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Items: 34


Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures.

Merienne N, Meunier C, Schneider A, Seguin J, Nair SS, Rocher AB, Le Gras S, Keime C, Faull R, Pellerin L, Chatton JY, Neri C, Merienne K, Déglon N.

Cell Rep. 2019 Feb 26;26(9):2477-2493.e9. doi: 10.1016/j.celrep.2019.02.003.


Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.

Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL.

EMBO Mol Med. 2018 Nov;10(11). pii: e8587. doi: 10.15252/emmm.201708587.


Neuroepigenetics and addictive behaviors: Where do we stand?

De Sa Nogueira D, Merienne K, Befort K.

Neurosci Biobehav Rev. 2018 Sep 8. pii: S0149-7634(18)30104-0. doi: 10.1016/j.neubiorev.2018.08.018. [Epub ahead of print] Review.


The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E.

Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057.


Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature.

Le Gras S, Keime C, Anthony A, Lotz C, De Longprez L, Brouillet E, Cassel JC, Boutillier AL, Merienne K.

Sci Rep. 2017 Feb 22;7:42875. doi: 10.1038/srep42875.


Contribution of Neuroepigenetics to Huntington's Disease.

Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K.

Front Hum Neurosci. 2017 Jan 30;11:17. doi: 10.3389/fnhum.2017.00017. eCollection 2017. Review.


[Epigenetic regulations and cerebral plasticity: towards new therapeutic options in neurodegenerative diseases?]

Merienne K, Boutillier AL.

Biol Aujourdhui. 2016;210(4):297-309. doi: 10.1051/jbio/2017002. Epub 2017 Mar 22. Review. French.


Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice.

Achour M, Le Gras S, Keime C, Parmentier F, Lejeune FX, Boutillier AL, Néri C, Davidson I, Merienne K.

Hum Mol Genet. 2015 Jun 15;24(12):3481-96. doi: 10.1093/hmg/ddv099. Epub 2015 Mar 17.


Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.

Goula AV, Merienne K.

Genes (Basel). 2013 Jul 25;4(3):375-87. doi: 10.3390/genes4030375.


Transcription elongation and tissue-specific somatic CAG instability.

Goula AV, Stys A, Chan JP, Trottier Y, Festenstein R, Merienne K.

PLoS Genet. 2012;8(11):e1003051. doi: 10.1371/journal.pgen.1003051. Epub 2012 Nov 29.


The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats.

Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM 3rd, Merienne K.

Biochemistry. 2012 May 8;51(18):3919-32. doi: 10.1021/bi300410d. Epub 2012 Apr 23.


Transcriptional activation of REST by Sp1 in Huntington's disease models.

Ravache M, Weber C, Mérienne K, Trottier Y.

PLoS One. 2010 Dec 14;5(12):e14311. doi: 10.1371/journal.pone.0014311.


Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

Goula AV, Berquist BR, Wilson DM 3rd, Wheeler VC, Trottier Y, Merienne K.

PLoS Genet. 2009 Dec;5(12):e1000749. doi: 10.1371/journal.pgen.1000749. Epub 2009 Dec 4.


SCA8 CAG/CTG expansions, a tale of two TOXICities: a unique or common case?

Merienne K, Trottier Y.

PLoS Genet. 2009 Aug;5(8):e1000593. doi: 10.1371/journal.pgen.1000593. Epub 2009 Aug 14. No abstract available.


Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

Roze E, Betuing S, Deyts C, Marcon E, Brami-Cherrier K, Pagès C, Humbert S, Mérienne K, Caboche J.

FASEB J. 2008 Apr;22(4):1083-93. Epub 2007 Nov 20.


Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy.

Merienne K, Friedman J, Akimoto M, Abou-Sleymane G, Weber C, Swaroop A, Trottier Y.

Neurobiol Dis. 2007 Mar;25(3):571-81. Epub 2006 Dec 26.


Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program.

Abou-Sleymane G, Chalmel F, Helmlinger D, Lardenois A, Thibault C, Weber C, Mérienne K, Mandel JL, Poch O, Devys D, Trottier Y.

Hum Mol Genet. 2006 Mar 1;15(5):691-703. Epub 2006 Jan 24.


Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway.

Merienne K, Helmlinger D, Perkin GR, Devys D, Trottier Y.

J Biol Chem. 2003 May 9;278(19):16957-67. Epub 2003 Feb 21.


Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice.

Helmlinger D, Yvert G, Picaud S, Merienne K, Sahel J, Mandel JL, Devys D.

Hum Mol Genet. 2002 Dec 15;11(26):3351-9.


The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cells.

Boeuf H, Merienne K, Jacquot S, Duval D, Zeniou M, Hauss C, Reinhardt B, Huss-Garcia Y, Dierich A, Frank DA, Hanauer A, Kedinger C.

J Biol Chem. 2001 Dec 7;276(49):46204-11. Epub 2001 Oct 1.


Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities.

Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P.

Mol Cell Biol. 2001 Oct;21(20):7089-96.


Mutations in the X-linked RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome.

Delaunoy J, Abidi F, Zeniou M, Jacquot S, Merienne K, Pannetier S, Schmitt M, Schwartz C, Hanauer A.

Hum Mutat. 2001 Feb;17(2):103-16.


Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway.

Mérienne K, Jacquot S, Zeniou M, Pannetier S, Sassone-Corsi P, Hanauer A.

Oncogene. 2000 Aug 31;19(37):4221-9.


A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

Frödin M, Jensen CJ, Merienne K, Gammeltoft S.

EMBO J. 2000 Jun 15;19(12):2924-34.


Unreported RSK2 missense mutation in two male sibs with an unusually mild form of Coffin-Lowry syndrome.

Manouvrier-Hanu S, Amiel J, Jacquot S, Merienne K, Moerman A, Coëslier A, Labarriere F, Vallée L, Croquette MF, Hanauer A.

J Med Genet. 1999 Oct;36(10):775-8.


Coffin-Lowry syndrome: current status.

Jacquot S, Merienne K, Trivier E, Zeniou M, Pannetier S, Hanauer A.

Am J Med Genet. 1999 Jul 30;85(3):214-5. No abstract available.


A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation.

Merienne K, Jacquot S, Pannetier S, Zeniou M, Bankier A, Gecz J, Mandel JL, Mulley J, Sassone-Corsi P, Hanauer A.

Nat Genet. 1999 May;22(1):13-4. No abstract available.


Germline mosaicism in Coffin-Lowry syndrome.

Jacquot S, Merienne K, Pannetier S, Blumenfeld S, Schinzel A, Hanauer A.

Eur J Hum Genet. 1998 Nov-Dec;6(6):578-82.


Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations.

Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel JL, Sassone-Corsi P, Hanauer A.

Am J Hum Genet. 1998 Dec;63(6):1631-40.


Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome.

Merienne K, Jacquot S, Trivier E, Pannetier S, Rossi A, Scott C, Schinzel A, Castellan C, Kress W, Hanauer A.

J Med Genet. 1998 Nov;35(11):890-4.


The functional architecture of an acetylcholine receptor-mimicking antibody.

Mérienne K, Germain N, Zinn-Justin S, Boulain JC, Ducancel F, Ménez A.

J Biol Chem. 1997 Sep 19;272(38):23775-83.


Mimicry between receptors and antibodies. Identification of snake toxin determinants recognized by the acetylcholine receptor and an acetylcholine receptor-mimicking monoclonal antibody.

Ducancel F, Mérienne K, Fromen-Romano C, Trémeau O, Pillet L, Drevet P, Zinn-Justin S, Boulain JC, Ménez A.

J Biol Chem. 1996 Dec 6;271(49):31345-53.

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