharmacology: past, present and future.

Gessi S, Merighi S, Borea PA.

Curr Pharm Des. 2010;16(32):3540-53.

PMID:
20977419
44.

Adenosine receptors and cancer.

Gessi S, Merighi S, Sacchetto V, Simioni C, Borea PA.

Biochim Biophys Acta. 2011 May;1808(5):1400-12. doi: 10.1016/j.bbamem.2010.09.020. Epub 2010 Oct 1. Review.

45.

Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development.

Romagnoli R, Baraldi PG, Tabrizi MA, Gessi S, Borea PA, Merighi S.

Curr Med Chem. 2010;17(30):3488-502. Review.

PMID:
20738250
46.

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.

Gessi S, Sacchetto V, Fogli E, Merighi S, Varani K, Baraldi PG, Tabrizi MA, Leung E, Maclennan S, Borea PA.

Biochem Pharmacol. 2010 May 15;79(10):1483-95. doi: 10.1016/j.bcp.2010.01.009. Epub 2010 Jan 21.

PMID:
20096265
47.

Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells.

Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, Leung E, Maclennan S, Borea PA.

Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):90-7. doi: 10.1161/ATVBAHA.109.194902. Epub 2009 Oct 15.

PMID:
19834107
48.

A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.

Merighi S, Simioni C, Gessi S, Varani K, Mirandola P, Tabrizi MA, Baraldi PG, Borea PA.

Neoplasia. 2009 Oct;11(10):1064-73.

49.

Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors.

Merighi S, Simioni C, Gessi S, Varani K, Borea PA.

Biochem Pharmacol. 2010 Feb 1;79(3):471-7. doi: 10.1016/j.bcp.2009.09.009. Epub 2009 Sep 18.

PMID:
19766600
50.

Pharmacological characterization of P2X1 and P2X3 purinergic receptors in bovine chondrocytes.

Varani K, De Mattei M, Vincenzi F, Tosi A, Gessi S, Merighi S, Pellati A, Masieri F, Ongaro A, Borea PA.

Osteoarthritis Cartilage. 2008 Nov;16(11):1421-9. doi: 10.1016/j.joca.2008.03.016. Epub 2008 Apr 29.

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