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Items: 1 to 50 of 136

1.

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ.

Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M.

Sci Rep. 2019 Jul 25;9(1):10811. doi: 10.1038/s41598-019-46948-5.

2.

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.

Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW.

Neuron. 2019 Jun 18. pii: S0896-6273(19)30524-0. doi: 10.1016/j.neuron.2019.05.048. [Epub ahead of print]

PMID:
31272829
3.

Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening.

Hnatiuk A, Mercola M.

Cell Stem Cell. 2019 Apr 4;24(4):506-507. doi: 10.1016/j.stem.2019.03.013.

PMID:
30951657
4.

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.

Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC.

Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624.

PMID:
30586709
5.

Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.

Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC.

Nat Protoc. 2018 Dec;13(12):3018-3041. doi: 10.1038/s41596-018-0076-8.

PMID:
30413796
6.

b-Annulated 1,4-dihydropyridines as Notch inhibitors.

Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR.

Bioorg Med Chem Lett. 2018 Nov 1;28(20):3363-3367. doi: 10.1016/j.bmcl.2018.09.002. Epub 2018 Sep 5.

PMID:
30201292
7.

Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?

Bruyneel AA, McKeithan WL, Feyen DA, Mercola M.

Curr Opin Pharmacol. 2018 Oct;42:55-61. doi: 10.1016/j.coph.2018.07.003. Epub 2018 Aug 3. Review.

PMID:
30081259
8.

Novel tertiary sulfonamides as potent anti-cancer agents.

Okolotowicz KJ, Dwyer M, Ryan D, Cheng J, Cashman EA, Moore S, Mercola M, Cashman JR.

Bioorg Med Chem. 2018 Aug 15;26(15):4441-4451. doi: 10.1016/j.bmc.2018.07.042. Epub 2018 Jul 25.

PMID:
30075999
9.

A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer.

Cheng J, Dwyer M, Okolotowicz KJ, Mercola M, Cashman JR.

Cancer Res. 2018 Sep 1;78(17):5072-5083. doi: 10.1158/0008-5472.CAN-17-2642. Epub 2018 Jul 21.

PMID:
30032112
10.

Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function.

Bruyneel AAN, McKeithan WL, Feyen DAM, Mercola M.

Curr Cardiol Rep. 2018 May 25;20(7):57. doi: 10.1007/s11886-018-1000-0. Review.

PMID:
29802473
11.

miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway.

Diez-Cuñado M, Wei K, Bushway PJ, Maurya MR, Perera R, Subramaniam S, Ruiz-Lozano P, Mercola M.

Cell Rep. 2018 May 15;23(7):2168-2174. doi: 10.1016/j.celrep.2018.04.049.

12.

miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.

Jeong D, Yoo J, Lee P, Kepreotis SV, Lee A, Wahlquist C, Brown BD, Kho C, Mercola M, Hajjar RJ.

Mol Ther. 2018 Mar 7;26(3):718-729. doi: 10.1016/j.ymthe.2017.11.014. Epub 2017 Nov 26.

13.

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.

McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M.

Front Physiol. 2017 Oct 11;8:766. doi: 10.3389/fphys.2017.00766. eCollection 2017.

14.

Id genes are essential for early heart formation.

Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR.

Genes Dev. 2017 Jul 1;31(13):1325-1338. doi: 10.1101/gad.300400.117. Epub 2017 Aug 9.

15.

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.

Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC.

Sci Transl Med. 2017 Feb 15;9(377). pii: eaaf2584. doi: 10.1126/scitranslmed.aaf2584.

16.

Bringing new dimensions to drug discovery screening: impact of cellular stimulation technologies.

Molokanova E, Mercola M, Savchenko A.

Drug Discov Today. 2017 Jul;22(7):1045-1055. doi: 10.1016/j.drudis.2017.01.015. Epub 2017 Feb 4. Review.

17.

Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound.

Crespo R, Wei K, Rodenak-Kladniew B, Mercola M, Ruiz-Lozano P, Hurtado C.

Life Sci. 2017 Mar 1;172:8-12. doi: 10.1016/j.lfs.2017.01.008. Epub 2017 Jan 25.

PMID:
28131760
18.

The CSRP2BP histone acetyltransferase drives smooth muscle gene expression.

Ma Y, Li Q, Li A, Wei Y, Long P, Jiang X, Sun F, Weiskirchen R, Wu B, Liang C, Grötzinger J, Wei Y, Yu W, Mercola M, Huang Y, Wang J, Yu Y, Schwartz RJ.

Nucleic Acids Res. 2017 Apr 7;45(6):3046-3058. doi: 10.1093/nar/gkw1227.

19.

miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification.

Shen X, Soibam B, Benham A, Xu X, Chopra M, Peng X, Yu W, Bao W, Liang R, Azares A, Liu P, Gunaratne PH, Mercola M, Cooney AJ, Schwartz RJ, Liu Y.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9551-6. doi: 10.1073/pnas.1608256113. Epub 2016 Aug 10.

20.

The All-Chemical Approach: A Solution for Converting Fibroblasts Into Myocytes.

Liu Y, Mercola M, Schwartz RJ.

Circ Res. 2016 Aug 5;119(4):505-7. doi: 10.1161/CIRCRESAHA.116.309146. No abstract available.

21.

Notch-independent RBPJ controls angiogenesis in the adult heart.

Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M.

Nat Commun. 2016 Jun 30;7:12088. doi: 10.1038/ncomms12088.

22.

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.

Del Álamo JC, Lemons D, Serrano R, Savchenko A, Cerignoli F, Bodmer R, Mercola M.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27. doi: 10.1016/j.bbamcr.2016.03.003. Epub 2016 Mar 4. Review.

23.

Metallic Nanoislands on Graphene as Highly Sensitive Transducers of Mechanical, Biological, and Optical Signals.

Zaretski AV, Root SE, Savchenko A, Molokanova E, Printz AD, Jibril L, Arya G, Mercola M, Lipomi DJ.

Nano Lett. 2016 Feb 10;16(2):1375-80. doi: 10.1021/acs.nanolett.5b04821. Epub 2016 Jan 14.

24.

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.

Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P.

Nature. 2015 Sep 24;525(7570):479-85. doi: 10.1038/nature15372. Epub 2015 Sep 16.

25.

Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.

Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G.

PLoS One. 2015 Sep 14;10(9):e0137894. doi: 10.1371/journal.pone.0137894. eCollection 2015.

26.

1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells.

Okolotowicz KJ, Bushway P, Lanier M, Gilley C, Mercola M, Cashman JR.

Bioorg Med Chem. 2015 Sep 1;23(17):5282-92. doi: 10.1016/j.bmc.2015.07.073. Epub 2015 Aug 4.

27.

Developmental origin of age-related coronary artery disease.

Wei K, Díaz-Trelles R, Liu Q, Diez-Cuñado M, Scimia MC, Cai W, Sawada J, Komatsu M, Boyle JJ, Zhou B, Ruiz-Lozano P, Mercola M.

Cardiovasc Res. 2015 Jul 15;107(2):287-94. doi: 10.1093/cvr/cvv167. Epub 2015 Jun 8.

28.

Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells.

Cabral-Teixeira J, Martinez-Fernandez A, Cai W, Terzic A, Mercola M, Willems E.

Stem Cell Res. 2015 Jul;15(1):88-95. doi: 10.1016/j.scr.2015.04.010. Epub 2015 May 14.

29.

High content screening for modulators of cardiac differentiation in human pluripotent stem cells.

Spiering S, Davidovics H, Bushway PJ, Mercola M, Willems E.

Methods Mol Biol. 2015;1263:43-61. doi: 10.1007/978-1-4939-2269-7_4.

30.

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling.

Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V.

J Mol Cell Cardiol. 2015 Feb;79:133-44. doi: 10.1016/j.yjmcc.2014.11.003. Epub 2014 Nov 13.

31.

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL.

Genes Dev. 2014 Apr 15;28(8):841-57. doi: 10.1101/gad.234468.113. Epub 2014 Mar 28.

32.

Inhibition of miR-25 improves cardiac contractility in the failing heart.

Wahlquist C, Jeong D, Rojas-Muñoz A, Kho C, Lee A, Mitsuyama S, van Mil A, Park WJ, Sluijter JP, Doevendans PA, Hajjar RJ, Mercola M.

Nature. 2014 Apr 24;508(7497):531-5. doi: 10.1038/nature13073. Epub 2014 Mar 12.

33.

Reprogramming the cardiac field.

Willems E, Mercola M.

Circ Res. 2014 Jan 31;114(3):409-11. doi: 10.1161/CIRCRESAHA.113.302946. No abstract available.

34.

Technical variations in low-input RNA-seq methodologies.

Bhargava V, Head SR, Ordoukhanian P, Mercola M, Subramaniam S.

Sci Rep. 2014 Jan 14;4:3678. doi: 10.1038/srep03678.

35.

Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.

Cai W, Albini S, Wei K, Willems E, Guzzo RM, Tsuda M, Giordani L, Spiering S, Kurian L, Yeo GW, Puri PL, Mercola M.

Genes Dev. 2013 Nov 1;27(21):2332-44. doi: 10.1101/gad.225144.113.

36.

Jumonji and cardiac fate.

Willems E, Mercola M.

Circ Res. 2013 Sep 13;113(7):837-9. doi: 10.1161/CIRCRESAHA.113.302202. No abstract available.

37.

Developing microRNA screening as a functional genomics tool for disease research.

Lemons D, Maurya MR, Subramaniam S, Mercola M.

Front Physiol. 2013 Aug 27;4:223. doi: 10.3389/fphys.2013.00223. eCollection 2013.

38.

Quantitative transcriptomics using designed primer-based amplification.

Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S.

Sci Rep. 2013;3:1740. doi: 10.1038/srep01740.

39.

Induced pluripotent stem cells in cardiovascular drug discovery.

Mercola M, Colas A, Willems E.

Circ Res. 2013 Feb 1;112(3):534-48. doi: 10.1161/CIRCRESAHA.111.250266. Review.

40.

Cardiovascular biology: A boost for heart regeneration.

Mercola M.

Nature. 2012 Dec 20;492(7429):360-2. doi: 10.1038/nature11763. Epub 2012 Dec 5. No abstract available.

PMID:
23222522
41.

BAF60 A, B, and Cs of muscle determination and renewal.

Puri PL, Mercola M.

Genes Dev. 2012 Dec 15;26(24):2673-83. doi: 10.1101/gad.207415.112. Epub 2012 Dec 7. Review.

42.

Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening.

McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M.

Curr Protoc Stem Cell Biol. 2012 Nov;Chapter 1:Unit 1F.13. doi: 10.1002/9780470151808.sc01f13s23.

43.

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.

Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, Mercola M.

Genes Dev. 2012 Dec 1;26(23):2567-79. doi: 10.1101/gad.200758.112. Epub 2012 Nov 14.

44.

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR.

J Med Chem. 2012 Nov 26;55(22):9946-57. doi: 10.1021/jm301144g. Epub 2012 Nov 6.

45.

Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte JC.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16196-201. doi: 10.1073/pnas.1202352109. Epub 2012 Sep 18.

46.

High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.

Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, Gallacher DJ, Towart R, Price JH, McDonough PM, Mercola M.

J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):246-56. doi: 10.1016/j.vascn.2012.08.167. Epub 2012 Aug 25.

47.

A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis.

Cai W, Guzzo RM, Wei K, Willems E, Davidovics H, Mercola M.

Circ Res. 2012 Sep 14;111(7):876-81. doi: 10.1161/CIRCRESAHA.112.270272. Epub 2012 Aug 7.

48.

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M.

Cell Stem Cell. 2012 Aug 3;11(2):242-52. doi: 10.1016/j.stem.2012.04.025.

49.

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.

Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F.

Chem Biol. 2012 Jul 27;19(7):806-18. doi: 10.1016/j.chembiol.2012.05.014.

50.

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.

Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13016-21. doi: 10.1073/pnas.1120299109. Epub 2012 Jul 23.

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