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Items: 12

1.

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.

Sollberger G, Choidas A, Burn GL, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Krüger R, Herzig A, Zychlinsky A.

Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. doi: 10.1126/sciimmunol.aar6689.

PMID:
30143555
2.

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Engel J, Richters A, Getlik M, Tomassi S, Keul M, Termathe M, Lategahn J, Becker C, Mayer-Wrangowski S, Grütter C, Uhlenbrock N, Krüll J, Schaumann N, Eppmann S, Kibies P, Hoffgaard F, Heil J, Menninger S, Ortiz-Cuaran S, Heuckmann JM, Tinnefeld V, Zahedi RP, Sos ML, Schultz-Fademrecht C, Thomas RK, Kast SM, Rauh D.

J Med Chem. 2015 Sep 10;58(17):6844-63. doi: 10.1021/acs.jmedchem.5b01082. Epub 2015 Aug 31.

PMID:
26275028
3.

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM.

Nature. 2014 Mar 27;507(7493):508-12. doi: 10.1038/nature12998. Epub 2014 Feb 19.

4.

Development of selective, potent RabGGTase inhibitors.

Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS.

J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s. Epub 2012 Oct 3.

PMID:
22963166
5.

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW.

J Am Chem Soc. 2012 May 2;134(17):7384-91. doi: 10.1021/ja211305j. Epub 2012 Apr 22.

PMID:
22480322
6.

Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.

Tóth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IA, Hübel K, Hussey PJ, Waldmann H, Coupland G.

Plant J. 2012 Jul;71(2):338-52. doi: 10.1111/j.1365-313X.2012.04991.x. Epub 2012 Jun 28.

7.

Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, Kumar K, Waldmann H.

Nat Chem Biol. 2011 Dec 25;8(2):179-84. doi: 10.1038/nchembio.758.

PMID:
22198731
8.

Structure-guided development of selective RabGGTase inhibitors.

Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H.

Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi: 10.1002/anie.201101210. Epub 2011 Apr 21. No abstract available.

PMID:
21520375
9.

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H.

Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25.

PMID:
20418879
10.

Total synthesis of chondramide C and its binding mode to F-actin.

Waldmann H, Hu TS, Renner S, Menninger S, Tannert R, Oda T, Arndt HD.

Angew Chem Int Ed Engl. 2008;47(34):6473-7. doi: 10.1002/anie.200801010. No abstract available.

PMID:
18624308
11.

Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus.

Schäfer A, Flierl U, Vogt C, Menninger S, Tas P, Ertl G, Bauersachs J.

Pharmacol Res. 2007 Sep;56(3):217-23. Epub 2007 Jun 19.

PMID:
17669665
12.

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.

Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H.

Chem Biol. 2007 Apr;14(4):443-51.

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