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Items: 24

1.

Regional Differences in Intestinal Drug Metabolism.

Iswandana R, Irianti MI, Oosterhuis D, Hofker HS, Merema MT, de Jager MH, Mutsaers HA, Olinga P.

Drug Metab Dispos. 2018 Oct 1. pii: dmd.118.083428. doi: 10.1124/dmd.118.083428. [Epub ahead of print]

PMID:
30275119
2.

Erratum to: Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 Jul;91(7):2711. doi: 10.1007/s00204-016-1895-4. No abstract available.

PMID:
27900403
3.

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 May;91(5):2079-2092. doi: 10.1007/s00204-016-1865-x. Epub 2016 Oct 7. Erratum in: Arch Toxicol. 2017 Jul;91(7):2711.

4.

Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium.

Starokozhko V, Abza GB, Maessen HC, Merema MT, Kuper F, Groothuis GM.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):288-99. doi: 10.1016/j.tiv.2015.10.008. Epub 2015 Oct 26.

PMID:
26514934
5.

Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.

Hadi M, Westra IM, Starokozhko V, Dragovic S, Merema MT, Groothuis GM.

Chem Res Toxicol. 2013 May 20;26(5):710-20. doi: 10.1021/tx300519p. Epub 2013 Apr 19.

PMID:
23565644
6.

Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.

Hadi M, Chen Y, Starokozhko V, Merema MT, Groothuis GM.

Chem Res Toxicol. 2012 Sep 17;25(9):1938-47. doi: 10.1021/tx300248j. Epub 2012 Aug 16.

PMID:
22870868
7.

Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models.

van Midwoud PM, Janse A, Merema MT, Groothuis GM, Verpoorte E.

Anal Chem. 2012 May 1;84(9):3938-44. doi: 10.1021/ac300771z. Epub 2012 Apr 11.

PMID:
22444457
8.

Microfluidics enables small-scale tissue-based drug metabolism studies with scarce human tissue.

van Midwoud PM, Merema MT, Verpoorte E, Groothuis GM.

J Lab Autom. 2011 Dec;16(6):468-76. doi: 10.1016/j.jala.2011.07.003. Epub 2011 Sep 22.

PMID:
22093304
9.

Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity.

van Midwoud PM, Merema MT, Verweij N, Groothuis GM, Verpoorte E.

Biotechnol Bioeng. 2011 Jun;108(6):1404-12. doi: 10.1002/bit.23053. Epub 2011 Jan 27.

PMID:
21274846
10.

On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices.

van Midwoud PM, Janssen J, Merema MT, de Graaf IA, Groothuis GM, Verpoorte E.

Anal Chem. 2011 Jan 1;83(1):84-91. doi: 10.1021/ac1018638. Epub 2010 Dec 3.

PMID:
21128611
11.

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.

van Midwoud PM, Merema MT, Verpoorte E, Groothuis GM.

Lab Chip. 2010 Oct 21;10(20):2778-86. doi: 10.1039/c0lc00043d. Epub 2010 Sep 7.

PMID:
20835427
12.

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM.

Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19.

PMID:
20725069
13.

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies.

van Midwoud PM, Groothuis GM, Merema MT, Verpoorte E.

Biotechnol Bioeng. 2010 Jan 1;105(1):184-94. doi: 10.1002/bit.22516.

PMID:
19718695
14.

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.

Elferink MG, Olinga P, Draaisma AL, Merema MT, Bauerschmidt S, Polman J, Schoonen WG, Groothuis GM.

Toxicol Appl Pharmacol. 2008 Jun 15;229(3):300-9. doi: 10.1016/j.taap.2008.01.037. Epub 2008 Feb 15.

PMID:
18346771
15.

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices.

Olinga P, Elferink MG, Draaisma AL, Merema MT, Castell JV, Pérez G, Groothuis GM.

Eur J Pharm Sci. 2008 Apr 23;33(4-5):380-9. doi: 10.1016/j.ejps.2008.01.008. Epub 2008 Feb 2.

PMID:
18328680
16.

Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.

van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P.

Toxicol Sci. 2005 May;85(1):632-8. Epub 2005 Feb 23.

PMID:
15728706
17.

The influence of brain death on liver function.

Olinga P, van der Hoeven JA, Merema MT, Freund RL, Ploeg RJ, Groothuis GM.

Liver Int. 2005 Feb;25(1):109-16.

PMID:
15698407
18.

Organ slice viability extended for pathway characterization: an in vitro model to investigate fibrosis.

Vickers AE, Saulnier M, Cruz E, Merema MT, Rose K, Bentley P, Olinga P.

Toxicol Sci. 2004 Dec;82(2):534-44. Epub 2004 Sep 29.

PMID:
15456927
19.

LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.

Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, Meijer DK, Groothuis GM.

Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G1008-16. Epub 2004 Jun 17.

20.

Rat liver slices as a tool to study LPS-induced inflammatory response in the liver.

Olinga P, Merema MT, de Jager MH, Derks F, Melgert BN, Moshage H, Slooff MJ, Meijer DK, Poelstra K, Groothuis GM.

J Hepatol. 2001 Aug;35(2):187-94.

PMID:
11580140
21.

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

Olinga P, Hof IH, Merema MT, Smit M, de Jager MH, Swart PJ, Slooff MJ, Meijer DK, Groothuis GM.

J Pharmacol Toxicol Methods. 2001 Jan-Feb;45(1):55-63.

PMID:
11489665
22.

Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney.

De Kanter R, Olinga P, De Jager MH, Merema MT, Meijer DK, Groothius GM.

Toxicol In Vitro. 1999 Aug-Oct;13(4-5):737-44.

PMID:
20654543
23.

Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.

Olinga P, Merema MT, Hof IH, De Jager MH, De Jong KP, Slooff MJ, Meijer DK, Groothuis GM.

Xenobiotica. 1998 Apr;28(4):349-60.

PMID:
9604299
24.

Maintenance of viability and transport function after preservation of isolated rat hepatocytes in various simplified University of Wisconsin solutions.

Sandker GW, Weert B, Merema MT, Kuipers W, Slooff MJ, Meijer DK, Groothuis GM.

Biochem Pharmacol. 1993 Dec 3;46(11):2093-6.

PMID:
8267658

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