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Items: 1 to 50 of 84

1.

Protein Interaction Domains and post-translational modifications: structural features and drug discovery applications.

Vincenzi M, Mercurio FA, Leone M.

Curr Med Chem. 2019 Jun 19. doi: 10.2174/0929867326666190620101637. [Epub ahead of print]

PMID:
31250750
2.

About TFE: Old and New Findings.

Vincenzi M, Mercurio FA, Leone M.

Curr Protein Pept Sci. 2019;20(5):425-451. doi: 10.2174/1389203720666190214152439.

PMID:
30767740
3.

The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures.

Tito A, Barbulova A, Zappelli C, Leone M, Ruvo M, Mercurio FA, Chambery A, Russo R, Colucci MG, Apone F.

Mol Biotechnol. 2019 Mar;61(3):209-220. doi: 10.1007/s12033-019-00154-w.

PMID:
30661170
4.

Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach.

Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M.

Bioorg Chem. 2019 Mar;84:434-443. doi: 10.1016/j.bioorg.2018.12.009. Epub 2018 Dec 8.

PMID:
30576907
5.

Sam domains in multiple diseases.

Vincenzi M, Mercurio FA, Leone M.

Curr Med Chem. 2018 Oct 9. doi: 10.2174/0929867325666181009114445. [Epub ahead of print]

PMID:
30306850
6.

The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments.

Mercurio FA, Scaloni A, Caira S, Leone M.

Peptides. 2019 Apr;114:50-58. doi: 10.1016/j.peptides.2018.09.004. Epub 2018 Sep 19.

PMID:
30243923
7.

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y.

Cell. 2018 Sep 20;175(1):171-185.e25. doi: 10.1016/j.cell.2018.07.045. Epub 2018 Aug 23.

8.

Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2.

Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M.

Bioorg Chem. 2018 Oct;80:602-610. doi: 10.1016/j.bioorg.2018.07.013. Epub 2018 Jul 20.

PMID:
30036816
9.

Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna.

Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E.

Aquat Toxicol. 2018 May;198:158-164. doi: 10.1016/j.aquatox.2018.03.001. Epub 2018 Mar 8.

PMID:
29547731
10.

Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates.

Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A.

Chemistry. 2018 Mar 26;24(18):4729-4735. doi: 10.1002/chem.201800279. Epub 2018 Feb 28.

PMID:
29377290
11.

The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors.

Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo R, Leone M.

Sci Rep. 2017 Dec 12;7(1):17474. doi: 10.1038/s41598-017-17684-5.

12.

Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?

Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M.

Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1095-1104. doi: 10.1016/j.bbapap.2017.06.003. Epub 2017 Jun 6.

PMID:
28602916
13.

Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces.

La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D.

Biochimie. 2017 Jul;138:106-115. doi: 10.1016/j.biochi.2017.05.002. Epub 2017 May 4.

PMID:
28479106
14.

Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin.

Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A.

Sci Rep. 2017 Mar 22;7(1):307. doi: 10.1038/s41598-017-00332-3.

15.

The Sam Domain of EphA2 Receptor and its Relevance to Cancer: A Novel Challenge for Drug Discovery?

Mercurio FA, Leone M.

Curr Med Chem. 2016;23(42):4718-4734. Review.

PMID:
27804871
16.

Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues.

Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M.

Chembiochem. 2016 Nov 17;17(22):2179-2188. doi: 10.1002/cbic.201600413. Epub 2016 Oct 20.

PMID:
27763725
17.

Self-assembly of PEGylated tetra-phenylalanine derivatives: structural insights from solution and solid state studies.

Diaferia C, Mercurio FA, Giannini C, Sibillano T, Morelli G, Leone M, Accardo A.

Sci Rep. 2016 May 25;6:26638. doi: 10.1038/srep26638.

18.

Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process.

Calce E, Mercurio FA, Leone M, Saviano M, De Luca S.

Carbohydr Polym. 2016 Jun 5;143:84-9. doi: 10.1016/j.carbpol.2016.02.001. Epub 2016 Feb 3.

PMID:
27083346
19.

Solid-Phase S-Alkylation Promoted by Molecular Sieves.

Calce E, Leone M, Mercurio FA, Monfregola L, De Luca S.

Org Lett. 2015 Nov 20;17(22):5646-9. doi: 10.1021/acs.orglett.5b02931. Epub 2015 Nov 2.

PMID:
26523342
20.

Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool.

Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S.

Int J Nanomedicine. 2015 Oct 15;10:6523-39. doi: 10.2147/IJN.S89610. eCollection 2015.

21.

Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam.

Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M.

Chembiochem. 2015 Jul 27;16(11):1629-36. doi: 10.1002/cbic.201500197. Epub 2015 Jun 26.

PMID:
26120079
22.

CD and NMR conformational studies of a peptide encompassing the Mid Loop interface of Ship2-Sam.

Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M.

Biopolymers. 2014 Nov;101(11):1088-98. doi: 10.1002/bip.22512.

PMID:
24889333
23.

Peptides targeting chemokine receptor CXCR4: structural behavior and biological binding studies.

Costantini S, Raucci R, Colonna G, Mercurio FA, Trotta AM, Paola R, Leone M, Rossi F, Pellegrino C, Castello G, Scala S.

J Pept Sci. 2014 Apr;20(4):270-8. doi: 10.1002/psc.2614. Epub 2014 Jan 28.

PMID:
24474664
24.

Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights.

Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone EM, Pellecchia M, Leone M.

Chembiochem. 2013 Jan 2;14(1):100-6. doi: 10.1002/cbic.201200592. Epub 2012 Dec 13.

25.

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.

Cento V, Mirabelli C, Salpini R, Dimonte S, Artese A, Costa G, Mercurio F, Svicher V, Parrotta L, Bertoli A, Ciotti M, Di Paolo D, Sarrecchia C, Andreoni M, Alcaro S, Angelico M, Perno CF, Ceccherini-Silberstein F.

PLoS One. 2012;7(7):e39652. doi: 10.1371/journal.pone.0039652. Epub 2012 Jul 6.

26.

Selected amino acid changes in HIV-1 subtype-C gp41 are associated with specific gp120(V3) signatures in the regulation of co-receptor usage.

Dimonte S, Babakir-Mina M, Mercurio F, Di Pinto D, Ceccherini-Silberstein F, Svicher V, Perno CF.

Virus Res. 2012 Sep;168(1-2):73-83. doi: 10.1016/j.virusres.2012.06.019. Epub 2012 Jun 23.

PMID:
22732432
27.

NF-κB and the link between inflammation and cancer.

DiDonato JA, Mercurio F, Karin M.

Immunol Rev. 2012 Mar;246(1):379-400. doi: 10.1111/j.1600-065X.2012.01099.x. Review.

PMID:
22435567
28.

Comparative analysis of drug resistance among B and the most prevalent non-B HIV type 1 subtypes (C, F, and CRF02_AG) in Italy.

Santoro MM, Alteri C, Ronga L, Flandre P, Fabeni L, Mercurio F, D'Arrigo R, Gori C, Palamara G, Bertoli A, Forbici F, Salpini R, Boumis E, Tozzi V, Visco-Comandini U, Zaccarelli M, Van Houtte M, Pattery T, Narciso P, Antinori A, Ceccherini-Silberstein F, Perno CF.

AIDS Res Hum Retroviruses. 2012 Oct;28(10):1285-93. Epub 2012 Apr 18.

29.

Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor.

Mercurio FA, Marasco D, Pirone L, Pedone EM, Pellecchia M, Leone M.

Biochemistry. 2012 Mar 13;51(10):2136-45. doi: 10.1021/bi300141h. Epub 2012 Mar 5.

30.

Genetic and structural analysis of HIV-1 Rev responsive element related to V38A and T18A enfuvirtide resistance mutations.

Dimonte S, Mercurio F, Svicher V, Perno CF, Ceccherini-Silberstein F.

Intervirology. 2012;55(5):385-90. doi: 10.1159/000334696. Epub 2011 Dec 21.

PMID:
22188777
31.

Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage.

Svicher V, Alteri C, Artese A, Zhang JM, Costa G, Mercurio F, D'Arrigo R, Alcaro S, Palù G, Clementi M, Zazzi M, Andreoni M, Antinori A, Lazzarin A, Ceccherini-Silberstein F, Perno CF; OSCAR study group.

Antivir Ther. 2011;16(7):1035-45. doi: 10.3851/IMP1862.

PMID:
22024519
32.

Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.

Svicher V, Cento V, Salpini R, Mercurio F, Fraune M, Beggel B, Han Y, Gori C, Wittkop L, Bertoli A, Micheli V, Gubertini G, Longo R, Romano S, Visca M, Gallinaro V, Marino N, Mazzotta F, De Sanctis GM, Fleury H, Trimoulet P, Angelico M, Cappiello G, Zhang XX, Verheyen J, Ceccherini-Silberstein F, Perno CF.

Dig Liver Dis. 2011 Dec;43(12):975-83. doi: 10.1016/j.dld.2011.07.002. Epub 2011 Aug 9.

PMID:
21831732
33.

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.

Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16.

34.

Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage.

Dimonte S, Mercurio F, Svicher V, D'Arrigo R, Perno CF, Ceccherini-Silberstein F.

Retrovirology. 2011 May 12;8:33. doi: 10.1186/1742-4690-8-33.

35.

Rapid prediction of sustained virological response in patients chronically infected with HCV by evaluation of RNA decay 48h after the start of treatment with pegylated interferon and ribavirin.

Parruti G, Polilli E, Sozio F, Cento V, Pieri A, Di Masi F, Mercurio F, Tontodonati M, Mazzotta E, Ceccherini-Silberstein F, Manzoli L, Perno CF.

Antiviral Res. 2010 Oct;88(1):124-7. doi: 10.1016/j.antiviral.2010.08.003. Epub 2010 Aug 11.

PMID:
20708036
36.

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases.

Xu Y, Li J, Ferguson GD, Mercurio F, Khambatta G, Morrison L, Lopez-Girona A, Corral LG, Webb DR, Bennett BL, Xie W.

Blood. 2009 Jul 9;114(2):338-45. doi: 10.1182/blood-2009-02-200543. Epub 2009 May 5.

37.

A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis.

Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, Dalton WS, Abraham RT.

J Biol Chem. 2008 May 9;283(19):13174-84. doi: 10.1074/jbc.M708008200. Epub 2008 Mar 6.

38.

Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.

Chen Q, Xie W, Kuhn DJ, Voorhees PM, Lopez-Girona A, Mendy D, Corral LG, Krenitsky VP, Xu W, Moutouh-de Parseval L, Webb DR, Mercurio F, Nakayama KI, Nakayama K, Orlowski RZ.

Blood. 2008 May 1;111(9):4690-9. doi: 10.1182/blood-2007-09-112904. Epub 2008 Feb 27.

39.

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M.

Cell. 2007 Jun 15;129(6):1165-76.

40.

Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.

Xu S, Abbasian M, Patel P, Jensen-Pergakes K, Lombardo CR, Cathers BE, Xie W, Mercurio F, Pagano M, Giegel D, Cox S.

J Biol Chem. 2007 May 25;282(21):15462-70. Epub 2007 Apr 4.

41.

In vitro SCFbeta-Trcp1-mediated IkappaBalpha ubiquitination assay for high-throughput screen.

Xu S, Patel P, Abbasian M, Giegel D, Xie W, Mercurio F, Cox S.

Methods Enzymol. 2005;399:729-40.

PMID:
16338392
42.

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT.

Mol Cell. 2005 Sep 2;19(5):607-18.

43.

Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).

Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, Verma IM.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12425-30. Epub 2005 Aug 22.

44.

Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.

Cavin LG, Venkatraman M, Factor VM, Kaur S, Schroeder I, Mercurio F, Beg AA, Thorgeirsson SS, Arsura M.

Cancer Res. 2004 Oct 1;64(19):7030-8.

45.

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.

Ducut Sigala JL, Bottero V, Young DB, Shevchenko A, Mercurio F, Verma IM.

Science. 2004 Jun 25;304(5679):1963-7.

46.

Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila.

Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T Jr, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA.

Genes Dev. 2004 Mar 1;18(5):584-94.

47.
48.

IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.

Kravchenko VV, Mathison JC, Schwamborn K, Mercurio F, Ulevitch RJ.

J Biol Chem. 2003 Jul 18;278(29):26612-9. Epub 2003 May 6.

49.

Potential new therapeutics for Waldenstrom's macroglobulinemia.

Zeldis JB, Schafer PH, Bennett BL, Mercurio F, Stirling DI.

Semin Oncol. 2003 Apr;30(2):275-81. Review.

PMID:
12720152
50.

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.

Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS, Sonenshein GE.

Oncogene. 2003 Jan 23;22(3):412-25.

PMID:
12545162

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