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Items: 22


Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.

Mercer DK, Stewart CS, Miller L, Robertson J, Duncan VMS, O'Neil DA.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18. doi: 10.1128/AAC.02117-18. Print 2019 May.


Cysteamine, an Endogenous Aminothiol, and Cystamine, the Disulfide Product of Oxidation, Increase Pseudomonas aeruginosa Sensitivity to Reactive Oxygen and Nitrogen Species and Potentiate Therapeutic Antibiotics against Bacterial Infection.

Fraser-Pitt DJ, Mercer DK, Smith D, Kowalczuk A, Robertson J, Lovie E, Perenyi P, Cole M, Doumith M, Hill RLR, Hopkins KL, Woodford N, O'Neil DA.

Infect Immun. 2018 May 22;86(6). pii: e00947-17. doi: 10.1128/IAI.00947-17. Print 2018 Jun.


Correction for Mercer et al., "NP108, an Antimicrobial Polymer with Activity against Methicillin- and Mupirocin-Resistant Staphylococcus aureus".

Mercer DK, Katvars LK, Hewitt F, Smith DW, Robertson J, Munro CA, O'Neil DA.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e00114-18. doi: 10.1128/AAC.00114-18. Print 2018 Mar. No abstract available.


Keratin hydrolysis by dermatophytes.

Mercer DK, Stewart CS.

Med Mycol. 2019 Jan 1;57(1):13-22. doi: 10.1093/mmy/myx160. Review.


NP108, an Antimicrobial Polymer with Activity against Methicillin- and Mupirocin-Resistant Staphylococcus aureus.

Mercer DK, Katvars LK, Hewitt F, Smith DW, Robertson J, O'Neil DA.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00502-17. doi: 10.1128/AAC.00502-17. Print 2017 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Feb 23;62(3):.


Expression of innate immune defence genes in healthy and onychomycotic nail and stratum corneum.

Mercer DK, Sairi T, Sroka E, Lamont H, Lawrie Y, O'Neil DA.

Br J Dermatol. 2017 Jul;177(1):279-281. doi: 10.1111/bjd.15063. Epub 2017 May 31. No abstract available.


A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses.

Mercer DK, Robertson J, Wright K, Miller L, Smith S, Stewart CS, O Neil DA.

PLoS One. 2013 Nov 18;8(11):e80760. doi: 10.1371/journal.pone.0080760. eCollection 2013.


Peptides as the next generation of anti-infectives.

Mercer DK, O'Neil DA.

Future Med Chem. 2013 Mar;5(3):315-37. doi: 10.4155/fmc.12.213. Review.


Production and evaluation of an antimicrobial peptide-containing wafer formulation for topical application.

O'Driscoll NH, Labovitiadi O, Cushnie TP, Matthews KH, Mercer DK, Lamb AJ.

Curr Microbiol. 2013 Mar;66(3):271-8. doi: 10.1007/s00284-012-0268-3. Epub 2012 Nov 25.


Quantitative measurement of mature collagen cross-links in human carotid artery plaques.

Hector EE, Robins SP, Mercer DK, Brittenden J, Wainwright CL.

Atherosclerosis. 2010 Aug;211(2):471-4. doi: 10.1016/j.atherosclerosis.2010.03.028. Epub 2010 Mar 27.


Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.

Ruotsalainen H, Sipilä L, Vapola M, Sormunen R, Salo AM, Uitto L, Mercer DK, Robins SP, Risteli M, Aszodi A, Fässler R, Myllylä R.

J Cell Sci. 2006 Feb 15;119(Pt 4):625-35.


Oxidative stress in colon tissue induced by vitamin E depletion.

Drew JE, Mercer DK, Mayer C, Farquharson AJ, Morrice PC, Arthur JR, Duthie GG.

Biochem Soc Trans. 2004 Dec;32(Pt 6):979-81.


Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms.

Mercer DK, Nicol PF, Kimbembe C, Robins SP.

Biochem Biophys Res Commun. 2003 Aug 8;307(4):803-9.


Involvement of the multidomain regulatory protein XynR in positive control of xylanase gene expression in the ruminal anaerobe Prevotella bryantii B(1)4.

Miyazaki K, Miyamoto H, Mercer DK, Hirase T, Martin JC, Kojima Y, Flint HJ.

J Bacteriol. 2003 Apr;185(7):2219-26.


Transformation of an oral bacterium via chromosomal integration of free DNA in the presence of human saliva.

Mercer DK, Scott KP, Melville CM, Glover LA, Flint HJ.

FEMS Microbiol Lett. 2001 Jun 25;200(2):163-7.


Chromosomal integration of the green fluorescent protein gene in lactic acid bacteria and the survival of marked strains in human gut simulations.

Scott KP, Mercer DK, Richardson AJ, Melville CM, Glover LA, Flint HJ.

FEMS Microbiol Lett. 2000 Jan 1;182(1):23-7.


Natural genetic transformation in the rumen bacterium Streptococcus bovis JB1.

Mercer DK, Melville CM, Scott KP, Flint HJ.

FEMS Microbiol Lett. 1999 Oct 15;179(2):485-90.


Fate of free DNA and transformation of the oral bacterium Streptococcus gordonii DL1 by plasmid DNA in human saliva.

Mercer DK, Scott KP, Bruce-Johnson WA, Glover LA, Flint HJ.

Appl Environ Microbiol. 1999 Jan;65(1):6-10.


Screening actinomycetes for extracellular peroxidase activity.

Mercer DK, Iqbal M, Miller P, McCarthy AJ.

Appl Environ Microbiol. 1996 Jun;62(6):2186-90.


Novel bioactive compounds from actinomycetes.

Sanglier JJ, Wellington EM, Behal V, Fiedler HP, Ellouz Ghorbel R, Finance C, Hacene M, Kamoun A, Kelly C, Mercer DK, et al.

Res Microbiol. 1993 Oct;144(8):661-3. Review.


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