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Items: 1 to 50 of 357

1.

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq.

Kotliar D, Veres A, Nagy MA, Tabrizi S, Hodis E, Melton DA, Sabeti PC.

Elife. 2019 Jul 8;8. pii: e43803. doi: 10.7554/eLife.43803.

2.

Advancing Progress in Stem Cells and Biomedicine: 2018-2019 Year in Review.

Melton D.

Stem Cell Reports. 2019 Jun 11;12(6):1179-1180. doi: 10.1016/j.stemcr.2019.05.019. No abstract available.

3.

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.

Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, Engquist EN, Trapnell C, Gifford DK, Melton DA.

Cell Rep. 2019 May 21;27(8):2281-2291.e5. doi: 10.1016/j.celrep.2019.04.083.

4.

Charting cellular identity during human in vitro β-cell differentiation.

Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA.

Nature. 2019 May;569(7756):368-373. doi: 10.1038/s41586-019-1168-5. Epub 2019 May 8.

PMID:
31068696
5.

Generation of hypoimmunogenic human pluripotent stem cells.

Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446. doi: 10.1073/pnas.1902566116. Epub 2019 Apr 30.

PMID:
31040209
6.

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.

Rosado-Olivieri EA, Anderson K, Kenty JH, Melton DA.

Nat Commun. 2019 Apr 1;10(1):1464. doi: 10.1038/s41467-019-09404-6.

7.

Regenerating the field of cardiovascular cell therapy.

Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL.

Nat Biotechnol. 2019 Mar;37(3):232-237. doi: 10.1038/s41587-019-0042-1. Epub 2019 Feb 18. Review.

PMID:
30778231
8.

Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.

Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC.

Am J Transplant. 2019 Jul;19(7):1930-1940. doi: 10.1111/ajt.15308. Epub 2019 Mar 25.

PMID:
30748094
9.

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.

Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D.

Cell. 2019 Feb 7;176(4):790-804.e13. doi: 10.1016/j.cell.2018.12.003. Epub 2019 Jan 17.

PMID:
30661759
10.

Blastemal progenitors modulate immune signaling during early limb regeneration.

Tsai SL, Baselga-Garriga C, Melton DA.

Development. 2019 Jan 2;146(1). pii: dev169128. doi: 10.1242/dev.169128.

11.

New Approaches, New Opportunities at the 2019 ISSCR Annual Meeting.

Melton D, Wernig M.

Stem Cell Reports. 2018 Dec 11;11(6):1305. doi: 10.1016/j.stemcr.2018.11.004. No abstract available.

12.

Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.

Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT.

PLoS One. 2018 Oct 10;13(10):e0204595. doi: 10.1371/journal.pone.0204595. eCollection 2018.

13.

Author Correction: Pancreas regeneration.

Zhou Q, Melton DA.

Nature. 2018 Aug;560(7720):E34. doi: 10.1038/s41586-018-0294-9.

PMID:
29925956
14.

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.

PMID:
29781950
15.

Pancreas regeneration.

Zhou Q, Melton DA.

Nature. 2018 May;557(7705):351-358. doi: 10.1038/s41586-018-0088-0. Epub 2018 May 16. Review. Erratum in: Nature. 2018 Aug;560(7720):E34.

16.

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3924-3929. doi: 10.1073/pnas.1702059115. Epub 2018 Mar 29.

17.

Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.

Song L, McNeil EM, Ritchie AM, Astell KR, Gourley C, Melton DW.

BMC Cancer. 2017 Dec 18;17(1):864. doi: 10.1186/s12885-017-3864-6.

18.

Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1.

Yang L, Ritchie AM, Melton DW.

Oncotarget. 2017 Jul 21;8(33):55246-55264. doi: 10.18632/oncotarget.19422. eCollection 2017 Aug 15.

19.

Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.

Yi P, Park JS, Melton DA.

Cell. 2017 Jan 12;168(1-2):326. doi: 10.1016/j.cell.2016.12.017. Epub 2016 Dec 28. No abstract available.

20.

Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration.

Melton DW, Roberts AC, Wang H, Sarwar Z, Wetzel MD, Wells JT, Porter L, Berton MT, McManus LM, Shireman PK.

J Leukoc Biol. 2016 Nov;100(5):1011-1025. Epub 2016 Aug 16.

21.

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.

Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I.

Cell Syst. 2016 Oct 26;3(4):346-360.e4. doi: 10.1016/j.cels.2016.08.011. Epub 2016 Sep 22.

22.

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes.

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.

Nat Commun. 2016 Aug 4;7:12379. doi: 10.1038/ncomms12379. No abstract available.

23.

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA.

PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.

24.

Generation of stem cell-derived β-cells from patients with type 1 diabetes.

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.

Nat Commun. 2016 May 10;7:11463. doi: 10.1038/ncomms11463. Erratum in: Nat Commun. 2016 Aug 04;7:12379.

25.

Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.

Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446e. No abstract available.

PMID:
27050590
26.

Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.

Melton DA.

Curr Top Dev Biol. 2016;117:65-73. doi: 10.1016/bs.ctdb.2015.11.013. Epub 2016 Jan 20. Review.

PMID:
26969972
27.

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.

Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q.

Cell Stem Cell. 2016 Mar 3;18(3):410-21. doi: 10.1016/j.stem.2016.01.003. Epub 2016 Feb 18.

28.

Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition.

Melton DW, Lei X, Gelfond JA, Shireman PK.

Physiol Genomics. 2016 May;48(5):345-60. doi: 10.1152/physiolgenomics.00098.2015. Epub 2016 Feb 16.

29.

A Study of the Amputee Experience of Viewing Self in the Mirror.

Freysteinson W, Thomas L, Sebastian-Deutsch A, Douglas D, Melton D, Celia T, Reeves K, Bowyer P.

Rehabil Nurs. 2017 Jan/Feb;42(1):22-32. doi: 10.1002/rnj.256.

30.

Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.

Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.

Nat Med. 2016 Mar;22(3):306-11. doi: 10.1038/nm.4030. Epub 2016 Jan 25. Erratum in: Nat Med. 2016 Apr;22(4):446.

31.

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.

Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15498-503. doi: 10.1073/pnas.1513872112. Epub 2015 Nov 30.

32.

Dealing With Catastrophic Outcomes and Amputations in the Mangled Limb.

Cannada LK, Melton DH, Deren ME, Hayda RA, Harvey EJ.

J Orthop Trauma. 2015 Dec;29 Suppl 12:S39-42. doi: 10.1097/BOT.0000000000000468. Review.

PMID:
26584265
33.

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.

Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, Melton DA.

J Cell Biol. 2015 Sep 28;210(7):1257-68. doi: 10.1083/jcb.201502035.

34.

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Wallace C, Gillen KJ, Bakrania P, Khurana P, Coombs PJ, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. doi: 10.1016/j.bmcl.2015.08.024. Epub 2015 Aug 14.

PMID:
26321360
35.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17.

PMID:
26318993
36.

Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.

Fearing CM, Melton DW, Lei X, Hancock H, Wang H, Sarwar ZU, Porter L, McHale M, McManus LM, Shireman PK.

J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):992-1004. doi: 10.1093/gerona/glv104. Epub 2015 Aug 13.

37.

Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.

McNeil EM, Astell KR, Ritchie AM, Shave S, Houston DR, Bakrania P, Jones HM, Khurana P, Wallace C, Chapman T, Wear MA, Walkinshaw MD, Saxty B, Melton DW.

DNA Repair (Amst). 2015 Jul;31:19-28. doi: 10.1016/j.dnarep.2015.04.002. Epub 2015 Apr 22.

PMID:
25956741
38.

Tactile, thermal, and electrical thresholds in patients with and without phantom limb pain after traumatic lower limb amputation.

Li S, Melton DH, Li S.

J Pain Res. 2015 Apr 20;8:169-74. doi: 10.2147/JPR.S77412. eCollection 2015.

39.

Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression.

Kenty JH, Melton DA.

PLoS One. 2015 Apr 8;10(4):e0122044. doi: 10.1371/journal.pone.0122044. eCollection 2015.

40.

Temporal phenotypic features distinguish polarized macrophages in vitro.

Melton DW, McManus LM, Gelfond JA, Shireman PK.

Autoimmunity. 2015 May;48(3):161-76. doi: 10.3109/08916934.2015.1027816. Epub 2015 Mar 31.

41.

Modeling human nutrition using human embryonic stem cells.

Ben-Zvi D, Melton DA.

Cell. 2015 Mar 26;161(1):12-17. doi: 10.1016/j.cell.2015.02.039.

42.

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma.

Ma Y, Faller WJ, Sansom OJ, Brown ER, Doig TN, Melton DW, Machesky LM.

Melanoma Res. 2015 Apr;25(2):169-72. doi: 10.1097/CMR.0000000000000135.

PMID:
25535872
43.

Perspectives on the activities of ANGPTL8/betatrophin.

Yi P, Park JS, Melton DA.

Cell. 2014 Oct 23;159(3):467-8. doi: 10.1016/j.cell.2014.09.028. No abstract available.

44.

Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.

Melton D, Lewis CD, Price NE, Gates KS.

Chem Res Toxicol. 2014 Dec 15;27(12):2113-8. doi: 10.1021/tx5003657. Epub 2014 Nov 18.

45.

Generation of functional human pancreatic β cells in vitro.

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.

Cell. 2014 Oct 9;159(2):428-39. doi: 10.1016/j.cell.2014.09.040.

46.

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA.

Elife. 2014 Sep 16;3:e02809. doi: 10.7554/eLife.02809.

47.

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.

Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q.

Elife. 2014 Jan 1;3:e01846. doi: 10.7554/eLife.01846.

48.

MARIS: method for analyzing RNA following intracellular sorting.

Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA.

PLoS One. 2014 Mar 3;9(3):e89459. doi: 10.1371/journal.pone.0089459. eCollection 2014.

49.

Altered macrophage phenotype transition impairs skeletal muscle regeneration.

Wang H, Melton DW, Porter L, Sarwar ZU, McManus LM, Shireman PK.

Am J Pathol. 2014 Apr;184(4):1167-1184. doi: 10.1016/j.ajpath.2013.12.020. Epub 2014 Feb 11.

50.

Differentiated human stem cells resemble fetal, not adult, β cells.

Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3038-43. doi: 10.1073/pnas.1400709111. Epub 2014 Feb 10.

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