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Items: 1 to 50 of 199

1.

Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.

Glieberman AL, Pope BD, Zimmerman JF, Liu Q, Ferrier JP, Kenty JHR, Schrell AM, Mukhitov N, Shores KL, Tepole AB, Melton DA, Roper MG, Parker KK.

Lab Chip. 2019 Sep 10;19(18):2993-3010. doi: 10.1039/c9lc00253g.

PMID:
31464325
2.

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq.

Kotliar D, Veres A, Nagy MA, Tabrizi S, Hodis E, Melton DA, Sabeti PC.

Elife. 2019 Jul 8;8. pii: e43803. doi: 10.7554/eLife.43803.

3.

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.

Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, Engquist EN, Trapnell C, Gifford DK, Melton DA.

Cell Rep. 2019 May 21;27(8):2281-2291.e5. doi: 10.1016/j.celrep.2019.04.083.

4.

Charting cellular identity during human in vitro β-cell differentiation.

Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA.

Nature. 2019 May;569(7756):368-373. doi: 10.1038/s41586-019-1168-5. Epub 2019 May 8.

PMID:
31068696
5.

Generation of hypoimmunogenic human pluripotent stem cells.

Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446. doi: 10.1073/pnas.1902566116. Epub 2019 Apr 30.

PMID:
31040209
6.

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.

Rosado-Olivieri EA, Anderson K, Kenty JH, Melton DA.

Nat Commun. 2019 Apr 1;10(1):1464. doi: 10.1038/s41467-019-09404-6.

7.

Regenerating the field of cardiovascular cell therapy.

Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL.

Nat Biotechnol. 2019 Mar;37(3):232-237. doi: 10.1038/s41587-019-0042-1. Epub 2019 Feb 18. Review.

PMID:
30778231
8.

Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.

Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC.

Am J Transplant. 2019 Jul;19(7):1930-1940. doi: 10.1111/ajt.15308. Epub 2019 Mar 25.

PMID:
30748094
9.

Blastemal progenitors modulate immune signaling during early limb regeneration.

Tsai SL, Baselga-Garriga C, Melton DA.

Development. 2019 Jan 2;146(1). pii: dev169128. doi: 10.1242/dev.169128.

10.

Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.

Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT.

PLoS One. 2018 Oct 10;13(10):e0204595. doi: 10.1371/journal.pone.0204595. eCollection 2018.

11.

Author Correction: Pancreas regeneration.

Zhou Q, Melton DA.

Nature. 2018 Aug;560(7720):E34. doi: 10.1038/s41586-018-0294-9.

PMID:
29925956
12.

Pancreas regeneration.

Zhou Q, Melton DA.

Nature. 2018 May;557(7705):351-358. doi: 10.1038/s41586-018-0088-0. Epub 2018 May 16. Review. Erratum in: Nature. 2018 Aug;560(7720):E34.

13.

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3924-3929. doi: 10.1073/pnas.1702059115. Epub 2018 Mar 29.

14.

Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.

Yi P, Park JS, Melton DA.

Cell. 2017 Jan 12;168(1-2):326. doi: 10.1016/j.cell.2016.12.017. Epub 2016 Dec 28. No abstract available.

15.

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.

Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I.

Cell Syst. 2016 Oct 26;3(4):346-360.e4. doi: 10.1016/j.cels.2016.08.011. Epub 2016 Sep 22.

16.

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes.

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.

Nat Commun. 2016 Aug 4;7:12379. doi: 10.1038/ncomms12379. No abstract available.

17.

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA.

PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.

18.

Generation of stem cell-derived β-cells from patients with type 1 diabetes.

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.

Nat Commun. 2016 May 10;7:11463. doi: 10.1038/ncomms11463. Erratum in: Nat Commun. 2016 Aug 04;7:12379.

19.

Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.

Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446e. No abstract available.

PMID:
27050590
20.

Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.

Melton DA.

Curr Top Dev Biol. 2016;117:65-73. doi: 10.1016/bs.ctdb.2015.11.013. Epub 2016 Jan 20. Review.

PMID:
26969972
21.

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q.

Cell Stem Cell. 2016 Mar 3;18(3):410-21. doi: 10.1016/j.stem.2016.01.003. Epub 2016 Feb 18.

22.

Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.

Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.

Nat Med. 2016 Mar;22(3):306-11. doi: 10.1038/nm.4030. Epub 2016 Jan 25. Erratum in: Nat Med. 2016 Apr;22(4):446.

23.

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.

Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15498-503. doi: 10.1073/pnas.1513872112. Epub 2015 Nov 30.

24.

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.

Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, Melton DA.

J Cell Biol. 2015 Sep 28;210(7):1257-68. doi: 10.1083/jcb.201502035.

25.

Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression.

Kenty JH, Melton DA.

PLoS One. 2015 Apr 8;10(4):e0122044. doi: 10.1371/journal.pone.0122044. eCollection 2015.

26.

Modeling human nutrition using human embryonic stem cells.

Ben-Zvi D, Melton DA.

Cell. 2015 Mar 26;161(1):12-17. doi: 10.1016/j.cell.2015.02.039.

27.

Perspectives on the activities of ANGPTL8/betatrophin.

Yi P, Park JS, Melton DA.

Cell. 2014 Oct 23;159(3):467-8. doi: 10.1016/j.cell.2014.09.028. No abstract available.

28.

Generation of functional human pancreatic β cells in vitro.

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.

Cell. 2014 Oct 9;159(2):428-39. doi: 10.1016/j.cell.2014.09.040.

29.

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA.

Elife. 2014 Sep 16;3:e02809. doi: 10.7554/eLife.02809.

30.

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.

Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q.

Elife. 2014 Jan 1;3:e01846. doi: 10.7554/eLife.01846.

31.

MARIS: method for analyzing RNA following intracellular sorting.

Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA.

PLoS One. 2014 Mar 3;9(3):e89459. doi: 10.1371/journal.pone.0089459. eCollection 2014.

32.

Differentiated human stem cells resemble fetal, not adult, β cells.

Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3038-43. doi: 10.1073/pnas.1400709111. Epub 2014 Feb 10.

33.

Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.

Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA.

Stem Cells. 2013 Dec;31(12):2833-41. doi: 10.1002/stem.1445.

34.

How to make a functional β-cell.

Pagliuca FW, Melton DA.

Development. 2013 Jun;140(12):2472-83. doi: 10.1242/dev.093187. Review.

35.

Betatrophin: a hormone that controls pancreatic β cell proliferation.

Yi P, Park JS, Melton DA.

Cell. 2013 May 9;153(4):747-58. doi: 10.1016/j.cell.2013.04.008. Epub 2013 Apr 25. Retraction in: Cell. 2017 Jan 12;168(1-2):326.

36.

A simple tool to improve pluripotent stem cell differentiation.

Chetty S, Pagliuca FW, Honore C, Kweudjeu A, Rezania A, Melton DA.

Nat Methods. 2013 Jun;10(6):553-6. doi: 10.1038/nmeth.2442. Epub 2013 Apr 14.

37.

Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.

Chen AE, Borowiak M, Sherwood RI, Kweudjeu A, Melton DA.

Development. 2013 Feb 1;140(3):675-86. doi: 10.1242/dev.085431.

38.

New findings in pancreatic and intestinal endocrine development to advance regenerative medicine.

Carolan PJ, Melton DA.

Curr Opin Endocrinol Diabetes Obes. 2013 Feb;20(1):1-7. doi: 10.1097/MED.0b013e32835bc380. Review.

PMID:
23249759
39.

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

Sneddon JB, Borowiak M, Melton DA.

Nature. 2012 Nov 29;491(7426):765-8. doi: 10.1038/nature11463. Epub 2012 Oct 7.

40.

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

Blum B, Hrvatin S, Schuetz C, Bonal C, Rezania A, Melton DA.

Nat Biotechnol. 2012 Feb 26;30(3):261-4. doi: 10.1038/nbt.2141.

41.

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication.

Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3915-20. doi: 10.1073/pnas.1201149109. Epub 2012 Feb 15.

42.

Impracticality of egg donor recruitment in the absence of compensation.

Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K.

Cell Stem Cell. 2011 Oct 4;9(4):293-4. doi: 10.1016/j.stem.2011.08.002. No abstract available.

43.

Reprogramming within hours following nuclear transfer into mouse but not human zygotes.

Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K.

Nat Commun. 2011 Oct 4;2:488. doi: 10.1038/ncomms1503.

44.

Wnt signaling specifies and patterns intestinal endoderm.

Sherwood RI, Maehr R, Mazzoni EO, Melton DA.

Mech Dev. 2011 Sep-Dec;128(7-10):387-400. doi: 10.1016/j.mod.2011.07.005. Epub 2011 Aug 10.

45.

Using stem cells to study and possibly treat type 1 diabetes.

Melton DA.

Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2307-11. doi: 10.1098/rstb.2011.0019. Review.

46.

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.

Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K.

Genes Dev. 2010 Feb 1;24(3):312-26. doi: 10.1101/gad.1833510.

47.

How to make beta cells?

Borowiak M, Melton DA.

Curr Opin Cell Biol. 2009 Dec;21(6):727-32. doi: 10.1016/j.ceb.2009.08.006. Epub 2009 Sep 24. Review.

48.

Generation of pluripotent stem cells from patients with type 1 diabetes.

Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15768-73. doi: 10.1073/pnas.0906894106. Epub 2009 Aug 31.

49.

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J.

Development. 2009 May;136(10):1751-9. doi: 10.1242/dev.029249. Epub 2009 Apr 15.

50.

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.

Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA.

Cell Stem Cell. 2009 Apr 3;4(4):348-58. doi: 10.1016/j.stem.2009.01.014.

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