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Convergent gain and loss of genomic islands drive lifestyle changes in plant-associated Pseudomonas.

Melnyk RA, Hossain SS, Haney CH.

ISME J. 2019 Feb 20. doi: 10.1038/s41396-019-0372-5. [Epub ahead of print]


Dismantling a Toxin to Disarm a Superbug.

Icho S, Melnyk RA.

Trends Pharmacol Sci. 2019 Mar;40(3):155-156. doi: 10.1016/ Epub 2019 Jan 23.


Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota.

Tam J, Hamza T, Ma B, Chen K, Beilhartz GL, Ravel J, Feng H, Melnyk RA.

Nat Commun. 2018 Dec 7;9(1):5233. doi: 10.1038/s41467-018-07705-w.


A Genome-Wide Screen Identifies Genes in Rhizosphere-Associated Pseudomonas Required to Evade Plant Defenses.

Liu Z, Beskrovnaya P, Melnyk RA, Hossain SS, Khorasani S, O'Sullivan LR, Wiesmann CL, Bush J, Richard JD, Haney CH.

MBio. 2018 Nov 6;9(6). pii: e00433-18. doi: 10.1128/mBio.00433-18.


Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.

Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA.

Mol Pharm. 2018 Nov 5;15(11):5217-5226. doi: 10.1021/acs.molpharmaceut.8b00735. Epub 2018 Sep 26.


Identification of a diphtheria toxin-like gene family beyond the Corynebacterium genus.

Mansfield MJ, Sugiman-Marangos SN, Melnyk RA, Doxey AC.

FEBS Lett. 2018 Aug;592(16):2693-2705. doi: 10.1002/1873-3468.13208. Epub 2018 Aug 16.


Direct Detection of Membrane-Inserting Fragments Defines the Translocation Pores of a Family of Pathogenic Toxins.

Orrell KE, Tellgren-Roth Å, Di Bernardo M, Zhang Z, Cuviello F, Lundqvist J, von Heijne G, Nilsson I, Melnyk RA.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3190-3199. doi: 10.1016/j.jmb.2018.07.001. Epub 2018 Jul 7.


Mutant phenotypes for thousands of bacterial genes of unknown function.

Price MN, Wetmore KM, Waters RJ, Callaghan M, Ray J, Liu H, Kuehl JV, Melnyk RA, Lamson JS, Suh Y, Carlson HK, Esquivel Z, Sadeeshkumar H, Chakraborty R, Zane GM, Rubin BE, Wall JD, Visel A, Bristow J, Blow MJ, Arkin AP, Deutschbauer AM.

Nature. 2018 May;557(7706):503-509. doi: 10.1038/s41586-018-0124-0. Epub 2018 May 16.


Functional Redundancy in Perchlorate and Nitrate Electron Transport Chains and Rewiring Respiratory Pathways to Alter Terminal Electron Acceptor Preference.

Wang O, Melnyk RA, Mehta-Kolte MG, Youngblut MD, Carlson HK, Coates JD.

Front Microbiol. 2018 Mar 6;9:376. doi: 10.3389/fmicb.2018.00376. eCollection 2018.


Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics.

Price MN, Zane GM, Kuehl JV, Melnyk RA, Wall JD, Deutschbauer AM, Arkin AP.

PLoS Genet. 2018 Jan 11;14(1):e1007147. doi: 10.1371/journal.pgen.1007147. eCollection 2018 Jan.


Bacterial genomics of plant adaptation.

Melnyk RA, Haney CH.

Nat Genet. 2018 Jan;50(1):2-4. doi: 10.1038/s41588-017-0019-2. No abstract available.


Plasmid-powered evolutionary transitions.

Melnyk RA, Haney CH.

Elife. 2017 Dec 12;6. pii: e33383. doi: 10.7554/eLife.33383.


A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.


Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens.

Haney CH, Wiesmann CL, Shapiro LR, Melnyk RA, O'Sullivan LR, Khorasani S, Xiao L, Han J, Bush J, Carrillo J, Pierce NE, Ausubel FM.

Mol Ecol. 2018 Apr;27(8):1833-1847. doi: 10.1111/mec.14400. Epub 2017 Nov 23.


Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors.

Lai MT, Tawa P, Auger A, Wang D, Su HP, Yan Y, Hazuda DJ, Miller MD, Asante-Appiah E, Melnyk RA.

J Antimicrob Chemother. 2018 Jan 1;73(1):109-117. doi: 10.1093/jac/dkx332.


Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA.

J Biol Chem. 2017 Oct 20;292(42):17290-17301. doi: 10.1074/jbc.M117.806687. Epub 2017 Aug 23.


Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.

Orrell KE, Zhang Z, Sugiman-Marangos SN, Melnyk RA.

Crit Rev Biochem Mol Biol. 2017 Aug;52(4):461-473. doi: 10.1080/10409238.2017.1325831. Epub 2017 May 26. Review.


Repurposing bacterial toxins for intracellular delivery of therapeutic proteins.

Beilhartz GL, Sugiman-Marangos SN, Melnyk RA.

Biochem Pharmacol. 2017 Oct 15;142:13-20. doi: 10.1016/j.bcp.2017.04.009. Epub 2017 Apr 10. Review.


Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Beilhartz GL, Tam J, Zhang Z, Melnyk RA.

Sci Transl Med. 2016 Dec 21;8(370):370tc2. doi: 10.1126/scitranslmed.aad8926.


Crystal structure of Clostridium difficile toxin A.

Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB.

Nat Microbiol. 2016 Jan 11;1:15002. doi: 10.1038/nmicrobiol.2015.2.


Crystal structure of Clostridium difficile toxin A.

Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB.

Nat Microbiol. 2016;1. pii: 15002. Epub 2016 Jan 11.


Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms.

Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL.

Sci Adv. 2016 May 20;2(5):e1501632. doi: 10.1126/sciadv.1501632. eCollection 2016 May.


MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria.

Hershey DM, Ren X, Melnyk RA, Browne PJ, Ozyamak E, Jones SR, Chang MC, Hurley JH, Komeili A.

PLoS Biol. 2016 Mar 16;14(3):e1002402. doi: 10.1371/journal.pbio.1002402. eCollection 2016 Mar.


Small Molecules Take A Big Step Against Clostridium difficile.

Beilhartz GL, Tam J, Melnyk RA.

Trends Microbiol. 2015 Dec;23(12):746-748. doi: 10.1016/j.tim.2015.10.009. Epub 2015 Nov 5.


Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.

Hamza T, Zhang Z, Melnyk RA, Feng H.

Pathog Dis. 2016 Feb;74(1):ftv098. doi: 10.1093/femspd/ftv098. Epub 2015 Oct 26.


The Perchlorate Reduction Genomic Island: Mechanisms and Pathways of Evolution by Horizontal Gene Transfer.

Melnyk RA, Coates JD.

BMC Genomics. 2015 Oct 26;16:862. doi: 10.1186/s12864-015-2011-5.


Efficient Delivery of Structurally Diverse Protein Cargo into Mammalian Cells by a Bacterial Toxin.

Auger A, Park M, Nitschke F, Minassian LM, Beilhartz GL, Minassian BA, Melnyk RA.

Mol Pharm. 2015 Aug 3;12(8):2962-71. doi: 10.1021/acs.molpharmaceut.5b00233. Epub 2015 Jul 2.


Synthetic and Evolutionary Construction of a Chlorate-Reducing Shewanella oneidensis MR-1.

Clark IC, Melnyk RA, Youngblut MD, Carlson HK, Iavarone AT, Coates JD.

MBio. 2015 May 19;6(3):e00282-15. doi: 10.1128/mBio.00282-15.


Molybdenum Availability Is Key to Nitrate Removal in Contaminated Groundwater Environments.

Thorgersen MP, Lancaster WA, Vaccaro BJ, Poole FL, Rocha AM, Mehlhorn T, Pettenato A, Ray J, Waters RJ, Melnyk RA, Chakraborty R, Hazen TC, Deutschbauer AM, Arkin AP, Adams MW.

Appl Environ Microbiol. 2015 Aug;81(15):4976-83. doi: 10.1128/AEM.00917-15. Epub 2015 May 15.


Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich Peptide and methionine sulfoxide reductase.

Melnyk RA, Youngblut MD, Clark IC, Carlson HK, Wetmore KM, Price MN, Iavarone AT, Deutschbauer AM, Arkin AP, Coates JD.

MBio. 2015 May 12;6(3):e00233-15. doi: 10.1128/mBio.00233-15.


Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.

Tam J, Beilhartz GL, Auger A, Gupta P, Therien AG, Melnyk RA.

Chem Biol. 2015 Feb 19;22(2):175-85. doi: 10.1016/j.chembiol.2014.12.010. Epub 2015 Jan 22.


Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.

Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, Lavoie R, Li L, Auger A, Melnyk RA, Grobler JA, Miller MD, Hazuda DJ, Hecht SM, Götte M.

J Biol Chem. 2015 Jan 16;290(3):1474-84. doi: 10.1074/jbc.M114.614305. Epub 2014 Oct 29.


Chlorate reduction in Shewanella algae ACDC is a recently acquired metabolism characterized by gene loss, suboptimal regulation and oxidative stress.

Clark IC, Melnyk RA, Iavarone AT, Novichkov PS, Coates JD.

Mol Microbiol. 2014 Oct;94(1):107-25. doi: 10.1111/mmi.12746. Epub 2014 Sep 5.


Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.

Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3721-6. doi: 10.1073/pnas.1400680111. Epub 2014 Feb 24.


Transposon and deletion mutagenesis of genes involved in perchlorate reduction in Azospira suillum PS.

Melnyk RA, Clark IC, Liao A, Coates JD.

MBio. 2013 Dec 31;5(1):e00769-13. doi: 10.1128/mBio.00769-13.


Structure and evolution of chlorate reduction composite transposons.

Clark IC, Melnyk RA, Engelbrektson A, Coates JD.

MBio. 2013 Aug 6;4(4). pii: e00379-13. doi: 10.1128/mBio.00379-13.


Physiological and genetic description of dissimilatory perchlorate reduction by the novel marine bacterium Arcobacter sp. strain CAB.

Carlström CI, Wang O, Melnyk RA, Bauer S, Lee J, Engelbrektson A, Coates JD.

MBio. 2013 May 21;4(3):e00217-13. doi: 10.1128/mBio.00217-13.


Toward a mechanistic understanding of anaerobic nitrate-dependent iron oxidation: balancing electron uptake and detoxification.

Carlson HK, Clark IC, Melnyk RA, Coates JD.

Front Microbiol. 2012 Feb 20;3:57. doi: 10.3389/fmicb.2012.00057. eCollection 2012.


Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram-positive bacteria.

Carlson HK, Iavarone AT, Gorur A, Yeo BS, Tran R, Melnyk RA, Mathies RA, Auer M, Coates JD.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1702-7. doi: 10.1073/pnas.1112905109. Epub 2012 Jan 17.


Evidence for direct electron transfer by a gram-positive bacterium isolated from a microbial fuel cell.

Wrighton KC, Thrash JC, Melnyk RA, Bigi JP, Byrne-Bailey KG, Remis JP, Schichnes D, Auer M, Chang CJ, Coates JD.

Appl Environ Microbiol. 2011 Nov;77(21):7633-9. doi: 10.1128/AEM.05365-11. Epub 2011 Sep 9.


Identification of a perchlorate reduction genomic island with novel regulatory and metabolic genes.

Melnyk RA, Engelbrektson A, Clark IC, Carlson HK, Byrne-Bailey K, Coates JD.

Appl Environ Microbiol. 2011 Oct;77(20):7401-4. doi: 10.1128/AEM.05758-11. Epub 2011 Aug 19.


Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.

Auger A, Beilhartz GL, Zhu S, Cauchon E, Falgueyret JP, Grobler JA, Ehteshami M, Götte M, Melnyk RA.

J Biol Chem. 2011 Aug 26;286(34):29575-83. doi: 10.1074/jbc.M111.268235. Epub 2011 Jul 7.


A high-throughput continuous assay for screening and characterization of inhibitors of HIV reverse-transcriptase DNA polymerase activity.

Cauchon E, Falgueyret JP, Auger A, Melnyk RA.

J Biomol Screen. 2011 Jun;16(5):518-24. doi: 10.1177/1087057111402201. Epub 2011 Apr 7.


An activity-based probe for high-throughput measurements of triacylglycerol lipases.

Tam J, Henault M, Li L, Wang Z, Partridge AW, Melnyk RA.

Anal Biochem. 2011 Jul 15;414(2):254-60. doi: 10.1016/j.ab.2011.03.008. Epub 2011 Mar 11.


Complete genome sequence of the electricity-producing "Thermincola potens" strain JR.

Byrne-Bailey KG, Wrighton KC, Melnyk RA, Agbo P, Hazen TC, Coates JD.

J Bacteriol. 2010 Aug;192(15):4078-9. doi: 10.1128/JB.00044-10. Epub 2010 Jun 4.


Renin and prorenin activate pathways implicated in organ damage in human mesangial cells independent of angiotensin II production.

Melnyk RA, Tam J, Boie Y, Kennedy BP, Percival MD.

Am J Nephrol. 2009;30(3):232-43. doi: 10.1159/000220260. Epub 2009 May 19.


Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.

Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A.

BMC Neurosci. 2008 Jan 30;9:17. doi: 10.1186/1471-2202-9-17.


Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation.

Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG.

Biochemistry. 2007 Dec 25;46(51):14928-36. Epub 2007 Nov 29.


Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin.

Juris SJ, Melnyk RA, Bolcome RE 3rd, Chan J, Collier RJ.

Infect Immun. 2007 Oct;75(10):5052-8. Epub 2007 Jul 16.


Lipid solvation effects contribute to the affinity of Gly-xxx-Gly motif-mediated helix-helix interactions.

Johnson RM, Rath A, Melnyk RA, Deber CM.

Biochemistry. 2006 Jul 18;45(28):8507-15.


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