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Items: 1 to 50 of 181

1.

Spatiotemporal Expression of 3-B-3(-) and 7-D-4 Chondroitin Sulfation, Tissue Remodeling, and Attempted Repair in an Ovine Model of Intervertebral Disc Degeneration.

Farrugia B, Smith SM, Shu CC, Melrose J.

Cartilage. 2019 Oct 3:1947603519876354. doi: 10.1177/1947603519876354. [Epub ahead of print]

PMID:
31578084
2.

Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration.

Shu CC, Dart A, Bell R, Dart C, Clarke E, Smith MM, Little CB, Melrose J.

JOR Spine. 2018 Oct 10;1(4):e1037. doi: 10.1002/jsp2.1037. eCollection 2018 Dec.

3.
4.

Clinician cognitive overload.

Melrose JP.

Future Healthc J. 2019 Jun;6(2):147. doi: 10.7861/futurehosp.6-2-147. No abstract available.

5.

Type XI collagen-perlecan-HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis.

Smith SM, Melrose J.

J Mol Histol. 2019 Jun;50(3):285-294. doi: 10.1007/s10735-019-09823-1. Epub 2019 Apr 16.

PMID:
30993430
7.
8.
10.
11.

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc.

Shu CC, Smith SM, Little CB, Melrose J.

Biochem J. 2019 Jan 18;476(2):225-243. doi: 10.1042/BCJ20180695.

PMID:
30563944
12.

A Perspective on the Potential Utility of a Viscosupplement Multifunctional Biotherapeutic: Proteoglycan-4: From mere lubricant to regulator of tissue homeostasis and inflammation.

Melrose J.

Bioessays. 2019 Jan;41(1):e1800215. doi: 10.1002/bies.201800215. Epub 2018 Nov 30. No abstract available.

PMID:
30500085
13.

Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate.

Hayes AJ, Melrose J.

Biochem J. 2018 Aug 16;475(15):2511-2545. doi: 10.1042/BCJ20180283. Review.

PMID:
30115748
15.

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.

James G, Sluka KA, Blomster L, Hall L, Schmid AB, Shu CC, Little CB, Melrose J, Hodges PW.

Eur Spine J. 2018 Aug;27(8):1744-1756. doi: 10.1007/s00586-018-5652-7. Epub 2018 Jun 12.

PMID:
29948327
16.

Concise Review: Stem/Progenitor Cell Proteoglycans Decorated with 7-D-4, 4-C-3, and 3-B-3(-) Chondroitin Sulfate Motifs Are Morphogenetic Markers of Tissue Development.

Hayes AJ, Smith SM, Caterson B, Melrose J.

Stem Cells. 2018 Oct;36(10):1475-1486. doi: 10.1002/stem.2860. Epub 2018 Jul 31. Review.

17.

Toward a New Brewing Control Chart for the 21st Century.

Melrose J, Roman-Corrochano B, Montoya-Guerra M, Bakalis S.

J Agric Food Chem. 2018 May 30;66(21):5301-5309. doi: 10.1021/acs.jafc.7b04848. Epub 2018 Apr 23.

PMID:
29656646
18.

Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair.

Farrugia BL, Lord MS, Whitelock JM, Melrose J.

Biomater Sci. 2018 May 1;6(5):947-957. doi: 10.1039/C7BM01158J. Review.

PMID:
29560990
19.

The multifaceted roles of perlecan in fibrosis.

Lord MS, Tang F, Rnjak-Kovacina J, Smith JGW, Melrose J, Whitelock JM.

Matrix Biol. 2018 Aug;68-69:150-166. doi: 10.1016/j.matbio.2018.02.013. Epub 2018 Feb 20. Review.

PMID:
29475023
20.

The adolescent idiopathic scoliotic IVD displays advanced aggrecanolysis and a glycosaminoglycan composition similar to that of aged human and ovine IVDs.

Shu CC, Melrose J.

Eur Spine J. 2018 Sep;27(9):2102-2113. doi: 10.1007/s00586-018-5515-2. Epub 2018 Feb 13.

PMID:
29441417
21.

Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis.

Hayes A, Sugahara K, Farrugia B, Whitelock JM, Caterson B, Melrose J.

Biochem J. 2018 Feb 9;475(3):587-620. doi: 10.1042/BCJ20170820. Review.

PMID:
29439148
22.

Keratan sulfate, a complex glycosaminoglycan with unique functional capability.

Caterson B, Melrose J.

Glycobiology. 2018 Apr 1;28(4):182-206. doi: 10.1093/glycob/cwy003. Review.

23.

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

Farrugia BL, Lord MS, Melrose J, Whitelock JM.

J Histochem Cytochem. 2018 Apr;66(4):321-336. doi: 10.1369/0022155417740881. Epub 2018 Jan 1. Review.

24.

Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?

Brown S, Matta A, Erwin M, Roberts S, Gruber HE, Hanley EN Jr, Little CB, Melrose J.

Stem Cells Dev. 2018 Feb 1;27(3):147-165. doi: 10.1089/scd.2017.0213. Epub 2018 Jan 16. Review.

PMID:
29241405
25.
26.

The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics.

Melrose J, Fuller ES, Little CB.

Connect Tissue Res. 2017 May - Jul;58(3-4):282-294. doi: 10.1080/03008207.2017.1284824. Epub 2017 Jan 25. Review.

PMID:
28121190
27.

Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages.

Shu C, Smith SM, Little CB, Melrose J.

Future Sci OA. 2016 Sep 22;2(4):FSO142. doi: 10.4155/fsoa-2016-0034. eCollection 2016 Dec.

28.

Hyaluronan oligosaccharides stimulate matrix metalloproteinase and anabolic gene expression in vitro by intervertebral disc cells and annular repair in vivo.

Fuller ES, Shu C, Smith MM, Little CB, Melrose J.

J Tissue Eng Regen Med. 2018 Jan;12(1):e216-e226. doi: 10.1002/term.2319. Epub 2017 Mar 22.

PMID:
27689852
29.

Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model.

Fuller E, Little CB, Melrose J.

Exp Mol Pathol. 2016 Oct;101(2):214-220. doi: 10.1016/j.yexmp.2016.09.001. Epub 2016 Sep 9.

PMID:
27615609
30.

Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds.

Melrose J.

Regen Med. 2016 Oct;11(7):705-24. doi: 10.2217/rme-2016-0069. Epub 2016 Sep 2. Review.

PMID:
27586197
31.

Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc.

Hayes AJ, Shu CC, Lord MS, Little CB, Whitelock JM, Melrose J.

Eur Cell Mater. 2016 Jul 5;32:40-57.

32.

The knee joint loose body as a source of viable autologous human chondrocytes.

Melrose J.

Eur J Histochem. 2016 Jun 10;60(2):2645. doi: 10.4081/ejh.2016.2645.

33.

Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.

James G, Blomster L, Hall L, Schmid AB, Shu CC, Little CB, Melrose J, Hodges PW.

Spine (Phila Pa 1976). 2016 Aug 1;41(15):1208-17. doi: 10.1097/BRS.0000000000001669.

PMID:
27135642
34.

The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice.

Shu C, Smith SM, Melrose J.

J Mol Histol. 2016 Jun;47(3):365-74. doi: 10.1007/s10735-016-9677-0. Epub 2016 Apr 21.

PMID:
27098652
35.

The CS Sulfation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow.

Hayes AJ, Hughes CE, Smith SM, Caterson B, Little CB, Melrose J.

Stem Cells Dev. 2016 Jun 1;25(11):836-47. doi: 10.1089/scd.2016.0054. Epub 2016 May 5.

PMID:
27068010
36.

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.

Melrose J, Shu C, Whitelock JM, Lord MS.

Matrix Biol. 2016 May-Jul;52-54:363-383. doi: 10.1016/j.matbio.2016.01.008. Epub 2016 Jan 23. Review.

PMID:
26807757
37.

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

Shu CC, Jackson MT, Smith MM, Smith SM, Penm S, Lord MS, Whitelock JM, Little CB, Melrose J.

Arthritis Rheumatol. 2016 Apr;68(4):868-79. doi: 10.1002/art.39529.

38.

Multifidus Muscle Changes After Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence.

Hodges PW, James G, Blomster L, Hall L, Schmid A, Shu C, Little C, Melrose J.

Spine (Phila Pa 1976). 2015 Jul 15;40(14):1057-71. doi: 10.1097/BRS.0000000000000972.

PMID:
25943090
39.

Proteoglycans in Normal and Healing Skin.

Smith MM, Melrose J.

Adv Wound Care (New Rochelle). 2015 Mar 1;4(3):152-173.

40.

Increased ventral-striatal activity during monetary decision making is a marker of problem poker gambling severity.

Brevers D, Noël X, He Q, Melrose JA, Bechara A.

Addict Biol. 2016 May;21(3):688-99. doi: 10.1111/adb.12239. Epub 2015 Mar 17.

41.

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

Farrugia BL, Lord MS, Melrose J, Whitelock JM.

Molecules. 2015 Mar 5;20(3):4254-76. doi: 10.3390/molecules20034254. Review.

42.

Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix.

Hayes AJ, Gibson MA, Shu C, Melrose J.

Tissue Cell. 2014 Jun;46(3):185-97. doi: 10.1016/j.tice.2014.04.002. Epub 2014 May 6.

PMID:
24867584
43.

Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?

Hodges PW, James G, Blomster L, Hall L, Schmid AB, Shu C, Little C, Melrose J.

Spine (Phila Pa 1976). 2014 Jun 1;39(13):1010-7. doi: 10.1097/BRS.0000000000000318.

PMID:
24718080
44.

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.

Lord MS, Chuang CY, Melrose J, Davies MJ, Iozzo RV, Whitelock JM.

Matrix Biol. 2014 Apr;35:112-22. doi: 10.1016/j.matbio.2014.01.016. Epub 2014 Feb 6.

45.

The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc.

Shu C, Hughes C, Smith SM, Smith MM, Hayes A, Caterson B, Little CB, Melrose J.

Glycoconj J. 2013 Oct;30(7):717-25. doi: 10.1007/s10719-013-9475-9. Epub 2013 Jun 13.

PMID:
23756834
46.

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.

Melton AC, Melrose J, Alajoki L, Privat S, Cho H, Brown N, Plavec AM, Nguyen D, Johnston ED, Yang J, Polokoff MA, Plavec I, Berg EL, O'Mahony A.

PLoS One. 2013;8(3):e58966. doi: 10.1371/journal.pone.0058966. Epub 2013 Mar 7.

48.

Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy.

Melrose J, Smith MM, Smith SM, Ravi V, Young AA, Dart AJ, Sonnabend DH, Little CB.

Tissue Cell. 2013 Feb;45(1):77-82. doi: 10.1016/j.tice.2012.10.001. Epub 2012 Dec 12.

PMID:
23245384
49.

Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.

Hayes AJ, Smith SM, Melrose J.

Histochem Cell Biol. 2013 Jan;139(1):1-11. doi: 10.1007/s00418-012-1041-1. Epub 2012 Oct 27.

PMID:
23104139
50.

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.

Melrose J, Isaacs MD, Smith SM, Hughes CE, Little CB, Caterson B, Hayes AJ.

Histochem Cell Biol. 2012 Sep;138(3):461-75. doi: 10.1007/s00418-012-0968-6. Epub 2012 May 23.

PMID:
22617995

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