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Items: 1 to 50 of 152


Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing.

Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM.

J Cell Sci. 2019 Jul 31;132(15). pii: jcs231241. doi: 10.1242/jcs.231241.


The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.

Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14174-14180. doi: 10.1073/pnas.1821194116. Epub 2019 Jun 24.


CD44 splice isoform switching determines breast cancer stem cell state.

Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C.

Genes Dev. 2019 Feb 1;33(3-4):166-179. doi: 10.1101/gad.319889.118. Epub 2019 Jan 28.


VEGF/Neuropilin Signaling in Cancer Stem Cells.

Mercurio AM.

Int J Mol Sci. 2019 Jan 23;20(3). pii: E490. doi: 10.3390/ijms20030490. Review.


Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.

Elaimy AL, Mercurio AM.

Sci Signal. 2018 Oct 16;11(552). pii: eaau1165. doi: 10.1126/scisignal.aau1165. Review.


Cell clustering mediated by the adhesion protein PVRL4 is necessary for α6β4 integrin-promoted ferroptosis resistance in matrix-detached cells.

Brown CW, Amante JJ, Mercurio AM.

J Biol Chem. 2018 Aug 17;293(33):12741-12748. doi: 10.1074/jbc.RA118.003017. Epub 2018 Jun 22.


IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer.

Samanta S, Guru S, Elaimy AL, Amante JJ, Ou J, Yu J, Zhu LJ, Mercurio AM.

Cell Rep. 2018 May 29;23(9):2559-2567. doi: 10.1016/j.celrep.2018.04.113.


Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays.

Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM.

Nanomedicine. 2018 Aug;14(6):1931-1939. doi: 10.1016/j.nano.2018.05.009. Epub 2018 May 17.


VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin.

Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM.

Sci Signal. 2018 May 1;11(528). pii: eaao6897. doi: 10.1126/scisignal.aao6897.


The α6β4 integrin promotes resistance to ferroptosis.

Brown CW, Amante JJ, Goel HL, Mercurio AM.

J Cell Biol. 2017 Dec 4;216(12):4287-4297. doi: 10.1083/jcb.201701136. Epub 2017 Sep 28.


Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine.

Yoshii T, Geng Y, Peyton S, Mercurio AM, Rotello VM.

Drug Discov Today. 2016 Sep;21(9):1489-1494. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Review.


P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM.

Cell Rep. 2016 Mar 8;14(9):2193-2208. doi: 10.1016/j.celrep.2016.02.016. Epub 2016 Feb 25.


Tead and AP1 Coordinate Transcription and Motility.

Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J.

Cell Rep. 2016 Feb 9;14(5):1169-1180. doi: 10.1016/j.celrep.2015.12.104. Epub 2016 Jan 28.


Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells.

Yoshii T, Geng Y, Le ND, Goel HL, Mercurio AM, Rotello VM.

Nanomedicine (Lond). 2015;10(23):3427-9. doi: 10.2217/nnm.15.179. Epub 2015 Nov 26. No abstract available.


ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1.

Mak P, Li J, Samanta S, Mercurio AM.

Oncotarget. 2015 Nov 24;6(37):40247-54. doi: 10.18632/oncotarget.5377.


Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.

Li J, Sun H, Feltri ML, Mercurio AM.

Dev Biol. 2015 Nov 15;407(2):313-20. doi: 10.1016/j.ydbio.2015.09.015. Epub 2015 Sep 30.


IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.

Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM.

Oncogene. 2016 Mar 3;35(9):1111-21. doi: 10.1038/onc.2015.164. Epub 2015 May 18.


Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor β repression.

Mak P, Li J, Samanta S, Chang C, Jerry DJ, Davis RJ, Leav I, Mercurio AM.

Cell Rep. 2015 Mar 31;10(12):1982-91. doi: 10.1016/j.celrep.2015.02.063. Epub 2015 Mar 26. Erratum in: Cell Rep. 2015 May 19;11(7):1147-9.


Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.

Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW.

Structure. 2015 Apr 7;23(4):677-87. doi: 10.1016/j.str.2015.01.018. Epub 2015 Mar 5.


A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells.

Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM.

Genes Dev. 2015 Jan 1;29(1):1-6. doi: 10.1101/gad.253682.114.


A cell-ECM screening method to predict breast cancer metastasis.

Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR.

Integr Biol (Camb). 2015 Feb;7(2):198-212. doi: 10.1039/c4ib00218k.


Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4.

Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H.

FASEB J. 2015 Jan;29(1):131-40. doi: 10.1096/fj.14-257550. Epub 2014 Oct 17.


Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.

Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM.

Cell Rep. 2014 May 8;7(3):747-61. doi: 10.1016/j.celrep.2014.03.059. Epub 2014 Apr 24.


IMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma.

Gao Y, Yang M, Jiang Z, Woda BA, Mercurio AM, Qin J, Huang X, Zhang F.

Hum Pathol. 2014 Jun;45(6):1184-91. doi: 10.1016/j.humpath.2014.01.016. Epub 2014 Feb 6.


VEGF targets the tumour cell.

Goel HL, Mercurio AM.

Nat Rev Cancer. 2013 Dec;13(12):871-82. doi: 10.1038/nrc3627. Review.


Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin β4.

Chang C, Yang X, Pursell B, Mercurio AM.

Mol Cell Biol. 2013 Oct;33(19):3795-804. doi: 10.1128/MCB.00434-13. Epub 2013 Jul 22.


IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression.

Samanta S, Pursell B, Mercurio AM.

J Biol Chem. 2013 May 3;288(18):12569-73. doi: 10.1074/jbc.C112.442319. Epub 2013 Mar 28.


Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.

Mak P, Chang C, Pursell B, Mercurio AM.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4708-13. doi: 10.1073/pnas.1221654110. Epub 2013 Mar 4.


GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.

Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM.

EMBO Mol Med. 2013 Apr;5(4):488-508. doi: 10.1002/emmm.201202078. Epub 2013 Feb 21.


Effects of β4 integrin expression on microRNA patterns in breast cancer.

Gerson KD, Maddula VS, Seligmann BE, Shearstone JR, Khan A, Mercurio AM.

Biol Open. 2012 Jul 15;1(7):658-66. doi: 10.1242/bio.20121628. Epub 2012 May 25.


Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology.

Goel HL, Mercurio AM.

Cell Adh Migr. 2012 Nov-Dec;6(6):554-60. doi: 10.4161/cam.22419. Epub 2012 Oct 17. Review.


VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.

Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM.

Cancer Discov. 2012 Oct;2(10):906-21. doi: 10.1158/2159-8290.CD-12-0085. Epub 2012 Jul 9.


Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.

Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I.

Cell. 2012 Apr 27;149(3):630-41. doi: 10.1016/j.cell.2012.02.056.


Integrin β4 regulates SPARC protein to promote invasion.

Gerson KD, Shearstone JR, Maddula VS, Seligmann BE, Mercurio AM.

J Biol Chem. 2012 Mar 23;287(13):9835-44. doi: 10.1074/jbc.M111.317727. Epub 2012 Feb 3.


Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling.

Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM.

J Cell Sci. 2012 Jan 15;125(Pt 2):497-506. doi: 10.1242/jcs.094433. Epub 2012 Feb 2.


Regulation of IMP3 by EGFR signaling and repression by ERβ: implications for triple-negative breast cancer.

Samanta S, Sharma VM, Khan A, Mercurio AM.

Oncogene. 2012 Nov 1;31(44):4689-97. doi: 10.1038/onc.2011.620. Epub 2012 Jan 23.


Role of JNK in mammary gland development and breast cancer.

Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ.

Cancer Res. 2012 Jan 15;72(2):472-81. doi: 10.1158/0008-5472.CAN-11-1628. Epub 2011 Nov 29.


IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer.

Lu D, Yang X, Jiang NY, Woda BA, Liu Q, Dresser K, Mercurio AM, Rock KL, Jiang Z.

Am J Surg Pathol. 2011 Nov;35(11):1638-45. doi: 10.1097/PAS.0b013e31823272d4.


ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM.

Mol Cancer Res. 2011 Nov;9(11):1449-61. doi: 10.1158/1541-7786.MCR-11-0100. Epub 2011 Aug 29.


Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.

Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM.

Development. 2011 Jul;138(14):2969-76. doi: 10.1242/dev.051318.


miR-10b targets Tiam1: implications for Rac activation and carcinoma migration.

Moriarty CH, Pursell B, Mercurio AM.

J Biol Chem. 2010 Jul 2;285(27):20541-6. doi: 10.1074/jbc.M110.121012. Epub 2010 May 5.


ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.

Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM, Mercurio AM.

Cancer Cell. 2010 Apr 13;17(4):319-32. doi: 10.1016/j.ccr.2010.02.030. Erratum in: Cancer Cell. 2010 Jun 15;17(6):622.


Transcriptional regulation of VEGF-A by the unfolded protein response pathway.

Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F.

PLoS One. 2010 Mar 8;5(3):e9575. doi: 10.1371/journal.pone.0009575.


IAP regulation of metastasis.

Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, Altieri DC.

Cancer Cell. 2010 Jan 19;17(1):53-64. doi: 10.1016/j.ccr.2009.11.021.


Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition.

Yang X, Pursell B, Lu S, Chang TK, Mercurio AM.

J Cell Sci. 2009 Jul 15;122(Pt 14):2473-80. doi: 10.1242/jcs.049148. Epub 2009 Jun 23.


Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.

Pankratz SL, Tan EY, Fine Y, Mercurio AM, Shaw LM.

J Biol Chem. 2009 Jan 23;284(4):2031-7. doi: 10.1074/jbc.M804776200. Epub 2008 Dec 4.


Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.

Bae D, Lu S, Taglienti CA, Mercurio AM.

J Biol Chem. 2008 Oct 17;283(42):28074-80. doi: 10.1074/jbc.M804203200. Epub 2008 Aug 14.


Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance.

Lu S, Simin K, Khan A, Mercurio AM.

Clin Cancer Res. 2008 Feb 15;14(4):1050-8. doi: 10.1158/1078-0432.CCR-07-4116.


Intrinsic signaling functions of the beta4 integrin intracellular domain.

Merdek KD, Yang X, Taglienti CA, Shaw LM, Mercurio AM.

J Biol Chem. 2007 Oct 12;282(41):30322-30. Epub 2007 Aug 21.


Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells.

Bates RC, Pursell BM, Mercurio AM.

Cells Tissues Organs. 2007;185(1-3):29-39. Review.


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