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Items: 1 to 50 of 97

1.

Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity.

Sharif S, Ueda N, Nakatani Y, Wise LM, Clifton S, Lateef Z, Mercer AA, Fleming SB.

Front Microbiol. 2019 Jun 25;10:1421. doi: 10.3389/fmicb.2019.01421. eCollection 2019.

2.

VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury.

Wise LM, Stuart GS, Real NC, Fleming SB, Mercer AA.

Adv Wound Care (New Rochelle). 2018 Aug 1;7(8):283-297. doi: 10.1089/wound.2016.0721.

3.

Treatment of limb wounds of horses with orf virus IL-10 and VEGF-E accelerates resolution of exuberant granulation tissue, but does not prevent its development.

Wise LM, Bodaan CJ, Stuart GS, Real NC, Lateef Z, Mercer AA, Riley CB, Theoret CL.

PLoS One. 2018 May 15;13(5):e0197223. doi: 10.1371/journal.pone.0197223. eCollection 2018.

4.

Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep.

Fleming SB, McCaughan C, Lateef Z, Dunn A, Wise LM, Real NC, Mercer AA.

Front Microbiol. 2017 Jan 24;8:46. doi: 10.3389/fmicb.2017.00046. eCollection 2017.

5.

A Broad-Spectrum Chemokine-Binding Protein of Bovine Papular Stomatitis Virus Inhibits Neutrophil and Monocyte Infiltration in Inflammatory and Wound Models of Mouse Skin.

Sharif S, Nakatani Y, Wise L, Corbett M, Real NC, Stuart GS, Lateef Z, Krause K, Mercer AA, Fleming SB.

PLoS One. 2016 Dec 9;11(12):e0168007. doi: 10.1371/journal.pone.0168007. eCollection 2016.

6.

Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway.

Chen DY, Fabrizio JA, Wilkins SE, Dave KA, Gorman JJ, Gleadle JM, Fleming SB, Peet DJ, Mercer AA.

J Virol. 2016 Dec 16;91(1). pii: e01430-16. doi: 10.1128/JVI.01430-16. Print 2017 Jan 1.

7.

Short-term treatment of equine wounds with orf virus IL-10 and VEGF-E dampens inflammation and promotes repair processes without accelerating closure.

Bodaan CJ, Wise LM, Wakelin KA, Stuart GS, Real NC, Mercer AA, Riley CB, Theoret C.

Wound Repair Regen. 2016 Nov;24(6):966-980. doi: 10.1111/wrr.12488. Epub 2016 Oct 18.

PMID:
27681311
8.

Orf virus interleukin-10 and vascular endothelial growth factor-E modulate gene expression in cultured equine dermal fibroblasts.

Wise LM, Bodaan CJ, Mercer AA, Riley CB, Theoret CL.

Vet Dermatol. 2016 Oct;27(5):434-e114. doi: 10.1111/vde.12370. Epub 2016 Aug 22.

PMID:
27550846
9.

Sex differences in cerebellar synaptic transmission and sex-specific responses to autism-linked Gabrb3 mutations in mice.

Mercer AA, Palarz KJ, Tabatadze N, Woolley CS, Raman IM.

Elife. 2016 Apr 14;5. pii: e07596. doi: 10.7554/eLife.07596.

10.

Orf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin.

Bennett JR, Lateef Z, Fleming SB, Mercer AA, Wise LM.

Virus Res. 2016 Feb 2;213:230-237. doi: 10.1016/j.virusres.2015.12.015. Epub 2015 Dec 28.

PMID:
26732486
11.

Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway.

Harvey R, McCaughan C, Wise LM, Mercer AA, Fleming SB.

Virus Res. 2015 Oct 2;208:180-8. doi: 10.1016/j.virusres.2015.06.014. Epub 2015 Jun 22.

PMID:
26113305
12.

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.

Couñago RM, Knapp KM, Nakatani Y, Fleming SB, Corbett M, Wise LM, Mercer AA, Krause KL.

Structure. 2015 Jul 7;23(7):1199-213. doi: 10.1016/j.str.2015.04.023. Epub 2015 Jun 18.

13.

Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin.

Fleming SB, Wise LM, Mercer AA.

Viruses. 2015 Mar 23;7(3):1505-39. doi: 10.3390/v7031505. Review.

14.

Poxviral ankyrin proteins.

Herbert MH, Squire CJ, Mercer AA.

Viruses. 2015 Feb 16;7(2):709-38. doi: 10.3390/v7020709. Review.

15.

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

Lee S, Chu HX, Kim HA, Real NC, Sharif S, Fleming SB, Mercer AA, Wise LM, Drummond GR, Sobey CG.

Stroke. 2015 Feb;46(2):537-44. doi: 10.1161/STROKEAHA.114.007298. Epub 2014 Dec 23.

PMID:
25538201
16.

Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring.

Wise LM, Stuart GS, Real NC, Fleming SB, Mercer AA.

Wound Repair Regen. 2014 May-Jun;22(3):356-67. doi: 10.1111/wrr.12169.

PMID:
24844335
17.

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.

Paulsen D, Urban A, Knorr A, Hirth-Dietrich C, Siegling A, Volk HD, Mercer AA, Limmer A, Schumak B, Knolle P, Ruebsamen-Schaeff H, Weber O.

PLoS One. 2013 Sep 16;8(9):e74605. doi: 10.1371/journal.pone.0074605. eCollection 2013.

18.

Persistent pseudocowpox virus infection of the skin of a foot in a cat.

Fairley RA, Mercer AA, Copland CI, Craig SM, Heslip PA.

N Z Vet J. 2013 Jul;61(4):242-3. doi: 10.1080/00480169.2012.757728. Epub 2013 Feb 28. No abstract available.

PMID:
23444961
19.

Therapeutic immunomodulation using a virus--the potential of inactivated orf virus.

Weber O, Mercer AA, Friebe A, Knolle P, Volk HD.

Eur J Clin Microbiol Infect Dis. 2013 Apr;32(4):451-60. doi: 10.1007/s10096-012-1780-x. Epub 2012 Nov 22. Review.

PMID:
23179251
20.

How viruses affect the cell cycle through manipulation of the APC/C.

Mo M, Shahar S, Fleming SB, Mercer AA.

Trends Microbiol. 2012 Sep;20(9):440-8. doi: 10.1016/j.tim.2012.05.007. Epub 2012 Jun 20. Review.

PMID:
22727131
21.

The vascular endothelial growth factor (VEGF)-E encoded by orf virus regulates keratinocyte proliferation and migration and promotes epidermal regeneration.

Wise LM, Inder MK, Real NC, Stuart GS, Fleming SB, Mercer AA.

Cell Microbiol. 2012 Sep;14(9):1376-90. doi: 10.1111/j.1462-5822.2012.01802.x. Epub 2012 May 15.

PMID:
22507661
22.

Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus.

Dutton S, Fleming SB, Ueda N, Heath DD, Hibma MH, Mercer AA.

Parasite Immunol. 2012 Jun;34(6):312-7. doi: 10.1111/j.1365-3024.2012.01360.x.

23.

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

Rintoul JL, Lemay CG, Tai LH, Stanford MM, Falls TJ, de Souza CT, Bridle BW, Daneshmand M, Ohashi PS, Wan Y, Lichty BD, Mercer AA, Auer RC, Atkins HL, Bell JC.

Mol Ther. 2012 Jun;20(6):1148-57. doi: 10.1038/mt.2011.301. Epub 2012 Jan 24.

24.

Development of orf virus as a bifunctional recombinant vaccine: surface display of Echinococcus granulosus antigen EG95 by fusion to membrane structural proteins.

Tan JL, Ueda N, Heath D, Mercer AA, Fleming SB.

Vaccine. 2012 Jan 5;30(2):398-406. doi: 10.1016/j.vaccine.2011.10.079. Epub 2011 Nov 12.

PMID:
22085551
25.

Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera.

Sonnberg S, Fleming SB, Mercer AA.

J Gen Virol. 2011 Nov;92(Pt 11):2596-607. doi: 10.1099/vir.0.033654-0. Epub 2011 Jul 13.

PMID:
21752962
26.

Vaccinia virus as a vaccine delivery system for marsupial wildlife.

Cross ML, Fleming SB, Cowan PE, Scobie S, Whelan E, Prada D, Mercer AA, Duckworth JA.

Vaccine. 2011 Jun 20;29(28):4537-43. doi: 10.1016/j.vaccine.2011.04.093. Epub 2011 May 12.

PMID:
21570435
27.

Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.

Mo M, Fleming SB, Mercer AA.

J Gen Virol. 2010 Dec;91(Pt 12):3010-5. doi: 10.1099/vir.0.026054-0. Epub 2010 Sep 8.

PMID:
20826619
28.

Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae).

Couñago RM, Fleming SB, Mercer AA, Krause KL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):819-23. doi: 10.1107/S1744309110018166. Epub 2010 Jun 24.

29.

Changing pace: viral mimicry of an anaphase promoting complex subunit.

Mo M, Fleming SB, Mercer AA.

Cell Cycle. 2010 Feb 15;9(4):632-3. Epub 2010 Feb 3. No abstract available.

PMID:
20107321
30.

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain.

Hautaniemi M, Ueda N, Tuimala J, Mercer AA, Lahdenperä J, McInnes CJ.

J Gen Virol. 2010 Jun;91(Pt 6):1560-76. doi: 10.1099/vir.0.018374-0. Epub 2010 Jan 27.

PMID:
20107016
31.

The chemokine-binding protein encoded by the poxvirus orf virus inhibits recruitment of dendritic cells to sites of skin inflammation and migration to peripheral lymph nodes.

Lateef Z, Baird MA, Wise LM, Young S, Mercer AA, Fleming SB.

Cell Microbiol. 2010 May 1;12(5):665-76. doi: 10.1111/j.1462-5822.2009.01425.x. Epub 2009 Dec 21.

PMID:
20039877
32.

Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11.

Mo M, Fleming SB, Mercer AA.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19527-32. doi: 10.1073/pnas.0905893106. Epub 2009 Nov 3.

33.

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.

Westphal D, Ledgerwood EC, Tyndall JD, Hibma MH, Ueda N, Fleming SB, Mercer AA.

Apoptosis. 2009 Nov;14(11):1317-30. doi: 10.1007/s10495-009-0403-1.

PMID:
19779821
34.

Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins.

Deane D, Ueda N, Wise LM, Wood AR, Percival A, Jepson C, Inglis NF, Fleming SB, Mercer AA, McInnes CJ.

J Gen Virol. 2009 Apr;90(Pt 4):970-7. doi: 10.1099/vir.0.006692-0. Epub 2009 Mar 4.

PMID:
19264672
35.

Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model.

Lateef Z, Baird MA, Wise LM, Mercer AA, Fleming SB.

J Gen Virol. 2009 Jun;90(Pt 6):1477-82. doi: 10.1099/vir.0.009589-0. Epub 2009 Mar 4.

PMID:
19264645
36.

A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex.

Sonnberg S, Fleming SB, Mercer AA.

J Gen Virol. 2009 May;90(Pt 5):1224-8. doi: 10.1099/vir.0.009324-0. Epub 2009 Mar 4.

PMID:
19264588
37.
38.

Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function.

Chang SJ, Hsiao JC, Sonnberg S, Chiang CT, Yang MH, Tzou DL, Mercer AA, Chang W.

J Virol. 2009 May;83(9):4140-52. doi: 10.1128/JVI.01835-08. Epub 2009 Feb 11.

39.

Recurrent localised cutaneous parapoxvirus infection in three cats.

Fairley RA, Whelan EM, Pesavento PA, Mercer AA.

N Z Vet J. 2008 Aug;56(4):196-201. doi: 10.1080/00480169.2008.36833.

PMID:
18690256
40.

Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes.

Sonnberg S, Seet BT, Pawson T, Fleming SB, Mercer AA.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10955-60. doi: 10.1073/pnas.0802042105. Epub 2008 Jul 30.

41.

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

Cébe-Suarez S, Grünewald FS, Jaussi R, Li X, Claesson-Welsh L, Spillmann D, Mercer AA, Prota AE, Ballmer-Hofer K.

FASEB J. 2008 Aug;22(8):3078-86. doi: 10.1096/fj.08-107219. Epub 2008 May 8.

PMID:
18467594
42.

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination.

Vijaysri S, Jentarra G, Heck MC, Mercer AA, McInnes CJ, Jacobs BL.

Vaccine. 2008 Jan 30;26(5):664-76. Epub 2007 Dec 4.

43.

The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1.

Inder MK, Wise LM, Fleming SB, Mercer AA.

FEBS J. 2008 Jan;275(1):207-17. Epub 2007 Dec 11.

44.
45.

Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor.

Fleming SB, Anderson IE, Thomson J, Deane DL, McInnes CJ, McCaughan CA, Mercer AA, Haig DM.

J Gen Virol. 2007 Jul;88(Pt 7):1922-7.

PMID:
17554023
46.

Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin.

Wise LM, Savory LJ, Dryden NH, Whelan EM, Fleming SB, Mercer AA.

Virus Res. 2007 Sep;128(1-2):115-25. Epub 2007 May 23.

PMID:
17524510
47.

Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation.

Wise L, McCaughan C, Tan CK, Mercer AA, Fleming SB.

J Gen Virol. 2007 Jun;88(Pt 6):1677-82.

PMID:
17485526
48.

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus.

Westphal D, Ledgerwood EC, Hibma MH, Fleming SB, Whelan EM, Mercer AA.

J Virol. 2007 Jul;81(13):7178-88. Epub 2007 May 2.

49.

Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2.

Dillon S, Sasagawa T, Crawford A, Prestidge J, Inder MK, Jerram J, Mercer AA, Hibma M.

J Gen Virol. 2007 Mar;88(Pt 3):803-13.

PMID:
17325352
50.

Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2.

Inder MK, Ueda N, Mercer AA, Fleming SB, Wise LM.

J Gen Virol. 2007 Mar;88(Pt 3):781-91.

PMID:
17325350

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