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Impact of FiuA Outer Membrane Receptor Polymorphism on the Resistance of Pseudomonas aeruginosa toward Peptidoglycan Lipid II-Targeting PaeM Pyocins.

Latino L, Patin D, Chérier D, Touzé T, Pourcel C, Barreteau H, Mengin-Lecreulx D.

J Bacteriol. 2019 Jun 10;201(13). pii: e00164-19. doi: 10.1128/JB.00164-19. Print 2019 Jul 1.


The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis.

Laddomada F, Miyachiro MM, Jessop M, Patin D, Job V, Mengin-Lecreulx D, Le Roy A, Ebel C, Breyton C, Gutsche I, Dessen A.

Sci Rep. 2019 Mar 15;9(1):4656. doi: 10.1038/s41598-019-40966-z.


Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation.

Maire J, Vincent-Monégat C, Balmand S, Vallier A, Hervé M, Masson F, Parisot N, Vigneron A, Anselme C, Perrin J, Orlans J, Rahioui I, Da Silva P, Fauvarque MO, Mengin-Lecreulx D, Zaidman-Rémy A, Heddi A.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5623-5632. doi: 10.1073/pnas.1821806116. Epub 2019 Feb 28.


Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.

Tosi T, Hoshiga F, Millership C, Singh R, Eldrid C, Patin D, Mengin-Lecreulx D, Thalassinos K, Freemont P, Gründling A.

PLoS Pathog. 2019 Jan 22;15(1):e1007537. doi: 10.1371/journal.ppat.1007537. eCollection 2019 Jan.


Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance.

Fonvielle M, Bouhss A, Hoareau C, Patin D, Mengin-Lecreulx D, Iannazzo L, Sakkas N, El Sagheer A, Brown T, Ethève-Quelquejeu M, Arthur M.

Chemistry. 2018 Oct 9;24(56):14911-14915. doi: 10.1002/chem.201802360. Epub 2018 Sep 6.


Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.

Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin D, Ethève-Quelquejeu M, Fonvielle M, Arthur M.

Chemistry. 2018 Apr 17;24(22):5743-5747. doi: 10.1002/chem.201706082. Epub 2018 Feb 21.


Dual regulation of activity and intracellular localization of the PASTA kinase PrkC during Bacillus subtilis growth.

Pompeo F, Byrne D, Mengin-Lecreulx D, Galinier A.

Sci Rep. 2018 Jan 26;8(1):1660. doi: 10.1038/s41598-018-20145-2.


Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc.

Su MY, Som N, Wu CY, Su SC, Kuo YT, Ke LC, Ho MR, Tzeng SR, Teng CH, Mengin-Lecreulx D, Reddy M, Chang CI.

Nat Commun. 2017 Nov 15;8(1):1516. doi: 10.1038/s41467-017-01697-9.


Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis.

Ghachi ME, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez JC, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F.

Cell Mol Life Sci. 2017 Jun;74(12):2319-2332. doi: 10.1007/s00018-017-2464-6. Epub 2017 Feb 6.


Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain.

Di Gregorio S, Fernandez S, Cuirolo A, Verlaine O, Amoroso A, Mengin-Lecreulx D, Famiglietti A, Joris B, Mollerach M.

Microb Drug Resist. 2017 Jan;23(1):44-50. doi: 10.1089/mdr.2016.0160. Epub 2016 Dec 19.


PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway.

Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B.

Immunity. 2016 Nov 15;45(5):1013-1023. doi: 10.1016/j.immuni.2016.10.029.


Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli.

Hugonnet JE, Mengin-Lecreulx D, Monton A, den Blaauwen T, Carbonnelle E, Veckerlé C, Brun YV, van Nieuwenhze M, Bouchier C, Tu K, Rice LB, Arthur M.

Elife. 2016 Oct 21;5. pii: e19469. doi: 10.7554/eLife.19469.


Pectocin M1 (PcaM1) Inhibits Escherichia coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression.

Chérier D, Giacomucci S, Patin D, Bouhss A, Touzé T, Blanot D, Mengin-Lecreulx D, Barreteau H.

Antibiotics (Basel). 2016 Oct 8;5(4). pii: E36.


Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes.

Fonvielle M, Sakkas N, Iannazzo L, Le Fournis C, Patin D, Mengin-Lecreulx D, El-Sagheer A, Braud E, Cardon S, Brown T, Arthur M, Etheve-Quelquejeu M.

Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13553-13557. doi: 10.1002/anie.201606843. Epub 2016 Sep 26.


Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily.

Al-Dabbagh B, Olatunji S, Crouvoisier M, El Ghachi M, Blanot D, Mengin-Lecreulx D, Bouhss A.

Biochimie. 2016 Aug;127:249-57. doi: 10.1016/j.biochi.2016.06.005. Epub 2016 Jun 14.


Identification and Partial Characterization of a Novel UDP-N-Acetylenolpyruvoylglucosamine Reductase/UDP-N-Acetylmuramate:l-Alanine Ligase Fusion Enzyme from Verrucomicrobium spinosum DSM 4136(T).

Naqvi KF, Patin D, Wheatley MS, Savka MA, Dobson RC, Gan HM, Barreteau H, Blanot D, Mengin-Lecreulx D, Hudson AO.

Front Microbiol. 2016 Mar 23;7:362. doi: 10.3389/fmicb.2016.00362. eCollection 2016.


Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae.

Patin D, Turk S, Barreteau H, Mainardi JL, Arthur M, Gobec S, Mengin-Lecreulx D, Blanot D.

Biochimie. 2016 Feb;121:209-18. doi: 10.1016/j.biochi.2015.12.006. Epub 2015 Dec 14.


Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase.

Manat G, El Ghachi M, Auger R, Baouche K, Olatunji S, Kerff F, Touzé T, Mengin-Lecreulx D, Bouhss A.

PLoS One. 2015 Nov 11;10(11):e0142870. doi: 10.1371/journal.pone.0142870. eCollection 2015.


Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains.

Xu Q, Mengin-Lecreulx D, Liu XW, Patin D, Farr CL, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA.

MBio. 2015 Sep 15;6(5):e02327-14. doi: 10.1128/mBio.02327-14.


5'-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling.

Fer MJ, Bouhss A, Patrão M, Le Corre L, Pietrancosta N, Amoroso A, Joris B, Mengin-Lecreulx D, Calvet-Vitale S, Gravier-Pelletier C.

Org Biomol Chem. 2015 Jul 14;13(26):7193-222. doi: 10.1039/c5ob00707k. Epub 2015 May 26.


In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.

Soudais C, Samassa F, Sarkis M, Le Bourhis L, Bessoles S, Blanot D, Hervé M, Schmidt F, Mengin-Lecreulx D, Lantz O.

J Immunol. 2015 May 15;194(10):4641-9. doi: 10.4049/jimmunol.1403224. Epub 2015 Apr 13.


Diaminopimelic Acid Amidation in Corynebacteriales: NEW INSIGHTS INTO THE ROLE OF LtsA IN PEPTIDOGLYCAN MODIFICATION.

Levefaudes M, Patin D, de Sousa-d'Auria C, Chami M, Blanot D, Hervé M, Arthur M, Houssin C, Mengin-Lecreulx D.

J Biol Chem. 2015 May 22;290(21):13079-94. doi: 10.1074/jbc.M115.642843. Epub 2015 Apr 6.


The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.

Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL.

Mol Microbiol. 2015 May;96(3):437-47. doi: 10.1111/mmi.12918. Epub 2015 Jan 30.


Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.

Xu Q, Mengin-Lecreulx D, Patin D, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA.

Structure. 2014 Dec 2;22(12):1799-1809. doi: 10.1016/j.str.2014.09.018. Epub 2014 Nov 20.


MurD enzymes: some recent developments.

Šink R, Barreteau H, Patin D, Mengin-Lecreulx D, Gobec S, Blanot D.

Biomol Concepts. 2013 Dec;4(6):539-56. doi: 10.1515/bmc-2013-0024. Review.


Purification and biochemical characterisation of GlmU from Yersinia pestis.

Patin D, Bayliss M, Mengin-Lecreulx D, Oyston P, Blanot D.

Arch Microbiol. 2015 Apr;197(3):371-8. doi: 10.1007/s00203-014-1065-0. Epub 2014 Nov 23.


Structural and biochemical characterization of the β-N-acetylglucosaminidase from Thermotoga maritima: toward rationalization of mechanistic knowledge in the GH73 family.

Lipski A, Hervé M, Lombard V, Nurizzo D, Mengin-Lecreulx D, Bourne Y, Vincent F.

Glycobiology. 2015 Mar;25(3):319-30. doi: 10.1093/glycob/cwu113. Epub 2014 Oct 24.


Deciphering the metabolism of undecaprenyl-phosphate: the bacterial cell-wall unit carrier at the membrane frontier.

Manat G, Roure S, Auger R, Bouhss A, Barreteau H, Mengin-Lecreulx D, Touzé T.

Microb Drug Resist. 2014 Jun;20(3):199-214. doi: 10.1089/mdr.2014.0035. Epub 2014 May 5. Review.


Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.

Das D, Hervé M, Elsliger MA, Kadam RU, Grant JC, Chiu HJ, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA.

J Bacteriol. 2013 Dec;195(24):5555-66. doi: 10.1128/JB.00900-13. Epub 2013 Oct 11.


Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI.

J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24.


Biochemical characterization of MurF from Streptococcus pneumoniae and the identification of a new MurF inhibitor through ligand-based virtual screening.

Turk S, Hrast M, Sosic I, Barreteau H, Mengin-Lecreulx D, Blanot D, Gobec S.

Acta Chim Slov. 2013;60(2):294-9.


Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21.


The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.

Ammam F, Meziane-Cherif D, Mengin-Lecreulx D, Blanot D, Patin D, Boneca IG, Courvalin P, Lambert T, Candela T.

Mol Microbiol. 2013 Aug;89(4):612-25. doi: 10.1111/mmi.12299. Epub 2013 Jul 12.


Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl).

Hervé M, Kovač A, Cardoso C, Patin D, Brus B, Barreteau H, Mengin-Lecreulx D, Gobec S, Blanot D.

Biochimie. 2013 Jun;95(6):1120-6. doi: 10.1016/j.biochi.2012.12.011. Epub 2012 Dec 25.


Efficient access to peptidyl-RNA conjugates for picomolar inhibition of non-ribosomal FemX(Wv) aminoacyl transferase.

Fonvielle M, Mellal D, Patin D, Lecerf M, Blanot D, Bouhss A, Santarem M, Mengin-Lecreulx D, Sollogoub M, Arthur M, Ethève-Quelquejeu M.

Chemistry. 2013 Jan 21;19(4):1357-63. doi: 10.1002/chem.201201999. Epub 2012 Nov 29.


Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?

Touzé T, Barreteau H, El Ghachi M, Bouhss A, Barnéoud-Arnoulet A, Patin D, Sacco E, Blanot D, Arthur M, Duché D, Lloubès R, Mengin-Lecreulx D.

Biochem Soc Trans. 2012 Dec 1;40(6):1522-7. doi: 10.1042/BST20120189.


Functional and structural characterization of PaeM, a colicin M-like bacteriocin produced by Pseudomonas aeruginosa.

Barreteau H, Tiouajni M, Graille M, Josseaume N, Bouhss A, Patin D, Blanot D, Fourgeaud M, Mainardi JL, Arthur M, van Tilbeurgh H, Mengin-Lecreulx D, Touzé T.

J Biol Chem. 2012 Oct 26;287(44):37395-405. doi: 10.1074/jbc.M112.406439. Epub 2012 Sep 12.


MpaA is a murein-tripeptide-specific zinc carboxypeptidase that functions as part of a catabolic pathway for peptidoglycan-derived peptides in γ-proteobacteria.

Maqbool A, Hervé M, Mengin-Lecreulx D, Wilkinson AJ, Thomas GH.

Biochem J. 2012 Dec 15;448(3):329-41. doi: 10.1042/BJ20121164.


MurD enzymes from different bacteria: evaluation of inhibitors.

Barreteau H, Sosič I, Turk S, Humljan J, Tomašić T, Zidar N, Hervé M, Boniface A, Peterlin-Mašič L, Kikelj D, Mengin-Lecreulx D, Gobec S, Blanot D.

Biochem Pharmacol. 2012 Sep 1;84(5):625-32. doi: 10.1016/j.bcp.2012.06.006. Epub 2012 Jun 15.


A peptidoglycan fragment triggers β-lactam resistance in Bacillus licheniformis.

Amoroso A, Boudet J, Berzigotti S, Duval V, Teller N, Mengin-Lecreulx D, Luxen A, Simorre JP, Joris B.

PLoS Pathog. 2012;8(3):e1002571. doi: 10.1371/journal.ppat.1002571. Epub 2012 Mar 15.


Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.

Barreteau H, El Ghachi M, Barnéoud-Arnoulet A, Sacco E, Touzé T, Duché D, Gérard F, Brooks M, Patin D, Bouhss A, Blanot D, van Tilbeurgh H, Arthur M, Lloubès R, Mengin-Lecreulx D.

Microb Drug Resist. 2012 Jun;18(3):222-9. doi: 10.1089/mdr.2011.0230. Epub 2012 Mar 20. Review.


Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem.

Patin D, Bostock J, Chopra I, Mengin-Lecreulx D, Blanot D.

Arch Microbiol. 2012 Jun;194(6):505-12. doi: 10.1007/s00203-011-0784-8. Epub 2012 Jan 10.


Colicin M hydrolyses branched lipids II from Gram-positive bacteria.

Patin D, Barreteau H, Auger G, Magnet S, Crouvoisier M, Bouhss A, Touzé T, Arthur M, Mengin-Lecreulx D, Blanot D.

Biochimie. 2012 Apr;94(4):985-90. doi: 10.1016/j.biochi.2011.12.019. Epub 2011 Dec 26.


Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors.

Tanino T, Al-Dabbagh B, Mengin-Lecreulx D, Bouhss A, Oyama H, Ichikawa S, Matsuda A.

J Med Chem. 2011 Dec 22;54(24):8421-39. doi: 10.1021/jm200906r. Epub 2011 Nov 15.


Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein.

Das D, Hervé M, Feuerhelm J, Farr CL, Chiu HJ, Elsliger MA, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA.

PLoS One. 2011 Mar 18;6(3):e17624. doi: 10.1371/journal.pone.0017624.


Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function.

Zaidman-Rémy A, Poidevin M, Hervé M, Welchman DP, Paredes JC, Fahlander C, Steiner H, Mengin-Lecreulx D, Lemaitre B.

PLoS One. 2011 Feb 18;6(2):e17231. doi: 10.1371/journal.pone.0017231.


X-ray structure and site-directed mutagenesis analysis of the Escherichia coli colicin M immunity protein.

Gérard F, Brooks MA, Barreteau H, Touzé T, Graille M, Bouhss A, Blanot D, van Tilbeurgh H, Mengin-Lecreulx D.

J Bacteriol. 2011 Jan;193(1):205-14. doi: 10.1128/JB.01119-10. Epub 2010 Oct 29.


The extended conformation of the 2.9-Å crystal structure of the three-PASTA domain of a Ser/Thr kinase from the human pathogen Staphylococcus aureus.

Paracuellos P, Ballandras A, Robert X, Kahn R, Hervé M, Mengin-Lecreulx D, Cozzone AJ, Duclos B, Gouet P.

J Mol Biol. 2010 Dec 17;404(5):847-58. doi: 10.1016/j.jmb.2010.10.012. Epub 2010 Oct 19.


Toxicity of the colicin M catalytic domain exported to the periplasm is FkpA independent.

Barnéoud-Arnoulet A, Barreteau H, Touzé T, Mengin-Lecreulx D, Lloubès R, Duché D.

J Bacteriol. 2010 Oct;192(19):5212-9. doi: 10.1128/JB.00431-10. Epub 2010 Jul 30.


Purification and biochemical characterization of Mur ligases from Staphylococcus aureus.

Patin D, Boniface A, Kovač A, Hervé M, Dementin S, Barreteau H, Mengin-Lecreulx D, Blanot D.

Biochimie. 2010 Dec;92(12):1793-800. doi: 10.1016/j.biochi.2010.07.009. Epub 2010 Jul 24.


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