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Items: 1 to 50 of 213

1.

Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies.

Zuffo M, Stucchi A, Campos-Salinas J, Cabello-Donayre M, Martínez-García M, Belmonte-Reche E, Pérez-Victoria JM, Mergny JL, Freccero M, Morales JC, Doria F.

Eur J Med Chem. 2018 Nov 19;163:54-66. doi: 10.1016/j.ejmech.2018.11.043. [Epub ahead of print]

PMID:
30503943
2.

Closing the Loop: Triazolylpyridine Coordination Drives the Self-Assembly of Metallomacrocycles with Tunable Topologies for Small-Molecule and Guanine-Quadruplex Recognition.

Miron CE, Colden Leung MR, Kennedy EI, Fleischel O, Khorasani MA, Wu N, Mergny JL, Petitjean A.

Chemistry. 2018 Sep 21. doi: 10.1002/chem.201803731. [Epub ahead of print]

PMID:
30239042
3.

Loop permutation affects the topology and stability of G-quadruplexes.

Cheng M, Cheng Y, Hao J, Jia G, Zhou J, Mergny JL, Li C.

Nucleic Acids Res. 2018 Oct 12;46(18):9264-9275. doi: 10.1093/nar/gky757.

4.

Structural dynamics of propeller loop: towards folding of RNA G-quadruplex.

Havrila M, Stadlbauer P, Kührová P, Banáš P, Mergny JL, Otyepka M, Šponer J.

Nucleic Acids Res. 2018 Sep 28;46(17):8754-8771. doi: 10.1093/nar/gky712.

5.

Multicarbazole scaffolds for selective G-quadruplex binding.

Ou A, Guédin A, Skelton BW, Amrane S, Evans CW, Norret M, Iyer KS, Mergny JL, Smith NM.

Chem Commun (Camb). 2018 Aug 23;54(69):9647-9650. doi: 10.1039/c8cc03945c.

PMID:
30101241
6.

More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand.

Zuffo M, Guédin A, Leriche ED, Doria F, Pirota V, Gabelica V, Mergny JL, Freccero M.

Nucleic Acids Res. 2018 Nov 2;46(19):e115. doi: 10.1093/nar/gky607.

7.

G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation.

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbé D, Mergny JL, Cook-Moreau J, Cogné M.

J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20. No abstract available.

PMID:
29935221
8.

Fishing for G-Quadruplexes in Solution with a Perylene Diimide Derivative Labeled with Biotins.

Busto N, Calvo P, Santolaya J, Leal JM, Guédin A, Barone G, Torroba T, Mergny JL, García B.

Chemistry. 2018 Aug 6;24(44):11292-11296. doi: 10.1002/chem.201802365. Epub 2018 Jul 10.

PMID:
29797628
9.

Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome.

Guédin A, Lin LY, Armane S, Lacroix L, Mergny JL, Thore S, Yatsunyk LA.

Nucleic Acids Res. 2018 Jun 1;46(10):5297-5307. doi: 10.1093/nar/gky290.

10.

Phenanthroline polyazamacrocycles as G-quadruplex DNA binders.

Carvalho J, Quintela T, Gueddouda NM, Bourdoncle A, Mergny JL, Salgado GF, Queiroz JA, Cruz C.

Org Biomol Chem. 2018 Apr 18;16(15):2776-2786. doi: 10.1039/c8ob00247a.

PMID:
29611599
11.

G-quadruplexes in Prague: A Bohemian Rhapsody.

O'Hagan MP, Mergny JL, Waller ZAE.

Biochimie. 2018 Apr;147:170-180. doi: 10.1016/j.biochi.2018.02.004. Epub 2018 Feb 13.

PMID:
29452278
12.

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC.

J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672. Epub 2018 Jan 27.

13.

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex.

Das RN, Chevret E, Desplat V, Rubio S, Mergny JL, Guillon J.

Molecules. 2017 Dec 30;23(1). pii: E81. doi: 10.3390/molecules23010081.

14.

Design, synthesis, and antiprotozoal evaluation of new 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives.

Guillon J, Cohen A, Das RN, Boudot C, Gueddouda NM, Moreau S, Ronga L, Savrimoutou S, Basmaciyan L, Tisnerat C, Mestanier S, Rubio S, Amaziane S, Dassonville-Klimpt A, Azas N, Courtioux B, Mergny JL, Mullié C, Sonnet P.

Chem Biol Drug Des. 2018 May;91(5):974-995. doi: 10.1111/cbdd.13164. Epub 2018 Jan 17.

PMID:
29266861
15.

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells.

Dzatko S, Krafcikova M, Hänsel-Hertsch R, Fessl T, Fiala R, Loja T, Krafcik D, Mergny JL, Foldynova-Trantirkova S, Trantirek L.

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2165-2169. doi: 10.1002/anie.201712284. Epub 2018 Jan 29.

16.

1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region.

Marquevielle J, Kumar MVV, Mergny JL, Salgado GF.

Biomol NMR Assign. 2018 Apr;12(1):123-127. doi: 10.1007/s12104-017-9793-0. Epub 2017 Nov 30.

PMID:
29189986
17.

Fluorescent light-up acridine orange derivatives bind and stabilize KRAS-22RT G-quadruplex.

Carvalho J, Pereira E, Marquevielle J, Campello MPC, Mergny JL, Paulo A, Salgado GF, Queiroz JA, Cruz C.

Biochimie. 2018 Jan;144:144-152. doi: 10.1016/j.biochi.2017.11.004. Epub 2017 Nov 10.

PMID:
29129745
18.

Relations between the loop transposition of DNA G-quadruplex and the catalytic function of DNAzyme.

Cheng M, Zhou J, Jia G, Ai X, Mergny JL, Li C.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1913-1920. doi: 10.1016/j.bbagen.2017.05.016. Epub 2017 May 19.

PMID:
28533132
19.

Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes.

Zhou J, Amrane S, Rosu F, Salgado GF, Bian Y, Tateishi-Karimata H, Largy E, Korkut DN, Bourdoncle A, Miyoshi D, Zhang J, Ju H, Wang W, Sugimoto N, Gabelica V, Mergny JL.

J Am Chem Soc. 2017 Jun 14;139(23):7768-7779. doi: 10.1021/jacs.7b00648. Epub 2017 Jun 5.

PMID:
28523907
20.

High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.

Kerkour A, Marquevielle J, Ivashchenko S, Yatsunyk LA, Mergny JL, Salgado GF.

J Biol Chem. 2017 May 12;292(19):8082-8091. doi: 10.1074/jbc.M117.781906. Epub 2017 Mar 22.

21.

Study of the interaction between indole-based compounds and biologically relevant G-quadruplexes.

Carvalho J, Nottelet P, Mergny JL, Queiroz JA, Salgado GF, Cruz C.

Biochimie. 2017 Apr;135:186-195. doi: 10.1016/j.biochi.2017.02.005. Epub 2017 Feb 21.

PMID:
28232078
22.

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.

Guillon J, Cohen A, Gueddouda NM, Das RN, Moreau S, Ronga L, Savrimoutou S, Basmaciyan L, Monnier A, Monget M, Rubio S, Garnerin T, Azas N, Mergny JL, Mullié C, Sonnet P.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):547-563. doi: 10.1080/14756366.2016.1268608.

PMID:
28114821
23.

G-quadruplexes unfolding by RHAU helicase.

Gueddouda NM, Mendoza O, Gomez D, Bourdoncle A, Mergny JL.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1382-1388. doi: 10.1016/j.bbagen.2017.01.006. Epub 2017 Jan 6.

PMID:
28065761
24.

NMR based model of human telomeric repeat G-quadruplex in complex with 2,4,6-triarylpyridine family ligand.

Kerkour A, Mergny JL, Salgado GF.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1293-1302. doi: 10.1016/j.bbagen.2016.12.016. Epub 2016 Dec 20.

PMID:
28007578
25.

Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.

Arévalo-Ruiz M, Doria F, Belmonte-Reche E, De Rache A, Campos-Salinas J, Lucas R, Falomir E, Carda M, Pérez-Victoria JM, Mergny JL, Freccero M, Morales JC.

Chemistry. 2017 Feb 10;23(9):2157-2164. doi: 10.1002/chem.201604886. Epub 2017 Jan 16.

PMID:
27925323
26.

Design, Synthesis, and Evaluation of 2,9-Bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands.

Gueddouda NM, Hurtado MR, Moreau S, Ronga L, Das RN, Savrimoutou S, Rubio S, Marchand A, Mendoza O, Marchivie M, Elmi L, Chansavang A, Desplat V, Gabelica V, Bourdoncle A, Mergny JL, Guillon J.

ChemMedChem. 2017 Jan 20;12(2):146-160. doi: 10.1002/cmdc.201600511. Epub 2017 Jan 3.

PMID:
27917615
27.

Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes.

Medeiros-Silva J, Guédin A, Salgado GF, Mergny JL, Queiroz JA, Cabrita EJ, Cruz C.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1281-1292. doi: 10.1016/j.bbagen.2016.11.024. Epub 2016 Nov 17.

PMID:
27865994
28.

Interaction of an Iridium(III) Complex with G-Quadruplex DNA and Its Application in Luminescent Switch-On Detection of Siglec-5.

Lin S, Lu L, Kang TS, Mergny JL, Leung CH, Ma DL.

Anal Chem. 2016 Oct 6. [Epub ahead of print]

PMID:
27678199
29.

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes.

De Rache A, Gueddouda NM, Bourdoncle A, Hommes P, Reissig HU, Mergny JL.

Chemistry. 2016 Aug 26;22(36):12651-4. doi: 10.1002/chem.201603021. Epub 2016 Jul 28.

PMID:
27410717
30.

Efficient Inhibition of Telomerase by Nickel-Salophen Complexes.

Lecarme L, Prado E, De Rache A, Nicolau-Travers ML, Gellon G, Dejeu J, Lavergne T, Jamet H, Gomez D, Mergny JL, Defrancq E, Jarjayes O, Thomas F.

ChemMedChem. 2016 Jun 6;11(11):1133-6. doi: 10.1002/cmdc.201600171. Epub 2016 May 11.

PMID:
27166712
31.

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior.

Wang M, Mao Z, Kang TS, Wong CY, Mergny JL, Leung CH, Ma DL.

Chem Sci. 2016 Apr 21;7(4):2516-2523. doi: 10.1039/c6sc00001k. Epub 2016 Jan 28.

32.

G-quadruplexes and helicases.

Mendoza O, Bourdoncle A, Boulé JB, Brosh RM Jr, Mergny JL.

Nucleic Acids Res. 2016 Mar 18;44(5):1989-2006. doi: 10.1093/nar/gkw079. Epub 2016 Feb 15. Review.

33.

Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability.

Largy E, Mergny JL, Gabelica V.

Met Ions Life Sci. 2016;16:203-58. doi: 10.1007/978-3-319-21756-7_7.

PMID:
26860303
34.

Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches.

Largy E, Marchand A, Amrane S, Gabelica V, Mergny JL.

J Am Chem Soc. 2016 Mar 2;138(8):2780-92. doi: 10.1021/jacs.5b13130. Epub 2016 Feb 18.

PMID:
26837276
35.

Re-evaluation of G-quadruplex propensity with G4Hunter.

Bedrat A, Lacroix L, Mergny JL.

Nucleic Acids Res. 2016 Feb 29;44(4):1746-59. doi: 10.1093/nar/gkw006. Epub 2016 Jan 20.

36.

The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium.

Saintomé C, Amrane S, Mergny JL, Alberti P.

Nucleic Acids Res. 2016 Apr 7;44(6):2926-35. doi: 10.1093/nar/gkw003. Epub 2016 Jan 13.

37.

Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA.

Sabharwal NC, Mendoza O, Nicoludis JM, Ruan T, Mergny JL, Yatsunyk LA.

J Biol Inorg Chem. 2016 Apr;21(2):227-39. doi: 10.1007/s00775-015-1325-8. Epub 2016 Jan 9.

38.

G-Quadruplexes Light up Localized DNA Circuits.

Mendoza O, Mergny JL, Aimé JP, Elezgaray J.

Nano Lett. 2016 Jan 13;16(1):624-8. doi: 10.1021/acs.nanolett.5b04354. Epub 2016 Jan 4.

PMID:
26717099
39.

Reevaluation of the stability of G-quadruplex structures under crowding conditions.

Zhou J, Tateishi-Karimata H, Mergny JL, Cheng M, Feng Z, Miyoshi D, Sugimoto N, Li C.

Biochimie. 2016 Feb;121:204-8. doi: 10.1016/j.biochi.2015.12.012. Epub 2015 Dec 17.

PMID:
26708323
40.

Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction.

Mendoza O, Elezgaray J, Mergny JL.

Data Brief. 2015 Nov 5;5:822-8. doi: 10.1016/j.dib.2015.10.039. eCollection 2015 Dec.

41.

Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+ solutions by single molecule FRET microscopy.

Noer SL, Preus S, Gudnason D, Aznauryan M, Mergny JL, Birkedal V.

Nucleic Acids Res. 2016 Jan 8;44(1):464-71. doi: 10.1093/nar/gkv1320. Epub 2015 Nov 28.

42.

Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound.

Merle P, Gueugneau M, Teulade-Fichou MP, Müller-Barthélémy M, Amiard S, Chautard E, Guetta C, Dedieu V, Communal Y, Mergny JL, Gallego M, White C, Verrelle P, Tchirkov A.

Sci Rep. 2015 Nov 6;5:16255. doi: 10.1038/srep16255.

43.

Kinetics of quadruplex to duplex conversion.

Mendoza O, Elezgaray J, Mergny JL.

Biochimie. 2015 Nov;118:225-33. doi: 10.1016/j.biochi.2015.09.031. Epub 2015 Sep 30.

PMID:
26427557
44.

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex.

Lin S, He B, Yang C, Leung CH, Mergny JL, Ma DL.

Chem Commun (Camb). 2015 Nov 18;51(89):16033-6. doi: 10.1039/c5cc06655g.

PMID:
26399215
45.

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.

Métifiot M, Amrane S, Mergny JL, Andreola ML.

Biochimie. 2015 Nov;118:173-5. doi: 10.1016/j.biochi.2015.09.009. Epub 2015 Sep 10.

PMID:
26363100
46.

Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands.

Castillo-González D, Mergny JL, De Rache A, Pérez-Machado G, Cabrera-Pérez MA, Nicolotti O, Introcaso A, Mangiatordi GF, Guédin A, Bourdoncle A, Garrigues T, Pallardó F, Cordeiro MN, Paz-Y-Miño C, Tejera E, Borges F, Cruz-Monteagudo M.

J Chem Inf Model. 2015 Oct 26;55(10):2094-110. doi: 10.1021/acs.jcim.5b00415. Epub 2015 Sep 18.

PMID:
26355653
47.

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe.

Lin S, Gao W, Tian Z, Yang C, Lu L, Mergny JL, Leung CH, Ma DL.

Chem Sci. 2015 Jul 1;6(7):4284-4290. doi: 10.1039/c5sc01320h. Epub 2015 May 18.

48.

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay.

De Rache A, Mergny JL.

Biochimie. 2015 Aug;115:194-202. doi: 10.1016/j.biochi.2015.06.002. Epub 2015 Jun 14.

PMID:
26079222
49.

G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy.

Salgado GF, Cazenave C, Kerkour A, Mergny JL.

Chem Sci. 2015 Jun 1;6(6):3314-3320. doi: 10.1039/c4sc03853c. Epub 2015 Jan 14.

50.

Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions.

Rajendran A, Endo M, Hidaka K, Teulade-Fichou MP, Mergny JL, Sugiyama H.

Chem Commun (Camb). 2015 Jun 4;51(44):9181-4. doi: 10.1039/c5cc01678a.

PMID:
25951794

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