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Science. 2003 Aug 29;301(5637):1223-5.

Synthesis of carbenes through substitution reactions at a carbene center.

Author information

1
Laboratoire Hétérochimie Fondamentale et Appliquée [Unité Mixte de Recherche (UMR) 5069], Université Paul Sabatier, 118, route de Narbonne, F-31062 Toulouse Cedex 04, France.

Abstract

An (amino)(phosphino) carbene can be transformed into (amino)(phosphonio) carbenes, which undergo nucleophilic intermolecular as well as intramolecular substitution reactions at the carbene center. A variety of carbenes can be synthesized starting from a single carbene precursor. The resulting gamut of electronic and steric effects possible should open the way not only to a detailed study of the mechanism, but also to the subsequent improvement of catalytic reactions that involve carbene-transition metal complexes.

PMID:
12947194
DOI:
10.1126/science.1086860
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