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Items: 1 to 50 of 175

1.

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

Oerlemans R, Berkers CR, Assaraf YG, Scheffer GL, Peters GJ, Verbrugge SE, Cloos J, Slootstra J, Meloen RH, Shoemaker RH, Dijkmans BAC, Scheper RJ, Ovaa H, Jansen G.

Invest New Drugs. 2018 Oct;36(5):797-809. doi: 10.1007/s10637-018-0569-x. Epub 2018 Feb 14.

2.

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity.

Wentink MQ, Hackeng TM, Tabruyn SP, Puijk WC, Schwamborn K, Altschuh D, Meloen RH, Schuurman T, Griffioen AW, Timmerman P.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12532-12537. Epub 2016 Oct 17.

3.

Pharmacological and toxicological assessment of a potential GnRH vaccine in young-adult male pigs.

Turkstra JA, van der Staay FJ, Stockhofe-Zurwieden N, Woelders H, Meloen RH, Schuurman T.

Vaccine. 2011 May 12;29(21):3791-801. doi: 10.1016/j.vaccine.2011.03.023. Epub 2011 Mar 23.

PMID:
21439319
4.

Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies.

Timmerman P, Shochat SG, Desmet J, Barderas R, Casal JI, Meloen RH, Altschuh D.

J Mol Recognit. 2010 Nov-Dec;23(6):559-68. doi: 10.1002/jmr.1017.

PMID:
21038356
5.

A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity.

Timmerman P, Barderas R, Desmet J, Altschuh D, Shochat S, Hollestelle MJ, Höppener JW, Monasterio A, Casal JI, Meloen RH.

J Biol Chem. 2009 Dec 4;284(49):34126-34. doi: 10.1074/jbc.M109.041459. Epub 2009 Oct 6.

6.

Heterologous stacking of prion protein peptides reveals structural details of fibrils and facilitates complete inhibition of fibril growth.

Boshuizen RS, Schulz V, Morbin M, Mazzoleni G, Meloen RH, Langedijk JP.

J Biol Chem. 2009 May 8;284(19):12809-20. doi: 10.1074/jbc.M809151200. Epub 2009 Mar 19.

7.

SUMO assay with peptide arrays on solid support: insights into SUMO target sites.

Schwamborn K, Knipscheer P, van Dijk E, van Dijk WJ, Sixma TK, Meloen RH, Langedijk JP.

J Biochem. 2008 Jul;144(1):39-49. doi: 10.1093/jb/mvn039. Epub 2008 Mar 15.

PMID:
18344540
8.

Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.

Hollestelle MJ, Timmerman P, Meloen RH, Höppener JW.

Endocr Relat Cancer. 2008 Mar;15(1):301-9. doi: 10.1677/ERC-07-0206.

PMID:
18310296
9.

Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology.

Timmerman P, Puijk WC, Meloen RH.

J Mol Recognit. 2007 Sep-Oct;20(5):283-99.

PMID:
18074397
10.
11.

Monitoring health by values of acute phase proteins.

Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ, van Dijk E, Meloen RH.

Acta Histochem. 2006;108(3):229-32. Epub 2006 May 22. Review.

PMID:
16714050
12.

GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms.

Turkstra JA, Schaaper WM, Oonk HB, Meloen RH.

Vaccine. 2005 Sep 30;23(41):4915-20.

PMID:
16006018
13.

Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces.

Timmerman P, Beld J, Puijk WC, Meloen RH.

Chembiochem. 2005 May;6(5):821-4. No abstract available.

PMID:
15812852
14.

Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis.

Marissen WE, Kramer RA, Rice A, Weldon WC, Niezgoda M, Faber M, Slootstra JW, Meloen RH, Clijsters-van der Horst M, Visser TJ, Jongeneelen M, Thijsse S, Throsby M, de Kruif J, Rupprecht CE, Dietzschold B, Goudsmit J, Bakker AB.

J Virol. 2005 Apr;79(8):4672-8.

15.

Effects of GnRH immunization in sexually mature pony stallions.

Turkstra JA, van der Meer FJ, Knaap J, Rottier PJ, Teerds KJ, Colenbrander B, Meloen RH.

Anim Reprod Sci. 2005 Apr;86(3-4):247-59.

PMID:
15766804
16.

Fast track selection of immunogens for novel vaccines through visualisation of the early onset of the B-cell response.

Scibelli A, van der Most RG, Turkstra JA, Ariaans MP, Arkesteijn G, Hensen EJ, Meloen RH.

Vaccine. 2005 Mar 14;23(16):1900-9.

PMID:
15734062
17.

An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.

Boshuizen RS, Langeveld JP, Salmona M, Williams A, Meloen RH, Langedijk JP.

Anal Biochem. 2004 Oct 15;333(2):372-80.

PMID:
15450815
18.

New transport peptides broaden the horizon of applications for peptidic pharmaceuticals.

Langedijk JP, Olijhoek T, Schut D, Autar R, Meloen RH.

Mol Divers. 2004;8(2):101-11.

PMID:
15209161
19.

Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan and Matrix Scan technology.

Timmerman P, Van Dijk E, Puijk W, Schaaper W, Slootstra J, Carlisle SJ, Coley J, Eida S, Gani M, Hunt T, Perry P, Piron G, Meloen RH.

Mol Divers. 2004;8(2):61-77.

PMID:
15209158
20.

Identification of an interleukin-15alpha receptor-binding site on human interleukin-15.

Bernard J, Harb C, Mortier E, Quéméner A, Meloen RH, Vermot-Desroches C, Wijdeness J, van Dijken P, Grötzinger J, Slootstra JW, Plet A, Jacques Y.

J Biol Chem. 2004 Jun 4;279(23):24313-22. Epub 2004 Mar 23.

21.

Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

de Jong MC, Scheffer GL, Broxterman HJ, Hooijberg JH, Slootstra JW, Meloen RH, Kreitman RJ, Husain SR, Joshi BH, Puri RK, Scheper RJ.

Clin Cancer Res. 2003 Oct 15;9(13):5009-17.

22.

Design of synthetic peptides for diagnostics.

Meloen RH, Puijk WC, Langeveld JP, Langedijk JP, Timmerman P.

Curr Protein Pept Sci. 2003 Aug;4(4):253-60. Review.

PMID:
14529532
23.

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

Nijenhuis WA, Kruijtzer JA, Wanders N, Vrinten DH, Garner KM, Schaaper WM, Meloen RH, Gispen WH, Liskamp RM, Adan RA.

Peptides. 2003 Feb;24(2):271-80.

PMID:
12668212
24.

Performance of male pigs immunized against GnRH is related to the time of onset of biological response.

Turkstra JA, Zengt XY, van Diepent JT, Jongbloed AW, Oonk HB, van de Wielt DF, Meloen RH.

J Anim Sci. 2002 Nov;80(11):2953-9.

PMID:
12462264
25.

Functional analysis of synthetic insectatachykinin analogs on recombinant neurokinin receptor expressing cell lines.

Torfs H, Akerman KE, Nachman RJ, Oonk HB, Detheux M, Poels J, Loy TV, Loof AD, Meloen RH, Vassart G, Parmentier M, Broeck JV.

Peptides. 2002 Nov;23(11):1999-2005.

PMID:
12431738
26.

Effects of active immunization against GnRH on serum LH, inhibin A, sexual development and growth rate in Chinese female pigs.

Zeng XY, Turkstra JA, Tsigos A, Meloen RH, Liu XY, Chen FQ, Schaaper WM, Oonk HB, Guo DZ, van de Wiel DF.

Theriogenology. 2002 Oct 15;58(7):1315-26.

PMID:
12387345
27.

A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide.

Langedijk JP, van Veelen PA, Schaaper WM, de Ru AH, Meloen RH, Hulst MM.

J Virol. 2002 Oct;76(20):10383-92.

28.

Active immunization against gonadotrophin-releasing hormone in Chinese male pigs: effects of dose on antibody titer, hormone levels and sexual development.

Zeng XY, Turkstra JA, Meloen RH, Liu XY, Chen FQ, Schaaper WM, Oonk HB, Guo DZ, van de Wiel DF.

Anim Reprod Sci. 2002 Apr 15;70(3-4):223-33.

PMID:
11943492
29.

Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide.

Villén J, Borràs E, Schaaper WM, Meloen RH, Dávila M, Domingo E, Giralt E, Andreu D.

Chembiochem. 2002 Mar 1;3(2-3):175-82.

PMID:
11921395
30.

Synthetic peptides as functional mimics of a viral discontinuous antigenic site.

Villén J, Borràs E, Schaaper WM, Meloen RH, Dávila M, Domingo E, Giralt E, Andreu D.

Biologicals. 2001 Sep-Dec;29(3-4):265-9.

PMID:
11851326
31.

Synthetic peptide vaccines: unexpected fulfillment of discarded hope?

Meloen RH, Langeveld JP, Schaaper WM, Slootstra JW.

Biologicals. 2001 Sep-Dec;29(3-4):233-6.

PMID:
11851321
33.

The nature of the bond between peptide and carrier molecule determines the immunogenicity of the construct.

Beekman NJ, Schaaper WM, Langeveld JP, Boshuizen RS, Meloen RH.

J Pept Res. 2001 Sep;58(3):237-45.

PMID:
11576330
34.

Definition of neutralizing sites on African horse sickness virus serotype 4 VP2 at the level of peptides.

Martínez-Torrecuadrada JL, Langeveld JP, Meloen RH, Casal JI.

J Gen Virol. 2001 Oct;82(Pt 10):2415-24.

PMID:
11562535
35.

Pharmacological characterization of STKR, an insect G protein-coupled receptor for tachykinin-like peptides.

Torfs H, Oonk HB, Broeck JV, Poels J, Van Poyer W, De Loof A, Guerrero F, Meloen RH, Akerman K, Nachman RJ.

Arch Insect Biochem Physiol. 2001 Sep;48(1):39-49.

PMID:
11519074
36.

Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus.

Langeveld JP, Brennan FR, Martínez-Torrecuadrada JL, Jones TD, Boshuizen RS, Vela C, Casal JI, Kamstrup S, Dalsgaard K, Meloen RH, Bendig MM, Hamilton WD.

Vaccine. 2001 Jun 14;19(27):3661-70.

PMID:
11395200
37.

Synthetic peptides derived from the beta2-beta3 loop of Raphanus sativus antifungal protein 2 that mimic the active site.

Schaaper WM, Posthuma GA, Plasman HH, Sijtsma L, Fant F, Borremans FA, Thevissen K, Broekaert WF, Meloen RH, van Amerongen A.

J Pept Res. 2001 May;57(5):409-18.

PMID:
11350601
38.

Active immunization against gonadotrophin-releasing hormone in Chinese male pigs.

Zeng XY, Turkstra JA, van de Wiel DF, Guo DZ, Liu XY, Meloen RH, Schaaper WM, Chen FQ, Oonk HB, Zhang X.

Reprod Domest Anim. 2001 Apr;36(2):101-5.

PMID:
11328563
39.

Peptide transport by the multidrug resistance protein MRP1.

de Jong MC, Slootstra JW, Scheffer GL, Schroeijers AB, Puijk WC, Dinkelberg R, Kool M, Broxterman HJ, Meloen RH, Scheper RJ.

Cancer Res. 2001 Mar 15;61(6):2552-7.

40.

Characterisation of a protective linear B cell epitope against feline parvoviruses.

Langeveld JP, Martinez-Torrecuadrada J, Boshuizen RS, Meloen RH, Ignacio Casal J.

Vaccine. 2001 Mar 21;19(17-19):2352-60.

PMID:
11257360
42.

Mimotopes: realization of an unlikely concept.

Meloen RH, Puijk WC, Slootstra JW.

J Mol Recognit. 2000 Nov-Dec;13(6):352-9.

PMID:
11114068
43.

Epitopes on glycoprotein E and on the glycoprotein E/glycoprotein I complex of bovine herpesvirus 1 are expressed by all of 222 isolates and 11 vaccine strains.

Rijsewijk FA, Kaashoek MJ, Langeveld JP, Maris-Veldhuis MA, Magdalena J, Verschuren SB, Meloen RH, van Oirschot JT.

Arch Virol. 2000;145(5):921-36.

PMID:
10881679
44.

Applicability of three anti-PrP peptide sera including staining of tonsils and brainstem of sheep with scrapie.

Garssen GJ, Van Keulen LJ, Farquhar CF, Smits MA, Jacobs JG, Bossers A, Meloen RH, Langeveld JP.

Microsc Res Tech. 2000 Jul 1;50(1):32-9.

PMID:
10871546
45.

Extending the CD4(+) T-cell epitope specificity of the Th1 immune response to an antigen using a Salmonella enterica serovar typhimurium delivery vehicle.

Lo-Man R, Langeveld JP, Dériaud E, Jehanno M, Rojas M, Clément JM, Meloen RH, Hofnung M, Leclerc C.

Infect Immun. 2000 Jun;68(6):3079-89.

46.
47.

The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.

Schroeijers AB, Siva AC, Scheffer GL, de Jong MC, Bolick SC, Dukers DF, Slootstra JW, Meloen RH, Wiemer E, Kickhoefer VA, Rome LH, Scheper RJ.

Cancer Res. 2000 Feb 15;60(4):1104-10.

49.

Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.

Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH.

Eur J Pharmacol. 1999 Aug 13;378(3):249-58.

PMID:
10493100
50.

Naturally occurring mutations within 39 amino acids in the envelope glycoprotein of maedi-visna virus alter the neutralization phenotype.

Skraban R, Matthíasdóttir S, Torsteinsdóttir S, Agnarsdóttir G, Gudmundsson B, Georgsson G, Meloen RH, Andrésson OS, Staskus KA, Thormar H, Andrésdóttir V.

J Virol. 1999 Oct;73(10):8064-72.

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