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Items: 1 to 50 of 64

1.

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.

Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G.

Nat Struct Mol Biol. 2018 Jul;25(7):591-600. doi: 10.1038/s41594-018-0083-z. Epub 2018 Jul 2.

2.

Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

Cui G, Botuyan MV, Mer G.

J Mol Biol. 2018 Jul 6;430(14):2042-2050. doi: 10.1016/j.jmb.2018.05.017. Epub 2018 May 18.

3.

A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.

Mer G, Botuyan MV.

Structure. 2017 Oct 3;25(10):1471-1472. doi: 10.1016/j.str.2017.09.011. Epub 2017 Oct 3.

4.

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18.

Hu Q, Botuyan MV, Cui G, Zhao D, Mer G.

Mol Cell. 2017 May 18;66(4):473-487.e9. doi: 10.1016/j.molcel.2017.04.009. Epub 2017 May 11.

5.

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D.

Nature. 2017 Mar 9;543(7644):211-216. doi: 10.1038/nature21358. Epub 2017 Feb 27.

6.

Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy.

Valieva ME, Gerasimova NS, Kudryashova KS, Kozlova AL, Kirpichnikov MP, Hu Q, Botuyan MV, Mer G, Feofanov AV, Studitsky VM.

Cancers (Basel). 2017 Jan 6;9(1). pii: E3. doi: 10.3390/cancers9010003.

7.

Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.

Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJ, Dyck PJ, Mauermann ML.

Ann Neurol. 2017 Feb;81(2):316-321. doi: 10.1002/ana.24854. Epub 2017 Jan 28.

8.

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.

Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG.

Cell Rep. 2016 Oct 18;17(4):1158-1170. doi: 10.1016/j.celrep.2016.09.056.

9.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

10.

[Bone-based anchorage failure].

Mer G, Brezulier D, Sorel O.

Orthod Fr. 2016 Mar;87(1):67-76. doi: 10.1051/orthodfr/2015038. Epub 2016 Apr 15. Review. French.

PMID:
27083224
11.

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.

Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ.

Brain. 2015 Apr;138(Pt 4):845-61. doi: 10.1093/brain/awv010. Epub 2015 Feb 11.

12.

An acetyl-methyl switch drives a conformational change in p53.

Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG.

Structure. 2015 Feb 3;23(2):322-31. doi: 10.1016/j.str.2014.12.010.

13.

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV.

ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28.

14.

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.

Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG.

Structure. 2015 Feb 3;23(2):312-21. doi: 10.1016/j.str.2014.11.013. Epub 2015 Jan 8.

15.

Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons.

Klein CJ, Wu Y, Vogel P, Goebel HH, Bönnemann C, Zukosky K, Botuyan MV, Duan X, Middha S, Atkinson EJ, Mer G, Dyck PJ.

Neurology. 2014 Mar 11;82(10):873-8. doi: 10.1212/WNL.0000000000000206. Epub 2014 Feb 5.

16.

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.

Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA.

Nat Struct Mol Biol. 2013 Mar;20(3):317-25. doi: 10.1038/nsmb.2499. Epub 2013 Feb 3.

17.

DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.

Klein CJ, Bird T, Ertekin-Taner N, Lincoln S, Hjorth R, Wu Y, Kwok J, Mer G, Dyck PJ, Nicholson GA.

Neurology. 2013 Feb 26;80(9):824-8. doi: 10.1212/WNL.0b013e318284076d. Epub 2013 Jan 30.

18.

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

Ramachandran PL, Craig TA, Atanasova EA, Cui G, Owen BA, Bergen HR 3rd, Mer G, Kumar R.

J Biol Chem. 2012 Nov 16;287(47):39439-48. doi: 10.1074/jbc.M112.398495. Epub 2012 Sep 27.

19.

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.

Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6. doi: 10.1073/pnas.1212366109. Epub 2012 Aug 20.

20.

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.

Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G.

Nat Struct Mol Biol. 2012 Sep;19(9):916-24. doi: 10.1038/nsmb.2353. Epub 2012 Aug 5.

21.

(1)H, (15)N and (13)C resonance assignments for the three LOTUS RNA binding domains of Tudor domain-containing protein TDRD7.

Cui G, Botuyan MV, Mer G.

Biomol NMR Assign. 2013 Apr;7(1):79-83. doi: 10.1007/s12104-012-9382-1. Epub 2012 Apr 6.

22.

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S.

EMBO J. 2012 Apr 18;31(8):1865-78. doi: 10.1038/emboj.2012.47. Epub 2012 Feb 28.

23.

Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers.

Fazly A, Li Q, Hu Q, Mer G, Horazdovsky B, Zhang Z.

J Biol Chem. 2012 Mar 30;287(14):10753-60. doi: 10.1074/jbc.M112.347450. Epub 2012 Feb 15.

24.

Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.

Su D, Hu Q, Li Q, Thompson JR, Cui G, Fazly A, Davies BA, Botuyan MV, Zhang Z, Mer G.

Nature. 2012 Feb 5;483(7387):104-7. doi: 10.1038/nature10861.

25.

Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.

Singh N, Wiltshire TD, Thompson JR, Mer G, Couch FJ.

J Biol Chem. 2012 Jan 20;287(4):2854-62. doi: 10.1074/jbc.M111.307868. Epub 2011 Dec 2.

26.

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.

Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J.

EMBO J. 2011 Jun 17;30(14):2829-42. doi: 10.1038/emboj.2011.193.

27.

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.

Klein CJ, Botuyan MV, Wu Y, Ward CJ, Nicholson GA, Hammans S, Hojo K, Yamanishi H, Karpf AR, Wallace DC, Simon M, Lander C, Boardman LA, Cunningham JM, Smith GE, Litchy WJ, Boes B, Atkinson EJ, Middha S, B Dyck PJ, Parisi JE, Mer G, Smith DI, Dyck PJ.

Nat Genet. 2011 Jun;43(6):595-600. doi: 10.1038/ng.830. Epub 2011 May 1.

28.

Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex.

Su D, Hu Q, Zhou H, Thompson JR, Xu RM, Zhang Z, Mer G.

J Biol Chem. 2011 May 6;286(18):15625-9. doi: 10.1074/jbc.C111.220715. Epub 2011 Mar 22.

29.

Structural basis of ubiquitin recognition by translesion synthesis DNA polymerase ι.

Cui G, Benirschke RC, Tuan HF, Juranić N, Macura S, Botuyan MV, Mer G.

Biochemistry. 2010 Nov 30;49(47):10198-207. doi: 10.1021/bi101303t. Epub 2010 Nov 4.

30.

Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.

Benirschke RC, Thompson JR, Nominé Y, Wasielewski E, Juranić N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G.

Structure. 2010 Aug 11;18(8):955-65. doi: 10.1016/j.str.2010.04.017.

31.

Heme-based sensing by the mammalian circadian protein CLOCK.

Lukat-Rodgers GS, Correia C, Botuyan MV, Mer G, Rodgers KR.

Inorg Chem. 2010 Jul 19;49(14):6349-65. doi: 10.1021/ic902388q.

32.

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.

Chadli A, Felts SJ, Wang Q, Sullivan WP, Botuyan MV, Fauq A, Ramirez-Alvarado M, Mer G.

J Biol Chem. 2010 Feb 5;285(6):4224-31. doi: 10.1074/jbc.M109.081018. Epub 2009 Dec 8.

33.

Preparation of recombinant peptides with site- and degree-specific lysine (13)C-methylation.

Cui G, Botuyan MV, Mer G.

Biochemistry. 2009 May 12;48(18):3798-800. doi: 10.1021/bi900348z.

34.

Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S.

Xu C, Cui G, Botuyan MV, Mer G.

Structure. 2008 Nov 12;16(11):1740-50. doi: 10.1016/j.str.2008.08.008. Epub 2008 Sep 25.

35.

Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.

Nominé Y, Botuyan MV, Bajzer Z, Owen WG, Caride AJ, Wasielewski E, Mer G.

Biochemistry. 2008 Sep 16;47(37):9866-79. doi: 10.1021/bi702247d. Epub 2008 Aug 22.

36.

Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.

Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G.

J Mol Biol. 2008 Aug 29;381(2):361-72. doi: 10.1016/j.jmb.2008.05.087. Epub 2008 Jun 14.

37.

Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity.

Park S, Lim BB, Perez-Terzic C, Mer G, Terzic A.

J Proteome Res. 2008 Apr;7(4):1721-8. doi: 10.1021/pr7007847. Epub 2008 Mar 1.

38.

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.

Lee J, Thompson JR, Botuyan MV, Mer G.

Nat Struct Mol Biol. 2008 Jan;15(1):109-11. Epub 2007 Dec 16.

39.

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.

Wood JL, Singh N, Mer G, Chen J.

J Biol Chem. 2007 Nov 30;282(48):35416-23. Epub 2007 Oct 9.

40.

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G.

Cell. 2006 Dec 29;127(7):1361-73.

41.

The tandem BRCT domain of 53BP1 is not required for its repair function.

Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J.

J Biol Chem. 2006 Dec 15;281(50):38472-7. Epub 2006 Oct 16.

42.

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop.

Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM.

Mol Pharmacol. 2006 Oct;70(4):1230-5. Epub 2006 Jul 17.

PMID:
16847142
43.

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.

Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G.

Structure. 2004 Jul;12(7):1137-46.

44.

The BRCT domain is a phospho-protein binding domain.

Yu X, Chini CC, He M, Mer G, Chen J.

Science. 2003 Oct 24;302(5645):639-42.

45.

Three-dimensional structure and function of replication protein A.

Mer G, Bochkarev A, Chazin WJ, Edwards AM.

Cold Spring Harb Symp Quant Biol. 2000;65:193-200. Review. No abstract available.

PMID:
12760033
46.

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.

Botuyan MV, Mer G, Yi GS, Koth CM, Case DA, Edwards AM, Chazin WJ, Arrowsmith CH.

J Mol Biol. 2001 Sep 7;312(1):177-86.

PMID:
11545595
47.

Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.

Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ, Edwards AM, Chazin WJ.

Cell. 2000 Oct 27;103(3):449-56.

48.

1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32 kDa subunit of human replication protein A.

Mer G, Edwards AM, Chazin WJ.

J Biomol NMR. 2000 Jun;17(2):179-80. No abstract available.

PMID:
10921783
49.

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C.

Botuyan MV, Koth CM, Mer G, Chakrabartty A, Conaway JW, Conaway RC, Edwards AM, Arrowsmith CH, Chazin WJ.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9033-8.

50.

Solution structure of a conformationally constrained Arg-Gly-Asp-like motif inserted into the alpha/beta scaffold of leiurotoxin I.

Kellenberger E, Mer G, Kellenberger C, Marguerie G, Lefèvre JF.

Eur J Biochem. 1999 Mar;260(3):810-7.

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