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A chromosome-scale draft sequence of the Canada fleabane genome.

Laforest M, Martin SL, Bisaillon K, Soufiane B, Meloche S, Page E.

Pest Manag Sci. 2020 Jan 17. doi: 10.1002/ps.5753. [Epub ahead of print]


Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.

Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S.

Mol Cell Biol. 2019 Mar 1;39(6). pii: e00527-18. doi: 10.1128/MCB.00527-18. Print 2019 Mar 15.


A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.

Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer T.

PLoS One. 2018 Oct 19;13(10):e0205585. doi: 10.1371/journal.pone.0205585. eCollection 2018.


Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.

Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00295-17. doi: 10.1128/MCB.00295-17. Print 2017 Dec 15.


Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD.

Bioconjug Chem. 2017 Jun 21;28(6):1677-1683. doi: 10.1021/acs.bioconjchem.7b00152. Epub 2017 May 12.


Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.

Mathien S, Déléris P, Soulez M, Voisin L, Meloche S.

Mol Cell Biol. 2017 Apr 14;37(9). pii: e00432-16. doi: 10.1128/MCB.00432-16. Print 2017 May 1.


Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.

Saba-El-Leil MK, Frémin C, Meloche S.

Methods Mol Biol. 2017;1487:243-253.


ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.

Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S.

Oncogene. 2016 Oct 27;35(43):5692-5698. doi: 10.1038/onc.2016.122. Epub 2016 Apr 18.


Redundancy in the World of MAP Kinases: All for One.

Saba-El-Leil MK, Frémin C, Meloche S.

Front Cell Dev Biol. 2016 Jun 27;4:67. doi: 10.3389/fcell.2016.00067. eCollection 2016. Review.


Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.

Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S.

Cell Cycle. 2016 Jun 17;15(12):1631-42. doi: 10.1080/15384101.2016.1183851. Epub 2016 May 6.


Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.

Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard K.

Am J Obstet Gynecol. 2016 Sep;215(3):384.e1-384.e89. doi: 10.1016/j.ajog.2016.04.043. Epub 2016 Apr 30.


Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G.

Blood. 2016 Jun 16;127(24):3054-61. doi: 10.1182/blood-2016-03-705053. Epub 2016 Mar 31.


The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G.

Nat Genet. 2015 Sep;47(9):1030-7. doi: 10.1038/ng.3371. Epub 2015 Aug 3.


Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.

Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche S.

Cell Rep. 2015 Aug 11;12(6):913-21. doi: 10.1016/j.celrep.2015.07.011. Epub 2015 Jul 30.


E4F1 is a master regulator of CHK1-mediated functions.

Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G.

Cell Rep. 2015 Apr 14;11(2):210-9. doi: 10.1016/j.celrep.2015.03.019. Epub 2015 Apr 2.


The atypical MAPK ERK3 controls positive selection of thymocytes.

Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N.

Immunology. 2015 May;145(1):161-9. doi: 10.1111/imm.12433.


UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.

Blood. 2014 Oct 9;124(15):2362-9. doi: 10.1182/blood-2014-01-548651. Epub 2014 Sep 2.


Towards the development of chromone-based MEK1/2 modulators.

Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M.

Eur J Med Chem. 2014 Oct 6;85:127-38. doi: 10.1016/j.ejmech.2014.07.018. Epub 2014 Jul 7.


The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.

Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N.

Mol Cell Biol. 2014 Sep 15;34(18):3374-87. doi: 10.1128/MCB.01701-13. Epub 2014 Jul 7.


Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.

Cuevas Guaman M, Sbrana E, Shope C, Showalter L, Hu M, Meloche S, Aagaard K.

Pediatr Res. 2014 Jul;76(1):24-32. doi: 10.1038/pr.2014.54. Epub 2014 Apr 14.


The non-classical MAP kinase ERK3 controls T cell activation.

Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N.

PLoS One. 2014 Jan 27;9(1):e86681. doi: 10.1371/journal.pone.0086681. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e104727.


ERKs in cancer: friends or foes?

Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G.

Cancer Res. 2014 Jan 15;74(2):412-9. doi: 10.1158/0008-5472.CAN-13-2381. Epub 2014 Jan 9. Review.


Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.

Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P.

Mol Syst Biol. 2013 May 28;9:669. doi: 10.1038/msb.2013.25.


Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J.

Blood. 2013 Jun 27;121(26):5203-7. doi: 10.1182/blood-2012-12-475863. Epub 2013 May 17.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.

Trost M, Sauvageau M, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P.

Blood. 2012 Aug 23;120(8):e17-27. doi: 10.1182/blood-2011-12-397844. Epub 2012 Jul 16.


RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.

Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP.

Oncogene. 2013 Jun 13;32(24):2917-2926. doi: 10.1038/onc.2012.312. Epub 2012 Jul 16.


Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.

van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ.

PLoS Pathog. 2012;8(7):e1002747. doi: 10.1371/journal.ppat.1002747. Epub 2012 Jul 5.


F-box proteins elongate translation during stress recovery.

Meloche S, Roux PP.

Sci Signal. 2012 Jun 5;5(227):pe25. doi: 10.1126/scisignal.2003163.


The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.

Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A.

Mol Cell Biol. 2012 Jul;32(13):2467-78. doi: 10.1128/MCB.06633-11. Epub 2012 Apr 16.


Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.

Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S.

Cancer Res. 2012 Feb 1;72(3):626-35. doi: 10.1158/0008-5472.CAN-11-2126.


Liver fibrosis protects mice from acute hepatocellular injury.

Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M.

Gastroenterology. 2012 Jan;142(1):130-139.e4. doi: 10.1053/j.gastro.2011.09.033. Epub 2011 Sep 21.


An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.

Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16.


ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.

Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P.

Proteomics. 2011 Jul;11(13):2654-71. doi: 10.1002/pmic.201000776. Epub 2011 May 31.


Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S.

J Biol Chem. 2011 Feb 25;286(8):6470-8. doi: 10.1074/jbc.M110.181529. Epub 2010 Dec 22.


Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.

Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD.

Circ Res. 2011 Jan 21;108(2):176-83. doi: 10.1161/CIRCRESAHA.110.231514. Epub 2010 Dec 2.


A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.

Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P.

Mol Cell Proteomics. 2011 Feb;10(2):M110.004796. doi: 10.1074/mcp.M110.004796. Epub 2010 Nov 22.


Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.

Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S.

Mol Cell Biol. 2010 Dec;30(24):5752-63. doi: 10.1128/MCB.01147-10. Epub 2010 Oct 18.


Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.

Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S.

Mol Cell Biol. 2010 Jun;30(12):2918-32. doi: 10.1128/MCB.00131-10. Epub 2010 Apr 5.


C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.

Tanguay PL, Rodier G, Meloche S.

Biochem J. 2010 Apr 28;428(1):103-11. doi: 10.1042/BJ20091604.


Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.

Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S.

Cell Cycle. 2010 Mar 1;9(5):975-9. Epub 2010 Mar 9.


From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.

Frémin C, Meloche S.

J Hematol Oncol. 2010 Feb 11;3:8. doi: 10.1186/1756-8722-3-8. Review.


Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.

Klinger S, Turgeon B, Lévesque K, Wood GA, Aagaard-Tillery KM, Meloche S.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16710-5. doi: 10.1073/pnas.0900919106. Epub 2009 Sep 15.


[Cdc14B/Skp2/p27 : a novel cancer axis of evil?].

Coulombe P, Rodier G, Meloche S.

Med Sci (Paris). 2009 Aug-Sep;25(8-9):673-5. doi: 10.1051/medsci/2009258-9673. French. No abstract available.


Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant.

White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin L.

Ann Pharmacother. 2009 May;43(5):831-9. doi: 10.1345/aph.1L602.


ER stress affects processing of MHC class I-associated peptides.

Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C.

BMC Immunol. 2009 Feb 16;10:10. doi: 10.1186/1471-2172-10-10.


The IKK-related kinases: from innate immunity to oncogenesis.

Clément JF, Meloche S, Servant MJ.

Cell Res. 2008 Sep;18(9):889-99. doi: 10.1038/cr.2008.273. Review.


Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.

Turgeon B, Meloche S.

Physiol Rev. 2009 Jan;89(1):1-26. doi: 10.1152/physrev.00040.2007. Review.


Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.

Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M, Meloche S.

BMC Cancer. 2008 Nov 17;8:337. doi: 10.1186/1471-2407-8-337.


Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites.

Gharib M, Marcantonio M, Lehmann SG, Courcelles M, Meloche S, Verreault A, Thibault P.

Mol Cell Proteomics. 2009 Mar;8(3):506-18. doi: 10.1074/mcp.M800327-MCP200. Epub 2008 Oct 20.

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