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Items: 1 to 50 of 935

1.

The effect of high vs. low dose lurasidone on eye movement biomarkers of prefrontal abilities in treatment-resistant schizophrenia.

Karpouzian-Rogers T, Stocks J, Meltzer HY, Reilly JL.

Schizophr Res. 2019 Nov 6. pii: S0920-9964(19)30439-6. doi: 10.1016/j.schres.2019.10.008. [Epub ahead of print]

PMID:
31706786
2.

A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs.

Yoshikawa A, Li J, Meltzer HY.

Pharmacogenomics J. 2019 Oct 21. doi: 10.1038/s41397-019-0101-5. [Epub ahead of print]

PMID:
31636356
3.

The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.

Huang M, He W, Kiss B, Farkas B, Adham N, Meltzer HY.

J Pharmacol Exp Ther. 2019 Nov;371(2):517-525. doi: 10.1124/jpet.119.259879. Epub 2019 Sep 11.

PMID:
31511365
4.

Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans.

Maciukiewicz M, Tiwari AK, Zai CC, Gorbovskaya I, Laughlin CP, Nurmi EL, Liebermann JA, Meltzer HY, Kennedy JL, Müller DJ.

Schizophr Res. 2019 Oct;212:204-212. doi: 10.1016/j.schres.2019.07.022. Epub 2019 Aug 22.

PMID:
31447353
5.

New insights into tardive dyskinesia genetics: Implementation of whole-exome sequencing approach.

Alkelai A, Greenbaum L, Heinzen EL, Baugh EH, Teitelbaum A, Zhu X, Strous RD, Tatarskyy P, Zai CC, Tiwari AK, Tampakeras M, Freeman N, Müller DJ, Voineskos AN, Lieberman JA, Delaney SL, Meltzer HY, Remington G, Kennedy JL, Pulver AE, Peabody EP, Levy DL, Lerer B.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109659. doi: 10.1016/j.pnpbp.2019.109659. Epub 2019 May 30.

PMID:
31153890
6.

Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.

Li J, Hashimoto H, Meltzer HY.

Front Psychiatry. 2019 Feb 15;10:58. doi: 10.3389/fpsyt.2019.00058. eCollection 2019.

7.

Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment.

Tümüklü MN, Tümüklü MM, Nesterenko V, Jayathilake K, Beasley CM Jr, Meltzer HY.

J Clin Psychopharmacol. 2019 Mar/Apr;39(2):100-107. doi: 10.1097/JCP.0000000000001003.

PMID:
30707117
8.

The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice.

Meltzer HY, Rajagopal L, Matrisciano F, Hao J, Svensson KA, Huang M.

Behav Brain Res. 2019 Apr 1;361:139-150. doi: 10.1016/j.bbr.2018.12.006. Epub 2018 Dec 3.

PMID:
30521930
9.

Investigation of the HSPG2 Gene in Tardive Dyskinesia - New Data and Meta-Analysis.

Zai CC, Lee FH, Tiwari AK, Lu JY, de Luca V, Maes MS, Herbert D, Shahmirian A, Cheema SY, Zai GC, Atukuri A, Sherman M, Shaikh SA, Tampakeras M, Freeman N, King N, Müller DJ, Greenbaum L, Lerer B, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL.

Front Pharmacol. 2018 Sep 18;9:974. doi: 10.3389/fphar.2018.00974. eCollection 2018.

10.

Genetic validation study of protein tyrosine phosphatase receptor type D (PTPRD) gene variants and risk for antipsychotic-induced weight gain.

Maciukiewicz M, Gorbovskaya I, Tiwari AK, Zai CC, Freeman N, Meltzer HY, Kennedy JL, Müller DJ.

J Neural Transm (Vienna). 2019 Jan;126(1):27-33. doi: 10.1007/s00702-018-1921-1. Epub 2018 Sep 18.

PMID:
30229349
11.

Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.

Lu JY, Tiwari AK, Zai GC, Rastogi A, Shaikh SA, Müller DJ, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Wong AHC, Kennedy JL, Zai CC.

Neurosci Lett. 2018 Nov 1;686:17-22. doi: 10.1016/j.neulet.2018.08.007. Epub 2018 Aug 15.

PMID:
30118782
12.

TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABAA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.

Rajagopal L, Huang M, Michael E, Kwon S, Meltzer HY.

Neuropsychopharmacology. 2018 Nov;43(12):2468-2477. doi: 10.1038/s41386-018-0160-3. Epub 2018 Jul 23.

13.

5-HT1A parital agonism and 5-HT7 antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.

Huang M, Kwon S, Rajagopal L, He W, Meltzer HY.

Psychopharmacology (Berl). 2018 Oct;235(10):2795-2808. doi: 10.1007/s00213-018-4972-y. Epub 2018 Jul 31.

PMID:
30066135
14.

A within-subject consideration of the psychotic spectrum disorder concept in a patient in remission associated with cortical gray matter recovery.

Meltzer HY, Sim MY, Anderson A, Cannistraci C, Jayathilake K, Share DB, Lee M.

CNS Neurosci Ther. 2018 Jul;24(7):641-651. doi: 10.1111/cns.12986.

15.

Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction.

Rajagopal L, Soni D, Meltzer HY.

Behav Brain Res. 2018 Sep 17;350:31-43. doi: 10.1016/j.bbr.2018.05.005. Epub 2018 May 24.

PMID:
29763637
16.

Identifying the genetic risk factors for treatment response to lurasidone by genome-wide association study: A meta-analysis of samples from three independent clinical trials.

Li J, Loebel A, Meltzer HY.

Schizophr Res. 2018 Sep;199:203-213. doi: 10.1016/j.schres.2018.04.006. Epub 2018 May 2.

PMID:
29730043
17.

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E.

Cell Stem Cell. 2018 Apr 5;22(4):559-574.e9. doi: 10.1016/j.stem.2018.02.012. Epub 2018 Mar 15.

18.

Hippocampal GABAA antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats.

Neugebauer NM, Miyauchi M, Sato T, Tadano J, Akal H, Ardehali H, Meltzer HY.

Behav Brain Res. 2018 Apr 16;342:11-18. doi: 10.1016/j.bbr.2017.12.033. Epub 2017 Dec 28.

PMID:
29289597
19.

Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats.

Miyauchi M, Neugebauer NM, Sato T, Ardehali H, Meltzer HY.

J Psychopharmacol. 2017 Dec;31(12):1588-1604. doi: 10.1177/0269881117731278. Epub 2017 Sep 25.

PMID:
28946779
20.

New Trends in the Treatment of Schizophrenia.

Meltzer HY.

CNS Neurol Disord Drug Targets. 2017;16(8):900-906. doi: 10.2174/1871527316666170728165355. Review.

PMID:
28758583
21.

Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.

Li J, Yoshikawa A, Meltzer HY.

J Psychiatr Res. 2017 Nov;94:54-61. doi: 10.1016/j.jpsychires.2017.06.005. Epub 2017 Jun 16.

PMID:
28668716
22.

Δ9-tetrahydrocannabinol (Δ9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice.

Rodríguez G, Neugebauer NM, Yao KL, Meltzer HY, Csernansky JG, Dong H.

Pharmacol Biochem Behav. 2017 Aug;159:6-11. doi: 10.1016/j.pbb.2017.06.010. Epub 2017 Jun 23.

PMID:
28648819
23.

Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain.

Zai CC, Tiwari AK, Chowdhury NI, Brandl EJ, Shaikh SA, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ.

Neuropsychobiology. 2016;74(3):169-175. doi: 10.1159/000457903. Epub 2017 May 23.

24.

Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.

Huang M, Kwon S, He W, Meltzer HY.

Pharmacol Biochem Behav. 2017 Jun;157:16-23. doi: 10.1016/j.pbb.2017.04.010. Epub 2017 Apr 25.

PMID:
28455126
25.

Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD study.

Fernandez HH, Factor SA, Hauser RA, Jimenez-Shahed J, Ondo WG, Jarskog LF, Meltzer HY, Woods SW, Bega D, LeDoux MS, Shprecher DR, Davis C, Davis MD, Stamler D, Anderson KE.

Neurology. 2017 May 23;88(21):2003-2010. doi: 10.1212/WNL.0000000000003960. Epub 2017 Apr 26.

26.

Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes.

Li J, Yoshikawa A, Brennan MD, Ramsey TL, Meltzer HY.

Schizophr Res. 2018 Feb;192:194-204. doi: 10.1016/j.schres.2017.04.009. Epub 2017 Apr 19.

PMID:
28431800
27.

Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia.

Zai CC, Tiwari AK, Chowdhury NI, Yilmaz Z, de Luca V, Müller DJ, Potkin SG, Lieberman JA, Meltzer HY, Voineskos AN, Remington G, Kennedy JL.

World J Biol Psychiatry. 2019 Jan;20(1):91-95. doi: 10.1080/15622975.2017.1301681. Epub 2017 Apr 10.

PMID:
28394697
28.

RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia.

Rajagopal L, Kwon S, Huang M, Michael E, Bhat L, Cantillon M, Meltzer HY.

Behav Brain Res. 2017 Aug 14;332:180-199. doi: 10.1016/j.bbr.2017.02.036. Epub 2017 Mar 31.

PMID:
28373127
29.

Dopamine D4 receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia.

Miyauchi M, Neugebauer NM, Meltzer HY.

J Psychopharmacol. 2017 Apr;31(4):442-452. doi: 10.1177/0269881117693746. Epub 2017 Feb 1.

PMID:
28347261
30.

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.

Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC.

Neuropsychopharmacology. 2017 Oct;42(11):2163-2177. doi: 10.1038/npp.2017.52. Epub 2017 Mar 15.

31.

Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine.

Taylor DL, Tiwari AK, Lieberman JA, Potkin SG, Meltzer HY, Knight J, Remington G, Müller DJ, Kennedy JL.

Mol Neuropsychiatry. 2017 Feb;2(4):185-197. doi: 10.1159/000449224. Epub 2016 Oct 12.

32.

Association study between the neurexin-1 gene and tardive dyskinesia.

Lanning R, Lett TA, Tiwari AK, Brandl EJ, de Luca V, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Müller DJ, Remington G, Kennedy JL, Zai CC.

Hum Psychopharmacol. 2017 Jan;32(1). doi: 10.1002/hup.2568.

PMID:
28120489
33.

GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.

Wang JR, Sun PH, Ren ZX, Meltzer HY, Zhen XC.

CNS Neurosci Ther. 2017 Feb;23(2):174-187. doi: 10.1111/cns.12664. Epub 2016 Dec 20.

34.

Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

Tiwari AK, Zhang D, Pouget JG, Zai CC, Chowdhury NI, Brandl EJ, Qin L, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ.

World J Biol Psychiatry. 2018;19(sup3):S97-S105. doi: 10.1080/15622975.2016.1262061. Epub 2016 Dec 15.

PMID:
27855565
35.

The role of the ITIH3 rs2535629 variant in antipsychotic response.

Brandl EJ, Lett TA, Chowdhury NI, Tiwari AK, Bakanidze G, Meltzer HY, Potkin SG, Lieberman JA, Kennedy JL, Müller DJ.

Schizophr Res. 2016 Oct;176(2-3):131-135. doi: 10.1016/j.schres.2016.06.032. Epub 2016 Jul 6.

PMID:
27396837
36.

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.

Alshammari TK, Alshammari MA, Nenov MN, Hoxha E, Cambiaghi M, Marcinno A, James TF, Singh P, Labate D, Li J, Meltzer HY, Sacchetti B, Tempia F, Laezza F.

Transl Psychiatry. 2016 May 10;6:e806. doi: 10.1038/tp.2016.66.

37.

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.

Kasper JM, McCue DL, Milton AJ, Szwed A, Sampson CM, Huang M, Carlton S, Meltzer HY, Cunningham KA, Hommel JD.

Biol Psychiatry. 2016 Dec 1;80(11):878-887. doi: 10.1016/j.biopsych.2016.02.031. Epub 2016 Mar 8.

38.

Genetic association analysis of N-methyl-D-aspartate receptor subunit gene GRIN2B and clinical response to clozapine.

Taylor DL, Tiwari AK, Lieberman JA, Potkin SG, Meltzer HY, Knight J, Remington G, Müller DJ, Kennedy JL.

Hum Psychopharmacol. 2016 Mar;31(2):121-34. doi: 10.1002/hup.2519. Epub 2016 Feb 15.

PMID:
26876050
39.

Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.

Huang E, Zai CC, Lisoway A, Maciukiewicz M, Felsky D, Tiwari AK, Bishop JR, Ikeda M, Molero P, Ortuno F, Porcelli S, Samochowiec J, Mierzejewski P, Gao S, Crespo-Facorro B, Pelayo-Terán JM, Kaur H, Kukreti R, Meltzer HY, Lieberman JA, Potkin SG, Müller DJ, Kennedy JL.

Int J Neuropsychopharmacol. 2016 Apr 29;19(5). pii: pyv132. doi: 10.1093/ijnp/pyv132. Print 2016 May. Review.

40.

Cariprazine in acute exacerbation of schizophrenia: a fixed-dose, phase 3, randomized, double-blind, placebo- and active-controlled trial.

Durgam S, Cutler AJ, Lu K, Migliore R, Ruth A, Laszlovszky I, Németh G, Meltzer HY.

J Clin Psychiatry. 2015 Dec;76(12):e1574-82. doi: 10.4088/JCP.15m09997.

41.

Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.

Huang E, Maciukiewicz M, Zai CC, Tiwari AK, Li J, Potkin SG, Lieberman JA, Meltzer HY, Müller DJ, Kennedy JL.

Pharmacogenomics. 2016;17(2):103-9. doi: 10.2217/pgs.15.155. Epub 2015 Dec 15.

PMID:
26666695
42.

GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice.

Rajagopal L, Burgdorf JS, Moskal JR, Meltzer HY.

Behav Brain Res. 2016 Feb 15;299:105-10. doi: 10.1016/j.bbr.2015.10.060. Epub 2015 Nov 26.

43.

Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice.

Rajagopal L, Massey BW, Michael E, Meltzer HY.

Psychopharmacology (Berl). 2016 Feb;233(4):649-60. doi: 10.1007/s00213-015-4137-1. Epub 2015 Nov 12.

PMID:
26558619
44.

Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition.

Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY.

Behav Brain Res. 2016 Mar 15;301:204-12. doi: 10.1016/j.bbr.2015.10.044. Epub 2015 Oct 28.

PMID:
26519556
45.

Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.

Tiwari AK, Brandl EJ, Zai CC, Goncalves VF, Chowdhury NI, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ.

World J Biol Psychiatry. 2016 Apr;17(3):221-9. doi: 10.3109/15622975.2015.1076173. Epub 2015 Oct 8.

PMID:
26447462
46.

Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement.

Huang M, Kwon S, Oyamada Y, Rajagopal L, Miyauchi M, Meltzer HY.

Pharmacol Biochem Behav. 2015 Nov;138:49-57. doi: 10.1016/j.pbb.2015.09.011. Epub 2015 Sep 14.

PMID:
26383990
47.

Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism.

Horiguchi M, Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY.

Behav Brain Res. 2016 Mar 15;301:132-41. doi: 10.1016/j.bbr.2015.08.040. Epub 2015 Sep 3.

PMID:
26342283
48.

Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample.

Brandl EJ, Tiwari AK, Zai CC, Nurmi EL, Chowdhury NI, Arenovich T, Sanches M, Goncalves VF, Shen JJ, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ.

Pharmacogenomics J. 2016 Aug;16(4):352-6. doi: 10.1038/tpj.2015.59. Epub 2015 Sep 1.

PMID:
26323598
49.

A randomized, double-blind, placebo-controlled trial of aripiprazole lauroxil in acute exacerbation of schizophrenia.

Meltzer HY, Risinger R, Nasrallah HA, Du Y, Zummo J, Corey L, Bose A, Stankovic S, Silverman BL, Ehrich EW.

J Clin Psychiatry. 2015 Aug;76(8):1085-90. doi: 10.4088/JCP.14m09741.

50.

Attention Must Be Paid: The Association of Plasma Clozapine/NDMC Ratio With Working Memory.

Meltzer HY.

Am J Psychiatry. 2015 Jun;172(6):502-4. doi: 10.1176/appi.ajp.2015.15030338. No abstract available.

PMID:
26029799

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