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Items: 18


MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification.

Kwon DH, Eom GH, Ko JH, Shin S, Joung H, Choe N, Nam YS, Min HK, Kook T, Yoon S, Kang W, Kim YS, Kim HS, Choi H, Koh JT, Kim N, Ahn Y, Cho HJ, Lee IK, Park DH, Suk K, Seo SB, Wissing ER, Mendrysa SM, Nam KI, Kook H.

Nat Commun. 2016 Feb 1;7:10492. doi: 10.1038/ncomms10492.


Mutations in Lyar and p53 are synergistically lethal in female mice.

Wang G, Fulkerson CM, Malek R, Ghassemifar S, Snyder PW, Mendrysa SM.

Birth Defects Res A Clin Mol Teratol. 2012 Sep;94(9):729-37. doi: 10.1002/bdra.23048. Epub 2012 Jul 19.


MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.

Ghassemifar S, Mendrysa SM.

Neurosci Lett. 2012 Mar 28;513(1):106-10. doi: 10.1016/j.neulet.2012.02.022. Epub 2012 Feb 17.


Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.

McGowan KA, Pang WW, Bhardwaj R, Perez MG, Pluvinage JV, Glader BE, Malek R, Mendrysa SM, Weissman IL, Park CY, Barsh GS.

Blood. 2011 Sep 29;118(13):3622-33. doi: 10.1182/blood-2010-11-318584. Epub 2011 Jul 25.


p53 in the CNS: Perspectives on Development, Stem Cells, and Cancer.

Mendrysa SM, Ghassemifar S, Malek R.

Genes Cancer. 2011 Apr;2(4):431-42. doi: 10.1177/1947601911409736.


The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.

Malek R, Matta J, Taylor N, Perry ME, Mendrysa SM.

PLoS One. 2011 Mar 18;6(3):e17884. doi: 10.1371/journal.pone.0017884.


An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.

Mendrysa SM, Akagi K, Roayaei J, Lien WH, Copeland NG, Jenkins NA, Eisenman RN.

Genes Cancer. 2010 May;1(5):465-479.


Inactivation of the p53 pathway in retinoblastoma.

Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA.

Nature. 2006 Nov 2;444(7115):61-6.


Tumor suppression by p53 without accelerated aging: just enough of a good thing?

Mendrysa SM, Perry ME.

Cell Cycle. 2006 Apr;5(7):714-7. Epub 2006 Apr 1. Review.


Tumor suppression and normal aging in mice with constitutively high p53 activity.

Mendrysa SM, O'Leary KA, McElwee MK, Michalowski J, Eisenman RN, Powell DA, Perry ME.

Genes Dev. 2006 Jan 1;20(1):16-21.


The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

Cowley SM, Iritani BM, Mendrysa SM, Xu T, Cheng PF, Yada J, Liggitt HD, Eisenman RN.

Mol Cell Biol. 2005 Aug;25(16):6990-7004.


Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues.

O'Leary KA, Mendrysa SM, Vaccaro A, Perry ME.

Mol Cell Biol. 2004 Jan;24(1):186-91.


mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.

Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, Perry ME.

Mol Cell Biol. 2003 Jan;23(2):462-72.


Defects in transcription coupled repair interfere with expression of p90(MDM2) in response to ultraviolet light.

Michalowski J, Seavey SE, Mendrysa SM, Perry ME.

Oncogene. 2001 Sep 13;20(41):5856-64.


Characterization of the 5' and 3' untranslated regions in murine mdm2 mRNAs.

Mendrysa SM, McElwee MK, Perry ME.

Gene. 2001 Feb 7;264(1):139-46.


p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

Perry ME, Mendrysa SM, Saucedo LJ, Tannous P, Holubar M.

J Biol Chem. 2000 Feb 25;275(8):5733-8.


Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease.

Bertin J, Mendrysa SM, LaCount DJ, Gaur S, Krebs JF, Armstrong RC, Tomaselli KJ, Friesen PD.

J Virol. 1996 Sep;70(9):6251-9.

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