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ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.

Salmon M, Schaheen B, Spinosa M, Montgomery W, Pope NH, Davis JP, Johnston WF, Sharma AK, Owens GK, Merchant JL, Zehner ZE, Upchurch GR Jr, Ailawadi G.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):73-88. doi: 10.1161/ATVBAHA.118.311136.


Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse.

Wang Z, Ocadiz-Ruiz R, Sundaresan S, Ding L, Hayes M, Sahoo N, Xu H, Merchant JL.

J Vis Exp. 2018 Aug 15;(138). doi: 10.3791/57629.


Mature enteroendocrine cells contribute to basal and pathological stem cell dynamics in the small intestine.

Sei Y, Feng J, Samsel L, White A, Zhao X, Yun S, Citrin D, McCoy JP, Sundaresan S, Hayes MM, Merchant JL, Leiter A, Wank SA.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G495-G510. doi: 10.1152/ajpgi.00036.2018. Epub 2018 May 31.


Parietal Cell Death by Cytokines.

Merchant JL.

Cell Mol Gastroenterol Hepatol. 2018 Feb 15;5(4):636-637. doi: 10.1016/j.jcmgh.2018.01.019. eCollection 2018. No abstract available.


Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.


ZBP-89 function in colonic stem cells and during butyrate-induced senescence.

Ocadiz-Ruiz R, Photenhauer AL, Hayes MM, Ding L, Fearon ER, Merchant JL.

Oncotarget. 2017 Oct 9;8(55):94330-94344. doi: 10.18632/oncotarget.21698. eCollection 2017 Nov 7.


Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.

Sundaresan S, Meininger CA, Kang AJ, Photenhauer AL, Hayes MM, Sahoo N, Grembecka J, Cierpicki T, Ding L, Giordano TJ, Else T, Madrigal DJ, Low MJ, Campbell F, Baker AM, Xu H, Wright NA, Merchant JL.

Gastroenterology. 2017 Dec;153(6):1555-1567.e15. doi: 10.1053/j.gastro.2017.08.038. Epub 2017 Aug 30.


Pathophysiology of Gastric NETs: Role of Gastrin and Menin.

Sundaresan S, Kang AJ, Merchant JL.

Curr Gastroenterol Rep. 2017 Jul;19(7):32. doi: 10.1007/s11894-017-0572-y. Review.


A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.

Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3. No abstract available.


Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H.

Dev Cell. 2017 May 8;41(3):262-273.e6. doi: 10.1016/j.devcel.2017.04.003.


Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions.

Merchant JL, Ding L.

Cell Mol Gastroenterol Hepatol. 2017 Jan 16;3(2):201-210. doi: 10.1016/j.jcmgh.2017.01.004. eCollection 2017 Mar. Review.


Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background.

Saqui-Salces M, Tsao AC, Gillilland MG 3rd, Merchant JL.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G15-G23. doi: 10.1152/ajpgi.00211.2016. Epub 2016 Nov 3.


NF-κB mediated transcription of DARPP-32 prevents Helicobacter pylori-induced cell death.

Merchant JL.

Gut. 2017 May;66(5):761-762. doi: 10.1136/gutjnl-2016-312822. Epub 2016 Oct 27. No abstract available.


Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.

Essien BE, Sundaresan S, Ocadiz-Ruiz R, Chavis A, Tsao AC, Tessier AJ, Hayes MM, Photenhauer A, Saqui-Salces M, Kang AJ, Shah YM, Győrffy B, Merchant JL.

Cancer Res. 2016 Dec 1;76(23):6877-6887. Epub 2016 Oct 10.


Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer.

Ding L, El Zaatari M, Merchant JL.

Adv Exp Med Biol. 2016;908:441-78. doi: 10.1007/978-3-319-41388-4_22. Review.


Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.

Ding L, Hayes MM, Photenhauer A, Eaton KA, Li Q, Ocadiz-Ruiz R, Merchant JL.

J Clin Invest. 2016 Aug 1;126(8):2867-80. doi: 10.1172/JCI82529. Epub 2016 Jul 18.


SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer.

Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL.

J Gastroenterol. 2017 Jan;52(1):39-49. doi: 10.1007/s00535-016-1202-4. Epub 2016 Mar 31.


Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.

Sundaresan S, Kang AJ, Hayes MM, Choi EK, Merchant JL.

Gut. 2017 Jun;66(6):1012-1021. doi: 10.1136/gutjnl-2015-310928. Epub 2016 Feb 9. Erratum in: Gut. 2017 Nov;66(11):2012.


Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways.

Syu LJ, Zhao X, Zhang Y, Grachtchouk M, Demitrack E, Ermilov A, Wilbert DM, Zheng X, Kaatz A, Greenson JK, Gumucio DL, Merchant JL, di Magliano MP, Samuelson LC, Dlugosz AA.

Oncotarget. 2016 Mar 1;7(9):10255-70. doi: 10.18632/oncotarget.7182.


Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.

Grasberger H, Gao J, Nagao-Kitamoto H, Kitamoto S, Zhang M, Kamada N, Eaton KA, El-Zaatari M, Shreiner AB, Merchant JL, Owyang C, Kao JY.

Gastroenterology. 2015 Dec;149(7):1849-59. doi: 10.1053/j.gastro.2015.07.062. Epub 2015 Aug 7.


Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1.

Shiotani A, Kusunoki H, Ishii M, Imamura H, Manabe N, Kamada T, Hata J, Merchant JL, Haruma K.

Neurogastroenterol Motil. 2015 Jan;27(1):82-91. doi: 10.1111/nmo.12473. Epub 2014 Nov 27.


Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA.

Stem Cells. 2014 Mar;32(3):791-801. doi: 10.1002/stem.1598.


Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.

Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL.

Am J Gastroenterol. 2013 Nov;108(11):1766-74. doi: 10.1038/ajg.2013.304. Epub 2013 Sep 24.


Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment.

Merchant JL, Saqui-Salces M.

Cancer Treat Rev. 2014 Feb;40(1):12-21. doi: 10.1016/j.ctrv.2013.08.003. Epub 2013 Aug 13. Review.


Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.

Ye CG, Chen GG, Ho RLK, Merchant JL, He ML, Lai PBS.

Biochim Biophys Acta. 2013 Dec;1833(12):2970-2979. doi: 10.1016/j.bbamcr.2013.08.001. Epub 2013 Aug 13.


Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.

Grasberger H, El-Zaatari M, Dang DT, Merchant JL.

Gastroenterology. 2013 Nov;145(5):1045-54. doi: 10.1053/j.gastro.2013.07.011. Epub 2013 Jul 13.


Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.

El-Zaatari M, Kao JY, Tessier A, Bai L, Hayes MM, Fontaine C, Eaton KA, Merchant JL.

PLoS One. 2013;8(3):e58935. doi: 10.1371/journal.pone.0058935. Epub 2013 Mar 8.


ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice.

Essien BE, Grasberger H, Romain RD, Law DJ, Veniaminova NA, Saqui-Salces M, El-Zaatari M, Tessier A, Hayes MM, Yang AC, Merchant JL.

Gastroenterology. 2013 Jun;144(7):1466-77, 1477.e1-9. doi: 10.1053/j.gastro.2013.01.057. Epub 2013 Feb 7.


Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.

Saqui-Salces M, Covés-Datson E, Veniaminova NA, Waghray M, Syu LJ, Dlugosz AA, Merchant JL.

PLoS One. 2012;7(10):e48039. doi: 10.1371/journal.pone.0048039. Epub 2012 Oct 24.


Butyrate increases IL-23 production by stimulated dendritic cells.

Berndt BE, Zhang M, Owyang SY, Cole TS, Wang TW, Luther J, Veniaminova NA, Merchant JL, Chen CC, Huffnagle GB, Kao JY.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1384-92. doi: 10.1152/ajpgi.00540.2011. Epub 2012 Oct 18.


Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.

Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson LC, Dlugosz AA.

Am J Pathol. 2012 Dec;181(6):2114-25. doi: 10.1016/j.ajpath.2012.08.017. Epub 2012 Oct 1.


Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.

Veniaminova NA, Hayes MM, Varney JM, Merchant JL.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G752-64. doi: 10.1152/ajpgi.00109.2012. Epub 2012 Jul 5.


IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice.

Liu Z, Demitrack ES, Keeley TM, Eaton KA, El-Zaatari M, Merchant JL, Samuelson LC.

Lab Invest. 2012 Jul;92(7):1045-57. doi: 10.1038/labinvest.2012.73. Epub 2012 Apr 23.


A high-fat diet regulates gastrin and acid secretion through primary cilia.

Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL.

FASEB J. 2012 Aug;26(8):3127-39. doi: 10.1096/fj.11-197426. Epub 2012 Apr 18.


Plasma Shh levels reduced in pancreatic cancer patients.

El-Zaatari M, Daignault S, Tessier A, Kelsey G, Travnikar LA, Cantu EF, Lee J, Plonka CM, Simeone DM, Anderson MA, Merchant JL.

Pancreas. 2012 Oct;41(7):1019-28. doi: 10.1097/MPA.0b013e31824a0eeb.


The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M.

Nature. 2012 Feb 12;482(7386):542-6. doi: 10.1038/nature10806.


Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.

Zhang CZ, Chen GG, Merchant JL, Lai PB.

Cell Cycle. 2012 Jan 15;11(2):322-34. doi: 10.4161/cc.11.2.18758. Epub 2012 Jan 15.


Hedgehog signalling in gut development, physiology and cancer.

Merchant JL.

J Physiol. 2012 Feb 1;590(3):421-32. doi: 10.1113/jphysiol.2011.220681. Epub 2011 Dec 5. Review.


Menin and JunD regulate gastrin gene expression through proximal DNA elements.

Mensah-Osman EJ, Veniaminova NA, Merchant JL.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G783-90. doi: 10.1152/ajpgi.00160.2011. Epub 2011 Aug 18.


Gastric tuft cells express DCLK1 and are expanded in hyperplasia.

Saqui-Salces M, Keeley TM, Grosse AS, Qiao XT, El-Zaatari M, Gumucio DL, Samuelson LC, Merchant JL.

Histochem Cell Biol. 2011 Aug;136(2):191-204. doi: 10.1007/s00418-011-0831-1. Epub 2011 Jun 18.


Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis.

Zavros Y, Mesiwala N, Waghray M, Todisco A, Shulkes A, Merchant JL.

World J Gastrointest Pathophysiol. 2010 Dec 15;1(5):154-65. doi: 10.4291/wjgp.v1.i5.154.


Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements.

Tucker TP, Gray BM, Eaton KA, Merchant JL.

Helicobacter. 2010 Oct;15(5):438-48. doi: 10.1111/j.1523-5378.2010.00787.x.


Hedgehog signaling in gastric physiology and cancer.

Merchant JL, Saqui-Salces M, El-Zaatari M.

Prog Mol Biol Transl Sci. 2010;96:133-56. doi: 10.1016/B978-0-12-381280-3.00006-3. Review.


ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells.

To AK, Chen GG, Chan UP, Ye C, Yun JP, Ho RL, Tessier A, Merchant JL, Lai PB.

Biochim Biophys Acta. 2011 Jan;1813(1):222-30. doi: 10.1016/j.bbamcr.2010.09.005. Epub 2010 Sep 17.


Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice.

Shinohara M, Mao M, Keeley TM, El-Zaatari M, Lee HJ, Eaton KA, Samuelson LC, Merchant JL, Goldenring JR, Todisco A.

Gastroenterology. 2010 Dec;139(6):2050-2060.e2. doi: 10.1053/j.gastro.2010.08.052. Epub 2010 Oct 16.


Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion.

El-Zaatari M, Zavros Y, Tessier A, Waghray M, Lentz S, Gumucio D, Todisco A, Merchant JL.

Gastroenterology. 2010 Dec;139(6):2061-2071.e2. doi: 10.1053/j.gastro.2010.08.047. Epub 2010 Oct 20.


Hedgehog signaling and gastrointestinal cancer.

Saqui-Salces M, Merchant JL.

Biochim Biophys Acta. 2010 Jul;1803(7):786-95. doi: 10.1016/j.bbamcr.2010.03.008. Epub 2010 Mar 19. Review.


Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria.

Zacharias WJ, Li X, Madison BB, Kretovich K, Kao JY, Merchant JL, Gumucio DL.

Gastroenterology. 2010 Jun;138(7):2368-77, 2377.e1-4. doi: 10.1053/j.gastro.2010.02.057. Epub 2010 Mar 3.


Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe.

Merchant JL, Omary MB.

Gastroenterology. 2010 Jan;138(1):19-26.e1-3. doi: 10.1053/j.gastro.2009.11.017. Epub 2009 Nov 26.


Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog.

Waghray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram CB, Todisco A, Eaton KA, Merchant JL.

Gastroenterology. 2010 Feb;138(2):562-72, 572.e1-2. doi: 10.1053/j.gastro.2009.10.043. Epub 2009 Oct 31.

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