Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 103

1.

Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.

Song L, McNeil EM, Ritchie AM, Astell KR, Gourley C, Melton DW.

BMC Cancer. 2017 Dec 18;17(1):864. doi: 10.1186/s12885-017-3864-6.

2.

Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1.

Yang L, Ritchie AM, Melton DW.

Oncotarget. 2017 Jul 21;8(33):55246-55264. doi: 10.18632/oncotarget.19422. eCollection 2017 Aug 15.

3.

Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration.

Melton DW, Roberts AC, Wang H, Sarwar Z, Wetzel MD, Wells JT, Porter L, Berton MT, McManus LM, Shireman PK.

J Leukoc Biol. 2016 Nov;100(5):1011-1025. Epub 2016 Aug 16.

4.

Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition.

Melton DW, Lei X, Gelfond JA, Shireman PK.

Physiol Genomics. 2016 May;48(5):345-60. doi: 10.1152/physiolgenomics.00098.2015. Epub 2016 Feb 16.

5.

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Wallace C, Gillen KJ, Bakrania P, Khurana P, Coombs PJ, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. doi: 10.1016/j.bmcl.2015.08.024. Epub 2015 Aug 14.

PMID:
26321360
6.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17.

PMID:
26318993
7.

Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.

Fearing CM, Melton DW, Lei X, Hancock H, Wang H, Sarwar ZU, Porter L, McHale M, McManus LM, Shireman PK.

J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):992-1004. doi: 10.1093/gerona/glv104. Epub 2015 Aug 13.

8.

Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.

McNeil EM, Astell KR, Ritchie AM, Shave S, Houston DR, Bakrania P, Jones HM, Khurana P, Wallace C, Chapman T, Wear MA, Walkinshaw MD, Saxty B, Melton DW.

DNA Repair (Amst). 2015 Jul;31:19-28. doi: 10.1016/j.dnarep.2015.04.002. Epub 2015 Apr 22.

PMID:
25956741
9.

Temporal phenotypic features distinguish polarized macrophages in vitro.

Melton DW, McManus LM, Gelfond JA, Shireman PK.

Autoimmunity. 2015 May;48(3):161-76. doi: 10.3109/08916934.2015.1027816. Epub 2015 Mar 31.

10.

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma.

Ma Y, Faller WJ, Sansom OJ, Brown ER, Doig TN, Melton DW, Machesky LM.

Melanoma Res. 2015 Apr;25(2):169-72. doi: 10.1097/CMR.0000000000000135.

PMID:
25535872
11.

Altered macrophage phenotype transition impairs skeletal muscle regeneration.

Wang H, Melton DW, Porter L, Sarwar ZU, McManus LM, Shireman PK.

Am J Pathol. 2014 Apr;184(4):1167-1184. doi: 10.1016/j.ajpath.2013.12.020. Epub 2014 Feb 11.

12.

Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications.

Xiao X, Melton DW, Gourley C.

Gynecol Oncol. 2014 Feb;132(2):506-12. doi: 10.1016/j.ygyno.2013.12.003. Epub 2013 Dec 10. Review.

PMID:
24333356
13.

The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment.

McNeil EM, Ritchie AM, Melton DW.

DNA Repair (Amst). 2013 Nov;12(11):1000-6. doi: 10.1016/j.dnarep.2013.08.017. Epub 2013 Sep 23.

PMID:
24070777
14.

Evaluation of macroporous and microporous carriers for CHO-K1 cell growth and monoclonal antibody production.

Rodrigues ME, Costa AR, Fernandes P, Henriques M, Cunnah P, Melton DW, Azeredo J, Oliveira R.

J Microbiol Biotechnol. 2013 Sep 28;23(9):1308-21.

15.

Advances and drawbacks of the adaptation to serum-free culture of CHO-K1 cells for monoclonal antibody production.

Rodrigues ME, Costa AR, Henriques M, Cunnah P, Melton DW, Azeredo J, Oliveira R.

Appl Biochem Biotechnol. 2013 Feb;169(4):1279-91. doi: 10.1007/s12010-012-0068-z. Epub 2013 Jan 11.

PMID:
23306891
16.

DNA repair and replication proteins as prognostic markers in melanoma.

Song L, Robson T, Doig T, Brenn T, Mathers M, Brown ER, Doherty V, Bartlett JM, Anderson N, Melton DW.

Histopathology. 2013 Jan;62(2):343-50. doi: 10.1111/j.1365-2559.2012.04362.x. Epub 2012 Sep 28.

PMID:
23020778
17.

MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation.

Chen Y, Melton DW, Gelfond JA, McManus LM, Shireman PK.

Physiol Genomics. 2012 Nov 1;44(21):1042-51. doi: 10.1152/physiolgenomics.00052.2012. Epub 2012 Sep 11.

18.

DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.

McNeil EM, Melton DW.

Nucleic Acids Res. 2012 Nov 1;40(20):9990-10004. doi: 10.1093/nar/gks818. Epub 2012 Aug 31. Review.

19.

ALDH2 mediates 5-nitrofuran activity in multiple species.

Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE.

Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017.

20.

Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.

Xu Y, Brenn T, Brown ER, Doherty V, Melton DW.

Br J Cancer. 2012 Jan 31;106(3):553-61. doi: 10.1038/bjc.2011.568. Epub 2012 Jan 5.

21.

Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype.

Li W, Song L, Ritchie AM, Melton DW.

Pigment Cell Melanoma Res. 2012 Mar;25(2):188-99. doi: 10.1111/j.1755-148X.2011.00949.x. Epub 2012 Jan 12.

PMID:
22171919
22.

Association of galectin-3 expression with melanoma progression and prognosis.

Brown ER, Doig T, Anderson N, Brenn T, Doherty V, Xu Y, Bartlett JM, Smyth JF, Melton DW.

Eur J Cancer. 2012 Apr;48(6):865-74. doi: 10.1016/j.ejca.2011.09.003. Epub 2011 Nov 7.

PMID:
22071132
23.

Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance.

Li W, Melton DW.

Oncogene. 2012 May 10;31(19):2412-22. doi: 10.1038/onc.2011.426. Epub 2011 Sep 26.

PMID:
21996734
24.

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

Borgesius NZ, de Waard MC, van der Pluijm I, Omrani A, Zondag GC, van der Horst GT, Melton DW, Hoeijmakers JH, Jaarsma D, Elgersma Y.

J Neurosci. 2011 Aug 31;31(35):12543-53. doi: 10.1523/JNEUROSCI.1589-11.2011.

25.

Identification of DNA repair gene Ercc1 as a novel target in melanoma.

Song L, Ritchie AM, McNeil EM, Li W, Melton DW.

Pigment Cell Melanoma Res. 2011 Oct;24(5):966-71. doi: 10.1111/j.1755-148X.2011.00882.x. Epub 2011 Jul 28.

PMID:
21722328
26.

Maternal germline-specific effect of DNA ligase I on CTG/CAG instability.

Tomé S, Panigrahi GB, López Castel A, Foiry L, Melton DW, Gourdon G, Pearson CE.

Hum Mol Genet. 2011 Jun 1;20(11):2131-43. doi: 10.1093/hmg/ddr099. Epub 2011 Mar 5.

PMID:
21378394
27.

Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs.

Kirschner K, Melton DW.

Anticancer Res. 2010 Sep;30(9):3223-32. Review.

PMID:
20944091
28.

A novel transcript for DNA repair gene Ercc1 in mouse skin.

Song L, Winter AG, Selfridge J, Melton DW.

Transgenic Res. 2011 Feb;20(1):109-22. doi: 10.1007/s11248-010-9396-3. Epub 2010 Apr 21.

PMID:
20407824
29.

Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.

Selfridge J, Song L, Brownstein DG, Melton DW.

DNA Repair (Amst). 2010 Jun 4;9(6):653-60. doi: 10.1016/j.dnarep.2010.02.018. Epub 2010 Apr 1.

PMID:
20362516
30.

Improved coinfection with amphotropic pseudotyped retroviral vectors.

Wu Y, Melton DW, Zhang Y, Hornsby PJ.

J Biomed Biotechnol. 2009;2009:901079. doi: 10.1155/2009/901079. Epub 2009 May 25.

31.

Topical thymidine dinucleotide application protects against UVB-induced skin cancer in mice with DNA repair gene (Ercc1)-deficient skin.

Lawrence NJ, Song L, Doig J, Ritchie AM, Brownstein DG, Melton DW.

DNA Repair (Amst). 2009 May 1;8(5):664-71. doi: 10.1016/j.dnarep.2009.01.020. Epub 2009 Mar 4.

PMID:
19264557
32.

A neurological phenotype in mice with DNA repair gene Ercc1 deficiency.

Lawrence NJ, Sacco JJ, Brownstein DG, Gillingwater TH, Melton DW.

DNA Repair (Amst). 2008 Feb 1;7(2):281-91. doi: 10.1016/j.dnarep.2007.10.005. Epub 2007 Dec 3.

PMID:
18221731
33.

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?

Paul C, Melton DW, Saunders PT.

Mol Hum Reprod. 2008 Jan;14(1):1-8. doi: 10.1093/molehr/gam089. Epub 2008 Jan 5. Review.

PMID:
18175790
34.
35.

DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma.

Povey JE, Darakhshan F, Robertson K, Bisset Y, Mekky M, Rees J, Doherty V, Kavanagh G, Anderson N, Campbell H, MacKie RM, Melton DW.

Carcinogenesis. 2007 May;28(5):1087-93. Epub 2007 Jan 8.

PMID:
17210993
36.

Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro.

Kirschner K, Singh R, Prost S, Melton DW.

DNA Repair (Amst). 2007 Mar 1;6(3):304-16. Epub 2006 Nov 27.

PMID:
17126084
37.

Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression.

Doig J, Anderson C, Lawrence NJ, Selfridge J, Brownstein DG, Melton DW.

Oncogene. 2006 Oct 12;25(47):6229-38. Epub 2006 May 8.

PMID:
16682947
38.

53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

Pryde F, Khalili S, Robertson K, Selfridge J, Ritchie AM, Melton DW, Jullien D, Adachi Y.

J Cell Sci. 2005 May 1;118(Pt 9):2043-55. Epub 2005 Apr 19.

39.

Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time.

Barron RM, Baybutt H, Tuzi NL, McCormack J, King D, Moore RC, Melton DW, Manson JC.

J Gen Virol. 2005 Mar;86(Pt 3):859-68.

40.

Expression of a splicing variant in the 5'-UTR of the human ERCC1 gene is not cancer related.

Winter AG, Dorgan C, Melton DW.

Oncogene. 2005 Mar 17;24(12):2110-3.

PMID:
15688021
41.

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.

Paisley D, Banks S, Selfridge J, McLennan NF, Ritchie AM, McEwan C, Irvine DS, Saunders PT, Manson JC, Melton DW.

Am J Pathol. 2004 Jun;164(6):2279-88.

42.

No association between p53 codon 72 polymorphisms and erythemal response.

Manson C, Naysmith L, Waterston K, Melton DW, Rees JL.

J Invest Dermatol. 2004 May;122(5):1334-5. No abstract available.

43.

A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination.

Ramirez A, Page A, Gandarillas A, Zanet J, Pibre S, Vidal M, Tusell L, Genesca A, Whitaker DA, Melton DW, Jorcano JL.

Genesis. 2004 May;39(1):52-7.

PMID:
15124227
44.

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

Plowman SJ, Williamson DJ, O'Sullivan MJ, Doig J, Ritchie AM, Harrison DJ, Melton DW, Arends MJ, Hooper ML, Patek CE.

Mol Cell Biol. 2003 Dec;23(24):9245-50.

45.

Replication and episomal maintenance of Epstein-Barr virus-based vectors in mouse embryonal fibroblasts enable synthetic lethality screens.

Einav Y, Shistik E, Shenfeld M, Simons AH, Melton DW, Canaani D.

Mol Cancer Ther. 2003 Nov;2(11):1121-8.

46.

Transmission of murine scrapie to P101L transgenic mice.

Barron RM, Thomson V, King D, Shaw J, Melton DW, Manson JC.

J Gen Virol. 2003 Nov;84(Pt 11):3165-72.

47.

Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice.

Chipchase MD, O'Neill M, Melton DW.

Hepatology. 2003 Oct;38(4):958-66.

PMID:
14512883
48.

A simple genotyping assay for the Hprt null allele in mice produced from the HM-1 and E14TG2a mouse embryonic stem cell lines.

McEwan C, Melton DW.

Transgenic Res. 2003 Aug;12(4):519-20. No abstract available.

PMID:
12885172
49.

Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer.

Mort R, Mo L, McEwan C, Melton DW.

Br J Cancer. 2003 Jul 21;89(2):333-7.

50.

p53 and a human premature ageing disorder.

O'Neill M, Núñez F, Melton DW.

Mech Ageing Dev. 2003 May;124(5):599-603.

PMID:
12735900

Supplemental Content

Loading ...
Support Center