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Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant M, Watson C, Prough RA, Cave MC.

Cell Signal. 2018 Oct 6;53:132-139. doi: 10.1016/j.cellsig.2018.10.004. [Epub ahead of print]


Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors.

Yen I, Shanahan F, Merchant M, Orr C, Hunsaker T, Durk M, La H, Zhang X, Martin SE, Lin E, Chan J, Yu Y, Amin D, Neve RM, Gustafson A, Venkatanarayan A, Foster SA, Rudolph J, Klijn C, Malek S.

Cancer Cell. 2018 Oct 8;34(4):611-625.e7. doi: 10.1016/j.ccell.2018.09.002.


Antibacterial activities of plasma from the common (Chelydra serpentina) and alligator snapping turtle (Macrochelys temminckii).

Baker SJ, Kessler EJ, Merchant ME.

J Exp Zool A Ecol Integr Physiol. 2018 Oct 1. doi: 10.1002/jez.2237. [Epub ahead of print]


Contraception after Abortion and Risk of Repeated Unintended Pregnancy among Health Plan Members.

Postlethwaite D, Lee J, Merchant M, Alabaster A, Raine-Bennett T.

Perm J. 2018 Sep 10;22. doi: 10.7812/TPP/18-058. [Epub ahead of print]


Precision medicine in lupus nephritis: can biomarkers get us there?

Caster DJ, Merchant ML, Klein JB, Powell DW.

Transl Res. 2018 Nov;201:26-39. doi: 10.1016/j.trsl.2018.08.002. Epub 2018 Aug 10. Review.


Alternative Treatment Utilization Before Hysterectomy for Benign Gynecologic Conditions at a Large Integrated Health System.

Nguyen NT, Merchant M, Ritterman Weintraub ML, Salyer C, Poceta J, Diaz L, Zaritsky EF.

J Minim Invasive Gynecol. 2018 Aug 28. pii: S1553-4650(18)30429-1. doi: 10.1016/j.jmig.2018.08.013. [Epub ahead of print]


Urine Inositol Pentakisphosphate 2-kinase and Changes in Kidney Structure in Early Diabetic Kidney Disease in Type 1 Diabetes.

Looker HC, Merchant ML, Rane MJ, Nelson RG, Kimmel PL, Rovin BH, Klein JB, Mauer M, Consortium CB.

Am J Physiol Renal Physiol. 2018 Aug 22. doi: 10.1152/ajprenal.00183.2018. [Epub ahead of print]


Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

Raisner R, Kharbanda S, Jin L, Jeng E, Chan E, Merchant M, Haverty PM, Bainer R, Cheung T, Arnott D, Flynn EM, Romero FA, Magnuson S, Gascoigne KE.

Cell Rep. 2018 Aug 14;24(7):1722-1729. doi: 10.1016/j.celrep.2018.07.041.


Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients.

Lam JO, Barnell GM, Merchant M, Ellis CG, Silverberg MJ.

HIV Med. 2018 Aug 6. doi: 10.1111/hiv.12663. [Epub ahead of print]


Safety and feasibility of outpatient robot-assisted radical prostatectomy.

Banapour P, Elliott P, Jabaji R, Parekh A, Pathak A, Merchant M, Tamaddon K.

J Robot Surg. 2018 Jul 13. doi: 10.1007/s11701-018-0848-8. [Epub ahead of print]


Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259T Cells in Synovial Sarcoma.

D'Angelo SP, Melchiori L, Merchant MS, Bernstein D, Glod J, Kaplan R, Grupp S, Tap WD, Chagin K, Binder GK, Basu S, Lowther DE, Wang R, Bath N, Tipping A, Betts G, Ramachandran I, Navenot JM, Zhang H, Wells DK, Van Winkle E, Kari G, Trivedi T, Holdich T, Pandite L, Amado R, Mackall CL.

Cancer Discov. 2018 Aug;8(8):944-957. doi: 10.1158/2159-8290.CD-17-1417. Epub 2018 Jun 11.


A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.

Wagle MC, Kirouac D, Klijn C, Liu B, Mahajan S, Junttila M, Moffat J, Merchant M, Huw L, Wongchenko M, Okrah K, Srinivasan S, Mounir Z, Sumiyoshi T, Haverty PM, Yauch RL, Yan Y, Kabbarah O, Hampton G, Amler L, Ramanujan S, Lackner MR, Huang SA.

NPJ Precis Oncol. 2018 Mar 7;2(1):7. doi: 10.1038/s41698-018-0051-4. eCollection 2018.


Measuring Listening Effort: Convergent Validity, Sensitivity, and Links With Cognitive and Personality Measures.

Strand JF, Brown VA, Merchant MB, Brown HE, Smith J.

J Speech Lang Hear Res. 2018 Jun 19;61(6):1463-1486. doi: 10.1044/2018_JSLHR-H-17-0257.


Biomarker enhanced risk prediction for development of AKI after cardiac surgery.

Merchant ML, Brier ME, Slaughter MS, Klein JB, McLeish KR.

BMC Nephrol. 2018 May 2;19(1):102. doi: 10.1186/s12882-018-0902-9.


Crocodiles Alter Skin Color in Response to Environmental Color Conditions.

Merchant M, Hale A, Brueggen J, Harbsmeier C, Adams C.

Sci Rep. 2018 Apr 18;8(1):6174. doi: 10.1038/s41598-018-24579-6.


Suicidal ideation in lung transplant recipients: A case series.

Rynar LZ, Merchant MS, Dilling DF.

Clin Transplant. 2018 Jun;32(6):e13263. doi: 10.1111/ctr.13263. Epub 2018 May 12.


Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice.

Baba SP, Zhang D, Singh M, Dassanayaka S, Xie Z, Jagatheesan G, Zhao J, Schmidtke VK, Brittian KR, Merchant ML, Conklin DJ, Jones SP, Bhatnagar A.

J Mol Cell Cardiol. 2018 May;118:183-192. doi: 10.1016/j.yjmcc.2018.04.002. Epub 2018 Apr 5.


Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.

Gosney JA, Wilkey DW, Merchant ML, Ceresa BP.

J Biol Chem. 2018 Apr 20;293(16):5895-5908. doi: 10.1074/jbc.RA117.000632. Epub 2018 Mar 9.


Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system.

England MJ, Bigelow AW, Merchant MJ, Velliou E, Welch D, Brenner DJ, Kirkby KJ.

Sens Actuators B Chem. 2017 Feb;239:1134-1143. doi: 10.1016/j.snb.2016.08.076. Epub 2016 Aug 16.


Antibacterial properties of plasma from the prairie rattlesnake (Crotalus viridis).

Baker SJ, Merchant ME.

Dev Comp Immunol. 2018 Jul;84:273-278. doi: 10.1016/j.dci.2018.03.002. Epub 2018 Mar 3.


Risk Factors Including Age, Stage and Anatomic Location that Impact the Outcomes of Patients with Synovial Sarcoma.

Pan M, Merchant M.

Med Sci (Basel). 2018 Mar 6;6(1). pii: E21. doi: 10.3390/medsci6010021.


In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density.

Henthorn NT, Warmenhoven JW, Sotiropoulos M, Mackay RI, Kirkby NF, Kirkby KJ, Merchant MJ.

Sci Rep. 2018 Feb 8;8(1):2654. doi: 10.1038/s41598-018-21111-8.


Abstract ID: 171 A Monte Carlo study to reduce range uncertainty in proton beam therapy via prompt gamma-ray detection.

Panaino C, Taylor MJ, MacKay R, Merchant MJ, Price T, Pheonix B, Green S.

Phys Med. 2018 Jan;45 Suppl 1:S2. doi: 10.1016/j.ejmp.2017.11.027.


Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2018 Jan 25;13(1):e0192059. doi: 10.1371/journal.pone.0192059. eCollection 2018.


Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.

Atay S, Wilkey DW, Milhem M, Merchant M, Godwin AK.

Mol Cell Proteomics. 2018 Mar;17(3):495-515. doi: 10.1074/mcp.RA117.000267. Epub 2017 Dec 14.


First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk.

Haque MM, Merchant M, Kumar PN, Dutta A, Mande SS.

Sci Rep. 2017 Nov 23;7(1):16145. doi: 10.1038/s41598-017-16352-y.


Modelling direct DNA damage for gold nanoparticle enhanced proton therapy.

Sotiropoulos M, Henthorn NT, Warmenhoven JW, Mackay RI, Kirkby KJ, Merchant MJ.

Nanoscale. 2017 Nov 30;9(46):18413-18422. doi: 10.1039/c7nr07310k.


Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery.

Merchant ML, Rood IM, Deegens JKJ, Klein JB.

Nat Rev Nephrol. 2017 Dec;13(12):731-749. doi: 10.1038/nrneph.2017.148. Epub 2017 Oct 30. Review.


LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease.

Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH Jr.

J Am Soc Nephrol. 2018 Feb;29(2):644-653. doi: 10.1681/ASN.2017060664. Epub 2017 Oct 26.


Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Merchant M, Moffat J, Schaefer G, Chan J, Wang X, Orr C, Cheng J, Hunsaker T, Shao L, Wang SJ, Wagle MC, Lin E, Haverty PM, Shahidi-Latham S, Ngu H, Solon M, Eastham-Anderson J, Koeppen H, Huang SA, Schwarz J, Belvin M, Kirouac D, Junttila MR.

PLoS One. 2017 Oct 5;12(10):e0185862. doi: 10.1371/journal.pone.0185862. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192059.


Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins.

Hudson SV, Dolin CE, Poole LG, Massey VL, Wilkey D, Beier JI, Merchant ML, Frieboes HB, Arteel GE.

Sci Rep. 2017 Sep 29;7(1):12444. doi: 10.1038/s41598-017-12691-y.


Knee Alignment Is Quantitatively Related to Periarticular Bone Morphometry and Density, Especially in Patients With Osteoarthritis.

Lo GH, Merchant MG, Driban JB, Duryea J, Price LL, Eaton CB, McAlindon TE.

Arthritis Rheumatol. 2018 Feb;70(2):212-221. doi: 10.1002/art.40325. Epub 2018 Jan 9.


Statistical analysis of ADCs and clinical biomarkers in detecting acute renal transplant rejection.

Hollis E, Shehata M, Abou El-Ghar M, Ghazal M, El-Diasty T, Merchant M, Switala AE, El-Baz A.

Br J Radiol. 2017 Dec;90(1080):20170125. doi: 10.1259/bjr.20170125. Epub 2017 Sep 13.


GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, Crawford TD, Cyr P, de Almeida Nagata D, Gascoigne KE, Grogan JL, Hatzivassiliou G, Huang W, Hunsaker TL, Kaufman S, Koenig SG, Li R, Li Y, Liang X, Liao J, Liu W, Ly J, Maher J, Masui C, Merchant M, Ran Y, Taylor AM, Wai J, Wang F, Wei X, Yu D, Zhu BY, Zhu X, Magnuson S.

J Med Chem. 2017 Nov 22;60(22):9162-9183. doi: 10.1021/acs.jmedchem.7b00796. Epub 2017 Sep 21.


Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Sep 4;3:25. doi: 10.1038/s41540-017-0026-z. eCollection 2017.


Voice Outcomes of Adults Diagnosed with Pediatric Vocal Fold Nodules and Impact of Speech Therapy.

Song BH, Merchant M, Schloegel L.

Otolaryngol Head Neck Surg. 2017 Nov;157(5):824-829. doi: 10.1177/0194599817726285. Epub 2017 Aug 22.


Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE.

Cancer Res. 2017 Oct 15;77(20):5564-5575. doi: 10.1158/0008-5472.CAN-17-0314. Epub 2017 Aug 17.


Nanodosimetric Simulation of Direct Ion-Induced DNA Damage Using Different Chromatin Geometry Models.

Henthorn NT, Warmenhoven JW, Sotiropoulos M, Mackay RI, Kirkby KJ, Merchant MJ.

Radiat Res. 2017 Dec;188(6):690-703. doi: 10.1667/RR14755.1. Epub 2017 Aug 9.


Crocodylian nuclear factor kappa B.

Merchant M, Morkotinis V, Hale A, White M, Moran C.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Nov;213:28-34. doi: 10.1016/j.cbpb.2017.07.009. Epub 2017 Jul 29. Review.


Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography.

Aden A, Anthony A, Brigi C, Merchant MS, Siraj H, Tomlins PH.

J Biomed Opt. 2017 Jul 1;22(7):76020. doi: 10.1117/1.JBO.22.7.076020.


Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.

Wheelock KM, Cai J, Looker HC, Merchant ML, Nelson RG, Fufaa GD, Weil EJ, Feldman HI, Vasan RS, Kimmel PL, Rovin BH, Mauer M, Klein JB; CKD Biomarkers Consortium.

PLoS One. 2017 Jul 10;12(7):e0180964. doi: 10.1371/journal.pone.0180964. eCollection 2017.


Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Jun 2;3:14. doi: 10.1038/s41540-017-0016-1. eCollection 2017. Erratum in: NPJ Syst Biol Appl. 2017 Sep 4;3:25.


Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.

Sahu N, Chan E, Chu F, Pham T, Koeppen H, Forrest W, Merchant M, Settleman J.

Mol Cancer Ther. 2017 Sep;16(9):1729-1738. doi: 10.1158/1535-7163.MCT-17-0009. Epub 2017 Jun 15.


Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

Majzner RG, Simon JS, Grosso JF, Martinez D, Pawel BR, Santi M, Merchant MS, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen PH, Mackall CL, Maris JM.

Cancer. 2017 Oct 1;123(19):3807-3815. doi: 10.1002/cncr.30724. Epub 2017 Jun 13.


Corrigendum to "Low dose ouabain stimulates Na-K ATPase 〈alpha〉 1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells" [Biochim. Biophys. Acta 1863/11 (2016) 2624-2636].

Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1922. doi: 10.1016/j.bbamcr.2017.06.002. Epub 2017 Jun 13. No abstract available.


Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.

Shields KM, Tooley JG, Petkowski JJ, Wilkey DW, Garbett NC, Merchant ML, Cheng A, Schaner Tooley CE.

Protein Sci. 2017 Aug;26(8):1639-1652. doi: 10.1002/pro.3202. Epub 2017 Jun 11.


Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ.

Am J Physiol Cell Physiol. 2017 Aug 1;313(2):C197-C206. doi: 10.1152/ajpcell.00219.2016. Epub 2017 May 17.


Changes in the buccolingual inclination of first molars with growth in untreated subjects: A longitudinal study.

Sayania B, Merchant M, Josephs P, Chung CH.

Angle Orthod. 2017 Sep;87(5):681-687. doi: 10.2319/120716-878.1. Epub 2017 May 8.


Detection of a synthetic sex steroid in the American crocodile (Crocodylus acutus): Evidence for a novel environmental androgen.

Murray CM, Merchant M, Easter M, Padilla S, Garrigós DB, Sasa Marin M, Guyer C.

Chemosphere. 2017 Aug;180:125-129. doi: 10.1016/j.chemosphere.2017.04.020. Epub 2017 Apr 5.


Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise.

Birmingham DJ, Merchant M, Waikar SS, Nagaraja H, Klein JB, Rovin BH.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i71-i79. doi: 10.1093/ndt/gfw300. Review.

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