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Items: 40

1.

Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter.

Provencher BA, Eshleman AJ, Johnson RA, Shi X, Kryatova O, Nelson J, Tian J, Gonzalez M, Meltzer PC, Janowsky A.

J Med Chem. 2018 Oct 25;61(20):9121-9131. doi: 10.1021/acs.jmedchem.8b00542. Epub 2018 Oct 4.

PMID:
30240563
2.

Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.

Torun L, Madras BK, Meltzer PC.

Bioorg Med Chem. 2012 Apr 15;20(8):2762-72. doi: 10.1016/j.bmc.2012.01.053. Epub 2012 Feb 8.

3.

The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.

Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):48-51. doi: 10.1016/j.bmcl.2010.11.076. Epub 2010 Nov 21.

4.
5.

Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.

Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ.

Biol Psychiatry. 2007 Nov 1;62(9):1059-61. Epub 2007 May 23.

6.

Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.

Pham-Huu DP, Deschamps JR, Liu S, Madras BK, Meltzer PC.

Bioorg Med Chem. 2007 Jan 15;15(2):1067-82. Epub 2006 Oct 27.

7.

Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.

Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ.

J Pharmacol Exp Ther. 2006 Nov;319(2):570-85. Epub 2006 Aug 2.

PMID:
16885433
8.
9.

Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.

Meltzer PC, Pham-Huu DP, Madras BK.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6007-10.

PMID:
15546718
10.

Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.

Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ.

Eur J Pharmacol. 2003 Oct 31;479(1-3):41-51.

PMID:
14612136
11.

Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.

Meltzer PC, McPhee M, Madras BK.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):4133-7.

PMID:
14592523
12.

A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.

Meltzer PC, Blundell P, Zona T, Yang L, Huang H, Bonab AA, Livni E, Fischman A, Madras BK.

J Med Chem. 2003 Jul 31;46(16):3483-96.

PMID:
12877586
13.
14.

Design and synthesis of an irreversible dopamine-sparing cocaine antagonist.

Meltzer PC, Liu S, Blanchette H, Blundell P, Madras BK.

Bioorg Med Chem. 2002 Nov;10(11):3583-91.

PMID:
12213473
15.

Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?

Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK.

Synapse. 2001 Dec 1;42(3):129-40.

PMID:
11746710
16.

Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.

Meltzer PC, Wang B, Chen Z, Blundell P, Jayaraman M, Gonzalez MD, George C, Madras BK.

J Med Chem. 2001 Aug 2;44(16):2619-35.

PMID:
11472216
17.

[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites.

Fischman AJ, Bonab AA, Babich JW, Livni E, Alpert NM, Meltzer PC, Madras BK.

Synapse. 2001 Mar 15;39(4):332-42.

PMID:
11169784
18.

2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.

Meltzer PC, Blundell P, Yong YF, Chen Z, George C, Gonzalez MD, Madras BK.

J Med Chem. 2000 Aug 10;43(16):2982-91.

PMID:
10956207
19.

Molecular and regional targets of cocaine in primate brain: liberation from prosaic views.

Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ.

Addict Biol. 2000 Jul 1;5(3):351-9. doi: 10.1111/j.1369-1600.2000.tb00202.x.

PMID:
20575852
20.

3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter.

Meltzer PC, Blundell P, Huang H, Liu S, Yong YF, Madras BK.

Bioorg Med Chem. 2000 Mar;8(3):581-90.

PMID:
10732975
21.

Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain.

De La Garza R 2nd, Meltzer PC, Madras BK.

Synapse. 1999 Oct;34(1):20-7.

PMID:
10459168
22.

Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.

Meltzer PC, Blundell P, Chen Z, Yong YF, Madras BK.

Bioorg Med Chem Lett. 1999 Mar 22;9(6):857-62.

PMID:
10206550
23.

Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters.

Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK.

Synapse. 1998 Jun;29(2):128-41.

PMID:
9593103
24.

Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.

Madras BK, Gracz LM, Fahey MA, Elmaleh D, Meltzer PC, Liang AY, Stopa EG, Babich J, Fischman AJ.

Synapse. 1998 Jun;29(2):116-27.

PMID:
9593102
25.

Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain.

Madras BK, Gracz LM, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ.

Synapse. 1998 Jun;29(2):105-15.

PMID:
9593101
26.

Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.

Madras BK, Meltzer PC, Liang AY, Elmaleh DR, Babich J, Fischman AJ.

Synapse. 1998 Jun;29(2):93-104.

PMID:
9593100
27.

2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.

Meltzer PC, Liang AY, Blundell P, Gonzalez MD, Chen Z, George C, Madras BK.

J Med Chem. 1997 Aug 15;40(17):2661-73.

PMID:
9276012
28.

A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.

Meltzer PC, Blundell P, Jones AG, Mahmood A, Garada B, Zimmerman RE, Davison A, Holman BL, Madras BK.

J Med Chem. 1997 Jun 6;40(12):1835-44.

PMID:
9191960
29.

Imaging of dopamine transporters in humans with technetium-99m TRODAT-1.

Meltzer PC, Madras BK.

Eur J Nucl Med. 1997 Apr;24(4):462-3. No abstract available.

PMID:
9198580
30.

Nitrogen-based drugs are not essential for blockade of monoamine transporters.

Madras BK, Pristupa ZB, Niznik HB, Liang AY, Blundell P, Gonzalez MD, Meltzer PC.

Synapse. 1996 Dec;24(4):340-8.

PMID:
10638825
31.

Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.

Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK.

J Nucl Med. 1996 Jul;37(7):1197-202.

32.

Cocaine congeners as PET imaging probes for dopamine terminals.

Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK.

J Nucl Med. 1996 Jul;37(7):1186-92.

33.

Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging.

Madras BK, Jones AG, Mahmood A, Zimmerman RE, Garada B, Holman BL, Davison A, Blundell P, Meltzer PC.

Synapse. 1996 Mar;22(3):239-46. No abstract available.

PMID:
9132992
35.
36.

O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.

Madras BK, Reith ME, Meltzer PC, Dutta AK.

Eur J Pharmacol. 1994 Apr 15;267(2):167-73.

PMID:
8050478
37.

Positron emission tomography of cocaine binding sites on the dopamine transporter.

Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL.

NIDA Res Monogr. 1994;138:57-69. Review. No abstract available.

PMID:
7603545
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