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A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons.

Chen DM, Ziolkowski L, Benz A, Qian M, Zorumski CF, Covey DF, Mennerick S.

Front Neurosci. 2018 Dec 6;12:923. doi: 10.3389/fnins.2018.00923. eCollection 2018.


Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization.

Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S.

Neuropharmacology. 2019 Jan;144:91-103. doi: 10.1016/j.neuropharm.2018.10.015. Epub 2018 Oct 15.


Chemogenetic Isolation Reveals Synaptic Contribution of δ GABAA Receptors in Mouse Dentate Granule Neurons.

Sun MY, Shu HJ, Benz A, Bracamontes J, Akk G, Zorumski CF, Steinbach JH, Mennerick SJ.

J Neurosci. 2018 Sep 19;38(38):8128-8145. doi: 10.1523/JNEUROSCI.0799-18.2018. Epub 2018 Aug 3.


Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.

Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G.

Sci Rep. 2018 Jul 9;8(1):10341. doi: 10.1038/s41598-018-28754-7.


Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation.

Sobieski C, Warikoo N, Shu HJ, Mennerick S.

PLoS One. 2018 Apr 4;13(4):e0195520. doi: 10.1371/journal.pone.0195520. eCollection 2018.


Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis.

Warikoo N, Brunwasser SJ, Benz A, Shu HJ, Paul SM, Lewis M, Doherty J, Quirk M, Piccio L, Zorumski CF, Day GS, Mennerick S.

J Neurosci. 2018 Mar 28;38(13):3218-3229. doi: 10.1523/JNEUROSCI.3377-17.2018. Epub 2018 Feb 23.


Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA.

Sun MY, Chisari M, Eisenman LN, Zorumski CF, Mennerick SJ.

J Neurophysiol. 2017 Jul 1;118(1):532-543. doi: 10.1152/jn.00106.2017. Epub 2017 Mar 29.


24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation.

Sun MY, Taylor A, Zorumski CF, Mennerick S.

PLoS One. 2017 Mar 27;12(3):e0174416. doi: 10.1371/journal.pone.0174416. eCollection 2017.


Differential Presynaptic ATP Supply for Basal and High-Demand Transmission.

Sobieski C, Fitzpatrick MJ, Mennerick SJ.

J Neurosci. 2017 Feb 15;37(7):1888-1899. doi: 10.1523/JNEUROSCI.2712-16.2017. Epub 2017 Jan 16.


A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.

Emnett C, Li H, Jiang X, Benz A, Boggiano J, Conyers S, Wozniak DF, Zorumski CF, Reichert DE, Mennerick S.

Sci Rep. 2016 Dec 16;6:38808. doi: 10.1038/srep38808.


Ketamine: NMDA Receptors and Beyond.

Zorumski CF, Izumi Y, Mennerick S.

J Neurosci. 2016 Nov 2;36(44):11158-11164.


Correcting mitochondrial fusion by manipulating mitofusin conformations.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II.

Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24.


A complement-microglial axis drives synapse loss during virus-induced memory impairment.

Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS.

Nature. 2016 Jun 23;534(7608):538-43. doi: 10.1038/nature18283.


A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition.

Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S.

Neuropharmacology. 2016 Sep;108:193-206. doi: 10.1016/j.neuropharm.2016.04.031. Epub 2016 Apr 22.


Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.

Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G.

Mol Pharmacol. 2016 Apr;89(4):399-406. doi: 10.1124/mol.115.102202. Epub 2016 Jan 14.


Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.

Sun MY, Izumi Y, Benz A, Zorumski CF, Mennerick S.

J Neurophysiol. 2016 Mar;115(3):1263-72. doi: 10.1152/jn.00890.2015. Epub 2015 Dec 23.


Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.

Zorumski CF, Nagele P, Mennerick S, Conway CR.

Front Psychiatry. 2015 Dec 9;6:172. doi: 10.3389/fpsyt.2015.00172. eCollection 2015. Review.


Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.

Sobieski C, Jiang X, Crawford DC, Mennerick S.

J Neurosci. 2015 Aug 5;35(31):11105-17. doi: 10.1523/JNEUROSCI.1289-15.2015.


Quantification of bursting and synchrony in cultured hippocampal neurons.

Eisenman LN, Emnett CM, Mohan J, Zorumski CF, Mennerick S.

J Neurophysiol. 2015 Aug;114(2):1059-71. doi: 10.1152/jn.00079.2015. Epub 2015 Jun 3.


24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.

Sun MY, Linsenbardt AJ, Emnett CM, Eisenman LN, Izumi Y, Zorumski CF, Mennerick S.

Neuroscientist. 2016 Apr;22(2):132-44. doi: 10.1177/1073858414568122. Epub 2015 Jan 27. Review.


Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.

Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S.

Br J Pharmacol. 2015 Mar;172(5):1333-47. doi: 10.1111/bph.13007. Epub 2015 Jan 13.


γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type.

Eaton MM, Bracamontes J, Shu HJ, Li P, Mennerick S, Steinbach JH, Akk G.

Mol Pharmacol. 2014 Dec;86(6):647-56. doi: 10.1124/mol.114.094813. Epub 2014 Sep 19.


Fast phasic release properties of dopamine studied with a channel biosensor.

Kress GJ, Shu HJ, Yu A, Taylor A, Benz A, Harmon S, Mennerick S.

J Neurosci. 2014 Aug 27;34(35):11792-802. doi: 10.1523/JNEUROSCI.2355-14.2014.


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.

Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G.

Br J Pharmacol. 2014 Dec;171(23):5446-57. doi: 10.1111/bph.12861.


Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.

Neuropharmacology. 2014 Oct;85:232-42. doi: 10.1016/j.neuropharm.2014.05.027. Epub 2014 May 27.


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS.

Psychopharmacology (Berl). 2014 Sep;231(17):3479-91. doi: 10.1007/s00213-014-3568-4. Epub 2014 Apr 23.


Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.

Mennerick S, Taylor AA, Zorumski CF.

Psychopharmacology (Berl). 2014 Sep;231(17):3493-501. doi: 10.1007/s00213-014-3486-5. Epub 2014 Feb 20.


Acute and chronic effects of ethanol on learning-related synaptic plasticity.

Zorumski CF, Mennerick S, Izumi Y.

Alcohol. 2014 Feb;48(1):1-17. doi: 10.1016/j.alcohol.2013.09.045. Epub 2013 Dec 16. Review.


A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation.

Jia L, Chisari M, Maktabi MH, Sobieski C, Zhou H, Konopko AM, Martin BR, Mennerick SJ, Blumer KJ.

J Biol Chem. 2014 Feb 28;289(9):6249-57. doi: 10.1074/jbc.M113.531475. Epub 2014 Jan 2.


Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2014 Jan 9;57(1):171-90. doi: 10.1021/jm401577c. Epub 2013 Dec 24.


The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.

Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF.

J Neurosci. 2013 Oct 30;33(44):17290-300. doi: 10.1523/JNEUROSCI.2619-13.2013.


Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine.

Emnett CM, Eisenman LN, Taylor AM, Izumi Y, Zorumski CF, Mennerick S.

Mol Pharmacol. 2013 Dec;84(6):935-47. doi: 10.1124/mol.113.089334. Epub 2013 Oct 7.


Detection of submillisecond spike timing differences based on delay-line anticoincidence detection.

Lyons-Warren AM, Kohashi T, Mennerick S, Carlson BA.

J Neurophysiol. 2013 Nov;110(10):2295-311. doi: 10.1152/jn.00444.2013. Epub 2013 Aug 21.


Retrograde fluorescent labeling allows for targeted extracellular single-unit recording from identified neurons in vivo.

Lyons-Warren AM, Kohashi T, Mennerick S, Carlson BA.

J Vis Exp. 2013 Jun 26;(76). doi: 10.3791/3921.


Neurosteroids as therapeutic leads in psychiatry.

Zorumski CF, Mennerick S.

JAMA Psychiatry. 2013 Jul;70(7):659-60. doi: 10.1001/jamapsychiatry.2013.245. No abstract available.


Differential requirement for protein synthesis in presynaptic unmuting and muting in hippocampal glutamate terminals.

Crawford DC, Jiang X, Taylor A, Moulder KL, Mennerick S.

PLoS One. 2012;7(12):e51930. doi: 10.1371/journal.pone.0051930. Epub 2012 Dec 13.


GIRK channel modulation by assembly with allosterically regulated RGS proteins.

Zhou H, Chisari M, Raehal KM, Kaltenbronn KM, Bohn LM, Mennerick SJ, Blumer KJ.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19977-82. doi: 10.1073/pnas.1214337109. Epub 2012 Nov 19.


Noncompetitive, voltage-dependent NMDA receptor antagonism by hydrophobic anions.

Linsenbardt AJ, Chisari M, Yu A, Shu HJ, Zorumski CF, Mennerick S.

Mol Pharmacol. 2013 Feb;83(2):354-66. doi: 10.1124/mol.112.081794. Epub 2012 Nov 9.


Neurosteroids, stress and depression: potential therapeutic opportunities.

Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S.

Neurosci Biobehav Rev. 2013 Jan;37(1):109-22. doi: 10.1016/j.neubiorev.2012.10.005. Epub 2012 Oct 17. Review.


Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.

Crawford DC, Jiang X, Taylor A, Mennerick S.

J Neurosci. 2012 Sep 19;32(38):13100-10.


Synaptic NMDA receptors mediate hypoxic excitotoxic death.

Wroge CM, Hogins J, Eisenman L, Mennerick S.

J Neurosci. 2012 May 9;32(19):6732-42. doi: 10.1523/JNEUROSCI.6371-11.2012.


Cross talk between synaptic receptors mediates NMDA-induced suppression of inhibition.

Chisari M, Zorumski CF, Mennerick S.

J Neurophysiol. 2012 May;107(9):2532-40. doi: 10.1152/jn.01145.2011. Epub 2012 Jan 25.


Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.

Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2012 Feb 9;55(3):1334-45. doi: 10.1021/jm2014925. Epub 2012 Jan 18.


Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.

Verghese PB, Sasaki Y, Yang D, Stewart F, Sabar F, Finn MB, Wroge CM, Mennerick S, Neil JJ, Milbrandt J, Holtzman DM.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19054-9. doi: 10.1073/pnas.1107325108. Epub 2011 Nov 4.


Excitotoxicity triggered by Neurobasal culture medium.

Hogins J, Crawford DC, Zorumski CF, Mennerick S.

PLoS One. 2011;6(9):e25633. doi: 10.1371/journal.pone.0025633. Epub 2011 Sep 28.


Input-output: The Role of Undergraduate Curriculum in Successful Graduate Training in the Neurosciences.

Mennerick S.

J Undergrad Neurosci Educ. 2011 Oct 15;10(1):E2-6. Print 2011 Fall.


Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S.

Br J Pharmacol. 2012 Apr;165(7):2228-43. doi: 10.1111/j.1476-5381.2011.01690.x.


Presynaptically silent synapses: dormancy and awakening of presynaptic vesicle release.

Crawford DC, Mennerick S.

Neuroscientist. 2012 Jun;18(3):216-23. doi: 10.1177/1073858411418525. Epub 2011 Sep 9. Review.


Don't curse the darkness, light a candle: fluorescence studies of axon excitability.

Mennerick S.

J Physiol. 2011 Sep 1;589(17):4087. doi: 10.1113/jphysiol.2011.214916. No abstract available.


Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults.

Hogins J, Crawford DC, Jiang X, Mennerick S.

Neurobiol Dis. 2011 Aug;43(2):516-25. doi: 10.1016/j.nbd.2011.05.005. Epub 2011 May 14.

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